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Article ; Online: Comparison of permeable cell culture inserts for use in culture of a human in vitro air-liquid interface model system.

Brocke, Stephanie A / Speen, Adam M / Masood, Syed / Worden, Cameron P / Jaspers, Ilona

2024 Volume 12, Issue 3, Page(s) e15921

Abstract: In this study, we compared 12 mm cell culture inserts with permeable polyester membranes (0.4 μm pores) from two different manufacturers: CELLTREAT® and Corning®. Physical dimensions and masses of the inserts were found to be very similar between the two ...

Abstract	In this study, we compared 12 mm cell culture inserts with permeable polyester membranes (0.4 μm pores) from two different manufacturers: CELLTREAT® and Corning®. Physical dimensions and masses of the inserts were found to be very similar between the two brands, with CELLTREAT® inserts having a slightly smaller diameter and growth area (11.91 mm; 1.11 cm
MeSH term(s)	Humans ; Male ; Cell Culture Techniques/methods ; Epithelial Cells/metabolism ; Respiratory System ; Cells, Cultured ; Cell Differentiation
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15921
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Article ; Online: Impact of inhaled pollutants on response to viral infection in controlled exposures.

Rebuli, Meghan E / Brocke, Stephanie A / Jaspers, Ilona

The Journal of allergy and clinical immunology

2021 Volume 148, Issue 6, Page(s) 1420–1429

Abstract: Air pollutants are a major source of increased risk of disease, hospitalization, morbidity, and mortality worldwide. The respiratory tract is a primary target of potential concurrent exposure to both inhaled pollutants and pathogens, including viruses. ... ...

Abstract	Air pollutants are a major source of increased risk of disease, hospitalization, morbidity, and mortality worldwide. The respiratory tract is a primary target of potential concurrent exposure to both inhaled pollutants and pathogens, including viruses. Although there are various associative studies linking adverse outcomes to co- or subsequent exposures to inhaled pollutants and viruses, knowledge about causal linkages and mechanisms by which pollutant exposure may alter human respiratory responses to viral infection is more limited. In this article, we review what is known about the impact of pollutant exposure on antiviral host defense responses and describe potential mechanisms by which pollutants can alter the viral infection cycle. This review focuses on evidence from human observational and controlled exposure, ex vivo, and in vitro studies. Overall, there are a myriad of points throughout the viral infection cycle that inhaled pollutants can alter to modulate appropriate host defense responses. These alterations may contribute to observed increases in rates of viral infection and associated morbidity and mortality in areas of the world with high ambient pollution levels or in people using tobacco products. Although the understanding of mechanisms of interaction is advancing through controlled in vivo and in vitro exposure models, more studies are needed because emerging infectious pathogens, such as severe acute respiratory syndrome coronavirus 2, present a significant threat to public health.
MeSH term(s)	Air Pollutants/adverse effects ; Air Pollution/adverse effects ; COVID-19 ; Environmental Exposure/adverse effects ; Environmental Monitoring/methods ; Environmental Pollutants ; Hospitalization ; Humans ; Pandemics ; Particulate Matter/adverse effects ; Respiratory System ; Virus Diseases
Chemical Substances	Air Pollutants ; Environmental Pollutants ; Particulate Matter
Language	English
Publishing date	2021-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2021.07.002
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Article ; Online: Woodsmoke particle exposure prior to SARS-CoV-2 infection alters antiviral response gene expression in human nasal epithelial cells in a sex-dependent manner.

Brocke, Stephanie A / Billings, Grant T / Taft-Benz, Sharon / Alexis, Neil E / Heise, Mark T / Jaspers, Ilona

American journal of physiology. Lung cellular and molecular physiology

2022 Volume 322, Issue 3, Page(s) L479–L494

Abstract: Inhalational exposure to particulate matter (PM) derived from natural or anthropogenic sources alters gene expression in the airways and increases susceptibility to respiratory viral infection. Woodsmoke-derived ambient PM from wildfire events during ... ...

Abstract	Inhalational exposure to particulate matter (PM) derived from natural or anthropogenic sources alters gene expression in the airways and increases susceptibility to respiratory viral infection. Woodsmoke-derived ambient PM from wildfire events during 2020 was associated with higher COVID-19 case rates in the western United States. We hypothesized that exposure to suspensions of woodsmoke particles (WSPs) or diesel exhaust particles (DEPs) prior to SARS-CoV-2 infection would alter host immune gene expression at the transcript level. Primary human nasal epithelial cells (hNECs) from both sexes were exposed to WSPs or DEPs (22 μg/cm
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00362.2021
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Article ; Online: Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing.

