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  1. Article: A One-Step Synthesis of

    Cunningham, Christopher W / Deschamps, Jeffrey R / Coop, Andrew

    Journal of pharmaceutical sciences and pharmacology

    2021  Volume 1, Issue 1, Page(s) 54–56

    Abstract: Opioid analgesics are the treatment of choice for chronic, severe pain. During the course of developing new derivatives of morphine and codeine, we observed an unanticipated ... ...

    Abstract Opioid analgesics are the treatment of choice for chronic, severe pain. During the course of developing new derivatives of morphine and codeine, we observed an unanticipated S
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 2333-3715
    ISSN 2333-3715
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  2. Article: Two Cu

    Vincent, Collin J / Giles, Ian D / Deschamps, Jeffrey R

    Acta crystallographica. Section E, Crystallographic communications

    2018  Volume 74, Issue Pt 3, Page(s) 357–362

    Abstract: The crystal structure of complexes of 3,4,5-tri-methyl- ... ...

    Abstract The crystal structure of complexes of 3,4,5-tri-methyl-1
    Language English
    Publishing date 2018-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989018002359
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  3. Article ; Online: Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines.

    Sulima, Agnieszka / Li, Fuying / Morgan, Jeffrey Brian / Truong, Phong / Antoline, Joshua F G / Oertel, Therese / Barrientos, Rodell C / Torres, Oscar B / Beck, Zoltan / Imler, Gregory H / Deschamps, Jeffrey R / Matyas, Gary R / Jacobson, Arthur E / Rice, Kenner C

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap ( ...

    Abstract In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (
    MeSH term(s) Heroin
    Chemical Substances Heroin (70D95007SX)
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051553
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Hydrochloride Salt of the GABAkine KRM-II-81.

    Mian, Md Yeunus / Divović, Branka / Sharmin, Dishary / Pandey, Kamal P / Golani, Lalit K / Tiruveedhula, V V N Phani Babu / Cerne, Rok / Smith, Jodi L / Ping, Xingjie / Jin, Xiaoming / Imler, Gregory H / Deschamps, Jeffrey R / Lippa, Arnold / Cook, James M / Savić, Miroslav M / Rowlett, James / Witkin, Jeffrey M

    ACS omega

    2022  Volume 7, Issue 31, Page(s) 27550–27559

    Abstract: Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)- ... ...

    Abstract Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03029
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  5. Article ; Online: Reply to the 'Comment on "Investigation of Zr(iv) and

    Guérard, François / Lee, Yong-Sok / Tripier, Raphaël / Szajek, Lawrence P / Deschamps, Jeffrey R / Brechbiel, Martin W

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 83, Page(s) 12667–12668

    Abstract: The alternative analysis of A. Bianchi and M. Savastano is a valuable contribution to the understanding of the complex systems at stake in the complexation chemistry of ... ...

    Abstract The alternative analysis of A. Bianchi and M. Savastano is a valuable contribution to the understanding of the complex systems at stake in the complexation chemistry of Zr
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc03594g
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  6. Article ; Online: Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids.

    Rahman, M Toufiqur / Deschamps, Jeffrey R / Imler, Gregory H / Cook, James M

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2018  Volume 24, Issue 10, Page(s) 2354–2359

    Abstract: Extension of the asymmetric Pictet-Spengler reaction to bulkier ... ...

    Abstract Extension of the asymmetric Pictet-Spengler reaction to bulkier N
    MeSH term(s) Ajmaline/chemical synthesis ; Indole Alkaloids/chemical synthesis ; Magnetic Resonance Spectroscopy/methods ; Molecular Structure ; Stereoisomerism ; Tryptophan/analogs & derivatives ; Tryptophan/chemical synthesis
    Chemical Substances Indole Alkaloids ; macroline ; Ajmaline (1PON08459R) ; Tryptophan (8DUH1N11BX) ; sarpagine (XD54MPV6VQ)
    Language English
    Publishing date 2018-02-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201705575
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  7. Article ; Online: Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.

    Nikolayevskiy, Herman / Scerba, Michael T / Deschamps, Jeffrey R / Appella, Daniel H

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2018  Volume 24, Issue 38, Page(s) 9485–9489

    Abstract: Mercaptobenzamide thioester SAMT-247 is a non-toxic, mutation-resistant HIV-1 maturation inhibitor with a unique mechanism of antiviral activity. NMR spectroscopic analyses of model reactions that mimic the cellular environment answered fundamental ... ...

