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Article ; Online: Results of a randomized, placebo-controlled, first-in-human trial of topical CY-002 in patients with cutaneous warts.

Pagan, L / Yfanti, C / Rijneveld, R / Todd, M / Jongste, P / Feijen, J J / Klaassen, E S / Bouwes Bavinck, J N / Struijk, L / de Koning, M N C / Prestegarden, L / Niemeyer-van der Kolk, T / van Poelgeest, M I E / Rissmann, R

Journal of the European Academy of Dermatology and Venereology : JEADV

2022 Volume 36, Issue 10, Page(s) e773–e775

MeSH term(s)	Administration, Cutaneous ; Double-Blind Method ; Humans ; Treatment Outcome ; Warts/drug therapy
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18291
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article: Introduction: Anti-inflammatory Treatment of Childhood Asthma: Cromoglycate and Nedocromil as Non-steroidal Alternatives?

de Jongste, J C

Mediators of inflammation

2008 Volume 3, Issue 7, Page(s) S5

Language	English
Publishing date	2008-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	0962-9351
ISSN	0962-9351
DOI	10.1155/S0962935194000670
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Zs.A 3575: Show issues

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Article ; Online: Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial.

Boeschoten, Shelley A / Buysse, Corinne M P / de Winter, Brenda C M / van Rosmalen, Joost / de Jongste, Johan C / de Jonge, Rogier C / Heisterkamp, Sabien G J / van Woensel, Job B / Kneyber, Martin C J / van Zwol, Annelies / Boehmer, Annemie L M / de Hoog, Matthijs

European journal of pediatrics

2022 Volume 181, Issue 10, Page(s) 3701–3709

Abstract: The optimal dose regimen for intravenous (IV) treatment in children with severe acute asthma (SAA) is still a matter of debate. We assessed the efficacy of adding a salbutamol loading dose to continuous infusion with salbutamol in children admitted to a ... ...

Abstract	The optimal dose regimen for intravenous (IV) treatment in children with severe acute asthma (SAA) is still a matter of debate. We assessed the efficacy of adding a salbutamol loading dose to continuous infusion with salbutamol in children admitted to a pediatric intensive care unit (PICU) with SAA. This multicentre, placebo-controlled randomized trial in the PICUs of four tertiary care children's hospitals included children (2-18 years) with SAA admitted between 2017 and 2019. Children were randomized to receive either a loading dose IV salbutamol (15 mcg/kg, max. 750 mcg) or normal saline while on continuous salbutamol infusion. The primary outcome was the asthma score (Qureshi) 1 h after the intervention. Analysis of covariance models was used to evaluate sensitivity to change in asthma scores. Serum concentrations of salbutamol were obtained. Fifty-eight children were included (29 in the intervention group). Median baseline asthma score was 12 (IQR 10-13) in the intervention group and 11 (9-12) in the control group (p = 0.032). The asthma score 1 h after the intervention did not differ significantly between the groups (p = 0.508, β-coefficient = 0.283). The median increase in salbutamol plasma levels 10 min after the intervention was 13 μg/L (IQR 5-24) in the intervention group and 4 μg/L (IQR 0-7) in the control group (p = 0.001). Side effects were comparable between both groups. Conclusion: We found no clinical benefit of adding a loading dose IV salbutamol to continuous infusion of salbutamol, in children admitted to the PICU with SAA. Clinically significant side effects from the loading dose were not encountered. What is known: • Pediatric asthma guidelines struggle with an evidence-based approach for the treatment of SAA beyond the initial steps of oxygen suppletion, repetitive administration of inhaled β2-agonists, and systemic steroids. • During an SAA episode, effective delivery of inhaled drugs is unpredictable due to severe airway obstruction. What is new: • This study found no beneficial effect of an additional loading dose IV salbutamol in children admitted to the PICU. • This study found no clinically significant side effects from the loading dose.
MeSH term(s)	Administration, Inhalation ; Albuterol ; Asthma/drug therapy ; Bronchodilator Agents ; Child ; Humans ; Intensive Care Units, Pediatric ; Oxygen ; Saline Solution/therapeutic use ; Status Asthmaticus
Chemical Substances	Bronchodilator Agents ; Saline Solution ; Albuterol (QF8SVZ843E) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-08-03
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-022-04576-8
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Article ; Online: Phase II trial of natalizumab for the treatment of anti-Hu associated paraneoplastic neurological syndromes.

Bastiaansen, Anna E M / de Jongste, Adriaan H C / de Bruijn, Marienke A A M / Crijnen, Yvette S / Schreurs, Marco W J / Verbeek, Marcel M / Dumoulin, Daphne W / Taal, Walter / Titulaer, Maarten J / Sillevis Smitt, Peter A E

Neuro-oncology advances

2021 Volume 3, Issue 1, Page(s) vdab145

Abstract: Background: Paraneoplastic neurological syndromes with anti-Hu antibodies (Hu-PNS) have a very poor prognosis: more than half of the patients become bedridden and median survival is less than 12 months. Several lines of evidence suggest a pathogenic T ... ...

