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Article ; Online: Psychometric Properties of the PANS 31-Item Symptom Rating Scale.

Bernstein, Gail A / Khan, Maroof H / Freese, Rebecca L / Manko, Cindy / Silverman, Melissa / Ahmed, Sana / Farhadian, Bahare / Ma, Meiqian / Thienemann, Margo / Murphy, Tanya K / Frankovich, Jennifer

Journal of child and adolescent psychopharmacology

2024 Volume 34, Issue 3, Page(s) 157–162

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Child ; Humans ; Psychometrics ; Psychiatric Status Rating Scales ; Reproducibility of Results ; Severity of Illness Index ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/psychology ; Nucleotidyltransferases ; Autoimmune Diseases
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-)
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1055410-5
ISSN	1557-8992 ; 1044-5463
ISSN (online)	1557-8992
ISSN	1044-5463
DOI	10.1089/cap.2023.0088
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Article: Parent Weight, Diet, Active Living, and Food-Related Outcomes of the Family-Focused:NU-HOME Randomized Controlled Trial: NU-HOME Randomized Controlled Trial.

Horning, Melissa L / Friend, Sarah / Freese, Rebecca L / Barr-Anderson, Daheia J / Linde, Jennifer A / Sidebottom, Abbey / Sommerness, Samantha A / Fulkerson, Jayne A

Journal of the Academy of Nutrition and Dietetics

2022 Volume 123, Issue 5, Page(s) 751–760.e1

Abstract: Background: Little is known about parent outcomes of rural, family-focused childhood obesity prevention trials.: Objective: Our aim was to evaluate parent outcomes of the rural, family-focused NU-HOME (New Ulm at HOME [Healthy Offerings via the ... ...

Abstract	Background: Little is known about parent outcomes of rural, family-focused childhood obesity prevention trials. Objective: Our aim was to evaluate parent outcomes of the rural, family-focused NU-HOME (New Ulm at HOME [Healthy Offerings via the Mealtime Environment]) randomized controlled trial designed to prevent obesity in children aged 7 through 10 years. Design: Families were randomized to the intervention or wait-list control group after baseline data collection. Staff measured parent height, weight, and percent body fat. Surveys measured parent cognitive and behavioral outcomes (eg, portion-size confidence, dietary intake, total and moderate-to-vigorous physical activity, and screen time). Post-intervention data were collected 8 to 10 months after baseline. Participants/setting: The randomized controlled trial took place in rural, south central Minnesota, and enrolled parent and child dyads (N = 114; 2017-2018); 98 parents provided data at post intervention (2018-2019) and comprise the analytic sample. Parent inclusion criteria were being the primary meal preparer, living with the child most of the time, and being willing to attend intervention sessions. Exclusion criteria were planning to move or having a medical condition that would contraindicate participation. Intervention: The theory-guided intervention (7 sessions and 4 goal-setting calls) focused on family eating and active living behaviors. Main outcome measures: Height, weight, and percent body fat were measured and the survey assessed diet, active living, and food-related outcomes. Statistical analyses performed: Multiple linear regression models tested change in parent outcomes from baseline to post intervention by treatment group adjusted for demographic characteristics and baseline values. Results: In the intervention group vs control group, parent total weekly hours of physical activity was 1.73 hours higher (95% CI 0.11 to 3.35 hours) and portion-size confidence was 1.49 points higher (95% CI 0.78 to 2.19). No other statistically significant changes were observed by treatment group. Conclusions: Findings indicate that parent cognitive and behavioral outcomes are amenable to change in family-focused childhood obesity prevention programs. Parent increases in portion-size confidence and total physical activity hours may support long-term parent health and provide positive context for child health.
MeSH term(s)	Child ; Humans ; Pediatric Obesity/prevention & control ; Diet ; Parents ; Exercise ; Meals
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2022.10.009
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Article ; Online: Weight outcomes of NU-HOME: a randomized controlled trial to prevent obesity among rural children.

Fulkerson, Jayne A / Horning, Melissa / Barr-Anderson, Daheia J / Sidebottom, Abbey / Linde, Jennifer A / Lindberg, Rebecca / Friend, Sarah / Beaudette, Jennifer / Flattum, Colleen / Freese, Rebecca L

The international journal of behavioral nutrition and physical activity

2022 Volume 19, Issue 1, Page(s) 29

Abstract: Background: Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused ... ...

