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Article ; Online: Endonasal FLI Approach for Rhinoplasty with Modified Cottle Low Strip Septoplasty.

López-Ulloa, Fausto / Jasso-Ramírez, Elizabeth / Friedman, Oren

2021 Volume 37, Issue 1, Page(s) 29–35

Abstract: ... to the anterior septal angle, the scroll, and internal nasal valve.The endonasal approach that Fausto Lopez ...

Abstract	To date, an endonasal approach has not been described that combines different incisions to provide exposure of all of the key anatomical structures, allowing for adequate, comprehensive visualization of the nasal architecture including the complete quadrangular cartilage and its extension with the upper lateral cartilages, including the caudal septal border from the ventral border and anterior nasal spine to the anterior septal angle, the scroll, and internal nasal valve.The endonasal approach that Fausto Lopez-Infante designed, the FLI technique, combines several basic known endonasal incisions that together allow excellent access and great visualization of the intranasal surgical field, enables extensive septal work, and preserves the natural anatomy of the dorsum as well as the tip support structures.This technique and approach to nasal surgery are based on an understanding of anatomy, allow standardization of the surgery, and make it reproducible. It is an outstanding option with excellent cosmetic and functional results.
MeSH term(s)	Cartilage ; Humans ; Nasal Septum/surgery ; Rhinoplasty
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	630090-x
ISSN	1098-8793 ; 0736-6825
ISSN (online)	1098-8793
ISSN	0736-6825
DOI	10.1055/s-0041-1722911
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Article ; Online: Preservation Rhinoplasty: The Endonasal Cottle Push-Down/Let-Down Approach.

Friedman, Oren / Ulloa, Fausto Lopez / Kern, Eugene B

Facial plastic surgery clinics of North America

2020 Volume 29, Issue 1, Page(s) 67–75

Abstract: Preservation rhinoplasty is a new term for an old technique. The authors have used the endonasal push-down and let-down techniques that are attributed to Dr Maurice Cottle throughout their careers on select patients with excellent success. The endonasal ... ...

Abstract	Preservation rhinoplasty is a new term for an old technique. The authors have used the endonasal push-down and let-down techniques that are attributed to Dr Maurice Cottle throughout their careers on select patients with excellent success. The endonasal Cottle technique allows the authors to manage the nasal dorsum in a conservative fashion, reducing the need for routine restructuring of the middle third and nasal dorsum. The details of their approach are presented in this publication.
MeSH term(s)	Humans ; Nasal Cartilages/surgery ; Nasal Septum/surgery ; Rhinoplasty/instrumentation ; Rhinoplasty/methods
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1315178-2
ISSN	1558-1926 ; 1064-7406
ISSN (online)	1558-1926
ISSN	1064-7406
DOI	10.1016/j.fsc.2020.08.006
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Article: Endonasal FLI Approach for Rhinoplasty with Modified Cottle Low Strip Septoplasty

López-Ulloa, Fausto / Jasso-Ramírez, Elizabeth / Friedman, Oren

Facial Plastic Surgery

(Preservation Rhinoplasty: An Update)

2021 Volume 37, Issue 01, Page(s) 29–35

Abstract: ... to the anterior septal angle, the scroll, and internal nasal valve. The endonasal approach that Fausto Lopez ...

Series title	Preservation Rhinoplasty: An Update
Abstract	To date, an endonasal approach has not been described that combines different incisions to provide exposure of all of the key anatomical structures, allowing for adequate, comprehensive visualization of the nasal architecture including the complete quadrangular cartilage and its extension with the upper lateral cartilages, including the caudal septal border from the ventral border and anterior nasal spine to the anterior septal angle, the scroll, and internal nasal valve. The endonasal approach that Fausto Lopez-Infante designed, the FLI technique, combines several basic known endonasal incisions that together allow excellent access and great visualization of the intranasal surgical field, enables extensive septal work, and preserves the natural anatomy of the dorsum as well as the tip support structures. This technique and approach to nasal surgery are based on an understanding of anatomy, allow standardization of the surgery, and make it reproducible. It is an outstanding option with excellent cosmetic and functional results.
Keywords	FLI approach ; endonasal approach ; septorhinoplasty ; technique ; nasal anatomy
Language	English
Publishing date	2021-02-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	630090-x
ISSN	1098-8793 ; 0736-6825
ISSN (online)	1098-8793
ISSN	0736-6825
DOI	10.1055/s-0041-1722911
Database	Thieme publisher's database

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Article ; Online: A mammalian-specific Alex3/Gα

Science signaling

2024 Volume 17, Issue 822, Page(s) eabq1007

Abstract: Mitochondrial dynamics and trafficking are essential to provide the energy required for neurotransmission and neural activity. We investigated how G protein-coupled receptors (GPCRs) and G proteins control mitochondrial dynamics and trafficking. The ... ...