    Abstract Mercaptobenzamide thioester SAMT-247 is a non-toxic, mutation-resistant HIV-1 maturation inhibitor with a unique mechanism of antiviral activity. NMR spectroscopic analyses of model reactions that mimic the cellular environment answered fundamental questions about the antiviral mechanism and inspired a high-yielding (64 % overall), scalable (75 mmol), and cost-effective ($4 mmol
    MeSH term(s) HIV-1/chemistry ; HIV-1/drug effects ; Humans ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/metabolism ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/pharmacology
    Chemical Substances Nucleocapsid Proteins ; Sulfhydryl Compounds
    Language English
    Publishing date 2018-05-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201801253
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  8. Article ; Online: X-ray crystallography of chemical compounds.

    Deschamps, Jeffrey R

    Life sciences

    2009  Volume 86, Issue 15-16, Page(s) 585–589

    Abstract: Aims: Accurate knowledge of molecular structure is a prerequisite for rational drug design. This review examines the role of X-ray crystallography in providing the required structural information and advances in the field of X-ray crystallography that ... ...

    Abstract Aims: Accurate knowledge of molecular structure is a prerequisite for rational drug design. This review examines the role of X-ray crystallography in providing the required structural information and advances in the field of X-ray crystallography that enhance or expand its role.
    Main methods: X-ray crystallography of new drugs candidates and intermediates can provide valuable information of new syntheses and parameters for quantitative structure activity relationships (QSAR).
    Key findings: Crystallographic studies play a vital role in many disciplines including materials science, chemistry, pharmacology, and molecular biology. X-ray crystallography is the most comprehensive technique available to determine molecular structure. A requirement for the high accuracy of crystallographic structures is that a 'good crystal' must be found, and this is often the rate-limiting step. In the past three decades developments in detectors, increases in computer power, and powerful graphics capabilities have contributed to a dramatic increase in the number of materials characterized by X-ray crystallography. More recently the advent of high-throughput crystallization techniques has enhanced our ability to produce that one good crystal required for crystallographic analysis.
    Significance: Continuing advances in all phases of a crystallographic study have expanded the ranges of samples which can be analyzes by X-ray crystallography to include larger molecules, smaller or weakly diffracting crystals, and twinned crystals.
    MeSH term(s) Chemistry, Pharmaceutical/methods ; Crystallization ; Crystallography, X-Ray/methods ; Drug Design ; Pharmaceutical Preparations/chemistry ; Quantitative Structure-Activity Relationship ; Technology, Pharmaceutical/methods
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2009-03-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2009.02.028
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: X-ray Crystallography and Unexpected Chiroptical Properties Reassign the Configuration of Haliclonadiamine.

    Liu, Hong-Bing / Imler, Gregory H / Baldridge, Kim K / O'Connor, Robert D / Siegel, Jay S / Deschamps, Jeffrey R / Bewley, Carole A

    Journal of the American Chemical Society

    2020  Volume 142, Issue 6, Page(s) 2755–2759

    Abstract: Haliclonadiamine and papuamine are bis-indane marine natural products isolated from the marine ... ...

    Abstract Haliclonadiamine and papuamine are bis-indane marine natural products isolated from the marine sponge
    MeSH term(s) Alkaloids/chemistry ; Crystallography, X-Ray/methods ; Magnetic Resonance Spectroscopy/methods ; Molecular Structure ; Optics and Photonics/methods
    Chemical Substances Alkaloids ; haliclonadiamine
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b12926
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  10. Article ; Online: Synthesis and Structural Elucidation of a Pyranomorphinan Opioid and in Vitro Studies.

    Ansari, Mohd Imran / Healy, Jason R / Hom, Kellie / Deschamps, Jeffrey R / Matsumoto, Rae R / Coop, Andrew

    Organic letters

    2018  Volume 20, Issue 10, Page(s) 2984–2987

    Abstract: During optimization of the synthesis of the mixed μ opioid agonist/δ opioid antagonist 5-(hydroxymethyl)oxymorphone (UMB425) for scale-up, it was unexpectedly discovered that the 4,5-epoxy bridge underwent rearrangement on treatment with boron tribromide ...

    Abstract During optimization of the synthesis of the mixed μ opioid agonist/δ opioid antagonist 5-(hydroxymethyl)oxymorphone (UMB425) for scale-up, it was unexpectedly discovered that the 4,5-epoxy bridge underwent rearrangement on treatment with boron tribromide (BBr
    MeSH term(s) Analgesics, Opioid/chemistry ; Drug Tolerance ; Molecular Structure ; Receptors, Opioid, delta ; Receptors, Opioid, mu
    Chemical Substances Analgesics, Opioid ; Receptors, Opioid, delta ; Receptors, Opioid, mu
    Language English
    Publishing date 2018-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.8b01025
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