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  1. Article ; Conference proceedings: Omodysplasie Typ II – Erstpublikation einer de novo Mutation im FZD2-Gen

    Jurk, S M / Schröck, K / Springer, C

    Geburtshilfe und Frauenheilkunde

    2022  Volume 82, Issue 06

    Event/congress Kongressabstracts zur 15. Jahrestagung der Mitteldeutschen Gesellschaft für Frauenheilkunde und Geburtshilfe e.V. (MGFG), Halle (Saale), 2022-06-17
    Language German
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/s-0042-1749737
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  2. Article ; Online: Infectious Illness Symptoms Are Associated with Elevated Anxiety in a Sample of Sexual and Gender Minority Young Adults During the COVID-19 Pandemic.

    Iyer, Chitra S / Schrock, Joshua M / Johnson, Anthony / Gorbach, Pamina M / Siminski, Sue / Newcomb, Michael E / McDade, Thomas W / Mustanski, Brian

    International journal of behavioral medicine

    2024  

    Abstract: Background: To evaluate whether infectious illness symptoms (IIS) are associated with generalized anxiety symptoms during the COVID-19 pandemic in sexual/gender (SGM) minority young adults assigned male at birth (AMAB).: Method: Four hundred eighteen ...

    Abstract Background: To evaluate whether infectious illness symptoms (IIS) are associated with generalized anxiety symptoms during the COVID-19 pandemic in sexual/gender (SGM) minority young adults assigned male at birth (AMAB).
    Method: Four hundred eighteen participants (median age = 25; range, 20-40) were recruited through RADAR, an ongoing Chicago-based cohort study of SGM-AMAB between September 2020 and February 2021. Participants completed online surveys. A subset (n = 145) provided dried blood spot samples to assess SARS-CoV-2 serostatus.
    Results: One hundred twenty participants (28.7%) had GAD-7 scores of 10 or greater, which indicates generalized anxiety symptoms that may be clinically significant. In a binomial logistic regression model adjusting age, gender identity, race/ethnicity, substance use, and HIV status, the authors found that having a higher IIS count since March 1, 2020, was associated with greater odds of having a GAD-7 score of 10 or greater (OR = 1.14; 95% CI, 1.04, 1.25; P = 0.007). This effect was more pronounced in a binomial logistic regression model adjusting for the same covariates but using current IIS count as the independent variable (OR = 1.39; 95% CI, 1.13, 1.74; P = 0.002).
    Conclusion: Among SGM-AMAB young adults, those who experienced ISS reported higher scores on the GAD-7, a widely used and validated screening measure for generalized anxiety symptoms. These findings highlight the importance of screening for anxiety disorders when patients present with IIS in clinical settings and psychobehavioral health follow-ups when indicated.
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1187972-5
    ISSN 1532-7558 ; 1070-5503
    ISSN (online) 1532-7558
    ISSN 1070-5503
    DOI 10.1007/s12529-023-10251-5
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  3. Article ; Online: Quantitative determination of phosphatidylethanol in dried blood spots for monitoring alcohol abstinence.

    Luginbühl, Marc / Stöth, Frederike / Schröck, Alexandra / Gaugler, Stefan / Weinmann, Wolfgang

    Nature protocols

    2020  Volume 16, Issue 1, Page(s) 283–308

    Abstract: Phosphatidylethanol (PEth), which is formed by enzymatic reaction between ethanol and phosphatidylcholine, is a direct marker for alcohol usage. PEth has a long elimination half-life (~5-10 d) and specimens can be sampled using minimally invasive ... ...

    Abstract Phosphatidylethanol (PEth), which is formed by enzymatic reaction between ethanol and phosphatidylcholine, is a direct marker for alcohol usage. PEth has a long elimination half-life (~5-10 d) and specimens can be sampled using minimally invasive microsampling strategies. In combination with rapid analysis procedures PEth has proved to be advantageous for the detection of abstinence over other direct (e.g., ethyl glucuronide in blood, urine or hair) and indirect (e.g., carbohydrate-deficient transferrin in serum) alcohol markers. Although PEth determination is widely applied around the world, laboratory protocols are not standardized. Here we provide general guidelines for the analysis of PEth in dried blood spots (DBSs), including reference material evaluation, synthesis of a deuterated internal standard, preparation of calibration samples (reference material in teetotaller blood), and analyte separation and detection. The protocol contains information to extract the DBSs either manually or with a fully automated autosampler. Extraction of the analytes from DBS filter paper cards is performed using an organic extraction, followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). For accurate and reliable measurement of PEth, the two most abundant analogs, PEth 16:0/18:1 and PEth 16:0/18:2, are quantified. We show data that provide guidelines on how to interpret the results for both demographic studies and forensic applications. The described protocol can be applied by experienced laboratory staff with basic LC-MS/MS knowledge and takes 2 d to perform.
    MeSH term(s) Alcohol Abstinence ; Alcohol Drinking/blood ; Biomarkers/blood ; Chromatography, Liquid/methods ; Dried Blood Spot Testing/methods ; Glycerophospholipids/blood ; Humans ; Tandem Mass Spectrometry/methods
    Chemical Substances Biomarkers ; Glycerophospholipids ; phosphatidylethanol
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-020-00416-x
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  4. Article ; Online: In Response to Dr. Steven Sorscher.