Armbruster, Diana / Brocke, Burkhard / Kirschbaum, Clemens / Witt, Stephanie H / Lesch, Klaus-Peter / Strobel, Alexander

Physiology & behavior

2020 Volume 219, Page(s) 112831

Abstract: Dysfunction in the circadian system has been linked to emotion regulation and mood disorders with genetic variation in clock genes as likely contributors. Here, we focused on endophenotypes of affective processing and investigated in two independent ... ...

Abstract	Dysfunction in the circadian system has been linked to emotion regulation and mood disorders with genetic variation in clock genes as likely contributors. Here, we focused on endophenotypes of affective processing and investigated in two independent samples of healthy individuals (n
MeSH term(s)	Affect ; CLOCK Proteins/genetics ; Emotions ; Facial Muscles ; Female ; Humans ; Reflex, Startle/genetics
Chemical Substances	CLOCK Proteins (EC 2.3.1.48) ; CLOCK protein, human (EC 2.3.1.48)
Language	English
Publishing date	2020-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2020.112831
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Article ; Online: Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes.

Hickman, Elise / Payton, Alexis / Duffney, Parker / Wells, Heather / Ceppe, Agathe S / Brocke, Stephanie / Bailey, Aleah / Rebuli, Meghan E / Robinette, Carole / Ring, Brian / Rager, Julia E / Alexis, Neil E / Jaspers, Ilona

American journal of respiratory and critical care medicine

2022 Volume 206, Issue 10, Page(s) 1248–1258

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Electronic Nicotine Delivery Systems ; Vaping/adverse effects ; Matrix Metalloproteinase 2 ; Vascular Endothelial Growth Factor A ; Tobacco Products ; Biomarkers ; Homeostasis
Chemical Substances	Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Vascular Endothelial Growth Factor A ; Biomarkers
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202202-0373OC
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Article: Woodsmoke particulates alter expression of antiviral host response genes in human nasal epithelial cells infected with SARS-CoV-2 in a sex-dependent manner.

Brocke, Stephanie A / Billings, Grant T / Taft-Benz, Sharon / Alexis, Neil E / Heise, Mark T / Jaspers, Ilona

bioRxiv : the preprint server for biology

2021

Abstract: We have previously shown that exposure to particulate air pollution, both from natural and anthropogenic sources, alters gene expression in the airways and increases susceptibility to respiratory viral infection. Additionally, we have shown that ... ...

Abstract	We have previously shown that exposure to particulate air pollution, both from natural and anthropogenic sources, alters gene expression in the airways and increases susceptibility to respiratory viral infection. Additionally, we have shown that woodsmoke particulates (WSP) affect responses to influenza in a sex-dependent manner. In the present study, we used human nasal epithelial cells (hNECs) from both sexes to investigate how particulate exposure could modulate gene expression in the context of SARS-CoV-2 infection. We used diesel exhaust particulate (DEP) as well as WSP derived from eucalyptus or red oak wood. HNECs were exposed to particulates at a concentration of 22 μg/cm
Language	English
Publishing date	2021-08-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.08.23.457411
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Article ; Online: Prediction of Membrane Permeation of Drug Molecules by Combining an Implicit Membrane Model with Machine Learning.

Brocke, Stephanie A / Degen, Alexandra / MacKerell, Alexander D / Dutagaci, Bercem / Feig, Michael

Journal of chemical information and modeling

2018 Volume 59, Issue 3, Page(s) 1147–1162

Abstract: Lipid membrane permeation of drug molecules was investigated with Heterogeneous Dielectric Generalized Born (HDGB)-based models using solubility-diffusion theory and machine learning. Free energy profiles were obtained for neutral molecules by the ... ...

Abstract	Lipid membrane permeation of drug molecules was investigated with Heterogeneous Dielectric Generalized Born (HDGB)-based models using solubility-diffusion theory and machine learning. Free energy profiles were obtained for neutral molecules by the standard HDGB and Dynamic HDGB (DHDGB) to account for the membrane deformation upon insertion of drugs. We also obtained hybrid free energy profiles where the neutralization of charged molecules was taken into account upon membrane insertion. The evaluation of the predictions was done against experimental permeability coefficients from Parallel Artificial Membrane Permeability Assays (PAMPA), and effects of partial charge sets, CGenFF, AM1-BCC, and OPLS, on the performance of the predictions were discussed. (D)HDGB-based models improved the predictions over the two-state implicit membrane models, and partial charge sets seemed to have a strong impact on the predictions. Machine learning increased the accuracy of the predictions, although it could not outperform the physics-based approach in terms of correlations.
MeSH term(s)	Cell Membrane Permeability/drug effects ; Drug Evaluation, Preclinical ; Machine Learning ; Models, Biological ; Thermodynamics
Language	English
Publishing date	2018-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.8b00648
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Article: Rhythm and blues

Armbruster, Diana / Brocke, Burkhard / Kirschbaum, Clemens / Witt, Stephanie H. / Lesch, Klaus-Peter / Strobel, Alexander

Physiology & Behavior

Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing

2020

Abstract: Abstract not released by ... ...

