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  1. Article ; Online: From X-inactivation to neurodevelopment: CHD8-transcription factors (TFs) competitive binding at regulatory regions of CHD8 target genes can contribute to correct neuronal differentiation.

    Cerase, Andrea / Avner, Philip

    Current research in neurobiology

    2023  Volume 5, Page(s) 100114

    Abstract: The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals ... ...

    Abstract The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with
    Language English
    Publishing date 2023-11-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2665-945X
    ISSN (online) 2665-945X
    DOI 10.1016/j.crneur.2023.100114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to Galupa et al: Discussing the role of Lppnx in the complexity of the X controlling element, Xce.

    Hierholzer, Andreas / Cerase, Andrea / Avner, Phil

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 7, Page(s) e2219685120

    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2219685120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Something Still Remains

    Andrea Cerase / Lorenzo Cugliari

    Sustainability, Vol 15, Iss 2787, p

    Factors Affecting Tsunami Risk Perception on the Coasts Hit by the Reggio Calabria-Messina 1908 Event (Italy)

    2023  Volume 2787

    Abstract: Mediterranean coasts are prone to tsunamis due to high seismicity in some well-known areas near plate margins. However, tsunamis have a low frequency of occurrence despite having highly destructive potential. The low frequency of occurrence and ... ...

    Abstract Mediterranean coasts are prone to tsunamis due to high seismicity in some well-known areas near plate margins. However, tsunamis have a low frequency of occurrence despite having highly destructive potential. The low frequency of occurrence and historicity of the most destructive events lead to minimizing or neglecting this risk. Past research identified socio-demographic and spatial factors that may affect tsunami risk perception. This research is based on CATI survey (Computer Assisted Telephone Interview) to a sample of 5842 respondents designed to investigate whether and how risk perception and risk knowledge were affected by a major event such as the 1908 Reggio Calabria Messina tsunami, by making a comparison between areas hit by that event and unaffected areas, also providing some explanatory hypotheses. Despite differences between Calabria and Sicily, data show higher levels of tsunami risk perception in the area affected by the 1908 event, along with a major role of interpersonal sources, playing a relevant role in information gathering and understanding. Research also suggests the need to better integrate different sources of knowledge to improve people’s understanding so as to effectively cope with tsunami risk.
    Keywords tsunami ; risk communication ; risk perception ; local knowledge ; media ; scientific communication ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: X chromosome inactivation: The importance of being inactive.

    Cerase, Andrea

    Seminars in cell & developmental biology

    2016  Volume 56, Page(s) 1–2

    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2016.07.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Phase separation drives X-chromosome inactivation.

    Cerase, Andrea / Calabrese, J Mauro / Tartaglia, Gian Gaetano

    Nature structural & molecular biology

    2022  Volume 29, Issue 3, Page(s) 183–185

    MeSH term(s) X Chromosome ; X Chromosome Inactivation
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-021-00697-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 56: Show issues

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  6. Article ; Online: Long non-coding RNA-polycomb intimate rendezvous.

    Cerase, Andrea / Tartaglia, Gian Gaetano

    Open biology

    2020  Volume 10, Issue 9, Page(s) 200126

    Abstract: The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific ... ...

    Abstract The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript
    MeSH term(s) Animals ; Catalysis ; Gene Expression Regulation ; Humans ; Immunohistochemistry ; Polycomb Repressive Complex 1/metabolism ; Polycomb Repressive Complex 2/metabolism ; Polycomb-Group Proteins/chemistry ; Polycomb-Group Proteins/metabolism ; Protein Binding ; RNA, Long Noncoding/chemistry ; RNA, Long Noncoding/genetics ; Structure-Activity Relationship
    Chemical Substances HOTAIR long untranslated RNA, human ; Polycomb-Group Proteins ; RNA, Long Noncoding ; XIST non-coding RNA ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Polycomb Repressive Complex 1 (EC 2.3.2.27)
    Language English
    Publishing date 2020-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.200126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Emerging Roles of Repetitive and Repeat-Containing RNA in Nuclear and Chromatin Organization and Gene Expression.

