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  1. Article ; Online: In reply to the Letter to Editor regarding 'Acute kidney injury associated with colistin sulfate vs. polymyxin B sulfate therapy: A real-world, retrospective cohort study'.

    Zhang, Yanfang / Ye, Ziqi / Jiang, Saiping

    International journal of antimicrobial agents

    2024  , Page(s) 107178

    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107178
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  2. Article ; Online: Associations of levels of high-molecular-weight adiponectin, secreted frizzled-related protein 5 and vascular endothelial growth factor-165 with diabetic retinopathy

    Fu Yanfang / Ye Shizhen / Peng Jianjun

    Romanian Journal of Laboratory Medicine, Vol 31, Iss 4, Pp 241-

    2023  Volume 250

    Abstract: Background: The pathogenesis of diabetic retinopathy (DR) remains unclear. The aim of the study was to explore the associations of DR with the levels of high-molecular-weight adiponectin (HMW-ADP), secreted frizzled-related protein 5 (SFRP-5) as well as ... ...

    Abstract Background: The pathogenesis of diabetic retinopathy (DR) remains unclear. The aim of the study was to explore the associations of DR with the levels of high-molecular-weight adiponectin (HMW-ADP), secreted frizzled-related protein 5 (SFRP-5) as well as vascular endothelial growth factor-165 (VEGF165).
    Keywords vascular endothelial growth factor-165 ; secreted frizzled-related protein 5 ; high molecular weight adiponectin ; diabetic retinopathy ; Medicine ; R
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: WITHDRAWN: Application of Chemotherapeutic Drugs and Convectionenhanced Delivery Technology in Glioma

    Zhou, Yishu / Xue, Yanfang / Ye, Feilong / Huang, Jinbai / Wang, Licui / Wang, Wei

    Anti-cancer agents in medicinal chemistry

    2023  

    Language English
    Publishing date 2023-05-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520623666230517144104
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    Zs.A 5583: Show issues Location:
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  4. Article ; Online: The double-edged functions of necroptosis.

    Ye, Keng / Chen, Zhimin / Xu, Yanfang

    Cell death & disease

    2023  Volume 14, Issue 2, Page(s) 163

    Abstract: Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that ...

    Abstract Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it has been implicated in the pathogenesis of many diseases, there is evidence to support that necroptosis is not purely a detrimental process. We propose that necroptosis is a "double-edged sword" in terms of physiology and pathology. On the one hand, necroptosis can trigger an uncontrolled inflammatory cascade response, resulting in severe tissue injury, disease chronicity, and even tumor progression. On the other hand, necroptosis functions as a host defense mechanism, exerting antipathogenic and antitumor effects through its powerful pro-inflammatory properties. Moreover, necroptosis plays an important role during both development and regeneration. Misestimation of the multifaceted features of necroptosis may influence the development of therapeutic approaches targeting necroptosis. In this review, we summarize current knowledge of the pathways involved in necroptosis as well as five important steps that determine its occurrence. The dual role of necroptosis in a variety of physiological and pathological conditions is also highlighted. Future studies and the development of therapeutic strategies targeting necroptosis should fully consider the complicated properties of this type of regulated cell death.
    MeSH term(s) Necroptosis ; Regulated Cell Death ; Cell Death
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-05691-6
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  5. Article: Identification of new immune subtypes of renal injury associated with anti-neutrophil cytoplasmic antibody-associated vasculitis based on integrated bioinformatics analysis.

    Lin, Lizhen / Ye, Keng / Chen, Fengbin / Xie, Jingzhi / Chen, Zhimin / Xu, Yanfang

    Frontiers in genetics

    2023  Volume 14, Page(s) 1119017

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1119017
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  6. Article ; Online: Downregulated lncRNA HOTAIR inhibits the proliferation of granulosa cells in endometriosis by upregulating p21.

    Ye, Huayang / Lin, Yanshan / Wang, Yanfang / Xing, Jia / Zhang, Jun

    Cellular and molecular biology (Noisy-le-Grand, France)

    2023  Volume 69, Issue 11, Page(s) 189–194

    Abstract: This study was carried out to elucidate the biological function of HOTAIR in granulosa cells of endometriosis and the underlying mechanism. Granulosa cells were extracted from endometriosis patients and subjects with fallopian tube factor alone who ... ...

