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  1. Book ; Thesis: Charakterisierung dysregulierter Signalwege in der Spinalen Muskelatrophie in vitro und in vivo

    Wessels, Inga

    molekularbiologische und biochemische Untersuchungen

    2018  

    Author's details vorgelegt von Inga Wessels, geb. Stockbrügger
    Language German
    Size XIV, 65 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2019
    HBZ-ID HT020391374
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 439 order for loan Magazin

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  2. Article ; Online: ICTEM 2022 special issue: The versatile aspects of trace elements and metals The diverse world of trace element and metal research.

    Wessels, Inga / Fischer, Henrike J

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2024  Volume 83, Page(s) 127392

    MeSH term(s) Trace Elements ; Metals, Heavy
    Chemical Substances Trace Elements ; Metals, Heavy
    Language English
    Publishing date 2024-01-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2024.127392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2279: Show issues Location:
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  3. Article ; Online: Regulation of matrix metalloproteinase-9 during monopoiesis and zinc deficiency by chromatin remodeling.

    Shahzad, Asad / Rink, Lothar / Wessels, Inga

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2023  Volume 78, Page(s) 127162

    Abstract: Introduction: Matrix metalloproteinase-9 (MMP-9) cleaves various extracellular matrix proteins, hence significantly contributes to numerous physiological but also pathological processes. Monocytic differentiation is associated with increased MMP-9 gene ... ...

    Abstract Introduction: Matrix metalloproteinase-9 (MMP-9) cleaves various extracellular matrix proteins, hence significantly contributes to numerous physiological but also pathological processes. Monocytic differentiation is associated with increased MMP-9 gene expression. Interestingly, MMP-9 upregulation during monocytic differentiation is paralleled by a decline in intracellular zinc levels. Hence, an influence of zinc on the regulation of MMP-9 expression may exist. Although, previous studies suggest a vital role of zinc regarding MMP-9 activity, the possible relevance of zinc homeostasis during transcriptional regulation of MMP-9 for example via epigenetic mechanisms is rather unclear.
    Aim: This study aims to find a correlation between zinc deficiency and MMP-9 transcriptional regulation, focusing on epigenetics as the possible mechanism behind zinc deficiency-induced changes.
    Methods: The effect of differentiation and zinc deficiency on MMP-9 expression and MMP9 promoter accessibility was investigated using the acute promyelocytic cell line NB4. Intracellular free zinc levels were detected by flow cytometry. MMP-9 gene expression was measured by real-time PCR and ELISA. Analysis of chromatin structures was done using chromatin accessibility by real-time PCR (CHART) assay.
    Results: During monocytic differentiation of NB4 cells, the decrease in intracellular zinc levels was paralleled by an increased production of MMP-9. Assessment of chromatin structure revealed increased accessibility of certain regions within the MMP-9 promoter in differentiated cells. Interestingly, upregulated activation-induced MMP-9 gene expression as well as a more accessible MMP-9 promoter were in zinc-deficient NB4 cells whereas zinc resupplementation reversed the effects.
    Conclusion: These data demonstrate an important role of epigenetic mechanisms in regulating MMP-9 expression under zinc deficiency. This could provide an encouraging step to expand the research on using zinc for the treatment of various pathological conditions such as inflammatory, vascular and autoimmune diseases resulting from MMP-9 deregulation.
    MeSH term(s) Chromatin ; Chromatin Assembly and Disassembly ; Gene Expression Regulation ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Zinc/pharmacology ; Zinc/metabolism ; Humans
    Chemical Substances Chromatin ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-04-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2023.127162
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  4. Article: Effects of Zinc Status on Expression of Zinc Transporters, Redox-Related Enzymes and Insulin-like Growth Factor in Asian Sea Bass Cells.

    Sansuwan, Kanokwan / Jintasataporn, Orapint / Rink, Lothar / Triwutanon, Supawit / Wessels, Inga

    Biology

    2023  Volume 12, Issue 3

    Abstract: Since Asian sea bass is one of the economically most important fish, aquaculture conditions are constantly optimized. Evidence from feeding studies combined with the current understanding of the importance of zinc for growth and immune defense suggest ... ...

