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  1. Book ; Online: Advances in Molecular Genetics of Brain Tumors

    Pećina-Šlaus, Nives / Pećina-Šlaus, Nives / Jovčevska, Ivana

    2023  

    Keywords Research & information: general ; Biology, life sciences ; Genetics (non-medical) ; Medicine ; Pharmacology ; DVL1 ; PDZ domain ; β-catenin ; Wnt signaling pathway ; intracranial meningioma ; microglia ; glioblastoma ; olfactomedin-like 3 ; TGFβ ; Glioblastoma ; Doublecortin ; DCX ; OLIG2 ; NES ; single cell RNA-seq ; immunohistochemistry ; immunofluorescence ; brain tumours ; brain tumor ; GBM ; cancer stem cell ; BIRC3 ; BMP4 ; stemness ; pediatric glioblastoma ; temozolomide ; NKCC1 ; KCC2 ; EZH2 ; PCNA ; CAM ; cancer ; neurodegeneration ; glioma ; Drosophila ; disease model ; PI3K ; EGFR ; genetics ; schwannoma ; NF2 ; bevacizumab ; VEGF ; SH3PXD2A-HTRA1 fusion ; molecular targeted therapy ; IDH1 mutation ; redox household ; nicotinamide phosphoribosyltransferase ; NAD+ synthesis ; cancer metabolism ; pentose phosphate pathway ; cell proliferation ; miRNA ; hypoxia ; angiogenesis ; treatment-related changes ; true progression ; pseudoprogression ; radiation necrosis ; biomarkers ; 18F-FET PET ; IDH mutation ; functional precision oncology ; drug sensitivity ; prognostic biomarkers ; systematic review ; meta-analysis ; cancer pathway ; mRNA ; multicriterial analysis ; n/a
    Language English
    Size 1 electronic resource (242 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722341
    ISBN 9783036566450 ; 3036566457
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Glioma Stem Cells-Features for New Therapy Design.

    Pećina-Šlaus, Nives / Hrašćan, Reno

    Cancers

    2024  Volume 16, Issue 8

    Abstract: On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- ... ...

    Abstract On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cells that behave like stem cells and are known as glioma cancer stem cells (GCSCs). They are responsible for tumor plasticity and are influenced by genetic drivers. Additionally, GCSCs also display greater migratory abilities. A great effort is under way in order to find ways to eliminate or neutralize GCSCs. Many different treatment strategies are currently being explored, including modulation of the tumor microenvironment, posttranscriptional regulation, epigenetic modulation and immunotherapy.
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Different Approaches to Study Molecular Blueprint and Biological Behavior of Brain Tumors: Editorial to the Special Issue "Advances in Molecular Genetics of Brain Tumors".

    Pećina-Šlaus, Nives / Jovčevska, Ivana

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Cancer remains one of the leading causes of mortality worldwide [ ... ]. ...

    Abstract Cancer remains one of the leading causes of mortality worldwide [...].
    MeSH term(s) Humans ; Brain Neoplasms/genetics ; Molecular Biology
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24020948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment.

    Pećina-Šlaus, Nives / Aničić, Sara / Bukovac, Anja / Kafka, Anja

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points to the strategy of the ... ...

    Abstract In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points to the strategy of the inhibition of its activity that would impact the clinical outcomes and survival of patients. Because the Wnt pathway is often mutated or epigenetically altered in tumors, which promotes its activation, inhibitors of Wnt signaling are being intensively investigated. It has been shown that knocking down specific components of the Wnt pathway has inhibitory effects on tumor growth in vivo and in vitro. Thus, similar effects are expected from the application of Wnt inhibitors. In the last decades, molecules acting as inhibitors on the pathway's specific molecular levels have been identified and characterized. This review will discuss the inhibitors of the canonical Wnt pathway, summarize knowledge on their effectiveness as therapeutics, and debate their side effects. The role of the components frequently mutated in various tumors that are principal targets for Wnt inhibitors is also going to be brought to the reader's attention. Some of the molecules identified as Wnt pathway inhibitors have reached early stages of clinical trials, and some have only just been discovered. All things considered, inhibition of the Wnt signaling pathway shows potential for the development of future therapies.
    MeSH term(s) Humans ; Wnt Signaling Pathway ; Neoplasms/drug therapy ; beta Catenin/metabolism
    Chemical Substances beta Catenin
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetics in ophthalmology: molecular blueprints of retinoblastoma.

