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  1. Article ; Online: Isoeugenol affects expression pattern of conidial hydrophobin gene RodA and transcriptional regulators MedA and SomA responsible for adherence and biofilm formation in Aspergillus fumigatus.

    Gupta, Lovely / Sen, Pooja / Bhattacharya, Asish K / Vijayaraghavan, Pooja

    Archives of microbiology

    2022  Volume 204, Issue 4, Page(s) 214

    Abstract: ... for hydrophobins (RodA), adhesion as well as biofilm formation (MedA and SomA) of A. fumigatus ...

    Abstract Aspergillus fumigatus is one of the major pathogenic fungal species, causing life-threatening infections. Due to a limited spectrum of available antifungals, exploration of new drug targets as well as potential antifungal molecules has become pertinent. Rodlet layer plays an important role in adherence of fungal conidia to hydrophobic cell surfaces in host, which also leads to A. fumigatus biofilm formation, contributing factor to fungal pathogenicity. From decades, natural sources have been known for the development of new active molecules. The present study investigates effect of isoeugenol on genes responsible for hydrophobins (RodA), adhesion as well as biofilm formation (MedA and SomA) of A. fumigatus. Minimum inhibitory concentrations (MIC and IC
    MeSH term(s) Aspergillus fumigatus/genetics ; Biofilms ; Eugenol/analogs & derivatives ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Spores, Fungal/genetics ; Spores, Fungal/metabolism
    Chemical Substances Fungal Proteins ; Eugenol (3T8H1794QW) ; isoeugenol (5M0MWY797U)
    Language English
    Publishing date 2022-03-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-022-02817-w
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  2. Article: Isoeugenol affects expression pattern of conidial hydrophobin gene RodA and transcriptional regulators MedA and SomA responsible for adherence and biofilm formation in Aspergillus fumigatus

    Gupta, Lovely / Sen, Pooja / Bhattacharya, Asish K. / Vijayaraghavan, Pooja

    Archives of microbiology. 2022 Apr., v. 204, no. 4

    2022  

    Abstract: ... for hydrophobins (RodA), adhesion as well as biofilm formation (MedA and SomA) of A. fumigatus ... downregulation of genes RodA, MedA, SomA and pksP involved in hydrophobicity and biofilm formation. SwissADME ...

    Abstract Aspergillus fumigatus is one of the major pathogenic fungal species, causing life-threatening infections. Due to a limited spectrum of available antifungals, exploration of new drug targets as well as potential antifungal molecules has become pertinent. Rodlet layer plays an important role in adherence of fungal conidia to hydrophobic cell surfaces in host, which also leads to A. fumigatus biofilm formation, contributing factor to fungal pathogenicity. From decades, natural sources have been known for the development of new active molecules. The present study investigates effect of isoeugenol on genes responsible for hydrophobins (RodA), adhesion as well as biofilm formation (MedA and SomA) of A. fumigatus. Minimum inhibitory concentrations (MIC and IC₅₀) of isoeugenol against A. fumigatus were determined using broth microdilution assay. The IC₅₀ results showed reduced hydrophobicity and biofilm formation as well as eradication after treatment with the compound and electron micrograph data corroborated these findings. The qRT-PCR showed a significant downregulation of genes RodA, MedA, SomA and pksP involved in hydrophobicity and biofilm formation. SwissADME studies potentiated drug-like propensity for isoeugenol which formed four hydrogen bonds with low binding energy (− 4.54 kcal/mol) at the catalytic site of RodA protein studied via AutoDock4. Hence, the findings conclude that isoeugenol inhibits conidial hydrophobicity and biofilm formation of A. fumigatus and further investigations are warranted in this direction.
    Keywords Aspergillus fumigatus ; active sites ; adhesion ; antifungal agents ; biofilm ; conidia ; energy ; eugenol ; fungi ; genes ; hydrogen ; hydrophobicity ; hydrophobins ; minimum inhibitory concentration ; pathogenicity ; transcription (genetics)
    Language English
    Dates of publication 2022-04
    Size p. 214.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-022-02817-w
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  3. Article ; Online: Diurnal cycle of summer season thunderstorm activity in India

    Sharma, Pradeep / Sen, Bikram / Balling, Robert C., Jr / Roy, Shouraseni Sen / Sen Roy, Soma

    Theor Appl Climatol. 2023 Feb., v. 151, no. 3-4 p.1567-1583

    2023  

    Abstract: The diurnal cycle of tropical convection over the Indian region has been analysed in this study for the period of March to June from the thunderstorm reports of ground-based observatories throughout India during 2016–2020. The analyses indicate that ... ...

