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Article: Identification of glutamyl-prolyl-tRNA synthetase as a new therapeutic target in hepatocellular carcinoma via a novel bioinformatic approach.

Shu, Jinyong / Luo, Pan / Zhang, Guifeng / Gao, Yi

2023 Volume 14, Issue 2, Page(s) 636–649

Abstract: Background: Hepatocellular carcinoma (HCC) has a high incidence, and current treatments are ineffective. We aimed to explore potential diagnostic and prognostic biomarkers for HCC by conducting bioinformatics analysis on genomic and proteomic data.: ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) has a high incidence, and current treatments are ineffective. We aimed to explore potential diagnostic and prognostic biomarkers for HCC by conducting bioinformatics analysis on genomic and proteomic data. Methods: Genome and proteome data were downloaded from The Cancer Genome Atlas (TCGA) and ProteomeXchange databases, respectively. Differentially expressed genes was determined using limma package. Functional enrichment analysis was conducted by Database for Annotation, Visualization, and Integrated Discovery (DAVID). Protein-protein analysis was established by STRING dataset. Using Cytoscope for network visualization and CytoHubba for hub gene identification. The gene mRNA and protein levels were validated using GEPIA and HPA, as well as RT-qPCR and Western blot. Results: A total of 127 up-regulated and 80 down-regulated common DEGPs were identified between the genomic and proteomic data, Mining 10 key genes/proteins(ACLY, ACACB, EPRS, CAD, HSPA4, ACACA, MTHFD1, DMGDH, ALDH2, and GLDC) through protein interaction networks. in addition, Glutamyl-prolyl-tRNA synthetase (EPRS) was highlighted as an HCC biomarker that is negatively correlated with survival. Differential EPRS expression analysis in HCC and paracancerous tissues showed that EPRS expression was elevated in HCC. RT-qPCR and Western blot analysis results showed that EPRS expression was upregulated in HCC cells. Conclusions: Our results suggest that EPRS is a potential therapeutic target for inhibiting HCC tumorigenesis and progression.
Language	English
Publishing date	2023-04-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-23-247
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.

Xu, Li / Ji, Caixia / Yu, Tingting / Luo, Jinyong

Tissue & cell

2023 Volume 84, Page(s) 102168

Abstract: Diseases, such as bone nonunion with bone defects, osteoporosis, etc, seriously endanger people's quality of life, and bone tissue engineering based on mesenchymal stem cells is an effective method to solve such problems. Several studies have shown that ... ...

Abstract	Diseases, such as bone nonunion with bone defects, osteoporosis, etc, seriously endanger people's quality of life, and bone tissue engineering based on mesenchymal stem cells is an effective method to solve such problems. Several studies have shown that BMP9 can effectively promote osteogenic differentiation of MSCs, but the underlying molecular mechanisms are still unclear. Gli1 and Gli2 were important transcription factors and play an important role in the Hedgehog signaling pathway. In this study, we investigated the role of Gli1 and Gli2 in BMP9-induced osteogenic differentiation of MSCs. We found that inhibition of Gli1 and Gli2 weakened BMP9-induced osteogenic differentiation of MSCs, and early osteogenic markers (alkaline phosphatase, ALP), late osteogenic markers (calcium salt deposition), the expression of pivotal osteogenic markers were attenuated, and inhibition of Gli1 and Gli2 weakened the expression of p-Smad1/5/8 and p-p38 induced by BMP9. In conclusion, our study shows that Gli1 and Gli2 play an important role in BMP9-induced osteogenic differentiation.
MeSH term(s)	Animals ; Mice ; Cell Differentiation ; Growth Differentiation Factor 2/metabolism ; Growth Differentiation Factor 2/pharmacology ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/pharmacology ; Mesenchymal Stem Cells ; Osteogenesis ; Quality of Life ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism ; Zinc Finger Protein GLI1/pharmacology ; Zinc Finger Protein Gli2
Chemical Substances	Gli2 protein, mouse ; Growth Differentiation Factor 2 ; Hedgehog Proteins ; Zinc Finger Protein GLI1 ; Zinc Finger Protein Gli2
Language	English
Publishing date	2023-07-17
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102168
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Article: Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer's disease-related pathology.

