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Article ; Online: Kidney Yang Deficiency Syndrome Exacerbates Aβ

Jiang, Xia / Chen, Lin / Fu, Qing / Ma, Dan Li / Liu, Xue Ting / Wang, Xiao Yi

2023 Volume 20, Issue 1, Page(s) 48–58

Abstract: ... considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical ... for 14 days was used to produce KDS-Yang. On the 15th day, Aβ: Results: Hyperphosphorylation of tau ... in Aβ: Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is ...

Abstract	Background: Traditional Chinese medicine (TCM) indicates that Alzheimer's disease (AD) is considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical characteristics to glucocorticoid withdrawal syndrome. Ginsenoside Re (G-Re) has been found to ameliorate the symptoms and pathological impairments of AD. However, it's not clear whether G-Re could protect memory and synapse lesions against kidney deficiency dementia. Methods: Subcutaneous injection of hydrocortisone for 14 days was used to produce KDS-Yang. On the 15th day, Aβ Results: Hyperphosphorylation of tau in Aβ Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is a potential ingredient for protecting against memory and synapse deficits in kidney deficiency dementia.
MeSH term(s)	Rats ; Animals ; Amyloid beta-Peptides/toxicity ; Yang Deficiency ; Alzheimer Disease/metabolism ; Disks Large Homolog 4 Protein ; Kidney/metabolism ; Kidney/pathology ; Synapses/metabolism ; Disease Models, Animal ; Peptide Fragments/toxicity
Chemical Substances	Amyloid beta-Peptides ; ginsenoside Re (46F3R0BL3I) ; Disks Large Homolog 4 Protein ; Peptide Fragments
Language	English
Publishing date	2023-05-12
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205170-3
ISSN	1875-5828 ; 1567-2050
ISSN (online)	1875-5828
ISSN	1567-2050
DOI	10.2174/1567205020666230512094230
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Article ; Online: Mitochondria as the Essence of Yang Qi in the Human Body.

Luo, Junjie / Shen, Shiwei / Xia, Jingjing / Wang, Jiucun / Gu, Zhenglong

Phenomics (Cham, Switzerland)

2022 Volume 2, Issue 5, Page(s) 336–348

Abstract: The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities ... This article discusses the similarities in various aspects between mitochondria and Yang Qi, including body ... temperature, aging, newborns, circadian rhythm, immunity, and meridian. It is well-known that Yang Qi is vital ...

Abstract	The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities with mitochondria in modern medicine. Both are indispensable to human beings and closely related to life and death. This article discusses the similarities in various aspects between mitochondria and Yang Qi, including body temperature, aging, newborns, circadian rhythm, immunity, and meridian. It is well-known that Yang Qi is vital for human health. Interestingly, decreased mitochondrial function is thought to be key to the development of various diseases. Here, we further explain diseases induced by Yang Qi deficiency, such as cancer, chronic fatigue syndrome, sleep disorder, senile dementia, and metabolic diseases, from the perspective of mitochondrial function. We aim to establish similarities and connections between two important concepts, and hope our essay can stimulate further discussion and investigation on unifying important concepts in western medicine and alternative medicine, especially TCM, and provide unique holistic insights into understanding human health.
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2730-5848
ISSN (online)	2730-5848
DOI	10.1007/s43657-022-00060-3
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Article: [Experimental study of cardioprotective effects of Cinnamomi Ramulus and Cinnamomi Cortex formula granules on myocardial ischemia/reperfusion injury in rats based on efficacy of "warming and coordinating heart Yang"].

Luan, Fei / Lei, Zi-Qin / Peng, Li-Xia / Rao, Zhi-Li / Yang, Ruo-Cong / Zeng, Nan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 3, Page(s) 725–735

Abstract: ... Yang". Ninety male SD rats were randomly divided into a sham group, a model group, CRFG low and high ...

