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Article ; Online: Investigation of a model for evaluating cognitive decline from facial photographs using AI.

Umeda-Kameyama, Yumi / Kameyama, Masashi / Kojima, Taro / Tanaka, Tomoki / Iijima, Katsuya / Ogawa, Sumito / Iizuka, Tomomichi / Akishita, Masahiro

Geriatrics & gerontology international

2024 Volume 24 Suppl 1, Page(s) 393–394

MeSH term(s)	Humans ; Face ; Cognitive Dysfunction/diagnosis ; Photography
Language	English
Publishing date	2024-01-02
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14793
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Article ; Online: Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy.

Iizuka, Masahiro / Etou, Takeshi / Sagara, Shiho

World journal of gastroenterology

2022 Volume 28, Issue 34, Page(s) 4959–4972

Abstract: For the optimal management of refractory ulcerative colitis (UC), secondary loss of response (LOR) and primary non-response to biologics is a critical issue. This article aimed to summarize the current literature on the use of cytapheresis (CAP) in ... ...

Abstract	For the optimal management of refractory ulcerative colitis (UC), secondary loss of response (LOR) and primary non-response to biologics is a critical issue. This article aimed to summarize the current literature on the use of cytapheresis (CAP) in patients with UC showing a poor response or LOR to biologics and discuss its advantages and limitations. Further, we summarized the efficacy of CAP in patients with UC showing insufficient response to thiopurines or immunomodulators (IM). Eight studies evaluated the efficacy of CAP in patients with UC with inadequate responses to thiopurines or IM. There were no significant differences in the rate of remission and steroid-free remission between patients exposed or not exposed to thiopurines or IM. Three studies evaluated the efficacy of CAP in patients with UC showing an insufficient response to biologic therapies. Mean remission rates of biologics exposed or unexposed patients were 29.4 % and 44.2%, respectively. Fourteen studies evaluated the efficacy of CAP in combination with biologics in patients with inflammatory bowel disease showing a poor response or LOR to biologics. The rates of remission/response and steroid-free remission in patients with UC ranged 32%-69% (mean: 48.0%, median: 42.9%) and 9%-75% (mean: 40.7%, median: 38%), respectively. CAP had the same effectiveness for remission induction with or without prior failure on thiopurines or IM but showed little benefit in patients with UC refractory to biologics. Although heterogeneity existed in the efficacy of the combination therapy with CAP and biologics, these combination therapies induced clinical remission/response and steroid-free remission in more than 40% of patients with UC refractory to biologics on average. Given the excellent safety profile of CAP, this combination therapy can be an alternative therapeutic strategy for UC refractory to biologics. Extensive prospective studies are needed to understand the efficacy of combination therapy with CAP and biologics.
MeSH term(s)	Biological Products/adverse effects ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Cytapheresis ; Humans ; Immunologic Factors/therapeutic use ; Remission Induction ; Steroids/therapeutic use ; Treatment Outcome
Chemical Substances	Biological Products ; Immunologic Factors ; Steroids
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i34.4959
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Article ; Online: Inhibition Effect of Eucommia ulmoides Leaf Extract on Interleukin 8 Production by A549 Cells.

Kaneko, Masahiro / Iizuka, Toru / Nakajima, Toshiharu

Biological & pharmaceutical bulletin

2021 Volume 44, Issue 12, Page(s) 1891–1893

Abstract: Asthma is characterized by chronic inflammation of the airway mucosa. As Eucommia ulmoides Oliv. leaf extract (ELE) has been known to have anti-inflammatory properties, herein, we investigated the effect of ELE on interleukin (IL-) 8 production in A549 ... ...