Abstract	Background: Paraneoplastic neurological syndromes with anti-Hu antibodies (Hu-PNS) have a very poor prognosis: more than half of the patients become bedridden and median survival is less than 12 months. Several lines of evidence suggest a pathogenic T cell-mediated immune response. Therefore, we conducted a prospective open-label phase II trial with natalizumab. Methods: Twenty Hu-PNS patients with progressive disease were treated with a maximum of three monthly natalizumab cycles (300 mg). The primary outcome measure was functional improvement, this was defined as at least one point decrease in modified Rankin Scale (mRS) score at the last treatment visit. In addition, treatment response was assessed wherein a mRS score ≤3 after treatment was defined as treatment responsive. Results: The median age at onset was 67.8 years (SD 8.4) with a female predominance ( Conclusions: Natalizumab may ameliorate the disease course in Hu-PNS, but no superior effects above other reported immunosuppressive and immunomodulatory were observed. More effective treatment modalities are highly needed. Trial registration: https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-000675-13/NL.
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdab145
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Article: De standaard 'Astma bij kinderen' (tweede herziening) van het Nederlands Huisartsen Genootschap; reactie vanuit de kinderpulmonologie.

de Jongste, J C

Nederlands tijdschrift voor geneeskunde

2008 Volume 152, Issue 10, Page(s) 543–545

Abstract: The second revised guideline 'Asthma in children' from the Dutch College of General Practitioners provides a well-documented and useful overview. Diagnostic recommendations depend heavily on the symptom 'wheezing', which may be difficult to detect in ... ...

Title translation	The practice guideline 'Asthma in children' (second revision) from the Dutch College of General Practitioners; a response from the perspective of paediatric pulmonology.
Abstract	The second revised guideline 'Asthma in children' from the Dutch College of General Practitioners provides a well-documented and useful overview. Diagnostic recommendations depend heavily on the symptom 'wheezing', which may be difficult to detect in young children. A uniform therapeutic approach for the various asthma phenotypes is recommended, including a therapeutic trial with inhaled corticosteroids for persistent symptoms. Pitfalls include the fact that inhalation of corticosteroids is sometimes difficult in young children, and that the use of corticosteroids in children with transient virus-induced wheeze is not evidence-based. The guideline no longer recommends the use of cromoglycate. Children who are refractory to inhaled steroids should be referred to a paediatrician before trying long-acting beta2-sympathomimetics or leukotriene antagonists. The current challenge is to effectively incorporate this new guideline into a coherent system of care for the asthmatic child in cooperation with paediatricians, asthma nurses and others involved in the diagnosis and treatment of childhood asthma.
MeSH term(s)	Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Age Factors ; Anti-Asthmatic Agents/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Child ; Child, Preschool ; Humans ; Netherlands ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Pulmonary Medicine/standards ; Respiratory Function Tests ; Societies, Medical
Chemical Substances	Adrenal Cortex Hormones ; Anti-Asthmatic Agents
Language	Dutch
Publishing date	2008-03-08
Publishing country	Netherlands
Document type	Comment ; English Abstract ; Journal Article ; Review
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Book ; Online: Shell flux and oxygen isotope data of North Atlantic foraminifera, supplementary data to: Jonkers, Lukas; Brummer, Geert-Jan A; Peeters, Frank J C; van Aken, Hendrik M; de Jong, M Femke (2010): Seasonal stratification, shell flux, and oxygen isotope dynamics of left-coiling N. pachyderma and T. quinqueloba in the western subpolar North Atlantic. Paleoceanography, 25, PA2204

Jonkers, Lukas / Brummer, Geert-Jan A / Peeters, Frank J C / de Jong, M Femke / van Aken, Hendrik M

2010

Abstract: We present an almost 3 year long time series of shell fluxes and oxygen isotopes of left-coiling Neogloboquadrina pachyderma and Turborotalita quinqueloba from sediment traps moored in the deep central Irminger Sea. We determined their response to the ... ...

