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  1. Article ; Online: Stem cell sheet therapy: another option for acute kidney injury?

    Yokoo, Takashi

    Kidney international

    2021  Volume 99, Issue 1, Page(s) 22–24

    Abstract: Recent advances in material engineering and gene editing techniques have now made it possible to use sheeted stem cells as distributors of therapeutic factors in clinical practice (e.g., as beating sheets for patients with heart failure). In this issue, ... ...

    Abstract Recent advances in material engineering and gene editing techniques have now made it possible to use sheeted stem cells as distributors of therapeutic factors in clinical practice (e.g., as beating sheets for patients with heart failure). In this issue, Park et al. report the effects of sheets of genome-engineered human umbilical cord-derived mesenchymal stem cells in preserving kidney function after ischemia-reperfusion injury, demonstrating a possible application for acute kidney injury treatment.
    MeSH term(s) Acute Kidney Injury/therapy ; Animals ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Reperfusion Injury/therapy ; Umbilical Cord
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.08.034
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    Zs.A 797: Show issues Location:
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  2. Article: Recurrence of crescentic IgA nephropathy 3 years after successful treatment.

    Yamashita, Hiroshi / Okabe, Masahiro / Ueda, Hiroyuki / Miyazaki, Yoichi / Yokoo, Takashi

    Clinical nephrology

    2024  Volume 101, Issue 4, Page(s) 199–202

    MeSH term(s) Humans ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/therapy ; Recurrence
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN111224
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    Zs.A 873: Show issues Location:
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  3. Article ; Online: Calcium-based phosphate binders and bone mineral density in patients undergoing hemodialysis: a retrospective cohort study.

    Kato, Kazuhiko / Nakashima, Akio / Morishita, Masamitsu / Ohkido, Ichiro / Yokoo, Takashi

    Clinical and experimental nephrology

    2024  

    Abstract: Background: Calcium supplements are commonly prescribed to prevent fractures in patients with osteoporosis. Nonetheless, they are generally eschewed in hemodialysis patients because they increase vascular calcification and induce cardiovascular disease. ...

    Abstract Background: Calcium supplements are commonly prescribed to prevent fractures in patients with osteoporosis. Nonetheless, they are generally eschewed in hemodialysis patients because they increase vascular calcification and induce cardiovascular disease. This retrospective cohort study aimed to investigate the effect of calcium-based phosphate binders (CBPB) on bone mineral density (BMD) in hemodialysis patients.
    Methods: Outpatients on dialysis who underwent BMD measurement from January to December 2017, whose data on BMD trends and CBPB administration were recorded over the next 4 years, were enrolled. Patients receiving anti-osteoporotic medications were excluded. The association between the presence and duration of CBPB administration and changes in BMD was evaluated.
    Results: The femoral neck's BMD decreased from 0.836 g/cm
    Conclusion: CBPB administration may be associated with BMD maintenance.
    Language English
    Publishing date 2024-04-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-024-02493-8
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  4. Article: A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy.

    Okabe, Masahiro / Tsuboi, Nobuo / Ueda, Hiroyuki / Hishida, Erika / Miyazaki, Yoichi / Yokoo, Takashi

    Clinical kidney journal

    2024  Volume 17, Issue 4, Page(s) sfae073

    Abstract: Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and ... ...

    Abstract Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and proteinuria and a lower birthweight than did her younger sister, and only the older sister experienced two childbirths. These raised concerns regarding her kidney outcomes. However, with timely multidisciplinary treatments, the older sister's kidney function remained preserved after 20 years of IgAN history. Our findings indicate the significant contribution of environmental/epigenetic factors to IgAN progression and the need for tailored medical care corresponding to life events.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae073
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  5. Article: [Kidney and regenerative medicine].

