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Article ; Online: Future therapeutic strategies for olfactory disorders: electrical stimulation, stem cell therapy, and transplantation of olfactory epithelium-an overview.

Gunder, N / Dörig, P / Witt, M / Welge-Lüssen, A / Menzel, S / Hummel, T

2023 Volume 71, Issue Suppl 1, Page(s) 35–43

Abstract: Olfactory disorders may be temporary or permanent and can have various causes. Currently, many COVID-19 patients report a reduced or complete loss of olfactory function. A wide range of treatment options have been investigated in the past, such as ... ...

Title translation	Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel – eine Übersicht.
Abstract	Olfactory disorders may be temporary or permanent and can have various causes. Currently, many COVID-19 patients report a reduced or complete loss of olfactory function. A wide range of treatment options have been investigated in the past, such as olfactory training, acupuncture, medical therapy, transcranial magnetic stimulation, or surgical excision of olfactory epithelium, e.g., in severe qualitative smell disorders. The development of a bioelectric nose, e.g., in connection with direct electrical stimulation or transplantation of olfactory epithelium or stem cells, represent treatment options of the future. The basis of these developments and the state of knowledge is discussed in the following work.
MeSH term(s)	Humans ; Smell/physiology ; COVID-19/therapy ; COVID-19/complications ; Olfaction Disorders/therapy ; Olfactory Mucosa ; Electric Stimulation/adverse effects ; Cell- and Tissue-Based Therapy/adverse effects
Language	English
Publishing date	2023-02-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-022-01249-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of BicDR in bristle shaft construction and support of BicD functions.

Jejina, Aleksandra / Ayala, Yeniffer / Beuchle, Dirk / Höhener, Thomas / Dörig, Ruth E / Vazquez-Pianzola, Paula / Hernández, Greco / Suter, Beat

Journal of cell science

2024 Volume 137, Issue 2

Abstract: Cell polarization requires asymmetric localization of numerous mRNAs, proteins and organelles. The movement of cargo towards the minus end of microtubules mostly depends on cytoplasmic dynein motors. In the dynein-dynactin-Bicaudal-D transport machinery, ...

Abstract	Cell polarization requires asymmetric localization of numerous mRNAs, proteins and organelles. The movement of cargo towards the minus end of microtubules mostly depends on cytoplasmic dynein motors. In the dynein-dynactin-Bicaudal-D transport machinery, Bicaudal-D (BicD) links the cargo to the motor. Here, we focus on the role of Drosophila BicD-related (BicDR, CG32137) in the development of the long bristles. Together with BicD, it contributes to the organization and stability of the actin cytoskeleton in the not-yet-chitinized bristle shaft. BicD and BicDR also support the stable expression and distribution of Rab6 and Spn-F in the bristle shaft, including the distal tip localization of Spn-F, pointing to the role of microtubule-dependent vesicle trafficking for bristle construction. BicDR supports the function of BicD, and we discuss the hypothesis whereby BicDR might transport cargo more locally, with BicD transporting cargo over long distances, such as to the distal tip. We also identified embryonic proteins that interact with BicDR and appear to be BicDR cargo. For one of them, EF1γ (also known as eEF1γ), we show that the encoding gene EF1γ interacts with BicD and BicDR in the construction of the bristles.
MeSH term(s)	Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Dyneins/genetics ; Dyneins/metabolism ; Drosophila/metabolism ; Microtubules/metabolism ; Dynactin Complex/genetics ; Dynactin Complex/metabolism ; Microtubule-Associated Proteins/metabolism
Chemical Substances	Drosophila Proteins ; Dyneins (EC 3.6.4.2) ; Dynactin Complex ; Microtubule-Associated Proteins ; BicD protein, Drosophila ; Spn-F protein, Drosophila
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.261408
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Zs.A 1200: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 14: Show issues

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Article ; Online: BackWards - Unveiling the brain's topographic organization of paraspinal sensory input.

Guekos, Alexandros / Cole, David M / Dörig, Monika / Stämpfli, Philipp / Schibli, Louis / Schuetz, Philipp / Schweinhardt, Petra / Meier, Michael L

NeuroImage

2023 Volume 283, Page(s) 120431

Abstract: Cortical reorganization and its potential pathological significance are being increasingly studied in musculoskeletal disorders such as chronic low back pain (CLBP) patients. However, detailed sensory-topographic maps of the human back are lacking, and a ...

