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  1. Article ; Online: Reducing Community Exposure to Protect Health Care Personnel in a Pandemic Environment.

    Breeher, Laura E

    Mayo Clinic proceedings

    2021  Volume 96, Issue 9, Page(s) 2295–2297

    MeSH term(s) Delivery of Health Care ; Health Personnel ; Humans ; Influenza, Human/epidemiology ; Pandemics/prevention & control
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.07.013
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  2. Article ; Online: Multiple SARS-CoV-2 Reinfections: A Case Series of Thrice-Infected Individuals.

    Swift, Melanie D / Hainy, Caitlin M / Sampathkumar, Priya / Breeher, Laura E

    Mayo Clinic proceedings

    2022  Volume 97, Issue 5, Page(s) 1021–1023

    MeSH term(s) COVID-19 ; Humans ; Reinfection ; Research ; SARS-CoV-2
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Letter
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.03.003
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  3. Article ; Online: Who is getting boosted? Disparities in COVID-19 vaccine booster uptake among health care workers.

    Farah, Wigdan / Breeher, Laura E / Hainy, Caitlin M / Tommaso, Christopher P / Swift, Melanie D

    Vaccine: X

    2023  Volume 13, Page(s) 100269

    Abstract: COVID-19 vaccination remains one of the most effective tools to reduce the risk of SARS-CoV-2 infection. Unfortunately, vaccine hesitancy has limited primary vaccination and booster uptake among the general population and HCWs. To gain a better ... ...

    Abstract COVID-19 vaccination remains one of the most effective tools to reduce the risk of SARS-CoV-2 infection. Unfortunately, vaccine hesitancy has limited primary vaccination and booster uptake among the general population and HCWs. To gain a better understanding of factors associated with booster vaccine uptake, we analyzed COVID-19 vaccine booster rates among HCWs and identified risk factors associated with nonacceptance. Of the 62,387 HCWs included in our analysis, the overall booster uptake rate was 64.8%. Older age, Non-Hispanic White racial group, early initial vaccine uptake and longer duration of employment were associated with higher booster uptake. Significant differences were observed between different job categories. This persistence of vaccine hesitancy and disparities in COVID-19 booster uptake among HCWs, almost 2 years after the rollout of the COVID-19 vaccination, call for further efforts to increase vaccine confidence among HCWs and the general population in light of the continued need for further COVID-19 protection.
    Language English
    Publishing date 2023-02-11
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2023.100269
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  4. Article ; Online: Evaluation of healthcare personnel exposures to patients with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) associated with personal protective equipment.

    Shah, Vishal P / Breeher, Laura E / Hainy, Caitlin M / Swift, Melanie D

    Infection control and hospital epidemiology

    2021  Volume 43, Issue 6, Page(s) 770–774

    Abstract: Objective: Personal protective equipment (PPE) is a critical aspect of preventing the transmission of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in healthcare settings. We aimed to identify factors related to lapses in PPE use that may ... ...

    Abstract Objective: Personal protective equipment (PPE) is a critical aspect of preventing the transmission of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in healthcare settings. We aimed to identify factors related to lapses in PPE use that may influence transmission of SARS-CoV-2 from patients to healthcare personnel (HCP).
    Design: Retrospective cohort study.
    Setting: Tertiary-care medical center in Minnesota.
    Participants: In total, 345 HCP who sustained a significant occupational exposure to a patient with coronavirus disease 2019 (COVID-19) from May 13, 2020, through November 30, 2020, were evaluated.
    Results: Overall, 8 HCP (2.3%) were found to have SARS-CoV-2 infection during their 14-day postexposure quarantine. A lack of eye protection during the care of a patient with COVID-19 was associated with HCP testing positive for SARS-CoV-2 by reverse-transcriptase polymerase chain reaction (RT-PCR) during the postexposure quarantine (relative risk [RR], 10.25; 95% confidence interval [CI], 1.28-82.39;
    Conclusions: The use of universal eye protection is a critical aspect of PPE to prevent patient-to-HCP transmission of SARS-CoV-2.
    MeSH term(s) COVID-19/prevention & control ; Delivery of Health Care ; Health Personnel ; Humans ; Personal Protective Equipment ; Retrospective Studies ; SARS-CoV-2 ; Virus Diseases
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2021.219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hybrid Immunity Provides Protective Advantage Over Vaccination or Prior Remote Coronavirus Disease 2019 Alone.

    Virk, Abinash / Johnson, Matthew G / Roellinger, Daniel L / Scott, Christopher G / Sampathkumar, Priya / Breeher, Laura E / Swift, Melanie

    Open forum infectious diseases

    2023  Volume 10, Issue 5, Page(s) ofad161

    Abstract: Background: The protective efficacy of prior coronavirus disease 2019 (COVID-19) with or without vaccination remains unknown. This study sought to understand if 2 or more messenger RNA (mRNA) vaccine doses provide additional protection in patients with ... ...

