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  1. Book ; Online: Edge Computing for Internet of Things

    Lee, Kevin / Man, Ka Lok

    2022  

    Keywords Technology: general issues ; History of engineering & technology ; Energy industries & utilities ; hierarchical edge computing ; WSN ; rapid response strategy ; edge node ; fog access points ; cache memory ; convolutional neural network ; proactive caching ; fog computing ; Internet of Things ; service placement ; fog service orchestration ; spectral classification ; portable optical fiber spectrometers ; dew computing ; edge computing ; smartphone ; job scheduling ; scheduling heuristics ; mobile edge computing ; mobile edge server placement ; multiagent RL ; edge security ; offloading computation ; distributed collaboration ; data processing ; dynamic offloading ; IoT ; gateways ; Internet of Things (IoT) ; failure recovery ; FP-Growth algorithm ; association rules ; frequency pattern analysis ; computational offloading ; orchestration ; functional programming ; n/a
    Language 0|e
    Size 1 electronic resource (186 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610652
    ISBN 9783036542751 ; 3036542752
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Blood failure: traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy.

    Lee, Jae Hyuk / Ward, Kevin R

    Clinical and experimental emergency medicine

    2024  Volume 11, Issue 1, Page(s) 9–21

    Abstract: This review explores the concept of "blood failure" in traumatic injury, which arises from the interplay of oxygen debt, the endotheliopathy of trauma (EoT), and acute traumatic coagulopathy (ATC). Traumatic hemorrhage leads to the accumulation of oxygen ...

    Abstract This review explores the concept of "blood failure" in traumatic injury, which arises from the interplay of oxygen debt, the endotheliopathy of trauma (EoT), and acute traumatic coagulopathy (ATC). Traumatic hemorrhage leads to the accumulation of oxygen debt, which can further exacerbate hemorrhage by triggering a cascade of events when severe. Such events include EoT, characterized by endothelial glycocalyx damage, and ATC, involving platelet dysfunction, fibrinogen depletion, and dysregulated fibrinolysis. To manage blood failure effectively, a multifaceted approach is crucial. Damage control resuscitation strategies such as use of permissive hypotension, early hemorrhage control, and aggressive transfusion of blood products including whole blood aim to minimize oxygen debt and promote its repayment while addressing endothelial damage and coagulation. Transfusions of red blood cells, plasma, and platelets, as well as the use of tranexamic acid, play key roles in hemostasis and countering ATC. Whole blood, whether fresh or cold-stored, is emerging as a promising option to address multiple needs in traumatic hemorrhage. This review underscores the intricate relationships between oxygen debt, EoT, and ATC and highlights the importance of comprehensive, integrated strategies in the management of traumatic hemorrhage to prevent blood failure. A multidisciplinary approach is essential to address these interconnected factors effectively and to improve patient outcomes.
    Language English
    Publishing date 2024-03-21
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2383-4625
    ISSN 2383-4625
    DOI 10.15441/ceem.23.127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: To be or not to be a pervious thrombus in acute ischemic stroke: does functional outcome after mechanical thrombectomy depend on clot time-attenuation curves?

    Chung, Kevin J / Lee, Ting-Yim

    European radiology

    2023  Volume 34, Issue 4, Page(s) 2195–2197

    MeSH term(s) Humans ; Ischemic Stroke/surgery ; Stroke/complications ; Brain Ischemia/complications ; Brain Ischemia/surgery ; Thrombectomy/methods ; Thrombosis/diagnostic imaging ; Thrombosis/surgery ; Ischemia
    Language English
    Publishing date 2023-10-18
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10313-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3300: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Botanical Briefs: Daffodils (Narcissus Species).

    Lee, Kevin P / Elston, Dirk M

    Cutis

    2023  Volume 111, Issue 1, Page(s) 41–45

    Abstract: Daffodils (Narcissus species) are the most common cause of irritant contact dermatitis among florists. Calcium oxalate crystals contained in the sap of the daffodil plants lead to irritant contact dermatitis on the skin. Daffodil rash commonly presents ... ...

    Abstract Daffodils (Narcissus species) are the most common cause of irritant contact dermatitis among florists. Calcium oxalate crystals contained in the sap of the daffodil plants lead to irritant contact dermatitis on the skin. Daffodil rash commonly presents with fissuring, scaling, and erythema of the fingertips, hands, and forearms. The best preventative measure is to wear appropriate protective gloves and clothing.
    MeSH term(s) Humans ; Narcissus ; Irritants ; Dermatitis, Irritant/etiology ; Plants ; Exanthema/complications
    Chemical Substances Irritants
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1315: Show issues Location:
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  5. Article: Editorial: Healthy adipose tissue expansion.

    Lee, Kevin Y / Emanuelli, Brice / Ussar, Siegfried

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1287533

    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1287533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Alectinib-induced hemolytic anemia.

    Lee, Chung-Shien / Sullivan, Kevin

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2023  Volume 29, Issue 5, Page(s) 1251–1254

    Abstract: Introduction: Alectinib is an oral anaplastic lymphoma kinase tyrosine kinase inhibitor with central nervous system activity. It is currently approved and a preferred first-line option for those with anaplastic lymphoma kinase-positive non-small cell ... ...

