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  1. Article ; Online: Electrospun nanofibrous membranes of recombinant human collagen type III promote cutaneous wound healing.

    Dong, Zuqin / Liu, Quanying / Han, Xiaowen / Zhang, Xinyue / Wang, Xinyue / Hu, Chen / Li, Xing / Liang, Jie / Chen, Yafang / Fan, Yujiang

    Journal of materials chemistry. B

    2023  Volume 11, Issue 27, Page(s) 6346–6360

    Abstract: Cutaneous wound healing is a complex process that strives to re-establish the original structure and functions of the skin. With the development of electrospinning technology, nanofibrous membrane biomaterials have emerged as promising pro-regenerative ... ...

    Abstract Cutaneous wound healing is a complex process that strives to re-establish the original structure and functions of the skin. With the development of electrospinning technology, nanofibrous membrane biomaterials have emerged as promising pro-regenerative strategies for recapitulating the structure and composition of the natural extracellular matrix (ECM). Herein, a nanofibrous membrane wound dressing material based on recombinant human collagen type III (rhCol III) crosslinked by EDC/NHS (rhCol III
    MeSH term(s) Mice ; Animals ; Humans ; Collagen Type III ; Nanofibers/chemistry ; Wound Healing ; Skin ; Integrins
    Chemical Substances Collagen Type III ; Integrins
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb00438d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources.

    Zhang, Zuqin / Yao, Wei / Wang, Yan / Long, Cheng / Fu, Xinmiao

    The Journal of infection

    2020  Volume 81, Issue 1, Page(s) 147–178

    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Equipment and Supplies/supply & distribution ; Hospitals ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; SARS-CoV-2 ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-03-21
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.018
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  3. Article ; Online: Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations.

    Wang, Zuqin / Wang, Jie / Wang, Yongjin / Xiang, Shuang / Zhou, Hengliang / Song, Shukai / Song, Xiaojuan / Tu, Zhengchao / Zhou, Yang / Ding, Ke / Zhang, Zhi-Min / Zhang, Zhang / Lu, Xiaoyun

    Journal of medicinal chemistry

    2023  Volume 66, Issue 18, Page(s) 12950–12965

    Abstract: The solvent-front (SF), gatekeeper, and xDFG motif mutations of tropomyosin receptor kinase (TRK) mediating acquired resistance of larotrectinib and entrectinib represent an unmet clinical need. To date, no effective drugs are being approved to overcome ... ...

    Abstract The solvent-front (SF), gatekeeper, and xDFG motif mutations of tropomyosin receptor kinase (TRK) mediating acquired resistance of larotrectinib and entrectinib represent an unmet clinical need. To date, no effective drugs are being approved to overcome these mutants. Thus, a series of macrocycle compounds were designed and synthesized as new type II TRK inhibitors to combat clinically relevant mutations. The representative compound
    MeSH term(s) Humans ; Receptor, trkA ; Mutation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Neoplasms/drug therapy
    Chemical Substances Receptor, trkA (EC 2.7.10.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00899
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  5. Article ; Online: Forecasting the Cumulative Number of COVID-19 Deaths in China: Can More Lives Be Saved?

    Zuqin Zhang / Cheng Long / Wei Yao / Qi Ying / Xinmiao Fu

    Abstract: Background: An outbreak of 2019 novel coronavirus diseases (COVID-19) caused by SARS-CoV-2 is on-going in China and appears to approach late phase. It is highly demanding to estimate how many COVID-19 patients will die eventually. In this study, an ... ...