He, Jiawei / Jin, Yijie / He, Chunxiang / Li, Ze / Yu, Wenjing / Zhou, Jinyong / Luo, Rongsiqing / Chen, Qi / Wu, Yixiao / Wang, Shiwei / Song, Zhenyan / Cheng, Shaowu

Frontiers in pharmacology

2024 Volume 14, Page(s) 1338804

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1338804
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Article ; Online: Enhancing 3D DNA Walker-Induced CRISPR/Cas12a Technology for Highly Sensitive Detection of ExomicroRNA Associated with Osteoporosis.

Luo, Lijuan / Dong, Fang / Li, Dandan / Li, Xinmin / Li, Xinyu / Fan, Yunpeng / Qi, Caihong / Luo, Jinyong / Li, Li / Shen, Bo

ACS sensors

2024 Volume 9, Issue 3, Page(s) 1438–1446

Abstract: Exosomal microRNAs (exomiRNAs) have emerged as promising biomarkers for the early clinical diagnosis of osteoporosis. However, their limited abundance and short length in peripheral blood present significant challenges for the accurate detection of ... ...

Abstract	Exosomal microRNAs (exomiRNAs) have emerged as promising biomarkers for the early clinical diagnosis of osteoporosis. However, their limited abundance and short length in peripheral blood present significant challenges for the accurate detection of exomiRNAs. Herein, we have designed and implemented an efficacious fluorescence-based biosensor for the highly sensitive detection of exomiRNA associated with osteoporosis, leveraging the enhancing 3D DNA walker-induced CRISPR/Cas12a technology. The engineered DNA walker is capable of efficiently transforming target exomiRNA into amplifying DNA strands, thereby enhancing the sensitivity of the developed biosensor. Concurrently, the liberated DNA strands serve as activators to trigger Cas12a
MeSH term(s)	Humans ; CRISPR-Cas Systems/genetics ; MicroRNAs ; DNA/genetics ; Osteoporosis/diagnosis ; Osteoporosis/genetics ; Technology
Chemical Substances	MicroRNAs ; DNA (9007-49-2)
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c02533
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Article ; Online: A Novel Active Noise Control Method Based on Variational Mode Decomposition and Gradient Boosting Decision Tree

Xiaobei Liang / Jinyong Yao / Lei Luo / Weifang Zhang / Yanrong Wang

Applied Sciences, Vol 13, Iss 5436, p

2023 Volume 5436

Abstract: Diversified noise sources pose great challenges in the engineering of an ANC (active noise control) system design. To solve this problem, this paper proposes an ANC method based on VMD (variational mode decomposition) and Ensemble Learning. VMD is used ... ...

Abstract	Diversified noise sources pose great challenges in the engineering of an ANC (active noise control) system design. To solve this problem, this paper proposes an ANC method based on VMD (variational mode decomposition) and Ensemble Learning. VMD is used to extract IMFs (Intrinsic Model Functions) of different types of noise and obtain the approximate entropy of each IMF. Clustering analysis on the output of VMD is conducted based on the PCA (principal component analysis) dimension reduction method and k-means++ method to get classification results for different noises. On the basis of the clustering results, different GBDT (gradient boosting decision tree) regressors are constructed for different noise types, in order to create a high-performance ANC system for multiple noise sources. To verify the effectiveness of the proposed method, this paper designed four simulation schemes for the ANC: obstacle-free rectangular enclosed space, rectangular enclosed space with obstacle, obstacle-free trapezoidal enclosed space and trapezoidal enclosed space with obstacle. When machine gun noise is used as an example, noise attenuation by the proposed method in four simulation schemes is −23.27 dB, −21.6 dB, −19.08 dB and −15.48 dB respectively.
Keywords	active noise control ; variational mode decomposition ; gradient boosting decision tree ; principal component analysis ; k-means++ ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to 'Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways' [Genes & Diseases 9 (2022) 466-478].