Abstract	Background: Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused randomized controlled trial (RCT) are described. We hypothesized that compared to control group children, intervention group children would have significantly lower weight-related post-intervention (PI) outcomes. Methods: Participants were 114 dyads (7-10 year-old rural children and a parent). In 2017-2018 and 2018-2019, research staff measured height, weight and body fat at baseline (BL) and PI. Families were randomized to intervention (n = 58) or control (n = 56) groups without blinding. Designed with Social Cognitive Theory and community engagement, the NU-HOME program included seven monthly sessions delivered in community settings and four goal-setting calls. The program engaged entire families to improve healthy eating, physical activity, family meals and the home food environment. Multiple linear and logistic regression models tested PI outcomes of child BMIz-score, percent body fat, percent over 50th percentile BMI, and overweight/obesity status by treatment group, adjusted for BL values and demographics (n = 102). Results: No statistically significant intervention effects were seen for child BMIz or overweight/obesity status. However, a promising reduction in boys' percent body fat (- 2.1, 95% CI [- 4.84, 0.63]) was associated with the intervention. Conclusions: Although our findings were in the hypothesized direction, making significant impacts on weight-related outcomes remains challenging in community trials. Comprehensive family-focused programming may require intensive multi-pronged interventions to mitigate complex factors associated with excess weight gain. Clinical trial registration: This study is registered with NIH ClinicalTrials.gov: NCT02973815 .
MeSH term(s)	Body Mass Index ; Child ; Diet, Healthy ; Exercise ; Humans ; Male ; Meals ; Pediatric Obesity/prevention & control ; Rural Population
Language	English
Publishing date	2022-03-19
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-022-01260-w
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Article ; Online: Weight outcomes of NU-HOME: a randomized controlled trial to prevent obesity among rural children

Fulkerson, Jayne A. / Horning, Melissa / Barr-Anderson, Daheia J. / Sidebottom, Abbey / Linde, Jennifer A. / Lindberg, Rebecca / Friend, Sarah / Beaudette, Jennifer / Flattum, Colleen / Freese, Rebecca L.

Int J Behav Nutr Phys Act. 2022 Dec., v. 19, no. 1 p.29-29

2022

Abstract: BACKGROUND: Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused ... ...

Abstract	BACKGROUND: Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused randomized controlled trial (RCT) are described. We hypothesized that compared to control group children, intervention group children would have significantly lower weight-related post-intervention (PI) outcomes. METHODS: Participants were 114 dyads (7–10 year-old rural children and a parent). In 2017–2018 and 2018–2019, research staff measured height, weight and body fat at baseline (BL) and PI. Families were randomized to intervention (n = 58) or control (n = 56) groups without blinding. Designed with Social Cognitive Theory and community engagement, the NU-HOME program included seven monthly sessions delivered in community settings and four goal-setting calls. The program engaged entire families to improve healthy eating, physical activity, family meals and the home food environment. Multiple linear and logistic regression models tested PI outcomes of child BMIz-score, percent body fat, percent over 50th percentile BMI, and overweight/obesity status by treatment group, adjusted for BL values and demographics (n = 102). RESULTS: No statistically significant intervention effects were seen for child BMIz or overweight/obesity status. However, a promising reduction in boys’ percent body fat (− 2.1, 95% CI [− 4.84, 0.63]) was associated with the intervention. CONCLUSIONS: Although our findings were in the hypothesized direction, making significant impacts on weight-related outcomes remains challenging in community trials. Comprehensive family-focused programming may require intensive multi-pronged interventions to mitigate complex factors associated with excess weight gain. CLINICAL TRIAL REGISTRATION: This study is registered with NIH ClinicalTrials.gov: NCT02973815 .
Keywords	body fat ; childhood obesity ; children ; cognition ; demographic statistics ; meals (menu) ; physical activity ; randomized clinical trials ; regression analysis ; risk ; weight gain
Language	English
Dates of publication	2022-12
Size	p. 29.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2134691-4
ISSN	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-022-01260-w
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Weight outcomes of NU-HOME

Jayne A. Fulkerson / Melissa Horning / Daheia J. Barr-Anderson / Abbey Sidebottom / Jennifer A. Linde / Rebecca Lindberg / Sarah Friend / Jennifer Beaudette / Colleen Flattum / Rebecca L. Freese

International Journal of Behavioral Nutrition and Physical Activity, Vol 19, Iss 1, Pp 1-

a randomized controlled trial to prevent obesity among rural children

2022 Volume 12

Abstract: Abstract Background Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused ... ...