Abstract	We present an almost 3 year long time series of shell fluxes and oxygen isotopes of left-coiling Neogloboquadrina pachyderma and Turborotalita quinqueloba from sediment traps moored in the deep central Irminger Sea. We determined their response to the seasonal change from a deeply mixed water column with occasional deep convection in winter to a thermally stratified water column with a surface mixed layer (SML) of around 50 m in summer. Both species display very low fluxes during winter with a remnant summer population holding out until replaced by a vital population that seeds the subsequent blooms. This annual population overturning is marked by a 0.7 per mill increase in d18O in both species. The shell flux of N. pachyderma peaks during the spring bloom and in late summer, when stratification is close to its minimum and maximum, respectively. Both export periods contribute about equally and account for >95% of the total annual flux. Shell fluxes of T. quinqueloba show only a single broad pulse in summer, thus following the seasonal stratification cycle. The d18O of N. pachyderma reflects temperatures just below the base of the seasonal SML without offset from isotopic equilibrium. The d18O pattern of T. quinqueloba shows a nearly identical amplitude and correlates highly with the d18O of N. pachyderma. Therefore T. quinqueloba also reflects temperature near the base of the SML but with a positive offset from isotopic equilibrium. These offsets contrast with observations elsewhere and suggest a variable offset from equilibrium calcification for both species. In the Irminger Sea the species consistently show a contrast in their flux timings. Their flux-weighted delta d18O will thus dominantly be determined by seasonal temperature differences at the base of the SML rather than by differences in their depth habitat. Consequently, their sedimentary delta d18O may be used to infer the seasonal contrast in temperature at the base of the SML.
Language	English
Dates of publication	2010-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1029/2009PA001849
DOI	10.1594/PANGAEA.753860
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Associations of eczema phenotypes with emotional and behavioural problems from birth until school age. The Generation R Study.

Hu, C / Nijsten, T / Pasmans, S G M A / de Jongste, J C / Jansen, P W / Duijts, L

The British journal of dermatology

2019 Volume 183, Issue 2, Page(s) 311–320

Abstract: Background: Eczema phenotypes and emotional and behavioural problems are highly prevalent in childhood, but their mutual relationship is not fully clear.: Objectives: To examine the associations of eczema phenotypes with school-age emotional and ... ...

Abstract	Background: Eczema phenotypes and emotional and behavioural problems are highly prevalent in childhood, but their mutual relationship is not fully clear. Objectives: To examine the associations of eczema phenotypes with school-age emotional and behavioural problems, and the bidirectional associations of eczema and emotional and behavioural problems from birth until 10 years. Methods: This study among 5265 individuals was embedded in a prospective population-based cohort study. Never, early transient, mid-transient, late transient and persistent eczema phenotypes were identified based on parent-reported, physician-diagnosed eczema from age 6 months until 10 years. Emotional (internalizing) and behavioural (externalizing) problems were measured repeatedly using the Child Behavior Checklist from age 1·5 to 10 years. Cross-lagged models were applied for bidirectional analyses. Results: All eczema phenotypes were associated with more internalizing problems and attention problems at age 10 years, compared with never having eczema: range of Z-score differences 0·14 [95% confidence interval (CI) 0·01-0·27] to 0·39 (95% CI 0·18-0·60). Children with early transient eczema had more aggressive behaviour symptoms at age 10 years (Z = 0·16, 95% CI 0·05-0·27). Bidirectional analysis showed that eczema at 0-2 years was associated with more internalizing and externalizing problems at ages 3-6 and 10 years, while, inversely, only internalizing problems at 0-2 years were associated with an increased risk of eczema at age 10 years. Conclusions: Eczema phenotypes are very modestly associated with more somatic symptoms and attention problems at school age. Early transient eczema is associated with more aggressive behaviour symptoms. Directional effects seem to occur from early-life eczema to later-life internalizing and externalizing problems, rather than the reverse.
MeSH term(s)	Child ; Child Behavior Disorders/epidemiology ; Child Behavior Disorders/etiology ; Child, Preschool ; Cohort Studies ; Eczema/epidemiology ; Humans ; Infant ; Phenotype ; Problem Behavior ; Prospective Studies ; Schools
Language	English
Publishing date	2019-12-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.18705
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Article: Yes to NO: the first studies on exhaled nitric oxide-driven asthma treatment.

de Jongste, J C

The European respiratory journal

2005 Volume 26, Issue 3, Page(s) 379–381

MeSH term(s)	Anti-Asthmatic Agents/administration & dosage ; Asthma/drug therapy ; Asthma/metabolism ; Breath Tests ; Clinical Trials as Topic ; Humans ; Nitric Oxide/metabolism ; Respiratory Function Tests ; Treatment Outcome
Chemical Substances	Anti-Asthmatic Agents ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2005-09
Publishing country	England
Document type	Editorial ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.05.00080705
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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Article ; Online: The analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate in children - clinical tools or scientific toys?

van Mastrigt, E / de Jongste, J C / Pijnenburg, M W

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2015 Volume 45, Issue 7, Page(s) 1170–1188

Abstract: Current monitoring strategies for respiratory diseases are mainly based on clinical features, lung function and imaging. As airway inflammation is the hallmark of many respiratory diseases in childhood, noninvasive methods to assess the presence and ... ...

