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  1. Article: Managing perplexing patients: the case of Helen.

    Smith, Marianne / Schultz, Susan K

    Issues in mental health nursing

    2005  Volume 26, Issue 1, Page(s) 47–63

    Abstract: ... understood by examining such a case. The hypothetical case of "Helen" illustrates the multi-dimensional and ...

    Abstract The challenges faced in provision of high quality and effective care to geriatric psychiatric inpatients are substantial for all members of the interdisciplinary team. Common care dilemmas, including the interplay of social, medical, and psychiatric factors in treating complex patients, are perhaps best understood by examining such a case. The hypothetical case of "Helen" illustrates the multi-dimensional and often perplexing care needs of patients admitted multiple times for inpatient care. Linked nursing diagnoses, outcomes and interventions, and interdisciplinary care plans emphasize the changing care needs of such patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Depressive Disorder/complications ; Depressive Disorder/psychology ; Depressive Disorder/therapy ; Family/psychology ; Frail Elderly ; Geriatric Assessment ; Geriatric Nursing/organization & administration ; Health Services Needs and Demand ; Humans ; Nursing Assessment ; Nursing Diagnosis ; Outcome Assessment (Health Care)/organization & administration ; Patient Care Planning/organization & administration ; Patient Care Team/organization & administration ; Patient Readmission ; Psychiatric Nursing/organization & administration ; Stroke/complications ; Stroke Rehabilitation
    Language English
    Publishing date 2005-03-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603180-8
    ISSN 0161-2840
    ISSN 0161-2840
    DOI 10.1080/01612840590883618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2562: Show issues Location:
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  2. Article: The challenge of advocacy: the different voices of Helen Keller and Burton Blatt.

    Smith, J D

    Mental retardation

    1997  Volume 35, Issue 2, Page(s) 138–140

    MeSH term(s) Blindness/history ; Disabled Persons/history ; Eugenics/history ; Famous Persons ; Female ; History, 20th Century ; Humans ; Intellectual Disability/history ; Patient Advocacy/history ; United States
    Language English
    Publishing date 1997-04
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 205744-x
    ISSN 0047-6765
    ISSN 0047-6765
    DOI 10.1352/0047-6765(1997)035<0138:TCOATD>2.0.CO;2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: How did Helen die?. Interview by N Blackford.

    Smith, R

    Nursing mirror

    1982  Volume 154, Issue 14, Page(s) 12

    MeSH term(s) Accidents ; England ; Female ; Homicide ; Humans ; Nurses ; Saudi Arabia
    Language English
    Publishing date 1982-04-07
    Publishing country England
    Document type Case Reports ; Interview ; Journal Article
    ZDB-ID 603412-3
    ISSN 0029-6511
    ISSN 0029-6511
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  4. Book ; Online ; E-Book: Wildlife Research in Australia

    Hampton, Jordan O. / Smith, Bradley P. / Waudby, Helen P. / Alberthsen, Corinne

    Practical and Applied Methods

    2022  

    Abstract: Supports best practice research methods and helps to navigate animal care approval processes. ...

    Abstract Supports best practice research methods and helps to navigate animal care approval processes.
    Keywords Zoology/Research ; Wildlife management
    Language English
    Size 1 online resource (657 pages)
    Publisher CSIRO Publishing
    Publishing place Collingwood
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-4863-1345-0 ; 9781486313440 ; 978-1-4863-1345-7 ; 1486313442
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Licensing Requirements for Poultry Veterinary Biologics in the United States.

    Schrader, Joan S / Smith, Helen E

    Avian diseases

    2024  Volume 67, Issue 4, Page(s) 467–473

    Abstract: The use of veterinary biologicals is an integral component of poultry health programs. All veterinary biologicals are licensed and sold by manufacturing firms under strict regulation by the U.S. Department of Agriculture to ensure purity, potency, ... ...

    Abstract The use of veterinary biologicals is an integral component of poultry health programs. All veterinary biologicals are licensed and sold by manufacturing firms under strict regulation by the U.S. Department of Agriculture to ensure purity, potency, efficacy, and safety of the product. The licensing process for a new vaccine is a complex process involving a defined set of studies for each type of vaccine that are performed by the biologics firm, according to approved protocols, with results submitted to the Center for Veterinary Biologics for review. There are 10 classifications of veterinary biologicals and four types of licenses. Manufacturing and testing procedures are also defined within the licensing process. Licensing requirements were initially codified into law. In addition, guidance documents in the form of memoranda and notices have been published to address licensing for additional classes of vaccines and disease agents. This overview of vaccine licensure in the United States is offered to provide a better understanding of the process, the participants, and the factors that influence the time required to produce a commercial product.
    MeSH term(s) Animals ; United States ; Biological Products ; Poultry ; Poultry Diseases ; Vaccines
    Chemical Substances Biological Products ; Vaccines
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 40871-2
    ISSN 1938-4351 ; 0005-2086
    ISSN (online) 1938-4351
    ISSN 0005-2086
    DOI 10.1637/aviandiseases-D-23-99993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Algorithmic bias: should students pay the price?

    Smith, Helen

    AI & society

    2020  Volume 35, Issue 4, Page(s) 1077–1078

    Keywords covid19
    Language English
    Publishing date 2020-09-12
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1458413-X
    ISSN 1435-5655 ; 0951-5666
    ISSN (online) 1435-5655
    ISSN 0951-5666
    DOI 10.1007/s00146-020-01054-3
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  7. Article ; Online: Characteristics of patients who received Sinopharm BIPB vaccine in Singapore general practice.

    Chng, Edwin Aik Chen / Chow, Aloysius / Smith, Helen Elizabeth

    Singapore medical journal

    2024  

    Language English
    Publishing date 2024-01-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2022-082
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  8. Article ; Online: Targeting RNA with small molecules-A safety perspective.

    Lightfoot, Helen L / Smith, Graham F

    British journal of pharmacology

    2023  

    Abstract: RNA is a major player in cellular function, and consequently can drive a number of disease pathologies. Over the past several years, small molecule-RNA targeting (smRNA targeting) has developed into a promising drug discovery approach. Numerous ... ...

    Abstract RNA is a major player in cellular function, and consequently can drive a number of disease pathologies. Over the past several years, small molecule-RNA targeting (smRNA targeting) has developed into a promising drug discovery approach. Numerous techniques, tools, and assays have been developed to support this field, and significant investments have been made by pharmaceutical and biotechnology companies. To date, the focus has been on identifying disease validated primary targets for smRNA drug development, yet RNA as a secondary (off) target for all small molecule drug programs largely has been unexplored. In this perspective, we discuss structure, target, and mechanism-driven safety aspects of smRNAs and highlight how these parameters can be evaluated in drug discovery programs to produce potentially safer drugs.
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16027
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  9. Book ; Online: Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

    Smith, Terry K. / Major, Louise L. / Denton, Helen

    2013  

    Abstract: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, ... ...

    Abstract In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions
    Keywords Medicine (General)
    Size 1 electronic resource ( p.)
    Publisher Intech
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101730
    ISBN 9789535109068 ; 9535109065
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Psychological impact of COVID-19 on employees in a primary healthcare group in Singapore and recommended strategies to improve employees' psychological well-being.

    Chng, Edwin Aik Chen / Chow, Aloysius / Smith, Helen Elizabeth

    Singapore medical journal

    2023  

    Language English
    Publishing date 2023-04-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2021-338
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