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  1. Article: Erratum for Musgrove et al., "Professional Development for Early Career DBER Scholars through In-Person and Virtual Career Panel Workshops".

    Musgrove, Miranda M Chen / Genné-Bacon, Elizabeth / Gray, Kelsey / Heim, Ashley B / Karippadath, Anupriya / Magalhães, Rita Margarida / Tripp, Brie / Zelaya, Anna J

    Journal of microbiology & biology education

    2022  Volume 23, Issue 2

    Abstract: This corrects the article DOI: 10.1128/jmbe.00190-21.]. ...

    Abstract [This corrects the article DOI: 10.1128/jmbe.00190-21.].
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Published Erratum
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.00045-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Estrogen receptor degradation: a CUE for endocrine resistance?

    Musgrove, Elizabeth A

    Breast cancer research : BCR

    2011  Volume 13, Issue 4, Page(s) 312

    Abstract: Despite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially respond will subsequently relapse. ... ...

    Abstract Despite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially respond will subsequently relapse. Deregulation of various aspects of estrogen receptor signaling has been highlighted as a mechanism of resistance and as a basis for alternative therapeutic approaches. However, a recent publication refocuses attention on the estrogen receptor itself by showing that the ubiquitin-binding CUE domain-containing protein 2 is a regulator of estrogen receptor protein degradation and a marker of endocrine resistance in breast cancer.
    MeSH term(s) Adaptor Proteins, Signal Transducing ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Carrier Proteins/metabolism ; Drug Resistance, Neoplasm ; Endocrine System/metabolism ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Membrane Proteins/metabolism ; Protein Structure, Tertiary
    Chemical Substances Adaptor Proteins, Signal Transducing ; CUEDC2 protein, human ; Carrier Proteins ; ESR1 protein, human ; Estrogen Receptor alpha ; Membrane Proteins
    Language English
    Publishing date 2011-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/bcr2914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

    Bomkamp, Claire / Musgrove, Lisa / Marques, Diana M. C. / Fernando, Gonçalo F. / Ferreira, Frederico C. / Specht, Elizabeth A.

    Mar Biotechnol. 2023 Feb., v. 25, no. 1 p.1-29

    2023  

    Abstract: Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated ... ...

    Abstract Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and—in the case of seafood—overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.
    Keywords Danio rerio ; animal welfare ; antibiotic resistance ; aquaculture ; environmental degradation ; fish ; food security ; meat ; muscles ; seafoods ; shellfish
    Language English
    Dates of publication 2023-02
    Size p. 1-29.
    Publishing place Springer US
    Document type Article ; Online
    Note Review
    ZDB-ID 1479877-3
    ISSN 1436-2236 ; 1436-2228
    ISSN (online) 1436-2236
    ISSN 1436-2228
    DOI 10.1007/s10126-022-10174-4
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.

    Bomkamp, Claire / Musgrove, Lisa / Marques, Diana M C / Fernando, Gonçalo F / Ferreira, Frederico C / Specht, Elizabeth A

    Marine biotechnology (New York, N.Y.)

    2022  Volume 25, Issue 1, Page(s) 1–29

    Abstract: Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated ... ...

    Abstract Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and-in the case of seafood-overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.
    MeSH term(s) Animals ; Conservation of Natural Resources ; Zebrafish ; Fisheries ; Seafood/analysis ; Muscles ; Adipocytes ; Cell Differentiation ; Developmental Biology ; Mammals
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1479877-3
    ISSN 1436-2236 ; 1436-2228
    ISSN (online) 1436-2236
    ISSN 1436-2228
    DOI 10.1007/s10126-022-10174-4
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  5. Article: Professional Development for Early Career DBER Scholars through In-Person and Virtual Career Panel Workshops.

    Musgrove, Miranda M Chen / Genné-Bacon, Elizabeth / Gray, Kelsey / Heim, Ashley B / Karippadath, Anupriya / Magalhães, Rita Margarida / Tripp, Brie / Zelaya, Anna J

    Journal of microbiology & biology education

    2022  Volume 23, Issue 1

    Abstract: In discipline-based education research (DBER), early career scholars, such as graduate students and postdoctoral researchers, observe a slew of possible career pathways. Yet, there is a lack of opportunities to learn about such pathways, particularly ... ...