Abstract	Current monitoring strategies for respiratory diseases are mainly based on clinical features, lung function and imaging. As airway inflammation is the hallmark of many respiratory diseases in childhood, noninvasive methods to assess the presence and severity of airway inflammation might be helpful in both diagnosing and monitoring paediatric respiratory diseases. At present, the measurement of fractional exhaled nitric oxide is the only noninvasive method available to assess eosinophilic airway inflammation in clinical practice. We aimed to evaluate whether the analysis of volatile organic compounds (VOCs) in exhaled breath (EB) and biomarkers in exhaled breath condensate (EBC) is helpful in diagnosing and monitoring respiratory diseases in children. An extensive literature search was conducted in Medline, Embase and PubMed on the analysis and applications of VOCs in EB and EBC in children. We retrieved 1165 papers, of which nine contained original data on VOCs in EB and 84 on biomarkers in EBC. These were included in this review. We give an overview of the clinical applications in childhood and summarize the methodological issues. Several VOCs in EB and biomarkers in EBC have the potential to distinguish patients from healthy controls and to monitor treatment responses. Lack of standardization of collection methods and analysis techniques hampers the introduction in clinical practice. The measurement of metabolomic profiles may have important advantages over detecting single markers. There is a lack of longitudinal studies and external validation to reveal whether EB and EBC analysis have added value in the diagnostic process and follow-up of children with respiratory diseases. In conclusion, the use of VOCs in EB and biomarkers in EBC as markers of inflammatory airway diseases in children is still a research tool and not validated for clinical use.
MeSH term(s)	Adolescent ; Age Factors ; Biomarkers ; Child ; Child, Preschool ; Exhalation ; Female ; Humans ; Infant ; Male ; Metabolomics/methods ; Play and Playthings ; Respiratory Tract Diseases/diagnosis ; Respiratory Tract Diseases/metabolism ; Volatile Organic Compounds/chemistry
Chemical Substances	Biomarkers ; Volatile Organic Compounds
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.12454
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Zs.A 767: Show issues

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Article ; Online: Antibiotic use in children with asthma: cohort study in UK and Dutch primary care databases.

Baan, Esmé J / Janssens, Hettie M / Kerckaert, Tine / Bindels, Patrick J E / de Jongste, Johan C / Sturkenboom, Miriam C J M / Verhamme, Katia M C

BMJ open

2018 Volume 8, Issue 11, Page(s) e022979

Abstract: Objectives: To compare the rate, indications and type of antibiotic prescriptions in children with and without asthma.: Design: A retrospective cohort study.: Setting: Two population-based primary care databases: Integrated Primary Care ... ...

Abstract	Objectives: To compare the rate, indications and type of antibiotic prescriptions in children with and without asthma. Design: A retrospective cohort study. Setting: Two population-based primary care databases: Integrated Primary Care Information database (IPCI; the Netherlands) and The Health Improvement Network (THIN; the UK). Participants: Children aged 5-18 years were included from January 2000 to December 2014. A child was categorised as having asthma if there were ≥2 prescriptions of respiratory drugs in the year following a code for asthma. Children were labelled as non-asthmatic if no asthma code was recorded in the patient file. Main outcome measures: Rate of antibiotic prescriptions, related indications and type of antibiotic drugs. Results: The cohorts in IPCI and THIN consisted of 946 143 and 7 241 271 person years (PY), respectively. In both cohorts, antibiotic use was significantly higher in asthmatic children (IPCI: 197vs126 users/1000 PY, THIN: 374vs250 users/1000 PY). In children with asthma, part of antibiotic prescriptions were for an asthma exacerbation only (IPCI: 14%, THIN: 4%) and prescriptions were more often due to lower respiratory tract infections then in non-asthmatic children (IPCI: 18%vs13%, THIN: 21%vs12%). Drug type and quality indicators depended more on age, gender and database than on asthma status. Conclusions: Use of antibiotics was higher in asthmatic children compared with non-asthmatic children. This was mostly due to diseases for which antibiotics are normally not indicated according to guidelines. Further awareness among physicians and patients is needed to minimise antibiotic overuse and limit antibiotic resistance.
MeSH term(s)	Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Asthma/drug therapy ; Bacterial Infections/drug therapy ; Case-Control Studies ; Child ; Child, Preschool ; Databases, Factual ; Drug Prescriptions/statistics & numerical data ; Drug Resistance, Microbial ; Female ; Humans ; Male ; Netherlands ; Patient Selection ; Pediatrics/methods ; Practice Patterns, Physicians' ; Primary Health Care ; Respiratory Tract Diseases/drug therapy ; Retrospective Studies ; United Kingdom ; Virus Diseases/drug therapy
Chemical Substances	Anti-Asthmatic Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2018-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2018-022979
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