Abstract	Mitochondrial dynamics and trafficking are essential to provide the energy required for neurotransmission and neural activity. We investigated how G protein-coupled receptors (GPCRs) and G proteins control mitochondrial dynamics and trafficking. The activation of Gα
MeSH term(s)	Animals ; Mice ; Axons/metabolism ; Mammals/metabolism ; Mitochondrial Proteins/metabolism ; Neurons/metabolism
Chemical Substances	Mitochondrial Proteins ; Gnaq protein, mouse
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abq1007
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Article ; Online: Twisted Nose: Preservation Rhinoplasty with Modified Push-Down/Let-Down Technique.

Jasso-Ramírez, Elizabeth / Burgos-Páez, Alan / Sánchez Y Béjar, Fernando / Friedman, Oren / Kern, Eugene / López-Ulloa, Fausto

Plastic and reconstructive surgery

2022 Volume 151, Issue 4, Page(s) 749–757

Abstract: Background: The authors present a retrospective, comparative, and analytical cohort study, that aimed to prove the utility of unilateral or asymmetrical bony wedge resection to straighten the twisted nose as applied in let-down and push-down methods. ... ...

Abstract	Background: The authors present a retrospective, comparative, and analytical cohort study, that aimed to prove the utility of unilateral or asymmetrical bony wedge resection to straighten the twisted nose as applied in let-down and push-down methods. The study involved objective angle measurements preoperatively and postoperatively on frontal view photographs. Methods: Preoperative and postoperative angle measurements were made on frontal view photographs of 78 patients with twisted noses classified as type C and type I. Angles of deviation were obtained using Scion Image software, measured in degrees. Statistical analysis was performed using Excel v15.13.3. Results: Forty-two patients had twisted nose type C and 28 patients had twisted nose type I. The mean age was 19 years. There was an 81% improvement ratio for twisted nose type C and 79% for twisted nose type I, and the angle correction for each type of nasal deformity was statistically significant ( P < 0.01). The majority of postoperative results were classified as excellent to good, with the exception of four cases with bad outcomes, including two patients with type C and two with type I deviations. Conclusions: Unilateral or asymmetrical bony wedge resection is a modification of the let-down rhinoplasty technique. This study demonstrates statistically significant improvements in straightening twisted noses among patients with or without preoperative hump and preserving the nasal dorsum. The authors found this modification better suited for type C deviations. Clinical question/level of evidence: Therapeutic, IV.
MeSH term(s)	Humans ; Young Adult ; Adult ; Rhinoplasty/methods ; Cohort Studies ; Retrospective Studies ; Nasal Septum/surgery ; Treatment Outcome ; Nose/surgery
Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000009990
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Article: Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion.

Martínez-Mármol, Ramón / Muhaisen, Ashraf / Cotrufo, Tiziana / Roselló-Busquets, Cristina / Ros, Oriol / Hernaiz-Llorens, Marc / Pérez-Branguli, Francesc / Andrés, Rosa Maria / Parcerisas, Antoni / Pascual, Marta / Ulloa, Fausto / Soriano, Eduardo

Frontiers in molecular neuroscience

2023 Volume 16, Page(s) 1253954

Abstract: Introduction: Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular ...

Abstract	Introduction: Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular machinery responsible for the correct response of growth cones are just being unveiled. Netrin-1 is a bifunctional molecule involved in axon pathfinding and cell migration that induces repulsion during postnatal cerebellar development. This process is mediated by UNC5 homolog receptors located on external granule layer (EGL) tracts. Methods: Biochemical, imaging and cell biology techniques, as well as syntaxin-1A/B (Stx1A/B) knock-out mice were used in primary cultures and brain explants. Results and discussion: Here, we demonstrate that this response is characterized by enhanced membrane internalization through macropinocytosis, but not clathrin-mediated endocytosis. We show that UNC5A, UNC5B, and UNC5C receptors form a protein complex with the t-SNARE syntaxin-1. By combining botulinum neurotoxins, an shRNA knock-down strategy and Stx1 knock-out mice, we demonstrate that this SNARE protein is required for Netrin1-induced macropinocytosis and chemorepulsion, suggesting that Stx1 is crucial in regulating Netrin-1-mediated axonal guidance.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2023.1253954
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Article ; Online: Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).

Ortega-Gascó, Alba / Parcerisas, Antoni / Hino, Keiko / Herranz-Pérez, Vicente / Ulloa, Fausto / Elias-Tersa, Alba / Bosch, Miquel / García-Verdugo, José Manuel / Simó, Sergi / Pujadas, Lluís / Soriano, Eduardo

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 21, Page(s) 10931–10948

Abstract: Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family ... ...