    Abstract Since Asian sea bass is one of the economically most important fish, aquaculture conditions are constantly optimized. Evidence from feeding studies combined with the current understanding of the importance of zinc for growth and immune defense suggest that zinc supplementation may be a possible approach to optimize aquacultures of Asian sea bass. To investigate the effects of zinc deficiency and zinc supplementation, cells from Asian sea bass were incubated in culture medium with different zinc contents. The expression of genes, important for zinc homeostasis, redox metabolism, and growth hormones was analyzed using RT-PCR. Zinc deficiency induced the expression of certain zinc transporters (ZIP14, ZIP10, ZIP6, ZIP4, ZnT4, ZnT9) as well as of SOD1, IGF I and IGF II, while expression of ZnT1 and metallothionein (MT) was reduced. Zinc supplementation decreased the expression of ZIP10, while expression of ZnT1 and MT were elevated. No differences in the effects of zinc supplementation with zinc sulfate compared to supplementation with zinc amino acid complexes were observed. Thus, extracellular zinc conditions may govern the cellular zinc homeostasis, the redox metabolism and growth hormone expression in cells from Asian sea bass as reported for other fish species. Our data indicate that supplementing aquacultures with zinc may be recommended to avoid detriments of zinc deficiency.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12030338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of Zinc Status on Expression of Zinc Transporters, Redox-Related Enzymes and Insulin-like Growth Factor in Asian Sea Bass Cells

    Kanokwan Sansuwan / Orapint Jintasataporn / Lothar Rink / Supawit Triwutanon / Inga Wessels

    Biology, Vol 12, Iss 338, p

    2023  Volume 338

    Abstract: Since Asian sea bass is one of the economically most important fish, aquaculture conditions are constantly optimized. Evidence from feeding studies combined with the current understanding of the importance of zinc for growth and immune defense suggest ... ...

    Abstract Since Asian sea bass is one of the economically most important fish, aquaculture conditions are constantly optimized. Evidence from feeding studies combined with the current understanding of the importance of zinc for growth and immune defense suggest that zinc supplementation may be a possible approach to optimize aquacultures of Asian sea bass. To investigate the effects of zinc deficiency and zinc supplementation, cells from Asian sea bass were incubated in culture medium with different zinc contents. The expression of genes, important for zinc homeostasis, redox metabolism, and growth hormones was analyzed using RT-PCR. Zinc deficiency induced the expression of certain zinc transporters (ZIP14, ZIP10, ZIP6, ZIP4, ZnT4, ZnT9) as well as of SOD1, IGF I and IGF II, while expression of ZnT1 and metallothionein (MT) was reduced. Zinc supplementation decreased the expression of ZIP10, while expression of ZnT1 and MT were elevated. No differences in the effects of zinc supplementation with zinc sulfate compared to supplementation with zinc amino acid complexes were observed. Thus, extracellular zinc conditions may govern the cellular zinc homeostasis, the redox metabolism and growth hormone expression in cells from Asian sea bass as reported for other fish species. Our data indicate that supplementing aquacultures with zinc may be recommended to avoid detriments of zinc deficiency.
    Keywords Asian sea bass ; zinc homeostasis ; zinc transporters ; metallothionein ; redox metabolism ; insulin-like growth factors ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A combined biochemical and cellular approach reveals Zn

    Kocyła, Anna M / Czogalla, Aleksander / Wessels, Inga / Rink, Lothar / Krężel, Artur

    Structure (London, England : 1993)

    2023  Volume 32, Issue 3, Page(s) 292–303.e7

    Abstract: The CD4 or CD8 co-receptors' interaction with the protein-tyrosine kinase Lck initiates the tyrosine phosphorylation cascade leading to T cell activation. A critical question is: to what extent are co-receptors and Lck coupled? Our contribution concerns ... ...

    Abstract The CD4 or CD8 co-receptors' interaction with the protein-tyrosine kinase Lck initiates the tyrosine phosphorylation cascade leading to T cell activation. A critical question is: to what extent are co-receptors and Lck coupled? Our contribution concerns Zn
    MeSH term(s) T-Lymphocytes/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; CD4 Antigens ; Signal Transduction ; Phosphorylation ; Zinc/metabolism ; Receptors, Antigen, T-Cell
    Chemical Substances Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; CD4 Antigens ; Zinc (J41CSQ7QDS) ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2023.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4141: Show issues Location:
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  7. Article ; Online: Vitamin D3 and zinc synergistically induce regulatory T cells and suppress interferon-γ production in mixed lymphocyte culture.