Abstract	This study aimed to parallelly investigate the cardioprotective activity of Cinnamomi Ramulus formula granules(CRFG) and Cinnamomi Cortex formula granules(CCFG) against acute myocardial ischemia/reperfusion injury(MI/RI) and the underlying mechanism based on the efficacy of "warming and coordinating the heart Yang". Ninety male SD rats were randomly divided into a sham group, a model group, CRFG low and high-dose(0.5 and 1.0 g·kg~(-1)) groups, and CCFG low and high-dose(0.5 and 1.0 g·kg~(-1)) groups, with 15 rats in each group. The sham group and the model group were given equal volumes of normal saline by gavage. Before modeling, the drug was given by gavage once a day for 7 consecutive days. One hour after the last administration, the MI/RI rat model was established by ligating the left anterior descending artery(LAD) for 30 min ischemia followed by 2 h reperfusion except the sham group. The sham group underwent the same procedures without LAD ligation. Heart function, cardiac infarct size, cardiac patho-logy, cardiomyocyte apoptosis, cardiac injury enzymes, and inflammatory cytokines were determined to assess the protective effects of CRFG and CCFG against MI/RI. The gene expression levels of nucleotide-binding oligomerization domain-like receptor family pyrin domain protein 3(NLRP3) inflammasome, apoptosis-associated speck-like protein containing a CARD(ASC), cysteinyl aspartate specific proteinase-1(caspase-1), Gasdermin-D(GSDMD), interleukin-1β(IL-1β), and interleukin-18(IL-18) were determined by real-time quantitative polymerase chain reaction(RT-PCR). The protein expression levels of NLRP3, caspase-1, GSDMD, and N-GSDMD were determined by Western blot. The results showed that both CRFG and CCFG pretreatments significantly improved cardiac function, decreased the cardiac infarct size, inhibited cardiomyocyte apoptosis, and reduced the content of lactic dehydrogenase(LDH), creatine kinase MB isoenzyme(CK-MB), aspartate transaminase(AST), and cardiac troponin Ⅰ(cTnⅠ). In addition, CRFG and CCFG pretreatments significantly decreased the levels of IL-1β, IL-6, and tumor necrosis factor-α(TNF-α) in serum. RT-PCR results showed that CRFG and CCFG pretreatment down-regulated the mRNA expression levels of NLRP3, caspase-1, ASC, and downstream pyroptosis-related effector substances including GSDMD, IL-18, and IL-1β in cardiac tissues. Western blot revealed that CRFG and CCFG pretreatments significantly decreased the protein expression levels of NLRP3, caspase-1, GSDMD, and N-GSDMD in cardiac tissues. In conclusion, CRFG and CCFG pretreatments have obvious cardioprotective effects on MI/RI in rats, and the under-lying mechanism may be related to the inhibition of NLRP3/caspase-1/GSDMD signaling pathway to reduce the cardiac inflammatory response.
MeSH term(s)	Male ; Animals ; Rats ; Rats, Sprague-Dawley ; Interleukin-18 ; Myocardial Reperfusion Injury ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tumor Necrosis Factor-alpha ; Myocardial Infarction ; Caspase 1
Chemical Substances	cinnamomi cortex ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tumor Necrosis Factor-alpha ; Caspase 1 (EC 3.4.22.36)
Language	Chinese
Publishing date	2023-03-02
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220915.401
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Article ; Online: The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.

Huang, Yu / Li, Liangpeng / Chen, Hongmei / Liao, Qiao / Yang, Xiaoli / Yang, Dezhong / Xia, Xuewei / Wang, Hongyong / Wang, Wei Eric / Chen, Lianglong / Zeng, Chunyu

Journal of the American Heart Association

2021 Volume 10, Issue 21, Page(s) e021895

Abstract: ... for myocardial infarction (MI) and post-MI heart failure. Transcription factor Yin-Yang 1 (YY1) is an essential regulator ...

