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  1. Book ; Online ; E-Book: WNT signaling in development and disease

    Yamaguchi, Terry P. / Willert, Karl

    (Issn Series)

    2023  

    Abstract: Wnt Signaling in Development and Disease, Volume 153 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter on topics such as The cell biology of Wnt gradient ... ...

    Author's details Terry P. Yamaguchi and Karl Willert
    Series title Issn Series
    Abstract Wnt Signaling in Development and Disease, Volume 153 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter on topics such as The cell biology of Wnt gradient formation, Approaches to visualize and trace Wnt signaling in vitro and in vivo, WNT signaling and the regulation of pluripotency, Wnt/Frizzled signaling in stem cells in development and cancer, Wnt signaling in hydra development and regeneration, Wnt signaling in whole body regeneration, Role of planar cell polarity and Wnt signaling in left-right asymmetry, Wnt signaling in axial progenitors, and more. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Wnt Signaling in Development and Disease.
    Keywords Cellular signal transduction ; Wnt proteins
    Subject code 572.64
    Language English
    Size 1 online resource (436 pages)
    Publisher Elsevier Inc
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-12-820167-1 ; 0-12-820164-9 ; 0-12-820167-3 ; 978-0-12-820164-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Preface.

    Yamaguchi, Terry P / Willert, Karl

    Current topics in developmental biology

    2023  Volume 153, Page(s) xv–xvi

    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Editorial
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/S0070-2153(23)00054-6
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  3. Article ; Online: Wnt signaling and the regulation of pluripotency.

    Sonavane, Pooja / Willert, Karl

    Current topics in developmental biology

    2023  Volume 153, Page(s) 95–119

    Abstract: The role of Wnt signaling in stem cells has been mired in seemingly contradictory findings. On one hand, Wnt has been heralded as a self-renewal factor. On the other hand, Wnt's association with differentiation and lineage commitment is indisputable. ... ...

    Abstract The role of Wnt signaling in stem cells has been mired in seemingly contradictory findings. On one hand, Wnt has been heralded as a self-renewal factor. On the other hand, Wnt's association with differentiation and lineage commitment is indisputable. This apparent contradiction is particularly evident in pluripotent stem cells, where Wnt promotes self-renewal as well as differentiation. To resolve this discrepancy one must delve into fundamental principles of pluripotency and gain an appreciation for the concept of pluripotency states, which exist in a continuum with intermediate metastable states, some of which have been stabilized in vitro. Wnt signaling is a critical regulator of transitions between pluripotent states. Here, we will discuss Wnt's roles in maintaining pluripotency, promoting differentiation, as well as stimulating reprogramming of somatic cells to an induced pluripotent state.
    MeSH term(s) Embryonic Stem Cells ; Wnt Signaling Pathway ; Cell Differentiation/physiology ; Pluripotent Stem Cells
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enrichment and Detection of Wnt Proteins from Cell Culture Media.

    Sonavane, Pooja R / Willert, Karl

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2438, Page(s) 123–131

    Abstract: Wnt proteins are secreted, lipid-modified growth factors with a wide range of activities across all metazoan species. Their production, secretion, and signaling range are under tight cellular control such that detection of Wnt proteins in biological ... ...

    Abstract Wnt proteins are secreted, lipid-modified growth factors with a wide range of activities across all metazoan species. Their production, secretion, and signaling range are under tight cellular control such that detection of Wnt proteins in biological samples is often extremely difficult. In this chapter, we describe a protocol to detect secreted Wnt proteins in the culture medium of cell lines that ectopically or endogenously express Wnt genes. This protocol uses an affinity resin, called Blue Sepharose, that binds and thereby enriches Wnt proteins, followed by immunoblotting for the Wnt protein of interest. This method for detecting Wnt proteins will aid in the isolation of biologically active Wnt proteins, provide an assay to study the molecular basis of Wnt secretion, and potentially offer a means to detect trace amounts of Wnt proteins associated with pathological states.
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Line ; Signal Transduction ; Wnt Proteins
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2035-9_8
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  5. Article: Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically.

    Sonavane, Pooja R / Willert, Karl

    Handbook of experimental pharmacology

    2021  Volume 269, Page(s) 3–28

    Abstract: Wnt signaling is critical for proper development of the embryo and for tissue homeostasis in the adult. Activation of this signaling cascade is initiated by binding of the secreted Wnts to their receptors. With the mammalian genome encoding multiple Wnts ...