    Abstract Background: The protective efficacy of prior coronavirus disease 2019 (COVID-19) with or without vaccination remains unknown. This study sought to understand if 2 or more messenger RNA (mRNA) vaccine doses provide additional protection in patients with prior infection, or if infection alone provides comparable protection.
    Methods: We conducted a retrospective cohort study of the risk of COVID-19 from 16 December 2020 through 15 March 2022, among vaccinated and unvaccinated patients of all ages with and without prior infection. A Simon-Makuch hazard plot illustrated the incidence of COVID-19 between groups. Multivariable Cox proportional hazards regression was used to examine the association of demographics, prior infection, and vaccination status with new infection.
    Results: Among 101 941 individuals with at least 1 COVID-19 polymerase chain reaction test prior to 15 March 2022, 72 361 (71.0%) received mRNA vaccination and 5957 (5.8%) were previously infected. The cumulative incidence of COVID-19 was substantially higher throughout the study period for those previously uninfected and unvaccinated, and lowest for those previously infected and vaccinated. After accounting for age, sex, and the interaction between vaccination and prior infection, a reduction in reinfection risk was noted during the Omicron and pre-Omicron phases of 26% (95% confidence interval [CI], 8%-41%;
    Conclusions: Vaccination was associated with lower risk of COVID-19, including in those with prior infection. Vaccination should be encouraged for all including those with prior infection, especially as new variants emerge and variant-specific booster vaccines become available.
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad161
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  6. Article ; Online: Early Experience With an Occupational JYNNEOS ( Orthopoxvirus ) Vaccination Program.

    Swift, Melanie D / McDermott, Mary C / Hainy, Caitlin M / Arendt, Christopher J / Anderson, Jennifer A / Mahoo, Jacqueline J / Breeher, Laura E

    Journal of occupational and environmental medicine

    2023  Volume 65, Issue 6, Page(s) 477–480

    Abstract: Objective: The aim of the study is to identify lessons learned implementing JYNNEOS vaccination for laboratory workers exposed to orthopoxviruses such as mpox.: Methods: Workers at risk of laboratory exposure were offered vaccine in a carefully ... ...

    Abstract Objective: The aim of the study is to identify lessons learned implementing JYNNEOS vaccination for laboratory workers exposed to orthopoxviruses such as mpox.
    Methods: Workers at risk of laboratory exposure were offered vaccine in a carefully planned occupational health program. Vaccine was procured from the Centers for Disease Control and Prevention (CDC) Drug Service, which has special requirements. Reasons for accepting or declining vaccine and adverse effects were obtained by survey.
    Results: Most workers accepted JYNNEOS, and occupational risk was the most commonly cited reason for acceptance. Most experienced mild local adverse effects. The administrative requirements of the Centers for Disease Control and Prevention Drug Service are documented.
    Conclusions: Occupational health programs caring for laboratory workers handling unusual biological agents require careful planning and coordination to facilitate access to vaccines that are not commercially available, anticipate and mitigate barriers to vaccination, and comply with special Centers for Disease Control and Prevention requirements.
    MeSH term(s) Humans ; Orthopoxvirus ; Smallpox Vaccine ; Vaccination ; Vaccines
    Chemical Substances smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (TU8J357395) ; Smallpox Vaccine ; Vaccines
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002846
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  7. Article ; Online: Precautions, Utilization of Personal Protective Equipment, and Conservation Strategies During the COVID-19 Pandemic.

    Sampathkumar, Priya / Beam, Elena / Breeher, Laura E / O'Horo, John C

    Mayo Clinic proceedings

    2020  Volume 95, Issue 9S, Page(s) S11–S13

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Guidelines as Topic ; Humans ; Pandemics/prevention & control ; Personal Protective Equipment/supply & distribution ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.05.038
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  8. Article ; Online: False-negative nasopharyngeal severe acute respiratory coronavirus virus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) in immunocompromised patients resulting in healthcare worker exposures.

    Beam, Elena / Meyer, Michelle L / O' Horo, John C / Breeher, Laura E

    Infection control and hospital epidemiology

    2021  , Page(s) 1–2

    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2021.447
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  9. Article ; Online: An Approach to Hazardous Medication Surveillance.

    Breeher, Laura E / Stonelake-French, Heather L

    Journal of occupational and environmental medicine

    2019  Volume 62, Issue 4, Page(s) 260–262

    Abstract: Many health care organizations are making changes to their hazardous medication surveillance program (HMSP) in response to United States Pharmacopeia (USP) ... standards. Absence of best practices for HMSPs and limitations on the ability of such ... ...

    Abstract : Many health care organizations are making changes to their hazardous medication surveillance program (HMSP) in response to United States Pharmacopeia (USP) <800> standards. Absence of best practices for HMSPs and limitations on the ability of such programs to correlate health effects identified on surveillance with workplace exposures historically have left health care institutions to determine if and how to design an HMSP for their workforce. Within this article one approach to the design of an HMSP is discussed and resources such as a health questionnaire and declination form are included that could be modified or adopted by other health care organizations. This information is intended to generate further discussion and collaboration among leaders of employee occupational health services on a national level to address the benefits and challenges of HMSPs.
    MeSH term(s) Humans ; Occupational Exposure/prevention & control ; Occupational Health Services ; Safety Management ; United States ; Workforce ; Workplace
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000001788
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  10. Article ; Online: Utility of Follow-up Coronavirus Disease 2019 (COVID-19) Antigen Tests After Acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Healthcare Personnel.

    Tande, Aaron J / Swift, Melanie D / Challener, Douglas W / Berbari, Elie F / Tommaso, Christopher P / Christopherson, Darrin R / Binnicker, Matthew J / Breeher, Laura E

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 1, Page(s) e347–e349

    Abstract: We report the utility of rapid antigen tests (RAgT) in a cohort of US healthcare personnel with coronavirus disease 2019 (COVID-19) infection who met symptom criteria to return to work at day 5 or later of isolation. In total, 11.9% of initial RAgT were ... ...

    Abstract We report the utility of rapid antigen tests (RAgT) in a cohort of US healthcare personnel with coronavirus disease 2019 (COVID-19) infection who met symptom criteria to return to work at day 5 or later of isolation. In total, 11.9% of initial RAgT were negative. RAgT can be helpful to guide return to work decisions.
    MeSH term(s) COVID-19/diagnosis ; Delivery of Health Care ; Follow-Up Studies ; Health Personnel ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac235
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