Abstract	Abstract Background Rural children are at greater obesity risk than their urban peers. The NU-HOME study is an innovative collaborative effort to prevent childhood obesity in rural communities. Weight outcomes of the NU-HOME study, a family-meal focused randomized controlled trial (RCT) are described. We hypothesized that compared to control group children, intervention group children would have significantly lower weight-related post-intervention (PI) outcomes. Methods Participants were 114 dyads (7–10 year-old rural children and a parent). In 2017–2018 and 2018–2019, research staff measured height, weight and body fat at baseline (BL) and PI. Families were randomized to intervention (n = 58) or control (n = 56) groups without blinding. Designed with Social Cognitive Theory and community engagement, the NU-HOME program included seven monthly sessions delivered in community settings and four goal-setting calls. The program engaged entire families to improve healthy eating, physical activity, family meals and the home food environment. Multiple linear and logistic regression models tested PI outcomes of child BMIz-score, percent body fat, percent over 50th percentile BMI, and overweight/obesity status by treatment group, adjusted for BL values and demographics (n = 102). Results No statistically significant intervention effects were seen for child BMIz or overweight/obesity status. However, a promising reduction in boys’ percent body fat (− 2.1, 95% CI [− 4.84, 0.63]) was associated with the intervention. Conclusions Although our findings were in the hypothesized direction, making significant impacts on weight-related outcomes remains challenging in community trials. Comprehensive family-focused programming may require intensive multi-pronged interventions to mitigate complex factors associated with excess weight gain. Clinical trial registration This study is registered with NIH ClinicalTrials.gov: NCT02973815 .
Keywords	Family meals ; Prevention ; Childhood obesity ; Healthy eating ; Home food environment ; Physical activity ; Nutritional diseases. Deficiency diseases ; RC620-627 ; Public aspects of medicine ; RA1-1270
Subject code	796 ; 360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parent Weight, Diet, Active Living Outcomes, and Food-Related Outcomes of the Family-Focused NU-HOME Randomized Controlled Trial

Horning, Melissa L. / Friend, Sarah / Freese, Rebecca L. / Barr-Anderson, Daheia J. / Linde, Jennifer A. / Sidebottom, Abbey / Sommerness, Samantha A. / Fulkerson, Jayne A.

Academy of Nutrition and Dietetics Journal of the Academy of Nutrition and Dietetics. 2022 Oct. 10,

2022

Abstract: Little is known about parent outcomes of rural, family-focused childhood obesity prevention trials. To evaluate parent outcomes of the rural, family-focused NU-HOME randomized controlled trial (RCT) designed to prevent obesity in children 7-10 years old. ...

Abstract	Little is known about parent outcomes of rural, family-focused childhood obesity prevention trials. To evaluate parent outcomes of the rural, family-focused NU-HOME randomized controlled trial (RCT) designed to prevent obesity in children 7-10 years old. Families were randomized to the intervention or waitlist control group following baseline data (BL) collection. Staff measured parent height, weight, and percent body fat. Surveys measured parent cognitive and behavioral outcomes (e.g., portion size confidence, dietary intake, total and moderate-to-vigorous physical activity (PA), screentime). Post-intervention (PI) data were collected 8-10 months after baseline. The RCT took place in rural, south central MN and enrolled parent and child dyads (N=114; 2017-2018); 98 parents provided data at PI (2018-2019) and comprise the analytic sample. Parent inclusion criteria included: being the primary meal preparer, living with the child most of the time, and being willing to attend intervention sessions. Exclusion criteria were: planning to move or having a medical condition that would contraindicate participation. The theory-guided intervention (7 sessions, 4 goal-setting calls) focused on family eating and active living behaviors. Measured height, weight and percent body fat; survey assessed diet, active living, and food-related outcomes. Multiple linear regression models tested change in parent outcomes from BL to PI by treatment group adjusted for demographics and BL values. In the intervention versus control group, parent total weekly hours of PA was 1.73 hours higher (95% CI=0.11,3.35) and portion size confidence was 1.49 points higher (95% CI=0.78,2.19). No other statistically significant changes were observed by treatment group. Findings demonstrate parent cognitive and behavioral outcomes are amenable to change in family-focused childhood obesity prevention programs. Parent increases in portion size confidence and total PA hours may support long-term parent health and provide positive context for child health.
Keywords	body fat ; child health ; childhood obesity ; children ; cognition ; demographic statistics ; dietetics ; physical activity ; portion size ; regression analysis ; surveys ; Minnesota ; childhood obesity prevention ; parent outcomes ; rural ; intervention ; randomized controlled trial
Language	English
Dates of publication	2022-1010
Size	p. 751-760.e1.
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2646718-5
ISSN	2212-2672
ISSN	2212-2672
DOI	10.1016/j.jand.2022.10.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Temporal patterns of olfactory bulb interneuron neurogenesis.