    Abstract Wnt signaling is critical for proper development of the embryo and for tissue homeostasis in the adult. Activation of this signaling cascade is initiated by binding of the secreted Wnts to their receptors. With the mammalian genome encoding multiple Wnts and Wnt receptors, a longstanding question in the field has been how Wnt-receptor specificities are achieved. Emerging from these studies is a picture of exquisite control over Wnt protein production, secretion, distribution, and receptor interactions, culminating in activation of downstream signaling cascades that control a myriad of biological processes. Here we discuss mechanisms by which Wnt protein activities are tuned and illustrate how the multiple layers of regulation can be leveraged for therapeutic interventions in disease.
    MeSH term(s) Adult ; Animals ; Frizzled Receptors ; Humans ; Wnt Proteins ; Wnt Signaling Pathway
    Chemical Substances Frizzled Receptors ; Wnt Proteins
    Language English
    Publishing date 2021-09-02
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_529
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  6. Article ; Online: Mechanisms of Wnt signaling and control.

    Grainger, Stephanie / Willert, Karl

    Wiley interdisciplinary reviews. Systems biology and medicine

    2018  , Page(s) e1422

    Abstract: The Wnt signaling pathway is a highly conserved system that regulates complex biological processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to break symmetry and provide cells with positional information that is ... ...

    Abstract The Wnt signaling pathway is a highly conserved system that regulates complex biological processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to break symmetry and provide cells with positional information that is critical to the patterning of the entire body plan. At the organismal level, Wnt signals are employed to orchestrate fundamental developmental processes, including the specification of the anterior-posterior body axis, induction of the primitive streak and ensuing gastrulation movements, and the generation of cell and tissue diversity. Wnt functions extend into adulthood where they regulate stem cell behavior, tissue homeostasis, and damage repair. Disruption of Wnt signaling activity during embryonic development or in adults results in a spectrum of abnormalities and diseases, including cancer. The molecular mechanisms that underlie the myriad of Wnt-regulated biological effects have been the subject of intense research for over three decades. This review is intended to summarize our current understanding of how Wnt signals are generated and interpreted. This article is categorized under: Biological Mechanisms > Cell Signaling Developmental Biology > Stem Cell Biology and Regeneration.
    Language English
    Publishing date 2018-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2503323-2
    ISSN 1939-005X ; 1939-5094
    ISSN (online) 1939-005X
    ISSN 1939-5094
    DOI 10.1002/wsbm.1422
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    Zs.A 6790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Wnt/β-catenin signaling during early vertebrate neural development.

    Brafman, David / Willert, Karl

    Developmental neurobiology

    2017  Volume 77, Issue 11, Page(s) 1239–1259

    Abstract: The vertebrate central nervous system (CNS) is comprised of vast number of distinct cell types arranged in a highly organized manner. This high degree of complexity is achieved by cellular communication, including direct cell-cell contact, cell-matrix ... ...

    Abstract The vertebrate central nervous system (CNS) is comprised of vast number of distinct cell types arranged in a highly organized manner. This high degree of complexity is achieved by cellular communication, including direct cell-cell contact, cell-matrix interactions, and cell-growth factor signaling. Among the several developmental signals controlling the development of the CNS, Wnt proteins have emerged as particularly critical and, hence, have captivated the attention of many researchers. With Wnts' evolutionarily conserved function as primordial symmetry breaking signals, these proteins and their downstream effects are responsible for simultaneously establishing cellular diversity and tissue organization. With their expansive repertoire of secreted agonists and antagonists, cell surface receptors, signaling cascades and downstream biological effects, Wnts are ideally suited to control the complex processes underlying vertebrate neural development. In this review, we will describe the mechanisms by which Wnts exert their potent effects on cells and tissues and highlight the many roles of Wnt signaling during neural development, starting from the initial induction of the neural plate, the subsequent patterning along the embryonic axes, to the intricately organized structure of the CNS. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1239-1259, 2017.
    MeSH term(s) Animals ; Body Patterning/physiology ; Central Nervous System/embryology ; Central Nervous System/growth & development ; Central Nervous System/metabolism ; Embryo, Nonmammalian/physiology ; Gene Expression Regulation, Developmental ; Vertebrates ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/physiology ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances Wnt Proteins ; beta Catenin
    Language English
    Publishing date 2017-08-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22517
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.