    Abstract Background: An outbreak of 2019 novel coronavirus diseases (COVID-19) caused by SARS-CoV-2 is on-going in China and appears to approach late phase. It is highly demanding to estimate how many COVID-19 patients will die eventually. In this study, an estimate of the potential total number of COVID-19 deaths in mainland China, Hubei Province, Wuhan City, and other provinces is provided. The results may help to eluate the severity of the epidemic and facilitate mental health care. Methods: Data of the cumulative number of COVID-19 deaths from January 21 to February 29, 2020, released daily by the National Health Commission of China and Hubei Provincial Health Commission, were used. The Boltzmann function was explored to simulate the data in each region. By using these established functions, the potential total number of deaths were forecasted. In addition, data of the cumulative number of 2003 SARS deaths in mainland China, Hong Kong and worldwide were collected from the WHO official website and analyzed in a similar manner. A Monte Carlo technique was applied to analyze the uncertainty of the estimates of the cumulative confirmed cases, and the results are presented using the resulting mean, median, and a 95% confidence interval (CI). For comparison, the potential total numbers of deaths were estimated by Richards function-based regression analyses. Findings: The data of cumulative number of COVID-19 deaths with respect to each region were all well-fitted to the Boltzmann function (R2 for all the regression analyses being close to 0.999). Consistently, the data for the cumulative numbers of 2003 SARS in mainland China, Hong Kong and worldwide were also well fitted to the Boltzmann function. The potential total number of COVID-19 deaths in mainland China, other provinces, Hubei Province, Wuhan City, and other cities in Hubei were estimated to be 3260 (95% CI 3187, 3394), 110 (109, 112), 3174 (3095, 3270), 2550 (2494, 2621) and 617 (607, 632), respectively. Similar results were obtained by Richards function-based regression analysis. Interpretation: The observation that the data of the cumulative numbers of deaths for both the on-going COVID-19 outbreak and the 2003 SARS epidemic in each geographic region were well fitted with the Boltzmann function strongly suggests that it is suitable for the simulation of deaths associated with coronaviruses-induced diseases. The estimation of COVID-19 deaths may help governments to evaluate the severity of the outbreak and also facilitate timely mental health care for the families of dead patients.
    Keywords covid19
    Publisher medrxiv
    Document type Article ; Online
    DOI 10.1101/2020.03.02.20030064
    Database COVID19

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  6. Article ; Online: Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy.

    Xiang, Shuang / Wang, Jie / Huang, Huisi / Wang, Zuqin / Song, Xiaojuan / Zhou, Yang / Jin, Feng / He, Xun / Zhang, Zhi-Min / Tu, Zhengchao / Ding, Ke / Zhang, Zhang / Lu, Xiaoyun

    European journal of medicinal chemistry

    2022  Volume 245, Issue Pt 1, Page(s) 114899

    Abstract: TRK xDFG mutation-induced acquired resistance of ... ...

    Abstract TRK xDFG mutation-induced acquired resistance of 1
    MeSH term(s) Humans ; Protein Kinase Inhibitors/pharmacology ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Protein Kinase Inhibitors
    Language English
    Publishing date 2022-11-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114899
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  7. Article ; Online: Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

    Zhang, Zuqin / Yao, Wei / Wang, Yan / Long, Cheng / Fu, Xinmiao

    Journal of Infection

    2020  Volume 81, Issue 1, Page(s) 147–178

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.03.018
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  8. Article ; Online: DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild‐Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression

    Zuqin Chen / Sunfan Li / Fangzhou Li / Cheng Qin / Xianlei Li / Guangchao Qing / Jinjin Wang / Bozhang Xia / Fuxue Zhang / Liangliang Meng / Xing‐Jie Liang / Yueyong Xiao

    Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Patients with triple‐negative breast cancer (TNBC) have the worst clinical outcomes when compared to other subtypes of breast cancer. Nanotechnology‐assisted photothermal therapy (PTT) opens new opportunities for precise cancer treatment. ... ...