Title translation	Rhythmus und Blues: Einfluss von CLOCK T3111C auf periphere elektrophysiologische Indikatoren negativer affektiver Verarbeitung (DeepL)
Abstract	Abstract not released by publisher
Keywords	Biologische Rhythmen beim Menschen ; CLOCK Gene ; CLOCK-Gen ; Emotional Responses ; Emotionale Reaktionen ; Emotionen ; Emotions ; Facial Muscles ; Gesichtsmuskeln ; Hautwiderstand ; Human Biological Rhythms ; Negative Emotionen ; Negative Emotions ; Skin Resistance
Language	English
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2020.112831
Database	PSYNDEX

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Article ; Online: Impact of FAAH genetic variation on fronto-amygdala function during emotional processing.

Gärtner, Anne / Dörfel, Denise / Diers, Kersten / Witt, Stephanie H / Strobel, Alexander / Brocke, Burkhard

European archives of psychiatry and clinical neuroscience

2018 Volume 269, Issue 2, Page(s) 209–221

Abstract: Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto- ... ...

Abstract	Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto-amygdala circuitry implicated in mood regulation and anxiety-like behaviors. While it has been shown that the variant that selectively enhances fronto-amygdala connectivity at rest is associated with decreased anxiety-like behaviors, no study so far has investigated whether this finding of FAAH-related differential plasticity extends to task-related differential functional expression and regulation during negative emotional processing. Using an imaging genetics approach, this study aimed to replicate and extend prior findings by examining functional activity and task-related connectivity in fronto-amygdala regions during emotion reactivity and emotional down-regulation of negative affect. Therefore, 48 healthy young adults underwent a functional MRI resting state measurement, completed an emotion regulation paradigm and provided self-reports on anxiety and use of emotion regulation strategies. In line with previous studies, preliminary evidence suggests that A-allele carriers demonstrate stronger fronto-amygdala connectivity during rest. In addition, exploratory whole-brain analyses indicate differential functional activity of A-allele carriers during emotion reactivity and emotion regulation. There were no associations with anxiety-related self-reports and use of emotional regulation strategies. Further research using larger samples and polygenic approaches is indicated to clarify the precise role and its underlying mechanisms in emotion processing.
MeSH term(s)	Adolescent ; Adult ; Amidohydrolases/genetics ; Amygdala/diagnostic imaging ; Amygdala/physiology ; Anxiety/diagnostic imaging ; Anxiety/genetics ; Anxiety/physiopathology ; Connectome/methods ; Emotions/physiology ; Female ; Genotype ; Humans ; Magnetic Resonance Imaging ; Male ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiology ; Young Adult
Chemical Substances	Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-)
Language	English
Publishing date	2018-10-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-018-0944-9
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Article ; Online: Growth dynamics of the

Ripoll, Juan-José / Zhu, Mingyuan / Brocke, Stephanie / Hon, Cindy T / Yanofsky, Martin F / Boudaoud, Arezki / Roeder, Adrienne H K

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 50, Page(s) 25333–25342

Abstract: Fruit have evolved a sophisticated tissue and cellular architecture to secure plant reproductive success. Postfertilization growth is perhaps the most dramatic event during fruit morphogenesis. Several studies have proposed that fertilized ovules and ... ...

Abstract	Fruit have evolved a sophisticated tissue and cellular architecture to secure plant reproductive success. Postfertilization growth is perhaps the most dramatic event during fruit morphogenesis. Several studies have proposed that fertilized ovules and developing seeds initiate signaling cascades to coordinate and promote the growth of the accompanying fruit tissues. This dynamic process allows the fruit to conspicuously increase its size and acquire its final shape and means for seed dispersal. All these features are key for plant survival and crop yield. Despite its importance, we lack a high-resolution spatiotemporal map of how postfertilization fruit growth proceeds at the cellular level. In this study, we have combined live imaging, mutant backgrounds in which fertilization can be controlled, and computational modeling to monitor and predict postfertilization fruit growth in
MeSH term(s)	Arabidopsis/cytology ; Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Division ; Fertilization ; Fruit/cytology ; Fruit/genetics ; Fruit/growth & development ; Fruit/metabolism ; Gene Expression Regulation, Plant ; Seeds/cytology ; Seeds/growth & development ; Seeds/metabolism
Chemical Substances	Arabidopsis Proteins
Language	English
Publishing date	2019-11-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1914096116
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