Pino, Darya / Freese, Jennifer L

The Journal of neuroscience : the official journal of the Society for Neuroscience

2008 Volume 28, Issue 33, Page(s) 8145–8147

MeSH term(s)	Age Factors ; Animals ; Cell Differentiation/physiology ; Humans ; Interneurons/classification ; Interneurons/cytology ; Interneurons/physiology ; Olfactory Bulb/cytology ; Olfactory Bulb/physiology ; Stem Cells/classification ; Stem Cells/cytology ; Stem Cells/physiology
Language	English
Publishing date	2008-08-13
Publishing country	United States
Document type	Comment ; Journal Article ; Review
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2321-08.2008
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Article ; Online: Universal childhood obesity prevention in a rural community: Study design, methods and baseline participant characteristics of the NU-HOME randomized controlled trial.

Fulkerson, Jayne A / Horning, Melissa L / Barr-Anderson, Daheia J / Linde, Jennifer A / Sidebottom, Abbey C / Lindberg, Rebecca / Friend, Sarah / Flattum, Colleen / Freese, Rebecca L

Contemporary clinical trials

2020 Volume 100, Page(s) 106160

Abstract: Childhood obesity is a major health concern in the United States (US) and those living in rural communities are at higher risk than their urban counterparts. Few prevention trials have engaged whole families of school-age children in community settings, ... ...

Abstract	Childhood obesity is a major health concern in the United States (US) and those living in rural communities are at higher risk than their urban counterparts. Few prevention trials have engaged whole families of school-age children in community settings, and none to date have promoted family meals, family activity and healthful home environments in rural settings through a rigorous, randomized controlled trial (RCT). The New Ulm at HOME (NU-HOME) study recruited 114 parent/child dyads in a two-arm (intervention versus wait-list control) RCT to test the efficacy of a family meals-focused program aimed to prevent excess weight gain among 7-10 year-old children in rural Minnesota. The NU-HOME program was adapted from a previously tested program for urban families through a unique community collaboration. The program included 7 monthly in-person sessions for all family members. Parents also participated in 4 motivational goal-setting phone calls. The primary outcome measures were age- and sex-adjusted child body mass index (BMI) z-score, percent body fat, and incidence of overweight and obesity post-intervention. Secondary outcomes included quality of food and beverage availability in the home; family meals and snacks; children's dietary intake quality (e.g., Healthy Eating Index (HEI)-2015, fruits and vegetables, sugar-sweetened beverages, snacks); and children's screen time and weekly minutes of moderate-to-vigorous physical activity, total physical activity, and sedentary behavior. The NU-HOME RCT was a collaborative effort of academic and health system researchers, interventionists and community leaders that aimed to prevent childhood obesity in rural communities through engagement of the whole family in an interactive intervention.
MeSH term(s)	Body Mass Index ; Child ; Exercise ; Health Promotion ; Humans ; Pediatric Obesity/epidemiology ; Pediatric Obesity/prevention & control ; Rural Population ; Sedentary Behavior
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2020.106160
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Article: Synaptic organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey.