    Abstract This study was carried out to elucidate the biological function of HOTAIR in granulosa cells of endometriosis and the underlying mechanism. Granulosa cells were extracted from endometriosis patients and subjects with fallopian tube factor alone who received IVF-ET. Relative levels of HOTAIR and p21 in the extracted granulosa cells were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, HOTAIR level in endometriosis patients in stage I-II or III-IV was determined. Regulatory effects of HOTAIR on the proliferation of KGN cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide), 5-Ethynyl-2'- deoxyuridine (EdU) and colony formation assay. Flow cytometry was conducted to evaluate the potential influence of HOTAIR on apoptosis of KGN cells. The interaction between HOTAIR and EZH2, SUV12 was detected by RNA binding protein immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assay. Finally, the potential role of the HOTAIR/p21 axis in mediating cellular behaviors of KGN cells was explored. HOTAIR was downregulated in granulosa cells extracted from endometriosis patients relative to those with fallopian tube factor alone who received IVF-ET. Knockdown of HOTAIR suppressed the proliferative ability and induced apoptosis of KGN cells. RIP and ChIP assay showed that silence of HOTAIR released EZH2 to suppress the DNA methylation of p21. Knockdown of p21 could reverse the regulatory effect of HOTAIR on the proliferative change of KGN cells. Downregulated HOTAIR suppresses the proliferative ability and induces apoptosis of granulosa cells in endometriosis by upregulating p21.
    MeSH term(s) Female ; Humans ; Apoptosis/genetics ; Cell Proliferation/genetics ; Endometriosis/genetics ; Granulosa Cells ; RNA, Long Noncoding/genetics
    Chemical Substances RNA, Long Noncoding ; HOTAIR long untranslated RNA, human ; CDKN1A protein, human
    Language English
    Publishing date 2023-11-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2023.69.11.28
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3812: Show issues Location:
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  7. Article ; Online: Correction: Design of an imaging magnetic microsphere based on photopolymerization for magnetic hyperthermia in tumor therapy.

    Xiao, Qinglin / Chen, Piaoyi / Chen, Mianrong / Zhou, Yanfang / Li, Jiesong / Lun, Yingying / Li, Qiuxia / Ye, Guodong

    Drug delivery and translational research

    2023  Volume 14, Issue 3, Page(s) 839

    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-023-01434-4
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  8. Article ; Online: Chronic exposure to gestodene impairs reproductive system in adult female zebrafish (Daniarerio).

    Zou, Hong / Yu, HongJun / Huang, YunYi / Guo, YanFang / Ye, MeiXin / Hou, LiPing

    Chemosphere

    2024  Volume 355, Page(s) 141876

    Abstract: Gestodene (GES) is widely used in human therapy and animal husbandry and is frequently detected in aquatic environments. Although GES adversely affects aquatic organisms at trace levels, its effects on the reproductive biology of fish remain inconclusive. ...

    Abstract Gestodene (GES) is widely used in human therapy and animal husbandry and is frequently detected in aquatic environments. Although GES adversely affects aquatic organisms at trace levels, its effects on the reproductive biology of fish remain inconclusive. In this study, female zebrafish (Danio rerio) were exposed to environmentally relevant levels of GES for the evaluation of the effects of GES on the reproductive system by using endpoints including gene expression, plasma steroid concentrations, histological and morphological analyses, copulatory behavior, and reproductive output. Adult female zebrafish exposed to environmentally relevant concentrations of GES (4.0, 40.2, and 372.7 ng/L) for 60 d demonstrated stagnant ovarian oocyte development, evidenced by an increase in the percentage of perinuclear and atretic oocytes and a decrease in the percentage of late vitellogenic oocytes. GES-exposed females were less attractive to males and had lower copulatory intimacy than females in control. Consequently, spawning (44.3-49.2 %) and egg fertilization rates (27.9-32.0 %) were decreased. The decreased survival of fertilized eggs and hatching rates were accompanied by increased malformations. These negative effects were associated with abnormal transcriptional levels of gonadal steroid hormones, which were regulated by genes (Hsd17β3, Hsd11β2, Hsd20β, Cyp19a1a, and Cyp11b). Overall, our findings suggest that GES impairs the reproductive system of zebrafish, which may threaten population stability.
    MeSH term(s) Animals ; Male ; Humans ; Female ; Zebrafish/metabolism ; Ovary ; Gonadal Steroid Hormones/metabolism ; Reproduction ; Water Pollutants, Chemical/metabolism ; Gonads ; Norpregnenes
    Chemical Substances Gestodene (1664P6E6MI) ; Gonadal Steroid Hormones ; Water Pollutants, Chemical ; Norpregnenes
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141876
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    Zs.A 2540: Show issues Location:
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  9. Article: Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application.

    Liu, Han / Wen, Zhiyang / Liu, Zihan / Yang, Yanfang / Wang, Hongliang / Xia, Xuejun / Ye, Jun / Liu, Yuling

    Acta pharmaceutica Sinica. B

    2023  Volume 14, Issue 2, Page(s) 602–622

    Abstract: Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and biodegradability. Calcium-based materials can also deliver contrast agents, which can enhance real-time imaging and exert ...

    Abstract Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and biodegradability. Calcium-based materials can also deliver contrast agents, which can enhance real-time imaging and exert a Ca
    Language English
    Publishing date 2023-09-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.08.027
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  10. Article ; Online: A Synergetic Strategy for Brand Characterization of Colla Corii Asini (Ejiao) by LIBS and NIR Combined with Partial Least Squares Discriminant Analysis.

    Xia, Ziyi / Che, Xiaoqing / Ye, Lei / Zhao, Na / Guo, Dongxiao / Peng, Yanfang / Lin, Yongqiang / Liu, Xiaona

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: A synergetic strategy was proposed to address the critical issue in the brand characterization ... ...

    Abstract A synergetic strategy was proposed to address the critical issue in the brand characterization of
    MeSH term(s) Discriminant Analysis ; Least-Squares Analysis ; Medicine, Chinese Traditional ; Spectroscopy, Near-Infrared/methods
    Chemical Substances colla corii asini
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041778
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    Zs.MO 81: Show issues

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