    Abstract In discipline-based education research (DBER), early career scholars, such as graduate students and postdoctoral researchers, observe a slew of possible career pathways. Yet, there is a lack of opportunities to learn about such pathways, particularly when transitioning from traditional science, technology, engineering, or math (STEM) disciplinary training into a DBER position. Thus, the DBER Scholars-in-Training Professional Development subcommittee was created within the Society for the Advancement of Biology Education Research (SABER) community to develop a collection of workshops that would serve the greatest professional development needs of early career scholars entering DBER. Through a series of surveys disseminated over multiple years, early career scholars expressed interest in better navigating their career options, which led to the development of the career panel workshop, held during the 2019 and 2020 SABER Annual National Conferences. In this report, we explore the development, implementation, and results of two career panel workshops and compare and contrast the 2019 in-person workshop with the 2020 virtual workshop. We also offer our insights on the value of the career workshop, discuss the next steps, and explore valuable resources for those planning on organizing similar events.
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.00190-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Endocrine therapy: defining the path of least resistance.

    Stone, Andrew / Musgrove, Elizabeth A

    Breast cancer research : BCR

    2014  Volume 16, Issue 3, Page(s) 101

    Abstract: One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling. In both endocrine-resistant disease and breast cancer stem ... ...

    Abstract One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling. In both endocrine-resistant disease and breast cancer stem cells, this is commonly caused by specific genetic lesions or amplification of key pathway components or both. These observations have generated two interesting hypotheses. Firstly, do these genetic anomalies provide clinically significant biomarkers predictive of endocrine resistance? Secondly, do tamoxifen-resistant breast cancer cells emerge from a stem-like cell population? New studies, published in Breast Cancer Research, raise the possibility that these hypotheses are intrinsically linked.
    MeSH term(s) Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Mutation ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phosphatidylinositol 3-Kinase/genetics ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Tamoxifen/therapeutic use
    Chemical Substances Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2014-05-22
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/bcr3659
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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Cyclins: roles in mitogenic signaling and oncogenic transformation.

    Musgrove, Elizabeth A

    Growth factors (Chur, Switzerland)

    2006  Volume 24, Issue 1, Page(s) 13–19

    Abstract: Cyclins are the regulatory subunits of kinases that control progress through the cell cycle. This review focuses on cyclins that are targets for extracellular signaling and frequently deregulated during oncogenesis, particularly cyclin D1. Receptor ... ...

    Abstract Cyclins are the regulatory subunits of kinases that control progress through the cell cycle. This review focuses on cyclins that are targets for extracellular signaling and frequently deregulated during oncogenesis, particularly cyclin D1. Receptor tyrosine kinases and adhesion molecules act through various effector pathways to modulate cyclin D1 abundance at multiple levels including transcription, translation and protein stability. In contrast, cyclin E-Cdk2 activity appears to be more commonly regulated by means other than regulation of cyclin E abundance. The importance of these pathways during oncogenesis is illustrated by the dependence of oncogenes such as Ras and Neu/ErbB2 on cyclin D1. Thus, understanding the roles of cyclins in growth factor and adhesion signaling is important for understanding the biology of both normal and neoplastic cells.
    MeSH term(s) Animals ; Cell Adhesion ; Cell Cycle ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Cyclin D1/metabolism ; Cyclin D1/physiology ; Cyclin E/metabolism ; Cyclin E/physiology ; Genes, erbB-2 ; Humans ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; ras GTPase-Activating Proteins/metabolism
    Chemical Substances Cyclin E ; ras GTPase-Activating Proteins ; Cyclin D1 (136601-57-5) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2006-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035755-5
    ISSN 0897-7194
    ISSN 0897-7194
    DOI 10.1080/08977190500361812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2612: Show issues Location:
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  8. Article ; Online: Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer.

    Caldon, C Elizabeth / Musgrove, Elizabeth A

    Cell division

    2010  Volume 5, Page(s) 2

    Abstract: The highly conserved E-type cyclins are core components of the cell cycle machinery, facilitating the transition into S phase through activation of the cyclin dependent kinases, and assembly of pre-replication complexes on DNA. Cyclin E1 and cyclin E2 ... ...

