LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 613

Search options

  1. Article: Authentication of Fennel, Star Anise, and Anise Essential Oils by Gas Chromatography (GC/MS) and Stable Isotope Ratio (GC/IRMS) Analyses.

    Murphy, Brett J / Wilson, Tyler M / Ziebarth, Emma A / Bowerbank, Christopher R / Carlson, Richard E

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: The aromatic compound ( ...

    Abstract The aromatic compound (
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020214
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: A systematic review of mucoadhesive vaginal tablet testing.

    Abidin, Ismin Zainol / Murphy, Emma J / Fehrenbach, Gustavo Waltzer / Rezoagli, Emanuele / Gately, Noel / Major, Ian

    Drug target insights

    2023  Volume 17, Page(s) 5–30

    Language English
    Publishing date 2023-01-16
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2423820-X
    ISSN 1177-3928
    ISSN 1177-3928
    DOI 10.33393/dti.2023.2477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Examining Adaptation and Resilience Frameworks

    Ana Andries / Stephen Morse / Richard J. Murphy / Emma R. Woolliams

    Sustainability, Vol 15, Iss 13641, p

    Data Quality’s Role in Supporting Climate Efforts

    2023  Volume 13641

    Abstract: The current landscape of climate change adaptation and resilience policies, frameworks, and indicators is rapidly changing as nations, organizations, and individuals acknowledge the urgent need to address its impacts. Various methods for adaptation and ... ...

    Abstract The current landscape of climate change adaptation and resilience policies, frameworks, and indicators is rapidly changing as nations, organizations, and individuals acknowledge the urgent need to address its impacts. Various methods for adaptation and resilience are developed and monitored through formal indicators. However, there are gaps in indicator development and monitoring, including the need for more indicators to address monitoring gaps, lacks in the availability of fit-for-purpose (quality and quantity) data sets, and interpretation challenges. Especially at the local level, these gaps are pronounced. In this study, we assessed current policies, frameworks, and indicators, and conducted semi-structured interviews with stakeholders. A key concern raised was the difficulty in handling insufficient, quality data, particularly in developing nations, hindering adaptation implementation. Respondents also noted the lack of a standardised approach/tool for planning, monitoring, and evaluation. To address this, stakeholders advocated for local indicators and a unified approach/tool. Comparable and consistent data, collected by qualified personnel, were emphasised. Effective adaptation plans are vital in responding to climate change, yet challenges persist in planning, implementation, and monitoring, reporting, and verification phases. A recommended solution involves a common measurement approach for adaptation and resilience, alongside tailored local strategies to ensure success of these plans.
    Keywords climate change ; resilience ; adaptation ; indicators ; frameworks ; data ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.

    Bradshaw, William J / Kennedy, Emma C / Moreira, Tiago / Smith, Luke A / Chalk, Rod / Katis, Vittorio L / Benesch, Justin L P / Brennan, Paul E / Murphy, Emma J / Gileadi, Opher

    Structure (London, England : 1993)

    2024  Volume 32, Issue 4, Page(s) 453–466.e6

    Abstract: SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug target will require structural knowledge and the design of selective small molecules. We have ... ...

    Abstract SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug target will require structural knowledge and the design of selective small molecules. We have determined apo, and magnesium and phosphate-bound structures of the phosphatase and C2 domains of SHIP1. The C2 domains of SHIP1 and the related SHIP2 modulate the activity of the phosphatase domain. To understand the mechanism, we performed activity assays, hydrogen-deuterium exchange mass spectrometry, and molecular dynamics on SHIP1 and SHIP2. Our findings demonstrate that the influence of the C2 domain is more pronounced for SHIP2 than SHIP1. We determined 91 structures of SHIP1 with fragments bound, with some near the interface between the two domains. We performed a mass spectrometry screen and determined four structures with covalent fragments. These structures could act as starting points for the development of potent, selective probes.
    MeSH term(s) C2 Domains ; Inositol Polyphosphate 5-Phosphatases/metabolism ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/chemistry ; Phosphoric Monoester Hydrolases/metabolism ; Humans
    Chemical Substances Inositol Polyphosphate 5-Phosphatases (EC 3.1.3.56) ; INPP5D protein, human (EC 3.1.3.86) ; INPPL1 protein, human (EC 3.1.3.86) ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases (EC 3.1.3.86) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation.

    Foley, Nicole M / Harris, Andrew J / Bredemeyer, Kevin R / Ruedi, Manuel / Puechmaille, Sebastien J / Teeling, Emma C / Criscitiello, Michael F / Murphy, William J

    Cell genomics

    2024  Volume 4, Issue 2, Page(s) 100482

    Abstract: The emergence of COVID-19 and severe acute respiratory syndrome (SARS) has prioritized understanding bats' viral tolerance. Myotis bats are exceptionally species rich and have evolved viral tolerance. They also exhibit swarming, a cryptic behavior where ... ...