Abstract	Asthma is characterized by chronic inflammation of the airway mucosa. As Eucommia ulmoides Oliv. leaf extract (ELE) has been known to have anti-inflammatory properties, herein, we investigated the effect of ELE on interleukin (IL-) 8 production in A549 cells, a human airway epithelial cell line. The addition of ELE 1 h before tumor necrosis factor-alpha (TNFα) stimulation inhibited IL-8 production by A549 cells in a concentration-dependent manner. The addition of geniposidic acid, the main component of ELE, also inhibited IL-8 production. To further investigate the mechanism by which ELE inhibits IL-8 production, the effect of ELE or geniposidic acid on TNFα-stimulated p38 phosphorylation was examined by Western blotting. After 30 min of TNFα stimulation, p38 phosphorylation was inhibited by the addition of ELE or geniposidic acid, suggesting that ELE inhibited IL-8 production in TNFα-stimulated A549 cells by suppressing one of the signal transducers of p38 phosphorylation. These results indicate that ELE can be used as an effective measure against asthma, particularly neutrophilic asthma.
MeSH term(s)	A549 Cells ; Anti-Inflammatory Agents/pharmacology ; Asthma/metabolism ; Asthma/pathology ; Asthma/prevention & control ; Eucommiaceae ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/prevention & control ; Interleukin-8/metabolism ; Phytotherapy ; Plant Extracts/pharmacology ; Plant Leaves ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Interleukin-8 ; Plant Extracts ; Tumor Necrosis Factor-alpha ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2021-12-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b21-00561
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Article: Effects of Long-Term Administration of Gardeniae Fructus on Intra-Abdominal Organs of Rats.

Takei, Hisato / Iizuka, Seiichi / Yamamoto, Masahiro

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 4201508

Abstract: Many recent reports have suggested a possible association between Japanese traditional (Kampo) medicines containing Gardeniae Fructus (GF, the fruit ... ...

Abstract	Many recent reports have suggested a possible association between Japanese traditional (Kampo) medicines containing Gardeniae Fructus (GF, the fruit of
Language	English
Publishing date	2020-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/4201508
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Article: [COVID-19 development during the treatment of paroxysmal nocturnal hemoglobinuria].

Shino, Masahiro / Iizuka, Hiromitsu / Fukushima, Hidehito / Takeyasu, Sho / Kamoda, Yoshimasa / Kida, Michiko / Ichikawa, Motoshi / Anazawa, Rie / Sakurai, Takayuki / Usuki, Kensuke

Rinsho ketsueki] The Japanese journal of clinical hematology

2023 Volume 64, Issue 3, Page(s) 224–229

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a disorder in which an activated complement causes intravascular hemolysis of erythrocytes that do not have complement regulators. It is critical to monitor the rapid progression of hemolysis caused by ... ...

Abstract	Paroxysmal nocturnal hemoglobinuria (PNH) is a disorder in which an activated complement causes intravascular hemolysis of erythrocytes that do not have complement regulators. It is critical to monitor the rapid progression of hemolysis caused by infection and thrombosis. As far as we can tell, this is the first report of 5 COVID-19 patients with PNH in Japan. Three patients were being treated with ravulizumab, one with eculizumab, and one with crovalimab. All five cases had received two or more COVID-19 vaccinations. COVID-19 was classified as mild in four cases and moderate in one. None of the cases required the use of oxygen, and none became severe. All of them experienced breakthrough hemolysis, and two required red blood cell transfusions. In any case, no thrombotic complications were observed.
MeSH term(s)	Humans ; Hemoglobinuria, Paroxysmal/therapy ; Hemolysis ; COVID-19 ; Antibodies, Monoclonal ; Erythrocytes ; Thrombosis
Chemical Substances	Antibodies, Monoclonal
Language	Japanese
Publishing date	2023-03-13
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.64.224
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Zs.A 1175: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Factors associated with the outcomes in ulcerative colitis patients undergoing granulocyte and monocyte adsorptive apheresis as remission induction therapy: A multicenter cohort study.

Ishiguro, Yoh / Ohmori, Toshihide / Umemura, Ken / Iizuka, Masahiro

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2020 Volume 25, Issue 4, Page(s) 502–512

Abstract: Ulcerative colitis (UC) patients harbor activated myeloid leukocytes, which exacerbate and perpetuate UC by releasing inflammatory cytokines. Granulocyte and monocyte adsorptive apheresis (GMA) with an Adacolumn depletes elevated myeloid leukocytes, ... ...