    Schmitt, Anne Kristina / Puppa, Mary-Ann / Wessels, Inga / Rink, Lothar

    The Journal of nutritional biochemistry

    2022  Volume 102, Page(s) 108942

    Abstract: Although vitamin D3 (cholecalciferol) and zinc are known to individually shift the immune response towards tolerance, little is known about the effect of their combined administration. This work contributes to understanding the combined action of zinc ... ...

    Abstract Although vitamin D3 (cholecalciferol) and zinc are known to individually shift the immune response towards tolerance, little is known about the effect of their combined administration. This work contributes to understanding the combined action of zinc and vitamin D3 in different in vitro models for immune reactions. Zinc and vitamin D3 in combination boosted the differentiation into Foxp3
    MeSH term(s) Cholecalciferol/metabolism ; Cholecalciferol/pharmacology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Humans ; Interferon-gamma/metabolism ; Leukocytes, Mononuclear/metabolism ; T-Lymphocytes, Regulatory ; Zinc/metabolism ; Zinc/pharmacology
    Chemical Substances Forkhead Transcription Factors ; Cholecalciferol (1C6V77QF41) ; Interferon-gamma (82115-62-6) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2022.108942
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    Zs.A 2838: Show issues Location:
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  8. Article ; Online: Intensity- and time-matched acute interval and continuous endurance exercise similarly induce an anti-inflammatory environment in recreationally active runners: focus on PD-1 expression in T

    Proschinger, Sebastian / Schenk, Alexander / Weßels, Inga / Donath, Lars / Rappelt, Ludwig / Metcalfe, Alan J / Zimmer, Philipp

    European journal of applied physiology

    2023  Volume 123, Issue 11, Page(s) 2575–2584

    Abstract: Purpose: Acute exercise elicits a transient anti-inflammatory state during the early recovery period. Since recent studies reported on regimen-specific effects on immune-related humoral factors and cellular subsets, this study compared the effects of ... ...

    Abstract Purpose: Acute exercise elicits a transient anti-inflammatory state during the early recovery period. Since recent studies reported on regimen-specific effects on immune-related humoral factors and cellular subsets, this study compared the effects of intensity- and time-matched acute interval and continuous exercise on peripheral anti-inflammatory cellular and humoral immune parameters with a particular focus on the PD-1 expression in CD4
    Methods: Twenty-four recreationally active runners (age: 29.7 ± 4.3 years, BMI: 22.2 ± 2.4, VO
    Results: PD-1 levels on T
    Conclusion: This is the first study that investigates PD-1 expression in circulating T
    MeSH term(s) Adult ; Humans ; Anti-Inflammatory Agents ; Exercise ; High-Intensity Interval Training ; Interleukin-10 ; Interleukin-6 ; Programmed Cell Death 1 Receptor
    Chemical Substances Anti-Inflammatory Agents ; Interleukin-10 (130068-27-8) ; Interleukin-6 ; Programmed Cell Death 1 Receptor ; IL6 protein, human ; IL10 protein, human ; PDCD1 protein, human
    Language English
    Publishing date 2023-06-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-023-05251-y
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  9. Article ; Online: Editorial GMS special issue.

    Rink, Lothar / Wessels, Inga

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2018  Volume 50, Page(s) 367

    Language English
    Publishing date 2018-08-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2018.08.001
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  10. Article ; Online: Dietary and Physiological Effects of Zinc on the Immune System.

    Wessels, Inga / Fischer, Henrike Josephine / Rink, Lothar

    Annual review of nutrition

    2021  Volume 41, Page(s) 133–175

    Abstract: Evidence for the importance of zinc for all immune cells and for mounting an efficient and balanced immune response to various environmental stressors has been accumulating in recent years. This article describes the role of zinc in fundamental ... ...

    Abstract Evidence for the importance of zinc for all immune cells and for mounting an efficient and balanced immune response to various environmental stressors has been accumulating in recent years. This article describes the role of zinc in fundamental biological processes and summarizes our current knowledge of zinc's effect on hematopoiesis, including differentiation into immune cell subtypes. In addition, the important role of zinc during activation and function of immune cells is detailed and associated with the specific immune responses to bacteria, parasites, and viruses. The association of zinc with autoimmune reactions and cancers as diseases with increased or decreased immune responses is also discussed. This article provides a broad overview of the manifold roles that zinc, or its deficiency, plays in physiology and during various diseases. Consequently, we discuss why zinc supplementation should be considered, especially for people at risk of deficiency.
    MeSH term(s) Diet ; Humans ; Immune System ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-122019-120635
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