Yang, Chunmei / Zhang, Lulu / Huang, Huakun / Yuan, Xiaohui / Zhang, Ping / Ye, Caihong / Wei, Mengqi / Huang, Yanran / Luo, Xiaoji / Luo, Jinyong

Genes & diseases

2023 Volume 10, Issue 2, Page(s) 620–623

Abstract: This corrects the article DOI: 10.1016/j.gendis.2020.07.014.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.gendis.2020.07.014.].
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.02.002
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Article ; Online: GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

Xu, Xiaoxiang / Ding, Xihui / Wang, Zizhuo / Ye, Shujiang / Xu, Jianguang / Liang, Zugang / Luo, Renfei / Xu, Jinyong / Li, Xiaohui / Ren, Zhenhua

Microvascular research

2024 Volume 154, Page(s) 104689

Abstract: Pathological retinal angiogenesis is not only the hallmark of retinopathies, but also a major cause of blindness. Guanylate binding protein 2 (GBP2) has been reported to be associated with retinal diseases such as diabetic retinopathy and hypoxic ... ...

Abstract	Pathological retinal angiogenesis is not only the hallmark of retinopathies, but also a major cause of blindness. Guanylate binding protein 2 (GBP2) has been reported to be associated with retinal diseases such as diabetic retinopathy and hypoxic retinopathy. However, GBP2-mediated pathological retinal angiogenesis remains largely unknown. The present study aimed to investigate the role of GBP2 in pathological retinal angiogenesis and its underlying molecular mechanism. In this study, we established oxygen-induced retinopathy (OIR) mice model for in vivo study and hypoxia-induced angiogenesis in ARPE-19 cells for in vitro study. We demonstrated that GBP2 expression was markedly downregulated in the retina of mice with OIR and ARPE-19 cells treated with hypoxia, which was associated with pathological retinal angiogenesis. The regulatory mechanism of GBP2 in ARPE-19 cells was studied by GBP2 silencing and overexpression. The regulatory mechanism of GBP2 in the retina was investigated by overexpressing GBP2 in the retina of OIR mice. Mechanistically, GBP2 downregulated the expression and secretion of vascular endothelial growth factor (VEGFA) in ARPE-19 cells and retina of OIR mice. Interestingly, overexpression of GBP2 significantly inhibited neovascularization in OIR mice, conditioned medium of GBP2 overexpressing ARPE-19 cells inhibited angiogenesis in human umbilical vein endothelial cells (HUVECs). Furthermore, we confirmed that GBP2 downregulated VEGFA expression and angiogenesis by inhibiting the AKT/mTOR signaling pathway. Taken together, we concluded that GBP2 inhibited pathological retinal angiogenesis via the AKT/mTOR/VEGFA axis, thereby suggesting that GBP2 may be a therapeutic target for pathological retinal angiogenesis.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80307-8
ISSN	1095-9319 ; 0026-2862
ISSN (online)	1095-9319
ISSN	0026-2862
DOI	10.1016/j.mvr.2024.104689
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Zs.A 746: Show issues

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Article: Outcomes and Predictors of Response of Duloxetine for the Treatment of Persistent Idiopathic Dentoalveolar Pain: A Retrospective Multicenter Observational Study.

Jia, Zipu / Yu, Jinyong / Zhao, Chunmei / Ren, Hao / Luo, Fang

Journal of pain research

2022 Volume 15, Page(s) 3031–3041

Abstract: Background: Duloxetine has been reported to significantly relieve the pain of persistent idiopathic dentoalveolar pain (PIDP); however, the number of studies available is scarce and no study has identified the predictors of response of duloxetine for ... ...

Abstract	Background: Duloxetine has been reported to significantly relieve the pain of persistent idiopathic dentoalveolar pain (PIDP); however, the number of studies available is scarce and no study has identified the predictors of response of duloxetine for the treatment of PIDP. Objective: To report the efficacy, safety, and identification of positive predictors of duloxetine for PIDP patients through a retrospective multicenter observational study. Methods: We retrospectively reviewed the clinical database of PIDP patients who were prescribed duloxetine at 3 hospitals between January 2018 and November 2021. Demographic and pain-related baseline data, efficacy of patients after 3 months of medication by visual analog scale (VAS) scores for pain and adverse events were extracted and analyzed. The predictors of pain-relieving effect of duloxetine were identified by logistic regression analysis. Results: A total of 135 patients were included in this study. Side effects occurred immediately after taking duloxetine in 24 (17.8%) patients, and the treatment with duloxetine was discontinued on 13 of them because they could not tolerate the side effects. Other 11 (8.1%) patients gradually tolerated the side effects within 2 weeks. Ninety-four out of 122 (77.0%) patients obtained pain relief with VAS significantly decreased (p < 0.01) and the other 28 (23.0%) patients stopped taking the drug because of weak efficacy. Binary logistic regression analysis showed that short disease duration (OR = 1.017, 95% CI = 1.004-1.030, P = 0.012) was an independent predictor of the positive response of duloxetine. Conclusion: This study confirmed that duloxetine can significantly improve chronic pain of PIDP patients, and the safety was tolerable. Patients with shorter disease duration had more benefit from duloxetine. Limitations: This is a retrospective observational study. Long-term efficacy and safety of duloxetine in the treatment of PIDP patients were not evaluated.
Language	English
Publishing date	2022-09-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S379430
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Article ; Online: Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways.

