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  1. Article ; Online: Temporal order of diagnosis between gambling disorder and substance use disorders: Longitudinal results from the Norwegian Patient Registry.

    Girard, Lisa-Christine / Griffiths, Mark D / Rossow, Ingeborg / Leino, Tony / Goudriaan, Anna E / Smith, Otto R F / Pallesen, Ståle

    Addictive behaviors reports

    2023  Volume 17, Page(s) 100501

    Abstract: Introduction: Previous research has established co-occurrence between substance use disorders (SUDs) and gambling disorder (GD). Less well understood is the temporal sequencing of onset between these disorders, and in particular whether SUD is a risk ... ...

    Abstract Introduction: Previous research has established co-occurrence between substance use disorders (SUDs) and gambling disorder (GD). Less well understood is the temporal sequencing of onset between these disorders, and in particular whether SUD is a risk factor for GD. The present study examined the temporal order between registered diagnoses of SUD and GD, stratified by sex.
    Methods: A study with a longitudinal design using objective registry data drawn from the Norwegian Patient Registry was carried out. Among the patients with a registered diagnosis of GD between 2008 and 2018 (
    Results: Results showed a significant directional path from SUD to GD but no support for the reversed path (i.e., from GD to SUD). This finding was similar overall for (i) both males and females, (ii) when different SUDs (alcohol, cannabis, sedatives, and polysubstance) were examined individually, and (iii) when specifying a 12-month time-lag between diagnoses.
    Conclusions: The findings suggest that experiencing SUD(s) is a risk marker for GD given the temporal precedence observed for patients in specialised healthcare services seeking treatment. These results should be considered alongside screening and prevention efforts for GD.
    Language English
    Publishing date 2023-06-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831558-3
    ISSN 2352-8532 ; 2352-8532
    ISSN (online) 2352-8532
    ISSN 2352-8532
    DOI 10.1016/j.abrep.2023.100501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS.

    Mouat, Isobel C / Allanach, Jessica R / Fettig, Naomi M / Fan, Vina / Girard, Anna M / Shanina, Iryna / Osborne, Lisa C / Vorobeychik, Galina / Horwitz, Marc S

    Science advances

    2022  Volume 8, Issue 47, Page(s) eade6844

    Abstract: While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared ... ...

    Abstract While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared CD11c
    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.ade6844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predicting postpartum depression among adolescent mothers: A systematic review of risk.

    Hymas, Rebecca / Girard, Lisa-Christine

    Journal of affective disorders

    2018  Volume 246, Page(s) 873–885

    Abstract: Background/aims: Postpartum depression (PPD) is a debilitating illness with negative consequences for affected mothers and their children (e.g., poor maternal-infant attachment, deficits in children's social, emotional, and cognitive development). While ...

    Abstract Background/aims: Postpartum depression (PPD) is a debilitating illness with negative consequences for affected mothers and their children (e.g., poor maternal-infant attachment, deficits in children's social, emotional, and cognitive development). While it is suggested that adolescent mothers are at increased risk of PPD, there is a paucity of research exploring factors that place adolescent mothers at risk. This systematic review aims to identify risk factors associated with adolescent PPD and appraise the quality of this evidence-base.
    Method: A systematic review was conducted in May of 2018, using PsycINFO, EMBASE, MEDLINE, ASSIA, CINAHL, MIDIRS, and ProQuest Dissertations and Theses Global database, following PRISMA guidelines. Inclusion criteria included studies from developed countries; published after 1992; using a validated measure of PPD; with onset of illness within 12 months of childbirth, but which had persisted past two-weeks postpartum; adolescent mothers < 20 years of age; and risk factor(s) that occurred prior to birth.
    Results: Fourteen studies were included, ranging from weak-to-strong in quality. Results suggest several risk factors implicated in the onset of adolescent PPD, including prior depression, lack of familial social support, and socio-economic hardship.
    Conclusions/limitations: Awareness of risk factors for healthcare professionals working with pregnant adolescents is of high importance to better facilitate early identification and to provide support for adolescents at risk. Future research ought to consider employing prospective longitudinal designs, along with clearly defined, timely and validated measurements of risk factors and PPD. Limitations include only studies published in English and low agreement on the included studies selection bias.
    MeSH term(s) Adolescent ; Depression, Postpartum/diagnosis ; Depression, Postpartum/etiology ; Female ; Humans ; Pregnancy ; Risk Assessment ; Risk Factors ; Social Support ; Socioeconomic Factors
    Language English
    Publishing date 2018-12-18
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2018.12.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease.