Abstract	Cortical reorganization and its potential pathological significance are being increasingly studied in musculoskeletal disorders such as chronic low back pain (CLBP) patients. However, detailed sensory-topographic maps of the human back are lacking, and a baseline characterization of such representations, reflecting the somatosensory organization of the healthy back, is needed before exploring potential sensory map reorganization. To this end, a novel pneumatic vibrotactile stimulation method was used to stimulate paraspinal sensory afferents, while studying their cortical representations in unprecedented detail. In 41 young healthy participants, vibrotactile stimulations at 20 Hz and 80 Hz were applied bilaterally at nine locations along the thoracolumbar axis while functional magnetic resonance imaging (fMRI) was performed. Model-based whole-brain searchlight representational similarity analysis (RSA) was used to investigate the organizational structure of brain activity patterns evoked by thoracolumbar sensory inputs. A model based on segmental distances best explained the similarity structure of brain activity patterns that were located in different areas of sensorimotor cortices, including the primary somatosensory and motor cortices and parts of the superior parietal cortex, suggesting that these brain areas process sensory input from the back in a "dermatomal" manner. The current findings provide a sound basis for testing the "cortical map reorganization theory" and its pathological relevance in CLBP.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Sensorimotor Cortex ; Brain Mapping/methods ; Somatosensory Cortex/physiology
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120431
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

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Article ; Online: Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel – eine Übersicht.

Dörig, P / Gunder, N / Witt, M / Welge-Lüssen, A / Hummel, T

HNO

2021 Volume 69, Issue 8, Page(s) 623–632

Title translation	Future therapeutic strategies for olfactory disorders: electrical stimulation, stem cell therapy, and transplantation of olfactory epithelium-an overview.
Abstract	Olfactory disorders may be temporary or permanent and can have various causes. Currently, many COVID-19 patients report a reduced or complete loss of olfactory function. A wide range of treatment options have been investigated in the past, such as olfactory training, acupuncture, medical therapy, transcranial magnetic stimulation, or surgical excision of olfactory epithelium, e.g., in severe qualitative smell disorders. The development of a bioelectric nose, e.g., in connection with direct electrical stimulation or transplantation of olfactory epithelium or stem cells, represent treatment options of the future. The basis of these developments and the state of knowledge is discussed in the following work.
MeSH term(s)	COVID-19 ; Electric Stimulation ; Humans ; Olfaction Disorders ; Olfactory Mucosa ; SARS-CoV-2 ; Smell ; Stem Cell Transplantation
Language	German
Publishing date	2021-05-14
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-021-01060-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.

Malinovska, Liliana / Cappelletti, Valentina / Kohler, Devon / Piazza, Ilaria / Tsai, Tsung-Heng / Pepelnjak, Monika / Stalder, Patrick / Dörig, Christian / Sesterhenn, Fabian / Elsässer, Franziska / Kralickova, Lucie / Beaton, Nigel / Reiter, Lukas / de Souza, Natalie / Vitek, Olga / Picotti, Paola

Nature protocols

2023 Volume 18, Issue 6, Page(s) 1979

Language	English
Publishing date	2023-01-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-023-00808-9
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Article ; Online: Serial weighting of micro-objects with resonant microchanneled cantilevers.

Ossola, Dario / Dörig, Pablo / Vörös, János / Zambelli, Tomaso / Vassalli, Massimo

Nanotechnology

2016 Volume 27, Issue 41, Page(s) 415502

Abstract: Atomic force microscopy (AFM) cantilevers have proven to be very effective mass sensors. The attachment of a small mass to a vibrating cantilever produces a resonance frequency shift that can be monitored, providing the ability to measure mass changes ... ...

Abstract	Atomic force microscopy (AFM) cantilevers have proven to be very effective mass sensors. The attachment of a small mass to a vibrating cantilever produces a resonance frequency shift that can be monitored, providing the ability to measure mass changes down to a few molecules resolution. Nevertheless, the lack of a practical method to handle the catch and release process required for dynamic weighting of microobjects strongly hindered the application of the technology beyond proof of concept measurements. Here, a method is proposed in which FluidFM hollow cantilevers are exploited to overcome the standard limitations of AFM-based mass sensors, providing high throughput single object weighting with picogram accuracy. The extension of the dynamic models of AFM cantilevers to hollow cantilevers was discussed and the effectiveness of mass weighting in air was validated on test samples.
Language	English
Publishing date	2016-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/0957-4484/27/41/415502
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Article ; Online: Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.

Nature protocols

2022 Volume 18, Issue 3, Page(s) 659–682

Abstract: Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to a perturbation, protein structure may be altered by various molecular events, such as post-translational modifications, ... ...