Lu, Qiuping / Huang, Huakun / Wang, Xiaoxuan / Luo, Lijuan / Xia, Haichao / Zhang, Lulu / Xu, Jingtao / Huang, Yanran / Luo, Xiaoji / Luo, Jinyong

Pharmacological research

2023 Volume 191, Page(s) 106760

Abstract: Osteosarcoma (OS) is a highly aggressive malignant bone tumor that mainly occurs in adolescents. At present, chemotherapy is the most commonly used method in clinical practice to treat OS. However, due to drug resistance, toxicity and long-term side ... ...

Abstract	Osteosarcoma (OS) is a highly aggressive malignant bone tumor that mainly occurs in adolescents. At present, chemotherapy is the most commonly used method in clinical practice to treat OS. However, due to drug resistance, toxicity and long-term side effects, chemotherapy can't always provide sufficient benefits for OS patients, especially those with metastasis and recurrence. Natural products have long been an excellent source of anti-tumor drug development. In the current study, we evaluated the anti-OS activity of Echinatin (Ecn), a natural active component from the roots and rhizomes of licorice, and explored the possible mechanism. We found that Ecn inhibited the proliferation of human OS cells and blocked cell cycle at S phase. In addition, Ecn suppressed the migration and invasion, while induced the apoptosis of human OS cells. However, Ecn had less cytotoxicity against normal cells. Moreover, Ecn inhibited the xenograft tumor growth of OS cells in vivo. Mechanistically, Ecn inactivated Wnt/β-catenin signaling pathway while activated p38 signaling pathway. β-catenin over-expression and the p38 inhibitor SB203580 both attenuated the inhibitory effect of Ecn on OS cells. Notably, we demonstrated that Ecn exhibited synergistic inhibitory effect with cisplatin (DDP) on OS cells in vitro and in vivo. Therefore, our results suggest that Ecn may exert anti-OS effects at least partly through regulating Wnt/β-catenin and p38 signaling pathways. Most meaningfully, the results obtained suggest a potential strategy to improve the DDP-induced tumor-killing effect on OS cells by combining with Ecn.
MeSH term(s)	Adolescent ; Humans ; beta Catenin/metabolism ; Cell Proliferation ; Osteosarcoma/metabolism ; Wnt Signaling Pathway ; Apoptosis ; Bone Neoplasms/metabolism ; Cell Line, Tumor ; Cell Movement
Chemical Substances	beta Catenin ; echinatin
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106760
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Zs.A 721: Show issues

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Article ; Online: [Retracted] Hedgehog signaling is involved in the BMP9‑induced osteogenic differentiation of mesenchymal stem cells.

Li, Li / Dong, Qian / Wang, Yufeng / Feng, Qiaoling / Zhou, Pengfei / Ou, Xinying / Meng, Qiurong / He, Tongchuan / Luo, Jinyong

International journal of molecular medicine

2023 Volume 51, Issue 4

Abstract: Subsequently to the publication of the above paper, a concerned reader drew to the authors' attention that there were a number of overlapping data panels featured in the cellular images shown in Fig. 2C on p. 1644, and Figs. 3D and 4 on p. 1645, such ... ...

Abstract	Subsequently to the publication of the above paper, a concerned reader drew to the authors' attention that there were a number of overlapping data panels featured in the cellular images shown in Fig. 2C on p. 1644, and Figs. 3D and 4 on p. 1645, such that data that were allegedly obtained under different experimental conditions appeared to have been derived from some of the same original sources. Given the number of errors that had been made during the compilation of the figures in this article, the Editor of
Language	English
Publishing date	2023-02-24
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2023.5233
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