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  1. Book ; Thesis: Untersuchungen über die Wirkung von Clostridium-botulinum-C2-Toxin auf die Aktivierung und Membranrezeptordynamik bei menschlichen neutrophilen Granulozyten

    Norgauer, Johannes

    1992  

    Author's details vorgelegt von Johannes Norgauer
    Language German
    Size 79 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Saarbrücken, Univ., Diss., 1993
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT006716546
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1995 MB 2013 order for loan Magazin

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  2. Article ; Online: Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement.

    Cubillos, Susana / Norgauer, Johannes

    International journal of molecular medicine

    2016  Volume 38, Issue 4, Page(s) 1083–1092

    Abstract: Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in ... ...

    Abstract Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in keratinocyte differentiation and bone metabolism. Intracellular calcium is regulated by calcium-sensing receptor (CASR), calcium release-activated calcium modulator (ORAI) and stromal interaction molecule (STIM). Other proteins modulated by vitamin D play important roles in calcium regulation e.g., calbindin 1 (CALB1) and transient receptor potential cation channel 6 (TRPV6). In this study, we aimed to investigate the expression of calcium-regulating proteins in the plaques of patients with psoriasis vulgaris with or without joint inflammation. We confirmed low calcium levels, keratinocyte hyperproliferation and an altered epidermal barrier. The CASR, ORAI1, ORAI3, STIM1, CALB1 and TRPV6 mRNA, as well as the sterol 27-hydroxylase (CYP27A1), 25-hydroxyvitamin D3 1-α-hydroxylase (CYP27B1) and 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) protein levels were low in the plaques of patients with psoriasis. We demonstrated S100 calcium-binding protein A7 (S100A7) overexpression in the plaques of patients with psoriasis vulgaris with joint inflammation, compared with those without joint involvement. We suggest an altered capacity to regulate the intracellular Ca2+ concentration ([Ca2+]i), characterized by a reduced expression of CASR, ORAI1, ORAI3, STIM1, CALB1 and TRPV6 associated with diminished levels of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], which may be associated with an altered balance between keratinocyte proliferation and differentiation in the psoriatic epidermis. Additionally, differences in S100A7 expression depend on the presence of joint involvement.
    MeSH term(s) Biomarkers/metabolism ; Calcium/metabolism ; Cell Differentiation ; Cell Proliferation ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression Regulation ; Humans ; Joints/pathology ; Keratinocytes/pathology ; Middle Aged ; Psoriasis/enzymology ; Psoriasis/genetics ; Psoriasis/pathology ; Receptors, Calcitriol/metabolism ; S100 Calcium Binding Protein A7 ; S100 Proteins/metabolism ; Vitamin D/pharmacology
    Chemical Substances Biomarkers ; Receptors, Calcitriol ; S100 Calcium Binding Protein A7 ; S100 Proteins ; S100A7 protein, human ; Vitamin D (1406-16-2) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2016.2718
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    Zs.A 4942: Show issues Location:
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  3. Article: Atopische Dermatitis. State of the Art

    Rödiger, Christiane / Norgauer, Johannes

    Kompendium ... Dermatologie

    2015  Volume 11, Issue 1, Page(s) 33

    Language German
    Document type Article
    ZDB-ID 2187350-1
    ISSN 1860-0565
    Database Current Contents Medicine

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  4. Article ; Online: Effect of Vitamin D on Peripheral Blood Mononuclear Cells from Patients with Psoriasis Vulgaris and Psoriatic Arthritis.

    Cubillos, Susana / Krieg, Nadine / Norgauer, Johannes

    PloS one

    2016  Volume 11, Issue 4, Page(s) e0153094

    Abstract: Background: Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as ... ...

    Abstract Background: Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as well as regulation of immune response. We aimed to study osteoclast differentiation and cytokine secretion of peripheral blood mononuclear cells (PBMCs) from patients with psoriasis vulgaris and psoriatic arthritis, in response to 1,25(OH)2D3.
    Methods: Serum levels of bone turnover markers were measured by ELISA in patients with psoriasis vulgaris and psoriatic arthritis, and healthy controls. PBMCs were isolated and cultured with or without RANKL/M-CSF and 1,25(OH)2D3. Osteoclast differentiation and cytokine secretion were assessed.
    Results: Psoriatic arthritis patients had lower osteocalcin, as well as higher C-telopeptide of type I collagen and cathepsin K serum levels compared with psoriasis vulgaris patients and controls. RANKL/M-CSF-stimulated PBMCs from psoriatic arthritis patients produced higher proinflammatory cytokine levels and had a differential secretion profile in response to 1,25(OH)2D3, compared with psoriasis vulgaris and control PBMCs.
    Conclusions: Our data confirmed altered bone turnover in psoriatic arthritis patients, and demonstrated increased osteoclastogenic potential and proinflammatory cytokine secretion capacity of these PBMCs compared with psoriasis vulgaris and controls. 1,25(OH)2D3 abrogated these effects.
    MeSH term(s) Arthritis, Psoriatic/blood ; Calcitonin/blood ; Calcitriol/pharmacology ; Calcium/blood ; Cytokines/metabolism ; Humans ; Monocytes/drug effects ; Osteoclasts/pathology ; Psoriasis/blood
    Chemical Substances Cytokines ; Calcitonin (9007-12-9) ; Calcitriol (FXC9231JVH) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0153094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Akrale Perfusionsdarstellung bei Patienten mit Sklerodermie mittels Xiralite im Vergleich zu Kotrollprobanden

    Tellenbach, Stefan [Verfasser] / Norgauer, Johannes [Gutachter] / Pfeil, Alexander [Gutachter] / Mockenhaupt, Maja [Gutachter]

    2019  

    Author's details Stefan Tellenbach ; Gutachter: Johannes Norgauer, Alexander Pfeil, Maja Mockenhaupt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Prospektive Studie zur Untersuchung der durchschnittlichen Behandlungszeit eines Patienten in der zentralen Notaufnahme und dafür relevanter Einflussfaktoren

    Wrede, Julian [Verfasser] / Behringer, Wilhelm [Gutachter] / Norgauer, Johannes [Gutachter] / Eisenburger, Philip [Gutachter]

    2019  

    Author's details Julian Wrede ; Gutachter: Wilhelm Behringer, Johannes Norgauer, Philip Eisenburger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Schiller-Universität Jena
    Publishing place Jena
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Effect of Vitamin D on Peripheral Blood Mononuclear Cells from Patients with Psoriasis Vulgaris and Psoriatic Arthritis.