Abstract	Ulcerative colitis (UC) patients harbor activated myeloid leukocytes, which exacerbate and perpetuate UC by releasing inflammatory cytokines. Granulocyte and monocyte adsorptive apheresis (GMA) with an Adacolumn depletes elevated myeloid leukocytes, inducing efficacy with favorable safety. To understand how the clinical outcome with GMA is affected by prior corticosteroid treatment or concomitant immunomodulators, a retrospective multicenter study in 102 UC patients, who had not responded well to first-line medications was undertaken. The remission rates after a course of GMA therapy were significantly higher in corticosteroid-naïve patients compared with those with prior corticosteroid exposure. Absence of corticosteroid background was an independent predictive factor of response to GMA. Further, in corticosteroid-naïve patients, the 1-year cumulative sustained remission rate in patients who did not receive immunomodulators was significantly higher than in patients who received immunomodulators. Accordingly, multivariate analysis revealed that immunomodulator was associated with higher risk of relapse. In conclusion, GMA was an effective treatment for corticosteroid-naïve patients and the efficacy sustained longer in those not receiving immunomodulators during GMA. GMA fulfills the notion that apheresis is to induce disease remission by removing from the body factors known to perpetuate disease. In therapeutic settings, these findings should help better decision making and avoid futile use of medical resources.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adsorption ; Adult ; Blood Component Removal/methods ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/therapy ; Female ; Granulocytes ; Humans ; Immunologic Factors/therapeutic use ; Male ; Middle Aged ; Monocytes ; Recurrence ; Remission Induction ; Retrospective Studies ; Risk Factors
Chemical Substances	Adrenal Cortex Hormones ; Immunologic Factors
Language	English
Publishing date	2020-11-28
Publishing country	Australia
Document type	Journal Article ; Multicenter Study
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13594
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Article ; Online: Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis.

Iizuka, Masahiro / Etou, Takeshi / Shimodaira, Yosuke / Hatakeyama, Takashi / Sagara, Shiho

World journal of gastroenterology

2021 Volume 27, Issue 12, Page(s) 1194–1212

Abstract: Background: It is a crucial issue for patients with refractory ulcerative colitis (UC), including steroid-dependent and steroid-refractory patients, to achieve and maintain steroid-free remission. However, clinical studies focused on the achievement of ... ...

Abstract	Background: It is a crucial issue for patients with refractory ulcerative colitis (UC), including steroid-dependent and steroid-refractory patients, to achieve and maintain steroid-free remission. However, clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient. Cytapheresis (CAP) is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects. This study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC patients. Aim: To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC patients. Methods: We retrospectively reviewed the collected data from 55 patients with refractory UC treated with CAP. We analyzed the following points: (1) Efficacy of the first course of CAP; (2) Efficacy of the second, third, and fourth courses of CAP in patients who experienced relapses during the observation period; (3) Efficacy of CAP in colonic mucosa; and (4) Long-term efficacy of CAP. Clinical efficacy was evaluated using Lichtiger's clinical activity index or Sutherland index (disease activity index). Mucosal healing was evaluated using Mayo endoscopic subscore. The primary and secondary endpoints were the rate of achievement of steroid-free remission and the rate of sustained steroid-free remission, respectively. Statistical analysis was performed using the paired t-test and chi-squared test. Results: The rates of clinical remission, steroid-free remission, and poor effectiveness after CAP were 69.1%, 45.5%, and 30.9%, respectively. There were no significant differences in rate of steroid-free remission between patients with steroid-dependent and steroid-refractory UC. The mean disease activity index and Lichtiger's clinical activity index scores were significantly decreased after CAP ( Conclusion: Our results suggest that CAP effectively induces and maintains steroid-free remission in refractory UC and re-induces steroid-free remission in patients achieving steroid-free remission after the first course of CAP.
MeSH term(s)	Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Cytapheresis ; Humans ; Remission Induction ; Retrospective Studies ; Steroids/therapeutic use ; Treatment Outcome
Chemical Substances	Steroids
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v27.i12.1194
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Article ; Online: Effects of Long-Term Administration of Gardeniae Fructus on Intra-Abdominal Organs of Rats

Hisato Takei / Seiichi Iizuka / Masahiro Yamamoto

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Many recent reports have suggested a possible association between Japanese traditional (Kampo) medicines containing Gardeniae Fructus (GF, the fruit of Gardenia jasminoides J. Ellis) and the mesenteric phlebosclerosis (MP). MP is a chronic orphan disease ...