    Abstract The diurnal cycle of tropical convection over the Indian region has been analysed in this study for the period of March to June from the thunderstorm reports of ground-based observatories throughout India during 2016–2020. The analyses indicate that during this period of the year, when the land progressively heats up diurnally, under conditions of deficient moisture, synoptic systems interact with the semi-permanent features of the atmosphere over the region to define areas of moisture and wind convergence, which in turn determine the frequency and diurnal cycle of thunderstorm activity. While the easterly and westerly waves are the major synoptic scale weather systems that affect the Indian region during March to May, the atmospheric changes are associated with the onset of the monsoon season in June. Amongst the semi-permanent features, the gradual intensification and migration of the shallow heat low to northwest India during May and June reinforce the western disturbances over this region, thereby intensifying the thunderstorm activity during the afternoon to evening hours over the western Himalayas and northwest Indian region. The role of the low-level anticyclones over the Arabian Sea and the Bay of Bengal is seen in the east–west-oriented moisture gradient across the Indian subcontinent which makes the east Indian subcontinent generally more prone to thunderstorm activity during this season. The east–west-oriented discontinuity line across north India is particularly intense during the morning hours along the foothills of the Himalayas. Its location directs moisture from the Bay of Bengal into the Himalayas causing early initiation of thunderstorm activity over the Himalayas. The discontinuity line moves southwards to the north Indian plains later in the day, although the western end becomes less marked. The north–south-oriented discontinuity line across the Indian subcontinent between the two anticyclones intensifies during the afternoon hours due to land heating and combines with the east–west wind discontinuity to become a T-shaped maximum convergence zone for thunderstorm activity during the afternoon hours over the Indian region, which intensifies as the months progress. With the onset of the southwest monsoon over the south peninsula and east Indian regions in June, the change in wind pattern from an easterly to a southwesterly flow regime over the south peninsula is reflected in an abrupt shift of the afternoon maximum of thunderstorm activity over the inland regions of the south peninsula to an early morning maximum over the southwest peninsular coast. Simultaneously, with the weakening of the anticyclone over the north Bay of Bengal and gradual strengthening of the southerly moisture flow into east and northeast India, there was in-phase increase in thunderstorm activity during the afternoon hours over the plains of east-central India, east India, and adjoining southern parts of northeast India during June. The diurnal pattern of tropical convection significantly affects human lives over the Indian subcontinent.
    Keywords coasts ; convection ; diurnal variation ; humans ; monsoon season ; storms ; summer ; wind ; Arabian Sea ; Bay of Bengal ; Himalayan region ; India
    Language English
    Dates of publication 2023-02
    Size p. 1567-1583.
    Publishing place Springer Vienna
    Document type Article ; Online
    ZDB-ID 1463177-5
    ISSN 1434-4483 ; 0177-798X
    ISSN (online) 1434-4483
    ISSN 0177-798X
    DOI 10.1007/s00704-022-04339-3
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  4. Article ; Online: A study on cancer awareness among people attending a tertiary level care hospital in West Bengal

    Debjani Sen Gupta / Soma Chakrabarty / Swati Majumdar / Subhadip Dutta / Spandan Mandal

    Asian Journal of Medical Sciences, Vol 14, Iss 3, Pp 136-

    2023  Volume 140

    Abstract: Background: A cross-sectional observational study conducted in the outpatient registration counter among people seeking registration ticket in a government Medical College. Sample size was 214 with equal representation of each sex. Aims and Objectives: ( ... ...

    Abstract Background: A cross-sectional observational study conducted in the outpatient registration counter among people seeking registration ticket in a government Medical College. Sample size was 214 with equal representation of each sex. Aims and Objectives: (1) The study’s aims at assessing the knowledge quotient about the occurrence, site presenting symptoms risk factors and outcome of various cancers. (2) Sex specific cancer screening program self-breast examination, mammography, pap smear awareness, and usage among females of study population have been investigated. Materials and Methods: A cross-sectional observational study. Predesigned pretested questionnaire was administered to consenting participants among those registering for outpatient tickets at Calcutta National Medical college Hospital. Statistical analysis Used: Descriptive statistics was used with MS Excel. Results: Awareness was 69.8% with 69% stating gastrointestinal tract to be the most common site, Of the population 70% stated pain was to be the most common presenting symptom, tobacco was said to be the most common causative agent by 72% and 70% stated it to be non-treatable. Among sex specific cancers 40% women identified breast as site of cancer presenting with nipple discharge and 34% stated the presenting feature to be lump. Screening method of self-breast examination and PAP smear was said by 5% and 2%, respectively. Conclusion: The awareness regarding site cardinal signs outcome and risk factors was not good among study population. Much effort is to be given to address the state of things.
    Keywords cancer awareness ; men and women ; sign symptoms treatment ; Medicine ; R
    Subject code 300
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Within a large healthcare system, the incidence of positive COVID-19 results and mortality are lower in patients on chronic hydroxychloroquine therapy.