Abstract	Background Exploring potential therapeutic target is of great significance for myocardial infarction (MI) and post-MI heart failure. Transcription factor Yin-Yang 1 (YY1) is an essential regulator of apoptosis and angiogenesis, but its role in MI is unclear. Methods and Results The expression of YY1 was assessed in the C57BL/6J mouse heart following MI. Overexpression or silencing of YY1 in the mouse heart was achieved by adeno-associated virus 9 injection. The survival, cardiac function, and scar size, as well as the apoptosis, angiogenesis, cardiac fibrosis, T helper 2 lymphocyte cytokine production, and macrophage polarization were assessed. The effects of YY1 on Akt phosphorylation and vascular endothelial growth factor production were also investigated. The expression of YY1 in heart was significantly stimulated by MI. The survival rate, cardiac function, scar size, and left ventricular volume of mice were improved by YY1 overexpression but worsened by YY1 silencing. YY1 alleviated cardiac apoptosis and fibrosis, promoted angiogenesis, T helper 2 cytokine production, and M2 macrophage polarization in the post-MI heart, it also enhanced the tube formation and migration ability of endothelial cells. Enhanced Akt phosphorylation, along with the increased vascular endothelial growth factor levels were observed in presence of YY1 overexpression. Conclusions YY1 ameliorates cardiac injury and remodeling after MI by repressing cardiomyocyte apoptosis and boosting angiogenesis, which might be ascribed to the enhancement of Akt phosphorylation and the subsequent vascular endothelial growth factor up-regulation. Increased T helper 2 cytokine production and M2 macrophage polarization may also be involved in YY1's cardioprotective effects. These findings supported YY1 as a potential target for therapeutic investigation of MI.
MeSH term(s)	Animals ; Apoptosis ; Cicatrix ; Cytokines ; Disease Models, Animal ; Endothelial Cells ; Heart Injuries ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/prevention & control ; Myocytes, Cardiac ; Proto-Oncogene Proteins c-akt ; Vascular Endothelial Growth Factor A ; Ventricular Remodeling ; Yin-Yang
Chemical Substances	Cytokines ; Vascular Endothelial Growth Factor A ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.021895
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Article ; Online: Metabolomics of Spleen-Yang deficiency syndrome and the therapeutic effect of Fuzi Lizhong pill on regulating endogenous metabolism.

Zhang, Zhen / Yang, Shasha / Lin, Xia / Huang, You / Wei, Xinyi / Zhou, Jinwei / Li, Rui / Deng, Bin / Fu, Chaomei

Journal of ethnopharmacology

2021 Volume 278, Page(s) 114281

Abstract: Ethnopharmacological relevance: Spleen-Yang deficiency (SYD) is one of the primary causes ...

Abstract	Ethnopharmacological relevance: Spleen-Yang deficiency (SYD) is one of the primary causes of many digestive diseases, such as ulcerative colitis (UC), and irritable bowel syndrome (IBS), but its endogenous metabolic characteristics are still unclear. Fuzi Lizhong pill (FLZP) is well-known for its powerful capacity for treating SYD; however, its mechanisms require further study. Aim of the study: Herein, our present study aimed to investigate the essence of SYD from the perspective of metabolomics, and tried to reveal the anti-SYD action mechanisms of FLZP. Materials and methods: Firstly, the compound factor modeling method with the principle of "indiscipline in diet + excessive fatigue + intragastric administration of Senna water extracts" was used to establish Sprague Dawley (SD) rats as SYD model. Then, the visceral index, motilin (MTL), malonaldehyde (MDA), Interleukin 1 alpha (IL-1α), and Interleukin 6 (IL-6) levels were used to verify the anti-SYD effect of FLZP. In addition, serum samples were analyzed by UPLC-QE/MS metabolomics technique. Finally, the metabolic pathways associated with specific biomarkers were analyzed to research the possible mechanism underlying the action of FLZP. Results: The expression of MTL, MDA, IL-1α, and IL-6 were regulated by FLZP, which suggested that it has relieved diarrhea and gastrointestinal motility disorder caused by SYD and had an anti-peroxidation, anti-inflammatory, and immune regulation effect. A total of 75 metabolites were found to be the potential biomarkers of SYD. Moreover, FLZP regulates 21 metabolites and 10 vital pathways including the tricarboxylic acid (TCA) cycle, sphingolipid metabolism, and histidine metabolism. Conclusion: SYD primarily causes disorders of amino acid metabolism, lipid metabolism, carbohydrate metabolism, metabolism of cofactors and vitamins, nucleotide metabolism, and translation. In addition, FLZP regulated carbohydrate, lipid, and amino acid metabolisms, gastrointestinal motility, digestive juice secretion, immune regulation, as well as antioxidant effects. Hence, FLZP had a good therapeutic effect on treatment of SYD. It might be a promising therapeutic agent for the treatment of SYD-related diseases.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Lipid Metabolism/drug effects ; Male ; Metabolomics ; Rats ; Rats, Sprague-Dawley ; Splenic Diseases/drug therapy ; Splenic Diseases/metabolism ; Syndrome ; Yang Deficiency/drug therapy ; Yang Deficiency/metabolism
Chemical Substances	Biomarkers ; Drugs, Chinese Herbal ; fuzi-lizhong
Language	English
Publishing date	2021-06-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114281
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Article ; Online: Heterotrophic Bacteria Play an Important Role in Endemism of Cephalostachyum pingbianense (Hsueh & Y.M. Yang ex Yi et al.) D.Z. Li & H.Q. Yang, 2007, a Full-Year Shooting Woody Bamboo