    Marković, Leon / Bukovac, Anja / Varošanec, Ana Maria / Šlaus, Nika / Pećina-Šlaus, Nives

    Human genomics

    2023  Volume 17, Issue 1, Page(s) 82

    Abstract: This review presents current knowledge on the molecular biology of retinoblastoma (RB). Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases of this ocular malignancy of the developing retina are diagnosed each year ... ...

    Abstract This review presents current knowledge on the molecular biology of retinoblastoma (RB). Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases of this ocular malignancy of the developing retina are diagnosed each year worldwide. The major gene responsible for retinoblastoma is RB1, and it harbors a large spectrum of pathogenic variants. Tumorigenesis begins with mutations that cause RB1 biallelic inactivation preventing the production of functional pRB proteins. Depending on the type of mutation the penetrance of RB is different. However, in small percent of tumors additional genes may be required, such as MYCN, BCOR and CREBBP. Additionally, epigenetic changes contribute to the progression of retinoblastoma as well. Besides its role in the cell cycle, pRB plays many additional roles, it regulates the nucleosome structure, participates in apoptosis, DNA replication, cellular senescence, differentiation, DNA repair and angiogenesis. Notably, pRB has an important role as a modulator of chromatin remodeling. In recent years high-throughput techniques are becoming essential for credible biomarker identification and patient management improvement. In spite of remarkable advances in retinoblastoma therapy, primarily in high-income countries, our understanding of retinoblastoma and its specific genetics still needs further clarification in order to predict the course of this disease and improve therapy. One such approach is the tumor free DNA that can be obtained from the anterior segment of the eye and be useful in diagnostics and prognostics.
    MeSH term(s) Humans ; Retinoblastoma/genetics ; Ophthalmology ; Retina ; Apoptosis ; Retinal Neoplasms/genetics
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2147618-4
    ISSN 1479-7364 ; 1479-7364
    ISSN (online) 1479-7364
    ISSN 1479-7364
    DOI 10.1186/s40246-023-00529-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment

    Nives Pećina-Šlaus / Sara Aničić / Anja Bukovac / Anja Kafka

    International Journal of Molecular Sciences, Vol 24, Iss 6733, p

    2023  Volume 6733

    Abstract: In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points to the strategy of the ... ...

    Abstract In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt signaling pathway has been recognized as a promising target. The altered functioning of the Wnt signaling in human tumors points to the strategy of the inhibition of its activity that would impact the clinical outcomes and survival of patients. Because the Wnt pathway is often mutated or epigenetically altered in tumors, which promotes its activation, inhibitors of Wnt signaling are being intensively investigated. It has been shown that knocking down specific components of the Wnt pathway has inhibitory effects on tumor growth in vivo and in vitro. Thus, similar effects are expected from the application of Wnt inhibitors. In the last decades, molecules acting as inhibitors on the pathway’s specific molecular levels have been identified and characterized. This review will discuss the inhibitors of the canonical Wnt pathway, summarize knowledge on their effectiveness as therapeutics, and debate their side effects. The role of the components frequently mutated in various tumors that are principal targets for Wnt inhibitors is also going to be brought to the reader’s attention. Some of the molecules identified as Wnt pathway inhibitors have reached early stages of clinical trials, and some have only just been discovered. All things considered, inhibition of the Wnt signaling pathway shows potential for the development of future therapies.
    Keywords Wnt signaling pathway ; β-catenin ; porcupine ; Wnt inhibitors ; mutations ; tumors ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain.

    Brlek, Petar / Kafka, Anja / Bukovac, Anja / Pećina-Šlaus, Nives

    Cancers

    2021  Volume 13, Issue 13

    Abstract: Diffuse gliomas are a heterogeneous group of tumors with aggressive biological behavior and a lack of effective treatment methods. Despite new molecular findings, the differences between pathohistological types still require better understanding. In this ...