    Trieger, Greg W / Pessentheiner, Ariane R / Purcell, Sean C / Green, Courtney R / DeForest, Natalie / Willert, Karl / Majithia, Amit R / Metallo, Christian M / Godula, Kamil / Gordts, Philip L S M

    The Journal of biological chemistry

    2023  Volume 299, Issue 5, Page(s) 104611

    Abstract: Adipose tissue plays a crucial role in maintaining metabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like adipose tissue become insulin resistant, decompensation of blood glucose levels ... ...

    Abstract Adipose tissue plays a crucial role in maintaining metabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like adipose tissue become insulin resistant, decompensation of blood glucose levels occurs causing type 2 diabetes (T2D). Currently, modulating the glycocalyx, a layer of cell-surface glycans, is an underexplored pharmacological treatment strategy to improve glucose homeostasis in T2D patients. Here, we show a novel role for cell-surface heparan sulfate (HS) in establishing glucose uptake capacity and metabolic utilization in differentiated adipocytes. Using a combination of chemical and genetic interventions, we identified that HS modulates this metabolic phenotype by attenuating levels of Wnt signaling during adipogenesis. By engineering, the glycocalyx of pre-adipocytes with exogenous synthetic HS mimetics, we were able to enhance glucose clearance capacity after differentiation through modulation of Wnt ligand availability. These findings establish the cellular glycocalyx as a possible new target for therapeutic intervention in T2D patients by enhancing glucose clearance capacity independent of insulin secretion.
    MeSH term(s) Humans ; Adipogenesis/genetics ; Glycocalyx/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Heparitin Sulfate ; Glucose/metabolism
    Chemical Substances Heparitin Sulfate (9050-30-0) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.104611
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    Uc I Zs.108: Show issues Location:
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  9. Article ; Online: The role of Wnt signaling in hematopoietic stem cell development.

    Richter, Jenna / Traver, David / Willert, Karl

    Critical reviews in biochemistry and molecular biology

    2017  Volume 52, Issue 4, Page(s) 414–424

    MeSH term(s) Animals ; Cell Polarity ; Hematopoiesis ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Liver/embryology ; Liver/metabolism ; Mice ; Wnt Signaling Pathway ; Zebrafish
    Language English
    Publishing date 2017-05-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1000977-2
    ISSN 1549-7798 ; 1381-3455 ; 1040-9238
    ISSN (online) 1549-7798
    ISSN 1381-3455 ; 1040-9238
    DOI 10.1080/10409238.2017.1325828
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    Zs.A 1024: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Wnt Signaling in Hematological Malignancies.

    Grainger, Stephanie / Traver, David / Willert, Karl

    Progress in molecular biology and translational science

    2017  Volume 153, Page(s) 321–341

    Abstract: Leukemia and lymphoma are a wide encompassing term for a diverse set of blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year (Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA ... ...

    Abstract Leukemia and lymphoma are a wide encompassing term for a diverse set of blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year (Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7-30.). Hematopoietic stem cells (HSCs) are tissue-specific stem cells at the apex of the hierarchy that gives rise to all of the terminally differentiated blood cells, through progressively restricted progenitor populations, a process that is known to be Wnt-responsive. In particular, the progenitor populations are subject to uncontrolled expansion during oncogenic processes, namely the common myeloid progenitor and common lymphoid progenitor, as well as the myeloblast and lymphoblast. Unregulated growth of these cell-types leads to mainly three types of blood cancers (i.e., leukemia, lymphoma, and myeloma), which frequently exhibit deregulation of the Wnt signaling pathway. Generally, leukemia is caused by the expansion of myeloid progenitors, leading to an overproduction of white blood cells; as such, patients are unable to make sufficient numbers of red blood cells and platelets. Likewise, an overproduction of lymphocytes leads to clogging of the lymph system and impairment of the immune system in lymphomas. Finally, cancer of the plasma cells in the blood is called myeloma, which also leads to immune system failure. Within each of these three types of blood cancers, there are multiple subtypes, usually characterized by their timeline of onset and their cell type of origin. Of these, 85% of leukemias are encompassed by the four most common diseases, that is, acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL); AML accounts for the majority of leukemia-related deaths (Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7-30.). Through understanding how HSCs are normally developed and maintained, we can understand how the normal functions of these pathways are disrupted during blood cancer progression; the Wnt pathway is important in regulation of both normal and malignant hematopoiesis. In this chapter, we will discuss the role of Wnt signaling in normal and aberrant hematopoiesis. Our understanding the relationship between Wnt and HSCs will provide novel insights into therapeutic targets.
    MeSH term(s) Animals ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/pathology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2017-12-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2017.11.002
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