    Yokoo, Takashi

    Nihon Jinzo Gakkai shi

    2016  Volume 58, Issue 1, Page(s) 1–4

    MeSH term(s) Animals ; Blastocyst/cytology ; Cell Differentiation/physiology ; Humans ; Kidney ; Models, Animal ; Regenerative Medicine ; Stem Cells/cytology
    Language Japanese
    Publishing date 2016
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1195538-7
    ISSN 0385-2385
    ISSN 0385-2385
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    Zs.A 1383: Show issues Location:
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  6. Article ; Online: Histiocytic Glomerulopathy With Noncrystalline Inclusion Associated With IgG-Kappa Plasma Cell Dyscrasia.

    Katsuma, Ai / Okabe, Masahiro / Ueda, Hiroyuki / Ehara, Takashi / Yamaguchi, Yutaka / Miyazaki, Yoichi / Yokoo, Takashi

    Kidney medicine

    2023  Volume 5, Issue 5, Page(s) 100617

    Abstract: The kidney pathology of monoclonal gammopathy of renal significance varies greatly. In this report, we present a woman in her 20s with nephrotic syndrome and monoclonal immunoglobulin G kappa (serum and urine) without diabetes. She had a family history ... ...

    Abstract The kidney pathology of monoclonal gammopathy of renal significance varies greatly. In this report, we present a woman in her 20s with nephrotic syndrome and monoclonal immunoglobulin G kappa (serum and urine) without diabetes. She had a family history of nephrotic syndrome as well as hematologic and connective tissue disorders. A kidney biopsy showed nodular glomerulosclerosis, with the glomerular capillary full of histiocytes, which were strongly positive for kappa, not lambda. Immunoelectron microscopy revealed that histiocytes had infiltrated the glomerular subendothelial space, and enlarged lysosomes of histiocytes contained kappa light chains, without apparent crystalline formation. Bone marrow examination was negative for malignancy; thus, we diagnosed this case as histiocytic glomerulopathy with noncrystalline inclusion associated with immunoglobulin G-kappa plasma cell dyscrasia. Hematologic treatment with bortezomib and daratumumab decreased her level of serum kappa chain and proteinuria. Two years after diagnosis, her kidney function remained normal, urinary protein level decreased to 1 g/d, and free light-chain ratio decreased to 3.1.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Case Reports
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2023.100617
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  7. Article ; Online: Bilateral or Unilateral Aldosterone Hypersecretion and Responsiveness to Therapy are Associated with Differences in Calcium/Phosphate Homeostasis in Patients with Primary Aldosteronism.

    Yarita-Kawana, Miki / Kidoguchi, Satoshi / Suehiro, Yohei / Sugano, Naoki / Yokoo, Takashi

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Introduction Primary aldosteronism is characterized by the autonomous excretion of aldosterone, which may induce bone mineral disorders. Patients and methods A total of 96 patients with primary aldosteronism were analyzed to identify differences in the ... ...

    Abstract Introduction Primary aldosteronism is characterized by the autonomous excretion of aldosterone, which may induce bone mineral disorders. Patients and methods A total of 96 patients with primary aldosteronism were analyzed to identify differences in the regulation of serum calcium/phosphate balance between patients with unilateral and bilateral aldosterone hypersecretion and to determine whether or not adrenalectomy or mineralocorticoid receptor blockers affected such differences. Results Serum phosphate concentrations were significantly lower in patients with unilateral aldosterone hypersecretion than in patients with bilateral aldosterone hypersecretion (2.96±0.45 vs. 3.36±0.55 mg/dL, P<0.05), and recovered after adrenalectomy (2.96±0.45 vs. 3.49±0.32 mg/dL, P<0.01). In patients with bilateral aldosterone hypersecretion, the baseline serum phosphate levels were significantly lower in responders to mineralocorticoid receptor blocker treatment, defined as post-treatment plasma renin activity ≥1 ng/mL/h, than in non-responders. In responders, these levels tended to recover after treatment. A weak negative correlation between the plasma aldosterone concentration (PAC) and serum phosphate was observed, but there were no associations between the PAC and serum calcium concentration or between the aldosterone renin ratio and serum calcium and phosphate concentrations. Conclusions The effects on calcium/phosphate homeostasis may differ according to the primary aldosteronism subtype.
    Language English
    Publishing date 2024-02-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3116-23
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    Zs.A 240: Show issues Location:
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  8. Article ; Online: Long-term effects of denosumab on bone mineral density and turnover markers in patients undergoing hemodialysis.