    Abstract Introduction: Alectinib is an oral anaplastic lymphoma kinase tyrosine kinase inhibitor with central nervous system activity. It is currently approved and a preferred first-line option for those with anaplastic lymphoma kinase-positive non-small cell lung cancer. Alectinib has been shown to cause anemia, usually mild.
    Case report: We report a case of alectinib-induced hemolytic anemia in a patient receiving alectinib as first-line treatment for anaplastic lymphoma kinase-positive non-small cell lung cancer.
    Management and outcome: The patient's dose was reduced from 600 mg twice daily to 450 mg twice daily and further down to 300 mg twice daily and eventually discontinued. At that point, the hemoglobin normalized.
    Discussion: Our case demonstrates objective evidence for hemolytic anemia induced by alectinib.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Anaplastic Lymphoma Kinase ; Protein Kinase Inhibitors/adverse effects ; Anemia, Hemolytic/chemically induced ; Anemia, Hemolytic/drug therapy
    Chemical Substances alectinib (LIJ4CT1Z3Y) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552221147840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4488: Show issues Location:
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  7. Article ; Online: What rheumatologists need to know about mRNA vaccines: current status and future of mRNA vaccines in autoimmune inflammatory rheumatic diseases.

    Park, Jin Kyun / Lee, Eun Bong / Winthrop, Kevin L

    Annals of the rheumatic diseases

    2024  

    Abstract: Messenger RNA (mRNA) vaccines as a novel vaccine platform offer new tools to effectively combat both emerging and existing pathogens which were previously not possible. The 'plug and play' feature of mRNA vaccines enables swift design and production of ... ...

    Abstract Messenger RNA (mRNA) vaccines as a novel vaccine platform offer new tools to effectively combat both emerging and existing pathogens which were previously not possible. The 'plug and play' feature of mRNA vaccines enables swift design and production of vaccines targeting complex antigens and rapid incorporation of new vaccine constituents as needed. This feature makes them likely to be adopted for widespread clinical use in the future.Currently approved mRNA vaccines include only those against SARS-CoV-2 virus. These vaccines demonstrate robust immunogenicity and offer substantial protection against severe disease. Numerous mRNA vaccines against viral pathogens are in the early to late phase of development. Several mRNA vaccines for influenza are tested in clinical trials, with some already in phase 3 studies. Other vaccines in the early and late phases of development include those targeting
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2024-225492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 167: Show issues

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  8. Article ; Online: Positive Selection Screens for Programmable Endonuclease Activity Using I-SceI.

    Mechikoff, Michael A / Lee, Kok Zhi / Solomon, Kevin V

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2760, Page(s) 253–265

    Abstract: Positive selection screens are high-throughput assays to characterize novel enzymes from environmental samples and enrich for more powerful variants from libraries in applications such as biodiversity mining and directed evolution. However, overly ... ...

    Abstract Positive selection screens are high-throughput assays to characterize novel enzymes from environmental samples and enrich for more powerful variants from libraries in applications such as biodiversity mining and directed evolution. However, overly stringent selection can limit the power of these screens due to a high false-negative rate. To create a more flexible and less restrictive screen for novel programmable DNA endonucleases, we developed a novel I-SceI-based platform. In this system, mutant E. coli genomes are cleaved upon induction of I-SceI to inhibit cell growth. Growth is rescued in an activity-dependent manner by plasmid curing or cleavage of the I-SceI expression plasmid via endonuclease candidates. More active candidates more readily proliferate and overtake growth of less active variants leading to enrichment. While demonstrated here with Cas9, this protocol can be readily adapted to any programmable DNA endonuclease and used to characterize single candidates or to enrich more powerful variants from pooled candidates or libraries.
    MeSH term(s) Saccharomyces cerevisiae Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Plasmids/genetics ; Endonucleases/genetics
    Chemical Substances Saccharomyces cerevisiae Proteins ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3658-9_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Therapeutic targeting of DNA methylation alterations in cancer.

    Lee, Abigail V / Nestler, Kevin A / Chiappinelli, Katherine B

    Pharmacology & therapeutics

    2024  Volume 258, Page(s) 108640

    Abstract: DNA methylation is a critical component of gene regulation and plays an important role in the development of cancer. Hypermethylation of tumor suppressor genes and silencing of DNA repair pathways facilitate uncontrolled cell growth and synergize with ... ...

    Abstract DNA methylation is a critical component of gene regulation and plays an important role in the development of cancer. Hypermethylation of tumor suppressor genes and silencing of DNA repair pathways facilitate uncontrolled cell growth and synergize with oncogenic mutations to perpetuate cancer phenotypes. Additionally, aberrant DNA methylation hinders immune responses crucial for antitumor immunity. Thus, inhibiting dysregulated DNA methylation is a promising cancer therapy. Pharmacologic inhibition of DNA methylation reactivates silenced tumor suppressors and bolster immune responses through induction of viral mimicry. Now, with the advent of immunotherapies and discovery of the immune-modulatory effects of DNA methylation inhibitors, there is great interest in understanding how targeting DNA methylation in combination with other therapies can enhance antitumor immunity. Here, we describe the role of aberrant DNA methylation in cancer and mechanisms by which it promotes tumorigenesis and modulates immune responses. Finally, we review the initial discoveries and ongoing efforts to target DNA methylation as a cancer therapeutic.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2024.108640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Radiation Exposure of Interventional Echocardiographers: Protecting and Nurturing a New Subspecialty.

    Kam, Kevin Ka-Ho / Lee, Alex Pui-Wai

    JACC. Asia

    2023  Volume 3, Issue 2, Page(s) 310–311

    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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