    Sen, Soma / Werner, Ann / Shekhar, Aditya

    Drugs & therapy perspectives : for rational drug selection and use

    2020  Volume 36, Issue 7, Page(s) 298–299

    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1197107-1
    ISSN 1179-1977 ; 1172-0360
    ISSN (online) 1179-1977
    ISSN 1172-0360
    DOI 10.1007/s40267-020-00741-x
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: An ecological framework for understanding HIV- and AIDS-related stigma among Asian American and Pacific Islander men who have sex with men living in the USA.

    Sen, Soma / Aguilar, Jemel P / Petty, Mac

    Culture, health & sexuality

    2020  Volume 23, Issue 1, Page(s) 85–97

    Abstract: Despite the fact that HIV- and AIDS-related stigma is consistently identified as an impediment to HIV prevention, a multilevel conceptualisation of HIV- and AIDS-related stigma continues to be poorly understood. The role of multilevel HIV- and AIDS- ... ...

    Abstract Despite the fact that HIV- and AIDS-related stigma is consistently identified as an impediment to HIV prevention, a multilevel conceptualisation of HIV- and AIDS-related stigma continues to be poorly understood. The role of multilevel HIV- and AIDS-related stigma in the HIV prevention and intervention behaviours of Asian American and Pacific Islander who have sex with men in the USA is particularly overlooked. Psychology has contributed significantly to the identification of individual or interpersonal level factors influencing HIV- and AIDS-related stigma, while sociology has contributed to a more societal perspective. This dichotomy has led to the absence of a multilevel conceptual framework for analysing the HIV- or AIDS-related stigma experienced by Asian American and Pacific Islander who have sex with men in the USA. In this paper, we argue for need to develop such a model which is culturally grounded and bridges the individual, interpersonal and societal conceptualisations of stigma prominent in the social science literature. To that end, we use Bronfenbrenner's ecological systems theory to explore the manifestation of HIV stigma at the micro, meso and macro levels and how these might impact on HIV testing and HIV service utilisation among Asian American and Pacific Islander men who have sex with men. We conclude by identifying some practice and research implications.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; Asian Americans ; HIV Infections ; Homosexuality, Male ; Humans ; Male ; Sexual and Gender Minorities ; United States
    Language English
    Publishing date 2020-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023577-X
    ISSN 1464-5351 ; 1369-1058
    ISSN (online) 1464-5351
    ISSN 1369-1058
    DOI 10.1080/13691058.2019.1690164
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  7. Article: Biofilm Producing

    Sengupta, Mallika / Sarkar, Soma / SenGupta, Manideepa / Ghosh, Sougata / Sarkar, Riya / Banerjee, Parthajit

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Background: Enterococcus: Methods: A prospective study was done in Medical College, Kolkata for a period of 2 years (from January 2018 to December 2019). After obtaining clearance from the Institutional Ethics Committee, : Results: During the ... ...

    Abstract Background: Enterococcus
    Methods: A prospective study was done in Medical College, Kolkata for a period of 2 years (from January 2018 to December 2019). After obtaining clearance from the Institutional Ethics Committee,
    Results: During the period of 2 years, 39 isolates of
    Conclusion: Biofilm production is an important virulence factor in
    Language English
    Publishing date 2021-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10091082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Within a large healthcare system, the incidence of positive COVID-19 results and mortality are lower in patients on chronic hydroxychloroquine therapy

    Sen, Soma / Werner, Ann / Shekhar, Aditya

    Drugs Ther Perspect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #324240
    Database COVID19

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  9. Article ; Online: Within a large healthcare system, the incidence of positive COVID-19 results and mortality are lower in patients on chronic hydroxychloroquine therapy

    Sen, Soma / Werner, Ann / Shekhar, Aditya

    Drugs & Therapy Perspectives

    2020  Volume 36, Issue 7, Page(s) 298–299

    Keywords Pharmacology (medical) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1197107-1
    ISSN 1179-1977 ; 1172-0360
    ISSN (online) 1179-1977
    ISSN 1172-0360
    DOI 10.1007/s40267-020-00741-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: HIV/AIDS and migration in sub-Saharan Africa

    Sen, Soma / Aguilar, Jemel P

    Migrant workers : social identity, occupational challenges and health practices , p. 61-75

    2016  , Page(s) 61–75

    Author's details Soma Sen and Jemel P. Aguilar
    Language English
    Publisher Nova Publishers
    Publishing place New York
    Document type Article
    ISBN 978-1-63485-272-2 ; 1-63485-272-9
    Database ECONomics Information System

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