    Kato, Kazuhiko / Yaginuma, Tatsuhiro / Kobayashi, Arisa / Nakashima, Akio / Ohkido, Ichiro / Yokoo, Takashi

    Journal of bone and mineral metabolism

    2024  Volume 42, Issue 2, Page(s) 264–270

    Abstract: Introduction: Denosumab, a fully human anti-RANKL monoclonal antibody, is a widely used osteoporosis treatment that is increasingly being used in patients undergoing dialysis; however, its long-term efficacy and safety in these patients remain unknown.!# ...

    Abstract Introduction: Denosumab, a fully human anti-RANKL monoclonal antibody, is a widely used osteoporosis treatment that is increasingly being used in patients undergoing dialysis; however, its long-term efficacy and safety in these patients remain unknown.
    Materials and methods: This observational study comprised individuals aged ≥ 20 years undergoing hemodialysis and receiving denosumab. After denosumab administration, we analyzed the long-term changes in bone mineral density (BMD) and levels of bone turnover markers (BTMs) and calcium.
    Results: The study included 45 patients who have been receiving denosumab for a median duration of 3.8 (interquartile range, 2.5-6.7) years. Tartrate-resistant acid phosphatase 5b (TRACP-5b) levels decreased from a median of 595 (434-778) mU/dL at baseline to 200 (141-430) mU/dL after 6 months of denosumab administration (P < 0.001) and remained low thereafter. Similarly, bone-specific alkaline phosphatase (BAP) levels decreased from a median of 18.2 (15.9-25.8) μg/L at baseline to 12.4 (9.9-15.6) μg/L after 6 months (P < 0.001) and remained low thereafter. Meanwhile, BMD, as assessed with dual energy X-ray absorptiometry and measured at the distal 1/3 of the radius, did not decrease (0.465 ± 0.112 g/cm
    Conclusion: The study showed long-term suppression of TRACP-5b and BAP levels and sustaining BMD after denosumab administration over an extended period in patients undergoing hemodialysis.
    MeSH term(s) Humans ; Bone Density ; Denosumab/pharmacology ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use ; Calcium/pharmacology ; Tartrate-Resistant Acid Phosphatase ; Bone Remodeling ; Alkaline Phosphatase ; Renal Dialysis ; Biomarkers
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents ; Calcium (SY7Q814VUP) ; Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2) ; Alkaline Phosphatase (EC 3.1.3.1) ; Biomarkers
    Language English
    Publishing date 2024-03-21
    Publishing country Japan
    Document type Observational Study ; Journal Article
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-024-01505-7
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  9. Article ; Online: Dapagliflozin and the initial glomerular filtration rate decline in advanced-stage non-diabetic chronic kidney disease.

    Matsumoto, Kei / Ueda, Hiroyuki / Tsuboi, Nobuo / Yokoo, Takashi

    Clinical and experimental nephrology

    2022  Volume 26, Issue 12, Page(s) 1242–1243

    MeSH term(s) Humans ; Glomerular Filtration Rate ; Glucosides/therapeutic use ; Benzhydryl Compounds/therapeutic use ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/drug therapy ; Kidney
    Chemical Substances dapagliflozin (1ULL0QJ8UC) ; Glucosides ; Benzhydryl Compounds
    Language English
    Publishing date 2022-08-01
    Publishing country Japan
    Document type Letter
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-022-02260-7
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  10. Article: Single-nephron assessment of urate excretion in patients with IgA nephropathy.

    Marumoto, Hirokazu / Tsuboi, Nobuo / Sasaki, Takaya / Okabayashi, Yusuke / Haruhara, Kotaro / Kanzaki, Go / Ichida, Kimiyoshi / Yokoo, Takashi

    Clinical kidney journal

    2024  Volume 17, Issue 3, Page(s) sfae036

    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae036
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