    Dwyer, Gaelen K / Mathews, Lisa R / Villegas, José A / Lucas, Anna / Gonzalez de Peredo, Anne / Blazar, Bruce R / Girard, Jean-Philippe / Poholek, Amanda C / Luther, Sanjiv A / Shlomchik, Warren / Turnquist, Hēth R

    The Journal of clinical investigation

    2022  Volume 132, Issue 12

    Abstract: Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ... ...

    Abstract Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular patterns (DAMPs) that generate proinflammatory APCs that secrete IL-12, which is a driver of donor Th1 responses, causing graft-versus-host disease (GVHD). Nevertheless, other mechanisms exist to initiate alloreactive T cell responses, as recipients with disrupted DAMP signaling or lacking IL-12 develop GVHD. We established that tissue damage signals are perceived directly by donor CD4+ T cells and promoted T cell expansion and differentiation. Specifically, the fibroblastic reticular cell-derived DAMP IL-33 is increased by recipient conditioning and is critical for the initial activation, proliferation, and differentiation of alloreactive Th1 cells. IL-33 stimulation of CD4+ T cells was not required for lymphopenia-induced expansion, however. IL-33 promoted IL-12-independent expression of Tbet and generation of Th1 cells that infiltrated GVHD target tissues. Mechanistically, IL-33 augmented CD4+ T cell TCR-associated signaling pathways in response to alloantigen. This enhanced T cell expansion and Th1 polarization, but inhibited the expression of regulatory molecules such as IL-10 and Foxp3. These data establish an unappreciated role for IL-33 as a costimulatory signal for donor Th1 generation after alloHCT.
    MeSH term(s) Animals ; Bone Marrow Transplantation/adverse effects ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Interleukin-12 ; Interleukin-33/genetics ; Mice ; Mice, Inbred BALB C ; Th1 Cells/pathology
    Chemical Substances Interleukin-33 ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI150927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease

    Gaelen K. Dwyer / Lisa R. Mathews / José A. Villegas / Anna Lucas / Anne Gonzalez de Peredo / Bruce R. Blazar / Jean-Philippe Girard / Amanda C. Poholek / Sanjiv A. Luther / Warren Shlomchik / Hēth R. Turnquist

    The Journal of Clinical Investigation, Vol 132, Iss

    2022  Volume 12

    Abstract: Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ... ...

    Abstract Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular patterns (DAMPs) that generate proinflammatory APCs that secrete IL-12, which is a driver of donor Th1 responses, causing graft-versus-host disease (GVHD). Nevertheless, other mechanisms exist to initiate alloreactive T cell responses, as recipients with disrupted DAMP signaling or lacking IL-12 develop GVHD. We established that tissue damage signals are perceived directly by donor CD4+ T cells and promoted T cell expansion and differentiation. Specifically, the fibroblastic reticular cell–derived DAMP IL-33 is increased by recipient conditioning and is critical for the initial activation, proliferation, and differentiation of alloreactive Th1 cells. IL-33 stimulation of CD4+ T cells was not required for lymphopenia-induced expansion, however. IL-33 promoted IL-12–independent expression of Tbet and generation of Th1 cells that infiltrated GVHD target tissues. Mechanistically, IL-33 augmented CD4+ T cell TCR-associated signaling pathways in response to alloantigen. This enhanced T cell expansion and Th1 polarization, but inhibited the expression of regulatory molecules such as IL-10 and Foxp3. These data establish an unappreciated role for IL-33 as a costimulatory signal for donor Th1 generation after alloHCT.
    Keywords Immunology ; Transplantation ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies.

    Patel, Ronak / Spreng, R Nathan / Shin, Lisa M / Girard, Todd A

    Neuroscience and biobehavioral reviews

    2012  Volume 36, Issue 9, Page(s) 2130–2142

    Abstract: Over the past two decades a relatively large number of studies have investigated the functional neuroanatomy of posttraumatic stress disorder (PTSD). However, findings are often inconsistent, thus challenging traditional neurocircuitry models of PTSD. As ...