Freese, Jennifer L / Amaral, David G

The Journal of comparative neurology

2006 Volume 496, Issue 5, Page(s) 655–667

Abstract: The primate amygdaloid complex projects to a number of visual cortices, including area V1, primary visual cortex, and area TE, a higher-order unimodal visual area involved in object recognition. We investigated the synaptic organization of these ... ...

Abstract	The primate amygdaloid complex projects to a number of visual cortices, including area V1, primary visual cortex, and area TE, a higher-order unimodal visual area involved in object recognition. We investigated the synaptic organization of these projections by injecting anterograde tracers into the amygdaloid complex of Macaca fascicularis monkeys and examining labeled boutons in areas TE and V1 using the electron microscope. The 256 boutons examined in area TE formed 263 synapses. Two hundred twenty-three (84%) of these were asymmetric synapses onto dendritic spines and 40 (15%) were asymmetric synapses onto dendritic shafts. Nine boutons (3.5%) formed double asymmetric synapses, generally on dendritic spines, and 2 (1%) of the boutons did not form a synapse. The 200 boutons examined in area V1 formed 211 synapses. One hundred eighty-nine (90%) were asymmetric synapses onto dendritic spines and 22 (10%) were asymmetric synapses onto dendritic shafts. Eleven boutons (5.5%) formed double synapses, usually with dendritic spines. We conclude from these observations that the amygdaloid complex provides an excitatory input to areas TE and V1 that primarily influences spiny, probably pyramidal, neurons in these cortices.
MeSH term(s)	Amygdala/physiology ; Amygdala/ultrastructure ; Animals ; Female ; Macaca fascicularis ; Male ; Synapses/physiology ; Synapses/ultrastructure ; Visual Cortex/physiology
Language	English
Publishing date	2006-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3086-7
ISSN	1096-9861 ; 0021-9967 ; 0092-7317
ISSN (online)	1096-9861
ISSN	0021-9967 ; 0092-7317
DOI	10.1002/cne.20945
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Article ; Online: Initial experience from a renal genetics clinic demonstrates a distinct role in patient management.

Thomas, Christie P / Freese, Margaret E / Ounda, Agnes / Jetton, Jennifer G / Holida, Myrl / Noureddine, Lama / Smith, Richard J

Genetics in medicine : official journal of the American College of Medical Genetics

2020 Volume 22, Issue 6, Page(s) 1025–1035

Abstract: Purpose: A Renal Genetics Clinic (RGC) was established to optimize diagnostic testing, facilitate genetic counseling, and direct clinical management.: Methods: Retrospective review of patients seen over a two-year period in the RGC.: Results: One ... ...

Abstract	Purpose: A Renal Genetics Clinic (RGC) was established to optimize diagnostic testing, facilitate genetic counseling, and direct clinical management. Methods: Retrospective review of patients seen over a two-year period in the RGC. Results: One hundred eleven patients (mean age: 39.9 years) were referred to the RGC: 65 for genetic evaluation, 19 for management of a known genetic disease, and 18 healthy living kidney donors (LKDs) and their 9 related transplant candidates for screening. Forty-three patients underwent genetic testing with a diagnosis in 60% of patients including 9 with Alport syndrome, 7 with autosomal dominant polycystic kidney disease (ADPKD), 2 with genetic focal segmental glomerulosclerosis (FSGS), 2 with PAX2-mediated CAKUT, and 1 each with autosomal recessive polycystic kidney disease (ARPKD), Dent, Frasier, Gordon, Gitelman, and Zellweger syndromes. Four of 18 LKDs were referred only for APOL1 screening. For the remaining 14 LKDs, their transplant candidates were first tested to establish a genetic diagnosis. Five LKDs tested negative for the familial genetic variant, four were positive for their familial variant. In five transplant candidates, a genetic variant could not be identified. Conclusion: An RGC that includes genetic counseling enhances care of renal patients by improving diagnosis, directing management, affording presymptomatic family focused genetic counseling, and assisting patients and LKDs to make informed decisions.
MeSH term(s)	Adult ; Apolipoprotein L1 ; Genetic Testing ; Humans ; Kidney ; Mass Screening ; Polycystic Kidney, Autosomal Dominant/genetics ; Retrospective Studies
Chemical Substances	APOL1 protein, human ; Apolipoprotein L1
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1038/s41436-020-0772-y
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