    Trigiante, Giuseppe / Blanes Ruiz, Nerea / Cerase, Andrea

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 735527

    Abstract: Genomic repeats have been intensely studied as regulatory elements controlling gene transcription, splicing and genome architecture. Our understanding of the role of the repetitive RNA such as the RNA coming from genomic repeats, or repetitive sequences ... ...

    Abstract Genomic repeats have been intensely studied as regulatory elements controlling gene transcription, splicing and genome architecture. Our understanding of the role of the repetitive RNA such as the RNA coming from genomic repeats, or repetitive sequences embedded in mRNA/lncRNAs, in nuclear and cellular functions is instead still limited. In this review we discuss evidence supporting the multifaceted roles of repetitive RNA and RNA binding proteins in nuclear organization, gene regulation, and in the formation of dynamic membrane-less aggregates. We hope that our review will further stimulate research in the consolidating field of repetitive RNA biology.
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.735527
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  8. Article ; Online: Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.

    Aliperti, Vincenza / Skonieczna, Justyna / Cerase, Andrea

    Non-coding RNA

    2021  Volume 7, Issue 2

    Abstract: Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of ... ...

    Abstract Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna7020036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tsunami risk perception, a state-of-the-art review with a focus in the NEAM region

    Lorenzo Cugliari / Andrea Cerase / Alessandro Amato

    Frontiers in Earth Science, Vol

    2022  Volume 10

    Abstract: Large-scale coastal urban sprawl, development of tourist accommodations and industrial maritime poles have highly increased the tsunami risk to people living and/or traveling along the coasts of our planet. The disastrous tsunamis in the Indian Ocean ( ... ...

    Abstract Large-scale coastal urban sprawl, development of tourist accommodations and industrial maritime poles have highly increased the tsunami risk to people living and/or traveling along the coasts of our planet. The disastrous tsunamis in the Indian Ocean (2004) and in the Pacific Ocean (2011), as well as a suite of other damaging events worldwide, have encouraged International Institutions, first of all UNESCO Intergovernmental Oceanographic Commission, National Governments and Local Communities to implement Tsunami Warning Systems (TWS), to raise awareness on tsunami risk, and to create a multilevel risk governance. In this framework, research on tsunami risk perception plays a key role. The results of these studies should be taken into account in designing risk mitigation programs and tools (such as drills, activities with local communities, emergency plans, etc.). This paper presents a review of such studies, carried out in several countries worldwide through many thousands of interviews performed with different techniques. Most tsunami risk perception studies were carried out in the regions where the Indian Ocean Tsunami Warning System and the Pacific Ocean one (PTWS) operate. In the NEAMTWS (North-East Atlantic, Mediterranean and connected seas Tsunami Warning Systems) region, only few specific studies were conducted, mostly within the EU-funded ASTARTE project (2013–2017) and more recently in a few extensive surveys on tsunami risk perception conducted in Italy between 2019 and 2021. Although the twenty-three studies analyzed in our review show a strong heterogeneity of methodological approaches and population samples, they allow us to outline some general considerations on tsunami risk as perceived by people in the different regions of the world. With the help of a table, we schematically summarized the emerging strengths, weaknesses and lessons learned in the twenty-three papers, noting an increase in the number of such studies in the last 5 years. The surveys were mostly concentrated in high-risk areas and ...
    Keywords tsunami risk ; perception ; communication ; preparedness ; awareness ; Europe ; Science ; Q
    Subject code 910
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Long non-coding RNA-polycomb intimate rendezvous

    Andrea Cerase / Gian Gaetano Tartaglia

    Open Biology, Vol 10, Iss

    2020  Volume 9

    Abstract: The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross- ... ...

    Abstract The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist, it might occur indirectly and, at least in part, through the process of liquid–liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus.
    Keywords long non-coding rnas (lncrna) ; xist rna ; hotair rna ; polycomb-repressive complexes 1/2 (prc1/2) ; rna–protein interaction ; rna secondary structure ; phase separation ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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