    Susana Cubillos / Nadine Krieg / Johannes Norgauer

    PLoS ONE, Vol 11, Iss 4, p e

    2016  Volume 0153094

    Abstract: BACKGROUND:Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as well ... ...

    Abstract BACKGROUND:Psoriasis, a chronic skin disease with or without joint inflammation, has increased circulating proinflammatory cytokine levels. Vitamin D is involved in calcium homeostasis, bone formation, osteoclastogenesis and osteoclast activity, as well as regulation of immune response. We aimed to study osteoclast differentiation and cytokine secretion of peripheral blood mononuclear cells (PBMCs) from patients with psoriasis vulgaris and psoriatic arthritis, in response to 1,25(OH)2D3. METHODS:Serum levels of bone turnover markers were measured by ELISA in patients with psoriasis vulgaris and psoriatic arthritis, and healthy controls. PBMCs were isolated and cultured with or without RANKL/M-CSF and 1,25(OH)2D3. Osteoclast differentiation and cytokine secretion were assessed. RESULTS:Psoriatic arthritis patients had lower osteocalcin, as well as higher C-telopeptide of type I collagen and cathepsin K serum levels compared with psoriasis vulgaris patients and controls. RANKL/M-CSF-stimulated PBMCs from psoriatic arthritis patients produced higher proinflammatory cytokine levels and had a differential secretion profile in response to 1,25(OH)2D3, compared with psoriasis vulgaris and control PBMCs. CONCLUSIONS:Our data confirmed altered bone turnover in psoriatic arthritis patients, and demonstrated increased osteoclastogenic potential and proinflammatory cytokine secretion capacity of these PBMCs compared with psoriasis vulgaris and controls. 1,25(OH)2D3 abrogated these effects.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: An unusual histologic variant of necrobiotic xanthogranuloma.

    Ziemer, Mirjana / Norgauer, Johannes / Simon, Jan-Christoph / Koehler, Martin Johannes

    The American Journal of dermatopathology

    2012  Volume 34, Issue 2, Page(s) e22–6

    Abstract: Necrobiotic xanthogranuloma (NXG) usually shows a stereotypical histopathologic presentation. However, few unusual cases have been published. We present a patient with NXG showing exceptional histopathologic features. NXG in our patient presents with ... ...

    Abstract Necrobiotic xanthogranuloma (NXG) usually shows a stereotypical histopathologic presentation. However, few unusual cases have been published. We present a patient with NXG showing exceptional histopathologic features. NXG in our patient presents with exclusively dermal granulomatous inflammation mimicking interstitial granuloma annulare. Not only subcutaneous involvement, but also, evident zones of degenerated collagen, foam cells, and cholesterol clefts were missing. Moreover, the case shows overlaps with recently published granulomatous scleromyxedema. Some common clinical and histopathologic features of NXG and scleromyxedema might be based on shared underlying paraproteinemia.
    MeSH term(s) Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance/complications ; Necrobiotic Xanthogranuloma/complications ; Necrobiotic Xanthogranuloma/drug therapy ; Necrobiotic Xanthogranuloma/pathology
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0b013e3182222aa8
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    Zs.A 1518: Show issues Location:
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  9. Article ; Online: Association of S100A7 gene polymorphisms with manifestations of common types of psoriasis: effect on serum calcium levels.

    Cubillos, Susana / Jaradat, Sameh W / Walther, Mario / Truta-Feles, Kristina / Koehler, Martin J / Norgauer, Johannes

    Experimental dermatology

    2015  Volume 24, Issue 11, Page(s) 894–896

    MeSH term(s) Adult ; Aged ; Calcium/blood ; Female ; Humans ; Male ; Middle Aged ; Psoriasis/blood ; Psoriasis/genetics ; S100 Calcium Binding Protein A7 ; S100 Proteins/genetics
    Chemical Substances S100 Calcium Binding Protein A7 ; S100 Proteins ; S100A7 protein, human ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2015-11
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.12799
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    Zs.A 3508: Show issues Location:
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  10. Article ; Online: Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin.

    Hallermann, Christine / Tittelbach, Jörg / Norgauer, Johannes / Ziemer, Mirjana

    Archives of dermatology

    2010  Volume 146, Issue 9, Page(s) 957–960

    MeSH term(s) Aged ; Biopsy, Needle ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Granuloma/drug therapy ; Granuloma/pathology ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunohistochemistry ; Injections, Intravenous ; Middle Aged ; Necrobiotic Disorders/drug therapy ; Necrobiotic Disorders/pathology ; Rare Diseases ; Severity of Illness Index ; Treatment Outcome ; Xanthomatosis/drug therapy ; Xanthomatosis/pathology
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 212139-6
    ISSN 1538-3652 ; 0003-987X
    ISSN (online) 1538-3652
    ISSN 0003-987X
    DOI 10.1001/archdermatol.2010.236
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