    Zhang, Shannon S / Schrock, Alexa B / Nagasaka, Misako / Ou, Sai-Hong Ignatius

    JTO clinical and research reports

    2022  Volume 4, Issue 1, Page(s) 100453

    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2022.100453
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  5. Article ; Online: Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model.

    Clausing, Maximilian / William, Doreen / Preussler, Matthias / Biedermann, Julia / Grützmann, Konrad / Richter, Susan / Buchholz, Frank / Temme, Achim / Schröck, Evelin / Klink, Barbara

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: ... The ... ...

    Abstract The IDH1
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Down-Regulation ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioma/genetics ; Glioma/metabolism ; Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; NAD/metabolism ; NADP/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics ; Nicotinamide Phosphoribosyltransferase/metabolism ; RNA Interference
    Chemical Substances Cytokines ; NAD (0U46U6E8UK) ; NADP (53-59-8) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; nicotinamide phosphoribosyltransferase, human (EC 2.4.2.12)
    Language English
    Publishing date 2022-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105787
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  6. Article: Greater chronic morbidity is associated with greater fatigue in six countries: A case of evolutionary mismatch?

    Schrock, Joshua M / Sugiyama, Lawrence S / Naidoo, Nirmala / Kowal, Paul / Snodgrass, J Josh

    Evolution, medicine, and public health

    2022  Volume 10, Issue 1, Page(s) 156–169

    Abstract: Background and objectives: Human susceptibility to chronic non-communicable disease may be explained, in part, by mismatches between our evolved biology and contemporary environmental conditions. Disease-induced fatigue may function to reduce physical ... ...

    Abstract Background and objectives: Human susceptibility to chronic non-communicable disease may be explained, in part, by mismatches between our evolved biology and contemporary environmental conditions. Disease-induced fatigue may function to reduce physical activity during acute infection, thereby making more energy available to mount an effective immune response. However, fatigue in the context of chronic disease may be maladaptive because long-term reductions in physical activity increase risks of disease progression and the acquisition of additional morbidities. Here, we test whether cumulative chronic morbidity is associated with subjective fatigue.
    Methodology: We constructed a cumulative chronic morbidity score using self-reported diagnoses and algorithm-based assessments, and a subjective fatigue score based on four questionnaire items using cross-sectional survey data from the Study on global AGEing and adult health, which features large samples of adults from six countries (China, Ghana, India, Mexico, Russia and South Africa).
    Results: In a mixed-effects linear model with participants nested in countries (
    Conclusions and implications: Fatigue is a common but perhaps maladaptive neuropsychological response to chronic morbidity. Disease-induced fatigue may mediate a self-perpetuating cycle, in which chronic morbidity reduces physical activity, and less physical activity increases cumulative chronic morbidity. Longitudinal research is needed to test whether chronic morbidity, fatigue and physical activity form a cyclical feedback loop.
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2684837-5
    ISSN 2050-6201
    ISSN 2050-6201
    DOI 10.1093/emph/eoac011
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  7. Article ; Online: Real-World Clinical Performance of a DNA-Based Comprehensive Genomic Profiling Assay for Detecting Targetable Fusions in Nonsquamous NSCLC.

    Mack, Philip C / Keller-Evans, Rachel B / Li, Gerald / Lofgren, Katherine T / Schrock, Alexa B / Trabucco, Sally E / Allen, Justin M / Tolba, Khaled / Oxnard, Geoffrey R / Huang, Richard S P

    The oncologist

    2024  

    Abstract: Background: Genomic fusions are potent oncogenic drivers across cancer types and many are targetable. We demonstrate the clinical performance of DNA-based comprehensive genomic profiling (CGP) for detecting targetable fusions.: Materials and methods: ...