Abstract	Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to a perturbation, protein structure may be altered by various molecular events, such as post-translational modifications, protein-protein interactions, aggregation, allostery or binding to other molecules. The ability to probe these structural changes in thousands of proteins simultaneously in cells or tissues can provide valuable information about the functional state of biological processes and pathways. Here, we present an updated protocol for LiP-MS, a proteomics technique combining limited proteolysis with mass spectrometry, to detect protein structural alterations in complex backgrounds and on a proteome-wide scale. In LiP-MS, proteins undergo a brief proteolysis in native conditions followed by complete digestion in denaturing conditions, to generate structurally informative proteolytic fragments that are analyzed by mass spectrometry. We describe advances in the throughput and robustness of the LiP-MS workflow and implementation of data-independent acquisition-based mass spectrometry, which together achieve high reproducibility and sensitivity, even on large sample sizes. We introduce MSstatsLiP, an R package dedicated to the analysis of LiP-MS data for the identification of structurally altered peptides and differentially abundant proteins. The experimental procedures take 3 d, mass spectrometric measurement time and data processing depend on sample number and statistical analysis typically requires ~1 d. These improvements expand the adaptability of LiP-MS and enable wide use in functional proteomics and translational applications.
MeSH term(s)	Proteolysis ; Proteome/analysis ; Reproducibility of Results ; Mass Spectrometry/methods ; Protein Processing, Post-Translational
Chemical Substances	Proteome
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-022-00771-x
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Article ; Online: Systematic detection of functional proteoform groups from bottom-up proteomic datasets.

Bludau, Isabell / Frank, Max / Dörig, Christian / Cai, Yujia / Heusel, Moritz / Rosenberger, George / Picotti, Paola / Collins, Ben C / Röst, Hannes / Aebersold, Ruedi

Nature communications

2021 Volume 12, Issue 1, Page(s) 3810

Abstract: To a large extent functional diversity in cells is achieved by the expansion of molecular complexity beyond that of the coding genome. Various processes create multiple distinct but related proteins per coding gene - so-called proteoforms - that expand ... ...

Abstract	To a large extent functional diversity in cells is achieved by the expansion of molecular complexity beyond that of the coding genome. Various processes create multiple distinct but related proteins per coding gene - so-called proteoforms - that expand the functional capacity of a cell. Evaluating proteoforms from classical bottom-up proteomics datasets, where peptides instead of intact proteoforms are measured, has remained difficult. Here we present COPF, a tool for COrrelation-based functional ProteoForm assessment in bottom-up proteomics data. It leverages the concept of peptide correlation analysis to systematically assign peptides to co-varying proteoform groups. We show applications of COPF to protein complex co-fractionation data as well as to more typical protein abundance vs. sample data matrices, demonstrating the systematic detection of assembly- and tissue-specific proteoform groups, respectively, in either dataset. We envision that the presented approach lays the foundation for a systematic assessment of proteoforms and their functional implications directly from bottom-up proteomic datasets.
MeSH term(s)	Algorithms ; Animals ; Benchmarking ; Humans ; Mice ; Peptides/analysis ; Peptides/metabolism ; Protein Isoforms/analysis ; Protein Isoforms/metabolism ; Proteomics/methods ; Proteomics/standards ; Tandem Mass Spectrometry ; Workflow
Chemical Substances	Peptides ; Protein Isoforms
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-24030-x
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Article: Altersvorsorge im Umbruch

Dörig, Rolf

Nach der Jahrhundertbaisse: was ist zu tun? : Tagungsband zum 11. Basler Bankentag, 13. November 2003 , p. 129-144

vom Umgang mit der neuen Wirklichkeit am Versicherungsmarkt

2004 , Page(s) 129–144

Author's details	Rolf Dörig
Keywords	50
Language	German
Publisher	Haupt
Publishing place	Bern [u.a.]
Document type	Article
Database	ECONomics Information System

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Article ; Online: Influence of different post-interventional maintenance concepts on periodontal outcomes: an evaluation of three systematic reviews.

Gartenmann, Stefanie J / Dörig, Iris / Sahrmann, Philipp / Held, Ulrike / Walter, Clemens / Schmidlin, Patrick R

BMC oral health

2016 Volume 17, Issue 1, Page(s) 19

Abstract: Background: To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment.: Methods: Three systematic reviews with ... ...

Abstract	Background: To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment. Methods: Three systematic reviews with different periodontal interventions, i.e. scaling and root planing (SRP), SRP with adjunctive antibiotics or regenerative periodontal surgery were evaluated focusing on their post-interventional maintenance care. Due to the early publication of one review an additional literature search update was undertaken. The search was executed for studies published from January 2001 till March 2015 through an electronic database to ensure the inclusion of resent studies on SRP. Two reviewers guided the study selection and assessed the validity of the three reviews found. Results: Within the group of scaling and root planing alone there have been nine studies with more than three appointments for maintenance care and five studies with more than two appointments in the first 2 months after the intervention. Chlorhexidine was the most frequently used antiseptic agent used for 2 weeks after non-surgical intervention. Scaling and root planing with adjunctive antibiotics showed a similar number of visits with professional biofilm debridement, whereas regenerative studies displayed more studies with more than three visits in the intervention group. In addition, the use of antiseptics was longer and lasted 4 to 8 weeks after the regenerative intervention. The latter studies also showed more stringent maintenance protocols. Conclusions: With increased interventional effort there was a greater tendency to increase frequency and duration of the maintenance care program and antiseptic agents.
Language	English
Publishing date	2016-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-016-0244-6
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