    Abstract Abstract Patients with triple‐negative breast cancer (TNBC) have the worst clinical outcomes when compared to other subtypes of breast cancer. Nanotechnology‐assisted photothermal therapy (PTT) opens new opportunities for precise cancer treatment. However, thermoresistance caused by PTT, as well as uncertainty in the physiological metabolism of existing phototherapeutic nanoformulations, severely limit their clinical applications. Herein, based on the clinically chemotherapeutic drug mitoxantrone (MTO), a multifunctional nanoplatform (MTO‐micelles) is developed to realize mutually synergistic mild‐photothermal chemotherapy. MTO with excellent near‐infrared absorption (≈669 nm) can function not only as a chemotherapeutic agent but also as a photothermal transduction agent with elevated photothermal conversion efficacy (ƞ = 54.62%). MTO‐micelles can accumulate at the tumor site through the enhanced permeability and retention effect. Following local near‐infrared irradiation, mild hyperthermia (<50 °C) assists MTO in binding tumor cell DNA, resulting in chemotherapeutic sensitization. In addition, downregulation of heat shock protein 70 (HSP70) expression due to enhanced DNA damage can in turn weaken tumor thermoresistance, boosting the efficacy of mild PTT. Both in vitro and in vivo studies indicate that MTO‐micelles possess excellent synergetic tumor inhibition effects. Therefore, the mild‐photothermal chemotherapy strategy based on MTO‐micelles has a promising prospect in the clinical transformation of TNBC treatment.
    Keywords chemotherapy ; DNA damage ; heat shock protein ; mild‐photothermal therapy ; mitoxantrone ; polymeric micelle ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild-Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression.

    Chen, Zuqin / Li, Sunfan / Li, Fangzhou / Qin, Cheng / Li, Xianlei / Qing, Guangchao / Wang, Jinjin / Xia, Bozhang / Zhang, Fuxue / Meng, Liangliang / Liang, Xing-Jie / Xiao, Yueyong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 16, Page(s) e2206707

    Abstract: Patients with triple-negative breast cancer (TNBC) have the worst clinical outcomes when compared to other subtypes of breast cancer. Nanotechnology-assisted photothermal therapy (PTT) opens new opportunities for precise cancer treatment. However, ... ...

    Abstract Patients with triple-negative breast cancer (TNBC) have the worst clinical outcomes when compared to other subtypes of breast cancer. Nanotechnology-assisted photothermal therapy (PTT) opens new opportunities for precise cancer treatment. However, thermoresistance caused by PTT, as well as uncertainty in the physiological metabolism of existing phototherapeutic nanoformulations, severely limit their clinical applications. Herein, based on the clinically chemotherapeutic drug mitoxantrone (MTO), a multifunctional nanoplatform (MTO-micelles) is developed to realize mutually synergistic mild-photothermal chemotherapy. MTO with excellent near-infrared absorption (≈669 nm) can function not only as a chemotherapeutic agent but also as a photothermal transduction agent with elevated photothermal conversion efficacy (ƞ = 54.62%). MTO-micelles can accumulate at the tumor site through the enhanced permeability and retention effect. Following local near-infrared irradiation, mild hyperthermia (<50 °C) assists MTO in binding tumor cell DNA, resulting in chemotherapeutic sensitization. In addition, downregulation of heat shock protein 70 (HSP70) expression due to enhanced DNA damage can in turn weaken tumor thermoresistance, boosting the efficacy of mild PTT. Both in vitro and in vivo studies indicate that MTO-micelles possess excellent synergetic tumor inhibition effects. Therefore, the mild-photothermal chemotherapy strategy based on MTO-micelles has a promising prospect in the clinical transformation of TNBC treatment.
    MeSH term(s) Humans ; Mitoxantrone ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Micelles ; HSP70 Heat-Shock Proteins ; Phototherapy/methods
    Chemical Substances Mitoxantrone (BZ114NVM5P) ; Micelles ; HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2023-04-17
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206707
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  10. Article ; Online: Clinical management of infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: A nationwide survey of tertiary hospitals in mainland China.

    Zha, Lei / Li, Shirong / Ren, Zhichu / Li, Xiang / Zhang, Dayan / Zou, Yi / Pan, Lingling / Xu, Qiancheng / Rui, Zuqin / Chen, Shanghua / Yang, Gang / Chen, Zhixiang / Tefsen, Boris / Guo, Jun

    The Journal of infection

    2022  Volume 84, Issue 6, Page(s) e108–e110

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenem-Resistant Enterobacteriaceae ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; China/epidemiology ; Critical Illness ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/epidemiology ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Tertiary Care Centers
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.03.023
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