Abstract	Many recent reports have suggested a possible association between Japanese traditional (Kampo) medicines containing Gardeniae Fructus (GF, the fruit of Gardenia jasminoides J. Ellis) and the mesenteric phlebosclerosis (MP). MP is a chronic orphan disease characterized by venous calcification extending from the colonic wall to the mesentery, usually developing in the proximal colon. In the present study, we administered GF to Wistar/ST female rats as 1% and 2% feed in the diet for 11 months to evaluate any calcification and/or fibrosis of veins in the colonic wall and mesentery. The reversibility of GF’s effects was examined by feeding a normal diet for an additional 3 months. A significant decrease in body weight gain and food consumption occurred in the 2% GF group. Pigmentation of the liver, kidney, and spleen in macroscopic or histopathological examination was observed after 11-month administration, which disappeared after the 3-month recovery period. Histopathological findings such as fibrous thickening and calcification of vein walls, characteristic of human MP, were not observed. Fibrosis in the colonic lamina propria was observed in the 2% GF group but not in the 1% GF group during the treatment period, but the incidence as well as grade of this type of fibrosis decreased in the recovery period, suggesting that the effects of GF were reversible. In the present study, chronic GF administration did not result in any venous pathological changes but induced pigmentation in the liver, kidneys, and spleen and moderate fibrosis in the colonic lamina propria, all of which being reversible. Further studies are required to determine the association between GF and MP.
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout.

Oizumi, Hiroaki / Miyamoto, Yuki / Seiwa, Chika / Yamamoto, Masahiro / Yoshioka, Nozomu / Iizuka, Seiichi / Torii, Tomohiro / Ohbuchi, Katsuya / Mizoguchi, Kazushige / Yamauchi, Junji / Asou, Hiroaki

iScience

2023 Volume 26, Issue 10, Page(s) 107448

Abstract: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking abrogates ... ...

Abstract	Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking abrogates oligodendrocyte migration and myelination. Herein, we show that MBP-driven Ddx54 knockout mice (
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107448
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Article ; Online: Factors associated with elevated blood lactate levels in patients undergoing maintenance hemodialysis.

Hori, Kazuyoshi / Uchida, Yasutaka / Kokubo, Kenichi / Matsuzawa, Naoya / Kamegamori, Anna / Iizuka, Tomoya / Saito, Yusuke / Shiota, Kenji / Kidooka, Satoshi / Inoue, Masahiro

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

2022 Volume 26, Issue 3, Page(s) 212–219

Abstract: Factors associated with chronic elevation of the blood lactate levels in patients undergoing chronic maintenance hemodialysis (hereinafter, hemodialysis patients) have not yet been thoroughly investigated. The purpose of the present study was to clarify ... ...

Abstract	Factors associated with chronic elevation of the blood lactate levels in patients undergoing chronic maintenance hemodialysis (hereinafter, hemodialysis patients) have not yet been thoroughly investigated. The purpose of the present study was to clarify factors associated with elevated blood lactate levels in hemodialysis patients. We divided the hemodialysis patients into two groups according the blood lactate levels (the high blood lactate group [> 2 mmol/L] and normal blood lactate group), and conducted a retrospective comparison of the following items between the two groups: (1) the creatinine generation rate (%CGR) and the geriatric nutrition risk index (GNRI) as indices of the nutritional status; (2) the left ventricular ejection fraction (LVEF) and E/A, an indicator of diastolic function; (3) the ankle-brachial index (ABI) and transcutaneous partial pressure of oxygen as indices of the adequacy of circulation in the peripheral blood vessels of the lower extremities; (4) the white blood cell count and serum level of C-reactive protein (CRP) before dialysis as markers of an inflammatory state. The mean age and serum CRP level were significantly higher in the high blood lactate group than in the normal blood lactate group. There were no significant differences in the markers of the nutritional status, cardiac function, or adequacy of circulation in the peripheral blood vessels of the lower extremities between the two groups. Advanced age and a state of chronic inflammation appear to be associated with elevated blood lactate levels in patients undergoing chronic maintenance hemodialysis.
MeSH term(s)	Humans ; Aged ; Kidney Failure, Chronic ; Stroke Volume ; Retrospective Studies ; Ventricular Function, Left ; Renal Dialysis ; Nutritional Status ; Risk Factors
Language	English
Publishing date	2022-08-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1463555-0
ISSN	1619-0904 ; 1434-7229
ISSN (online)	1619-0904
ISSN	1434-7229
DOI	10.1007/s10047-022-01355-y
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