    Abstract Diffuse gliomas are a heterogeneous group of tumors with aggressive biological behavior and a lack of effective treatment methods. Despite new molecular findings, the differences between pathohistological types still require better understanding. In this in silico analysis, we investigated
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13133247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bilateral Meningioma: A Case Report and Review of the Literature.

    Bukovac, Anja / Panić, Hana / Mrgan, Tomislava / Šlaus, Nika / Kafka, Anja / Njirić, Niko / Pećina-Šlaus, Nives

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Here, we present a rarely seen example of bilateral meningiomas exhibiting different malignancy grades, I (meningothelial) and II (atypical), recorded in a 72-year-old patient. The presence of two separated lesions of different grades in a single patient ...

    Abstract Here, we present a rarely seen example of bilateral meningiomas exhibiting different malignancy grades, I (meningothelial) and II (atypical), recorded in a 72-year-old patient. The presence of two separated lesions of different grades in a single patient can elucidate meningioma progression. To this end, the involvement of specific protein markers of epithelial to mesenchymal transition (EMT), the process responsible for progression, was tested in both tumors. Protein expression status of specific epithelial (E-cadherin) and mesenchymal markers (N-cadherin, SNAIL&SLUG and TWIST1) was investigated. Furthermore, markers that are connected to Wnt signaling pathway-beta-catenin, GSK3beta and DVL1-were also analyzed. For signs of neurofibromatosis and schwanomatosis genetic testing was performed. Immunohistochemistry evaluated by immunoreactivity score (IRS) was used to determine the signal strengths and proteins' location. Our results indicated that, in comparison to the grade I tumor, mesenchymal markers SNAIL and SLUG were upregulated in the atypical meningioma. TWIST1, beta-catenin and GSK3beta were upregulated in both grades, while E-cadherin was partially lost. A pronounced cadherin switch could not be established; however, N-cadherin showed widespread tissue presence. Genetic testing did not detect changes of
    MeSH term(s) Aged ; Biomarkers, Tumor/genetics ; Female ; Genetic Testing/methods ; Humans ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/pathology ; Meningioma/genetics ; Meningioma/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mismatch Repair Pathway, Genome Stability and Cancer.

    Pećina-Šlaus, Nives / Kafka, Anja / Salamon, Iva / Bukovac, Anja

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 122

    Abstract: The acquisition of genomic instability is one of the key characteristics of the cancer cell, and microsatellite instability (MSI) is an important segment of this phenomenon. This review aims to describe the mismatch DNA repair (MMR) system whose ... ...

    Abstract The acquisition of genomic instability is one of the key characteristics of the cancer cell, and microsatellite instability (MSI) is an important segment of this phenomenon. This review aims to describe the mismatch DNA repair (MMR) system whose deficiency is responsible for MSI and discuss the cellular roles of MMR genes. Malfunctioning of the MMR repair pathway increases the mutational burden of specific cancers and is often involved in its etiology, sometimes as an influential bystander and sometimes as the main driving force. Detecting the presence of MSI has for a long time been an important part of clinical diagnostics, but has still not achieved its full potential. The MSI blueprints of specific tumors are useful for precize grading, evaluation of cancer chance and prognosis and to help us understand how and why therapy-resistant cancers arise. Furthermore, evidence indicates that MSI is an important predictive biomarker for the application of immunotherapy.
    Language English
    Publishing date 2020-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Only one health, and so many omics.

    Pećina-Šlaus, Nives / Pećina, Marko

    Cancer cell international

    2015  Volume 15, Page(s) 64

    Abstract: The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis. The causes of complex diseases have been directed to the genome examination bringing ... ...

    Abstract The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis. The causes of complex diseases have been directed to the genome examination bringing formidable knowledge. We can study genome, but also proteome, exome, transcriptome, epigenome, metabolome, and newcomers too such as microbiome, connectome and exposome. The title of this editorial is paraphrasing the famous saying of Victor Schlichter from Buenos Aires children hospital in Argentina who said "How unfair! Only one health, and so many diseases". Today there is indeed a whole lot of omics. We think that we are lucky to have all the omics possible, but we also wanted to stress the importance of future holistic approach in integrating the knowledge omics has rewarded us.
    Language English
    Publishing date 2015-06-23
    Publishing country England
    Document type Journal Article
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-015-0212-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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