Tize Xia / Lushuang Li / Bin Li / Peitong Dou / Hanqi Yang

Forests, Vol 13, Iss 121, p

2022 Volume 121

Abstract: ... bacterial community in woody bamboo forests. Cephalostachyum pingbianense (Hsueh & Y.M. Yang ex Yi et al.) D ... Z. Li & H.Q. Yang, 2007 is known as the only bamboo species producing shoots all year round ...

Abstract	The previous studies show soil microbes play a key role in the material and nutrient cycles in the forest ecosystem, but little is known about how soil microbes respond to plant distribution, especially in the soil bacterial community in woody bamboo forests. Cephalostachyum pingbianense (Hsueh & Y.M. Yang ex Yi et al.) D.Z. Li & H.Q. Yang, 2007 is known as the only bamboo species producing shoots all year round in natural conditions. Endemic to the Dawei mountain in Yunnan of China, this species is a good case to study how soil bacteria respond to plant endemic distribution. In this work, we assayed the soil chemical properties, enzyme activity, changes in the bacterial community along the distribution range of the C. pingbianense forest. The results showed that soil nutrients at the range edge were nitrogen-rich but phosphorus-deficient, and soil pH value and soil urease activity were significantly lower than that of the central range. No significant difference was detected in soil bacterial diversity, community composition, and function between the central and marginal range of C. pingbianense forest. Notably, the relative abundance of heterotrophy bacteria, such as Variibacter and Acidothermus , in the soil of the C. pingbianense forest was significantly higher than that of the outside range, which may lead to a higher soil organic carbon mineralization rate. These results imply that abundant heterotrophy bacteria were linked to the endemism and full-year shooting in C. pingbianense . Our study is amongst the first cases demonstrating the important role of heterotrophy bacteria in the distribution formation of endemic woody bamboos in special soil habitats, and provides insight into germplasm conservation and forest management in woody bamboos.
Keywords	Cephalostachyum pingbianense ; bacterial community ; distribution range limit ; soil chemical properties ; soil urease ; Plant ecology ; QK900-989
Subject code	580
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nanotoxicology and Nanomedicine: The Yin and Yang of Nano-Bio Interactions for the New Decade.

Bondarenko, Olesja / Mortimer, Monika / Kahru, Anne / Feliu, Neus / Javed, Ibrahim / Kakinen, Aleksandr / Lin, Sijie / Xia, Tian / Song, Yang / Davis, Thomas P / Lynch, Iseult / Parak, Wolfgang J / Leong, David Tai / Ke, Pu Chun / Chen, Chunying / Zhao, Yuliang

Nano today

2021 Volume 39

Abstract: ... for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two ...

Abstract	Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials - the main subjects of nanotoxicology - have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2224882-1
ISSN	1878-044X ; 1748-0132
ISSN (online)	1878-044X
ISSN	1748-0132
DOI	10.1016/j.nantod.2021.101184
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Article ; Online: High Performance and Multifunction Moisture-Driven Yin-Yang-Interface Actuators Derived from Polyacrylamide Hydrogel.

Li, Jingjing / Zhang, Guanghao / Cui, Zhanpeng / Bao, Lili / Xia, Zhigang / Liu, Zunfeng / Zhou, Xiang

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 38, Page(s) e2303228

Abstract: ... a moisture-driven tri-layer actuator with a Yin-Yang-interface (YYI) design is investigated ... in which a moisture-responsive polyacrylamide (PAM) hydrogel layer (Yang) is combined with a moisture-inert ... mechanical grippers, and crawling and jumping motions. The Yin-Yang-interface design proposed in this work ...