    Abstract Over the past two decades a relatively large number of studies have investigated the functional neuroanatomy of posttraumatic stress disorder (PTSD). However, findings are often inconsistent, thus challenging traditional neurocircuitry models of PTSD. As evidence mounts that cognition and behavior is an emergent property of interacting brain networks, the question arises whether PTSD can be understood by examining dysfunction in large-scale, spatially distributed neural networks. We used the activation likelihood estimation quantitative meta-analytic technique to synthesize findings across functional neuroimaging studies of PTSD that either used a non-trauma (N=20) or trauma-exposed (N=19) comparison control group. In line with neurocircuitry models, our findings support hyperactive amygdala and hypoactive medial prefrontal regions, but suggest hyperactive hippocampi. Characterization of additional regions under a triple network model showed functional alterations that largely overlapped with the salience network, central executive network, and default network. However, heterogeneity was observed within and across the neurocircuitry and triple network models, and between results based on comparisons to non-trauma and trauma-exposed control groups. Nonetheless, these results warrant further exploration of the neurocircuitry and large-scale network models in PTSD using connectivity analyses.
    MeSH term(s) Brain/physiopathology ; Functional Neuroimaging ; Humans ; Nerve Net/physiopathology ; Stress Disorders, Post-Traumatic/physiopathology
    Language English
    Publishing date 2012-10
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2012.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tissue-Like 3D Standard and Protocols for Microscope Quality Management.

    Abrams, Benjamin / Pengo, Thomas / Wee, Tse-Luen / Deagle, Rebecca C / Vuillemin, Nelly / Callahan, Linda M / Smith, Megan A / Kubow, Kristopher E / Girard, Anne-Marie / Rappoport, Joshua Z / Bayles, Carol J / Cameron, Lisa A / Cole, Richard / Brown, Claire M

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 2, Page(s) 616–634

    Abstract: This article outlines a global study conducted by the Association of Biomedical Resource Facilities (ABRF) Light Microscopy Research Group (LMRG). The results present a novel 3D tissue-like biologically relevant standard sample that is affordable and ... ...

    Abstract This article outlines a global study conducted by the Association of Biomedical Resource Facilities (ABRF) Light Microscopy Research Group (LMRG). The results present a novel 3D tissue-like biologically relevant standard sample that is affordable and straightforward to prepare. Detailed sample preparation, instrument-specific image acquisition protocols and image analysis methods are presented and made available to the community. The standard consists of sub-resolution and large well characterized relative intensity fluorescence microspheres embedded in a 120 µm thick 3D gel with a refractive index of 1.365. The standard allows the evaluation of several properties as a function of depth. These include the following: 1) microscope resolution with automated analysis of the point-spread function (PSF), 2) automated signal-to-noise ratio analysis, 3) calibration and correction of fluorescence intensity loss, and 4) quantitative relative intensity. Results demonstrate expected refractive index mismatch dependent losses in intensity and resolution with depth, but the relative intensities of different objects at similar depths are maintained. This is a robust standard showing reproducible results across laboratories, microscope manufacturers and objective lens types (e.g., magnification, immersion medium). Thus, these tools will be valuable for the global community to benchmark fluorescence microscopes and will contribute to improved scientific rigor and reproducibility.
    MeSH term(s) Reproducibility of Results ; Microscopy, Fluorescence/methods ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disease trajectory of SLE clinical endpoints and covariates affecting disease severity and probability of response: Analysis of pooled patient-level placebo (Standard-of-Care) data to enable model-informed drug development.

    Goteti, Kosalaram / French, Jonathan / Garcia, Ramon / Li, Ying / Casset-Semanaz, Florence / Aydemir, Aida / Townsend, Robert / Mateo, Cristina Vazquez / Studham, Matthew / Guenther, Oliver / Kao, Amy / Gastonguay, Marc / Girard, Pascal / Benincosa, Lisa / Venkatakrishnan, Karthik

    CPT: pharmacometrics & systems pharmacology

    2022  Volume 12, Issue 2, Page(s) 180–195

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems. Many investigational agents have failed or shown only modest effects when added to standard of care (SoC) therapy in placebo-controlled trials, and only two ... ...