    Abstract Background: Genomic fusions are potent oncogenic drivers across cancer types and many are targetable. We demonstrate the clinical performance of DNA-based comprehensive genomic profiling (CGP) for detecting targetable fusions.
    Materials and methods: We analyzed targetable fusion genes in >450 000 tissue specimens profiled using DNA CGP (FoundationOne CDx, FoundationOne). Using a de-identified nationwide (US-based) non-small cell lung cancer (NSCLC) clinico-genomic database, we assessed outcomes in patients with nonsquamous NSCLC (NonSqNSCLC) who received matched therapy based on a fusion identified using DNA CGP. Lastly, we modeled the added value of RNA CGP for fusion detection in NonSqNSCLC.
    Results: We observed a broad diversity of fusion partners detected with DNA CGP in conjunction with targetable fusion genes (ALK, BRAF, FGFR2, FGFR3, NTRK1/2/3, RET, and ROS1). In NonSqNSCLC with oncogenic ALK, NTRK, RET, and ROS1 fusions detected by DNA CGP, patients treated with a matched tyrosine kinase inhibitor had better real-world progression-free survival than those receiving alternative treatment regimens and benefit was observed regardless of the results of orthogonal fusion testing. An estimated 1.3% of patients with NonSqNSCLC were predicted to have an oncogenic driver fusion identified by RNA, but not DNA CGP, according to a model that accounts for multiple real-world factors.
    Conclusion: A well-designed DNA CGP assay is capable of robust fusion detection and these fusion calls are reliable for informing clinical decision-making. While DNA CGP detects most driver fusions, the clinical impact of fusion detection is substantial for individual patients and exhaustive efforts, inclusive of additional RNA-based testing, should be considered when an oncogenic driver is not clearly identified.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyae028
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    Zs.A 4845: Show issues Location:
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  8. Article ; Online: Significant Clinical Response to a MEK Inhibitor Therapy in a Patient With Metastatic Melanoma Harboring an

    Kim, Kevin B / Semrad, Thomas / Schrock, Alexa B / Ali, Siraj M / Ross, Jeffrey S / Singer, Mark / Kashani-Sabet, Mohammed

    JCO precision oncology

    2022  Volume 2, Page(s) 1–6

    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.17.00138
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  9. Article ; Online: Application of phosphatidylethanol (PEth) in whole blood in comparison to ethyl glucuronide in hair (hEtG) in driving aptitude assessment (DAA).

    Schröck, Alexandra / Pfäffli, Matthias / König, Stefan / Weinmann, Wolfgang

    International journal of legal medicine

    2016  Volume 130, Issue 6, Page(s) 1527–1533

    Abstract: For driving aptitude assessment (DAA), the analysis of several alcohol biomarkers is essential for the detection of alcohol intake besides psycho-medical exploration. In Switzerland, EtG in hair (hEtG) is often the only direct marker for abstinence ... ...

    Abstract For driving aptitude assessment (DAA), the analysis of several alcohol biomarkers is essential for the detection of alcohol intake besides psycho-medical exploration. In Switzerland, EtG in hair (hEtG) is often the only direct marker for abstinence monitoring in DAA. Therefore, the suitability of phosphatidylethanol (PEth) was investigated as additional biomarker. PEth 16:0/18:1 and 16:0/18:2 were determined by online-SPE-LC-MS/MS in 136 blood samples of persons undergoing DAA and compared to hEtG, determined in hair segments taken at the same time. With a PEth 16:0/18:1 threshold of 210 ng/mL for excessive alcohol consumption, all (n = 30) but one tested person also had hEtG values ≥30 pg/mg. In 54 cases, results are not in contradiction to an abstinence as neither PEth (<20 ng/mL) nor hEtG (<7 pg/mg) was detected. In eight cases, both markers showed moderate consumption. Altogether, PEth and hEtG were in accordance in 68 % of the samples, although covering different time periods of alcohol consumption. With receiver operating characteristic analysis, PEth was evaluated to differentiate abstinence, moderate, and excessive alcohol consumption in accordance with hEtG limits. A PEth 16:0/18:1 threshold of 150 ng/mL resulted in the best sensitivity (70.6 %) and specificity (98.8 %) for excessive consumption. Values between 20 and 150 ng/mL passed for moderate consumption, values <20 ng/mL passed for abstinence. As PEth mostly has a shorter detection window (2-4 weeks) than hEtG (up to 6 months depending on hair length), changes in drinking behavior can be detected earlier by PEth than by hEtG analysis alone. Therefore, PEth helps to improve the diagnostic information and is a valuable additional alcohol marker for DAA.
    MeSH term(s) Adult ; Aged ; Alcohol Abstinence/legislation & jurisprudence ; Alcohol Drinking ; Biomarkers/blood ; Chromatography, Liquid ; Driving Under the Influence/legislation & jurisprudence ; Female ; Glucuronates/analysis ; Glycerophospholipids/blood ; Hair/chemistry ; Humans ; Male ; Mass Spectrometry ; Middle Aged ; Solid Phase Extraction ; Switzerland ; Young Adult
    Chemical Substances Biomarkers ; Glucuronates ; Glycerophospholipids ; phosphatidylethanol ; ethyl glucuronide (17685-04-0)
    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-016-1394-4
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  10. Article ; Online: Iron deficiency in blood donors: perceptions and management among general practitioners and internists.

    Amrein, Karin / Macher, Susanne / Schröck, Martin / Schlenke, Peter / Drexler, Camilla

    Transfusion

    2017  Volume 57, Issue 10, Page(s) 2548–2549

    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.14297
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