Abstract	High actuation performance of a moisture actuator highly depends on the presence of a large property difference between the two layers, which may cause interfacial delamination. Improving interfacial adhesion strength while increasing the difference between the layers is a challenge. In this study, a moisture-driven tri-layer actuator with a Yin-Yang-interface (YYI) design is investigated in which a moisture-responsive polyacrylamide (PAM) hydrogel layer (Yang) is combined with a moisture-inert polyethylene terephthalate (PET) layer (Yin) using an interfacial poly(2-ethylhexyl acrylate) (PEA) adhesion layer. Fast and large reversible bending, oscillation, and programmable morphing motions in response to moisture are realized. The response time, bending curvature, and response speed normalized by thickness are among the best compared with those of previously reported moisture-driven actuators. The excellent actuation performance of the actuator has potential multifunctional applications in moisture-controlled switches, mechanical grippers, and crawling and jumping motions. The Yin-Yang-interface design proposed in this work provides a new design strategy for high-performance intelligent materials and devices.
Language	English
Publishing date	2023-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202303228
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Article: Heterotrophic Bacteria Play an Important Role in Endemism of Cephalostachyum pingbianense (Hsueh & Y.M. Yang ex Yi et al.) D.Z. Li & H.Q. Yang, 2007, a Full-Year Shooting Woody Bamboo

Xia, Tize / Li, Lushuang / Li, Bin / Dou, Peitong / Yang, Hanqi

Forests. 2022 Jan. 14, v. 13, no. 1

2022

Abstract	The previous studies show soil microbes play a key role in the material and nutrient cycles in the forest ecosystem, but little is known about how soil microbes respond to plant distribution, especially in the soil bacterial community in woody bamboo forests. Cephalostachyum pingbianense (Hsueh & Y.M. Yang ex Yi et al.) D.Z. Li & H.Q. Yang, 2007 is known as the only bamboo species producing shoots all year round in natural conditions. Endemic to the Dawei mountain in Yunnan of China, this species is a good case to study how soil bacteria respond to plant endemic distribution. In this work, we assayed the soil chemical properties, enzyme activity, changes in the bacterial community along the distribution range of the C. pingbianense forest. The results showed that soil nutrients at the range edge were nitrogen-rich but phosphorus-deficient, and soil pH value and soil urease activity were significantly lower than that of the central range. No significant difference was detected in soil bacterial diversity, community composition, and function between the central and marginal range of C. pingbianense forest. Notably, the relative abundance of heterotrophy bacteria, such as Variibacter and Acidothermus, in the soil of the C. pingbianense forest was significantly higher than that of the outside range, which may lead to a higher soil organic carbon mineralization rate. These results imply that abundant heterotrophy bacteria were linked to the endemism and full-year shooting in C. pingbianense. Our study is amongst the first cases demonstrating the important role of heterotrophy bacteria in the distribution formation of endemic woody bamboos in special soil habitats, and provides insight into germplasm conservation and forest management in woody bamboos.
Keywords	Acidothermus ; Cephalostachyum pingbianense ; bacterial communities ; bamboos ; community structure ; enzyme activity ; forest ecosystems ; forest management ; forests ; germplasm conservation ; indigenous species ; mineralization ; population distribution ; soil bacteria ; soil organic carbon ; soil pH ; urease ; China
Language	English
Dates of publication	2022-0114
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f13010121
Database	NAL-Catalogue (AGRICOLA)

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Article: Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study.

Zhang, Ming-Liang / Zhao, Xu / Li, Wei-Xia / Wang, Xiao-Yan / Niu, Ming / Zhang, Hui / Chen, Yu-Long / Kong, De-Xin / Gao, Yuan / Guo, Yu-Ming / Bai, Zhao-Fang / Zhao, Yan-Ling / Tang, Jin-Fa / Xiao, Xiao-He

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 102

Abstract: ... traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang: Aim of the study: Liver ... to investigate the differential responses to BGZ in Yang: Materials and methods: The corresponding ... animal models of Yang: Results: The level changes of liver organ index, alanine aminotransferase (ALT), and ...

Abstract	Ethnopharmacological relevance: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang Aim of the study: Liver injury caused by TCM is a rare but potentially serious adverse drug reaction, and the identification of predisposed individuals for drug-induced liver injury (DILI) remains challenging. The study aimed to investigate the differential responses to BGZ in Yang Materials and methods: The corresponding animal models of Yang Results: The level changes of liver organ index, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), suggested that BGZ has liver-protective and liver-damaging effects on Yang Conclusions: Yin
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00793-x
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