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems. Many investigational agents have failed or shown only modest effects when added to standard of care (SoC) therapy in placebo-controlled trials, and only two therapies have been approved for SLE in the last 60 years. Clinical trial outcomes have shown discordance in drug effects between clinical endpoints. Herein, we characterized longitudinal disease activity in the SLE population and the sources of variability by developing a latent disease trajectory model for SLE component endpoints (Systemic Lupus Erythematosus Disease Activity Index [SLEDAI], Physician's Global Assessment [PGA], British Isles Lupus Assessment Group Index [BILAG]) and composite endpoints (Systemic Lupus Erythematosus Responder Index [SRI], BILAG-based Composite Lupus Assessment [BICLA], and Lupus Low Disease Activity State [LLDAS]) using patient-level historical SoC data from nine phase II and III studies. Across all endpoints, in predictions up to 52 weeks from the final disease trajectory model, the following baseline covariates were associated with a greater decrease in SLE disease activity and higher response to placebo + SoC: Hispanic ethnicity from Central/South America, absence of hypocomplementemia, recent SLE diagnosis, and high baseline disease activity score using SLEDAI and BILAG separately. No discernible differences were observed in the trajectory of response to placebo + SoC across different SoC medications (antimalarial and immunosuppressant such as mycophenolate, methotrexate, and azathioprine). Across all endpoints, disease trajectory showed no difference in Asian versus non-Asian patients, supporting Asia-inclusive global SLE drug development. These results describe the first population approach to support a model-informed drug development framework in SLE.
    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Severity of Illness Index ; Treatment Outcome ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/diagnosis ; Immunosuppressive Agents/therapeutic use ; Patient Acuity ; Probability
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III.

    Ward, Denham S / Absalom, Anthony R / Aitken, Leanne M / Balas, Michele C / Brown, David L / Burry, Lisa / Colantuoni, Elizabeth / Coursin, Douglas / Devlin, John W / Dexter, Franklin / Dworkin, Robert H / Egan, Talmage D / Elliott, Doug / Egerod, Ingrid / Flood, Pamela / Fraser, Gilles L / Girard, Timothy D / Gozal, David / Hopkins, Ramona O /
    Kress, John / Maze, Mervyn / Needham, Dale M / Pandharipande, Pratik / Riker, Richard / Sessler, Daniel I / Shafer, Steven L / Shehabi, Yahya / Spies, Claudia / Sun, Lena S / Tung, Avery / Urman, Richard D

    Critical care medicine

    2021  Volume 49, Issue 10, Page(s) 1684–1693

    Abstract: Objectives: Clinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to ... ...

    Abstract Objectives: Clinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to compare results across studies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations convened a meeting of multidisciplinary experts to develop recommendations for key methodologic elements of sedation trials in the ICU to help guide academic and industry clinical investigators.
    Design: A 2-day in-person meeting was held in Washington, DC, on March 28-29, 2019, followed by a three-round, online modified Delphi consensus process.
    Participants: Thirty-six participants from academia, industry, and the Food and Drug Administration with expertise in relevant content areas, including two former ICU patients attended the in-person meeting, and the majority completed an online follow-up survey and participated in the modified Delphi process.
    Measurements and main results: The final recommendations were iteratively refined based on the survey results, participants' reactions to those results, summaries written by panel moderators, and a review of the meeting transcripts made from audio recordings. Fifteen recommendations were developed for study design and conduct, subject enrollment, outcomes, and measurement instruments. Consensus recommendations included obtaining input from ICU survivors and/or their families, ensuring adequate training for personnel using validated instruments for assessments of sedation, pain, and delirium in the ICU environment, and the need for methodological standardization.
    Conclusions: These recommendations are intended to assist researchers in the design, conduct, selection of endpoints, and reporting of clinical trials involving sedative medications and/or sedation protocols for adult ICU patients who require mechanical ventilation. These recommendations should be viewed as a starting point to improve clinical trials and help reduce methodological heterogeneity in future clinical trials.
    MeSH term(s) Congresses as Topic ; Consensus ; Delphi Technique ; District of Columbia ; Humans ; Hypnotics and Sedatives/pharmacokinetics ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use ; Respiration, Artificial/instrumentation ; Respiration, Artificial/methods ; Time Factors
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8

    Naigeon, Marie / Roulleaux Dugage, Matthieu / Danlos, François-Xavier / Boselli, Lisa / Jouniaux, Jean-Mehdi / de Oliveira, Caroline / Ferrara, Roberto / Duchemann, Boris / Berthot, Caroline / Girard, Lou / Flippot, Ronan / Albiges, Laurence / Farhane, Siham / Saulnier, Patrick / Lacroix, Ludovic / Griscelli, Frank / Roman, Gabriel / Hulett, Tyler / Marabelle, Aurélien /
    Cassard, Lydie / Besse, Benjamin / Chaput, Nathalie

    Science advances

    2023  Volume 9, Issue 45, Page(s) eadh0708

    Abstract: Circulating senescent ... ...

    Abstract Circulating senescent CD8
    MeSH term(s) Humans ; Cytomegalovirus ; CD8-Positive T-Lymphocytes ; Carcinoma, Non-Small-Cell Lung ; Cytomegalovirus Infections ; Virome ; Lung Neoplasms/drug therapy
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh0708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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