    Abstract The highly conserved E-type cyclins are core components of the cell cycle machinery, facilitating the transition into S phase through activation of the cyclin dependent kinases, and assembly of pre-replication complexes on DNA. Cyclin E1 and cyclin E2 are assumed to be functionally redundant, as cyclin E1-/- E2-/- mice are embryonic lethal while cyclin E1-/- and E2-/- single knockout mice have primarily normal phenotypes. However more detailed studies of the functions and regulation of the E-cyclins have unveiled potential additional roles for these proteins, such as in endoreplication and meiosis, which are more closely associated with either cyclin E1 or cyclin E2. Moreover, expression of each E-cyclin can be independently regulated by distinct transcription factors and microRNAs, allowing for context-specific expression. Furthermore, cyclins E1 and E2 are frequently expressed independently of one another in human cancer, with unique associations to signatures of poor prognosis. These data imply an absence of co-regulation of cyclins E1 and E2 during tumorigenesis and possibly different contributions to cancer progression. This is supported by in vitro data identifying divergent regulation of the two genes, as well as potentially different roles in vivo.
    Language English
    Publishing date 2010-01-17
    Publishing country England
    Document type Journal Article
    ISSN 1747-1028
    ISSN (online) 1747-1028
    DOI 10.1186/1747-1028-5-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?

    Musgrove, Elizabeth A

    Breast cancer research : BCR

    2004  Volume 6, Issue 2, Page(s) 65–68

    Abstract: Recent data have suggested the epidermal-growth-factor receptor (EGFR) as a point of convergence for several different classes of receptor. Civenni and colleagues have now demonstrated crosstalk between Wnt signalling and the EGFR, showing that in breast ...

    Abstract Recent data have suggested the epidermal-growth-factor receptor (EGFR) as a point of convergence for several different classes of receptor. Civenni and colleagues have now demonstrated crosstalk between Wnt signalling and the EGFR, showing that in breast epithelial cells Wnts activate downstream targets of the EGFR, including cyclin D1. Given the role of members of these pathways in the aetiology of breast cancer and as markers of outcome and potential therapeutic targets in breast cancer, this observation has a number of potential implications important for both the basic biology of breast cancer and the clinical management of the disease.
    MeSH term(s) Animals ; Breast Neoplasms/genetics ; Intercellular Signaling Peptides and Proteins/physiology ; Receptor, Epidermal Growth Factor/physiology ; Signal Transduction/physiology ; Wnt Proteins
    Chemical Substances Intercellular Signaling Peptides and Proteins ; Wnt Proteins ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2004
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/bcr737
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  10. Article ; Online: Entomology beyond research and education: 2022 student debates.

    Sandhi, Ramandeep Kaur / Pickens, Victoria / Bello, Elizabeth / Elzay, Sarah / Salgado, Sara / Hauri, Kayleigh C / Ternest, John J / Constancio, Natalie / Gula, Scott / Gearner, Olivia M / Anderson, Magdeline / Edeburn, Molly / Hall, Brandon / Maille, Jacqueline / Toth, Mollie / Khadka, Arjun / Doherty, Ethan / Musgrove, Tyler / Silva, Tiago /
    Desoto, Alexia / Rampone, Emily / Jocson, Dowen / Luppino, Mario / Pautzke, Kellen / Wagstaff, Camille

    Journal of insect science (Online)

    2023  Volume 23, Issue 3

    Abstract: The 2022 student debates of the Entomological Society of America (ESA) happened during the Joint Annual Meeting of the Entomological Societies of America, Canada, and British Columbia in Vancouver, BC, and addressed entomological aspects beyond research ... ...

    Abstract The 2022 student debates of the Entomological Society of America (ESA) happened during the Joint Annual Meeting of the Entomological Societies of America, Canada, and British Columbia in Vancouver, BC, and addressed entomological aspects beyond research and education. The Student Debates Subcommittee of the ESA Student Affairs Committee and the participating student team members communicated for 8 months and prepared for the debates. The theme of the ESA meeting in 2022 was "Entomology as inspiration: Insects through art, science, and culture". There were 2 unbiased speakers who introduced the debate topics as well as 4 teams who debated the following 2 topics: (i) Is forensic entomology viable in criminal case investigations and court cases today? and (ii) Are insects being treated ethically in scientific research? The teams prepared for about 8 months, debated their arguments, and shared their thoughts with the audience. The teams were judged by a panel and the winners were recognized at the ESA Student Awards Session during the annual meeting.
    MeSH term(s) Animals ; Humans ; Students ; Insecta ; Entomology ; British Columbia ; Postmortem Changes
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2049098-7
    ISSN 1536-2442 ; 1536-2442
    ISSN (online) 1536-2442
    ISSN 1536-2442
    DOI 10.1093/jisesa/iead036
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