Abstract	Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family of cell adhesion molecules (CAMs), which participate in signal transduction and regulate the survival, division, and differentiation of radial glial progenitors (RGPs). Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during corticogenesis. We characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus, revealing different levels of NCAM2 amid the progression of RGPs and the formation of neurons. We showed that Ncam2 overexpression in adult mice arrested progenitors in an RGP-like state, affecting the normal course of young-adult neurogenesis. Furthermore, changes in Ncam2 levels during corticogenesis led to transient migratory deficits but did not affect the survival and proliferation of RGPs, suggesting a differential role of NCAM2 in adult and embryonic stages. Our data reinforce the relevance of CAMs in the neurogenic process by revealing a significant role of Ncam2 levels in the regulation of RGPs during young-adult neurogenesis in the hippocampus.
MeSH term(s)	Mice ; Animals ; Neurons/physiology ; Neurogenesis/physiology ; Cell Differentiation/physiology ; Neural Cell Adhesion Molecules/metabolism ; Hippocampus/metabolism ; Mammals/metabolism
Chemical Substances	Neural Cell Adhesion Molecules ; Ncam2 protein, mouse
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad340
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Article ; Online: Global Practice Patterns of Dorsal Preservation Rhinoplasty.

Patel, Priyesh N / Kandathil, Cherian K / Buba, Cibele Madsen / Neves, José Carlos / Cobo, Roxana / Robotti, Enrico / López-Ulloa, Fausto / Ferraz, Mario / Saedi, Babak / Pham, Tuan / Saleh, Hesham A / Most, Sam P

Facial plastic surgery & aesthetic medicine

2021 Volume 24, Issue 3, Page(s) 171–177

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Europe ; Humans ; Rhinoplasty/methods ; Surgeons ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3006458-2
ISSN	2689-3622 ; 2689-3614
ISSN (online)	2689-3622
ISSN	2689-3614
DOI	10.1089/fpsam.2021.0055
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Article ; Online: Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors.

Hernaiz-Llorens, Marc / Roselló-Busquets, Cristina / Durisic, Nela / Filip, Adam / Ulloa, Fausto / Martínez-Mármol, Ramón / Soriano, Eduardo

Cellular and molecular life sciences : CMLS

2020 Volume 78, Issue 6, Page(s) 2797–2820

Abstract: During brain development, Uncoordinated locomotion 5 (UNC5) receptors control axonal extension through their sensing of the guidance molecule Netrin-1. The correct positioning of receptors into cholesterol-enriched membrane raft microdomains is crucial ... ...

Abstract	During brain development, Uncoordinated locomotion 5 (UNC5) receptors control axonal extension through their sensing of the guidance molecule Netrin-1. The correct positioning of receptors into cholesterol-enriched membrane raft microdomains is crucial for the efficient transduction of the recognized signals. However, whether such microdomains are required for the appropriate axonal guidance mediated by UNC5 receptors remains unknown. Here, we combine the use of confocal microscopy, live-cell FRAP analysis and single-particle tracking PALM to characterize the distribution of UNC5 receptors into raft microdomains, revealing differences in their membrane mobility properties. Using pharmacological and genetic approaches in primary neuronal cultures and brain cerebellar explants we further demonstrate that disrupting raft microdomains inhibits the chemorepulsive response of growth cones and axons against Netrin-1. Together, our findings indicate that the distribution of all UNC5 receptors into cholesterol-enriched raft microdomains is heterogeneous and that the specific localization has functional consequences for the axonal chemorepulsion against Netrin-1.
MeSH term(s)	Animals ; Axons/metabolism ; Cells, Cultured ; Cholesterol/metabolism ; Cholesterol 24-Hydroxylase/genetics ; Cholesterol 24-Hydroxylase/metabolism ; Female ; Fluorescence Recovery After Photobleaching ; HEK293 Cells ; Humans ; Membrane Microdomains/metabolism ; Mice ; Netrin Receptors/genetics ; Netrin Receptors/metabolism ; Netrin-1/metabolism ; Neurons/cytology ; Neurons/metabolism ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism
Chemical Substances	Netrin Receptors ; Receptors, Cell Surface ; UNC5A protein, human ; UNC5B protein, human ; UNC5C protein, human ; UNC5D protein, human ; Netrin-1 (158651-98-0) ; Cholesterol (97C5T2UQ7J) ; Cholesterol 24-Hydroxylase (EC 1.14.14.25)
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-020-03663-z
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Article ; Online: Acute oral toxicity of a novel functional drink based on

Paladines-Santacruz, Geovanna / Orellana-Manzano, Andrea / Sarmiento, Glenda / Pilozo, Glenda / Iñiga, Elsy / Zaruma-Torres, Fausto / Ortíz-Ulloa, Johana / Quijano-Avilés, María / Di Grumo, Davide / Orellana-Manzano, Silvia / Villacrés, María Del Carmen / Manzano, Patricia / Vanden Berghe, Wim

Toxicology reports

2021 Volume 8, Page(s) 747–752

Abstract: A novel functional drink with nutraceutical properties was formulated from the aqueous extracts ... ...

Abstract	A novel functional drink with nutraceutical properties was formulated from the aqueous extracts of
Language	English
Publishing date	2021-04-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.03.026
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