    Abstract The emergence of COVID-19 and severe acute respiratory syndrome (SARS) has prioritized understanding bats' viral tolerance. Myotis bats are exceptionally species rich and have evolved viral tolerance. They also exhibit swarming, a cryptic behavior where large, multi-species assemblages gather for mating, which has been hypothesized to promote interspecific hybridization. To resolve the coevolution of genome architecture and their unusual antiviral tolerance, we undertook a phylogenomic analysis of 60 Old World Myotis genomes. We demonstrate an extensive history of introgressive hybridization that has replaced the species phylogeny across 17%-93% of the genome except for pericentromeric regions of macrochromosomes. Introgression tracts were enriched on microchromosome regions containing key antiviral pathway genes overexpressed during viral challenge experiments. Together, these results suggest that the unusual Myotis karyotype may have evolved to selectively position immune-related genes in high recombining genomic regions prone to introgression of divergent alleles, including a diversity of interleukin loci responsible for the release of pro-inflammatory cytokines.
    MeSH term(s) Animals ; Chiroptera/genetics ; Genome ; Genomics ; Karyotype ; Antiviral Agents
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100482
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Sustainable production and pharmaceutical applications of β-glucan from microbial sources

    Murphy, Emma J. / Rezoagli, Emanuele / Collins, Catherine / Saha, Sushanta Kumar / Major, Ian / Murray, Patrick

    Microbiological Research. 2023 Sept., v. 274 p.127424-

    2023  

    Abstract: β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is ... ...

    Abstract β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is substantial clinical interest in β-glucans; as they can be used for a variety of diseases including cancer and cardiovascular conditions. Suitable sources of β-glucans for biopharmaceutical applications include bacteria, microalgae, mycelium, and yeast. Environmental factors including culture medium can influence the biomass and ultimately β-glucan content. Therefore, cultivation conditions for the above organisms can be controlled for sustainable enhanced production of β-glucans. This review discusses the various sources of β-glucans and their cultivation conditions that may be optimised to exploit sustainable production. Finally, this article discusses the immune-modulatory potential of β-glucans from these sources.
    Keywords barley ; biomass ; biopharmaceuticals ; culture media ; microalgae ; mycelium ; polysaccharides ; research ; yeasts ; β-glucan ; Micro-algae ; Yeast ; Fungi ; Bacteria ; Immune-modulation
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier GmbH
    Document type Article ; Online
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2023.127424
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide.

    Buckley, Ciara / Murphy, Emma J / Montgomery, Therese R / Major, Ian

    Polymers

    2022  Volume 14, Issue 17

    Abstract: The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of ... ...

    Abstract The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14173442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Impaired cognitive and motor function are coincident with L-DOPA-induced dyskinesia in a model of Parkinson's disease.

    Lelos, Mariah J / Murphy, Ellen M / Lindgren, Hanna S / Dunnett, Stephen B / Lane, Emma L

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17697

    Abstract: Dopamine transmission has been implicated in motor and cognitive function. In Parkinson's disease (PD), dopamine replacement using the precursor drug L-DOPA is the predominant treatment approach, but long-term exposure leads to the onset of dyskinesias ( ... ...

    Abstract Dopamine transmission has been implicated in motor and cognitive function. In Parkinson's disease (PD), dopamine replacement using the precursor drug L-DOPA is the predominant treatment approach, but long-term exposure leads to the onset of dyskinesias (LIDs). Chronic L-DOPA exposure has been associated with changes in gene expression and altered cortico-striatal plasticity. The aim of this research was to assess the functional consequence of long-term L-DOPA exposure on cognitive and motor function using a rodent model of PD. Across two independent experiments, we assessed the impact of chronic L-DOPA exposure, or a control D
    MeSH term(s) Rats ; Animals ; Levodopa/therapeutic use ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Dopamine/metabolism ; Rats, Sprague-Dawley ; Oxidopamine/metabolism ; Dyskinesia, Drug-Induced/metabolism ; Corpus Striatum/metabolism ; Cognition ; Disease Models, Animal
    Chemical Substances Levodopa (46627O600J) ; Dopamine (VTD58H1Z2X) ; Oxidopamine (8HW4YBZ748)
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44869-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Sustainable production and pharmaceutical applications of β-glucan from microbial sources.

    Murphy, Emma J / Rezoagli, Emanuele / Collins, Catherine / Saha, Sushanta Kumar / Major, Ian / Murray, Patrick

    Microbiological research

    2023  Volume 274, Page(s) 127424

    Abstract: β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is ... ...

    Abstract β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is substantial clinical interest in β-glucans; as they can be used for a variety of diseases including cancer and cardiovascular conditions. Suitable sources of β-glucans for biopharmaceutical applications include bacteria, microalgae, mycelium, and yeast. Environmental factors including culture medium can influence the biomass and ultimately β-glucan content. Therefore, cultivation conditions for the above organisms can be controlled for sustainable enhanced production of β-glucans. This review discusses the various sources of β-glucans and their cultivation conditions that may be optimised to exploit sustainable production. Finally, this article discusses the immune-modulatory potential of β-glucans from these sources.
    MeSH term(s) Humans ; beta-Glucans ; Agaricales ; Immunity ; Neoplasms ; Saccharomyces cerevisiae ; Pharmaceutical Preparations
    Chemical Substances beta-Glucans ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2023.127424
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Essential Oil Composition and Stable Isotope Profile of

    Wilson, Tyler M / Murphy, Brett J / Ziebarth, Emma A / Poulson, Ariel / Packer, Chris / Carlson, Richard E

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 20

    Abstract: Osmorhiza ... ...

    Abstract Osmorhiza occidentalis
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11202685
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top