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  1. Article ; Online: Qualitative Evaluation of α-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder.

    Preethy, Senthilkumar / Raghavan, Kadalraja / Ikewaki, Nobunao / Abraham, Samuel J K

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2022  Volume 32, Issue 1, Page(s) 96–97

    MeSH term(s) Humans ; Autism Spectrum Disorder ; alpha-Synuclein ; Qualitative Research
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000527728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antibody dependent disease enhancement (ADE) after COVID-19 vaccination and beta glucans as a safer strategy in management.

    Ikewaki, Nobunao / Kurosawa, Gene / Levy, Gary A / Preethy, Senthilkumar / Abraham, Samuel J K

    Vaccine

    2023  Volume 41, Issue 15, Page(s) 2427–2429

    Abstract: A potential risk associated with vaccines for COVID-19 is antibody-dependent disease enhancement (ADE) in which vaccine induced antibody mediated immune responses may lead to enhanced SARS CoV- 2 acquisition or increased disease severity. Though ADE has ... ...

    Abstract A potential risk associated with vaccines for COVID-19 is antibody-dependent disease enhancement (ADE) in which vaccine induced antibody mediated immune responses may lead to enhanced SARS CoV- 2 acquisition or increased disease severity. Though ADE has not been clinically demonstrated with any of the COVID-19 vaccines so far, when neutralizing antibodies are suboptimal, the severity of COVID-19 has been reported to be greater. ADE is presumed to occur via abnormal macrophages induced by the vaccine based immune response by antibody-mediated virus uptake into Fc gamma receptor IIa (FcγRIIa) or by the formation of Fc-mediated excessive antibody effector functions. Beta-glucans which are naturally occurring polysaccharides known for unique immunomodulation by capability to interact with macrophages, eliciting a specific beneficial immune-response and enhancing all arms of the immune system, importantly without over-activation are suggested as safer nutritional supplement-based vaccine adjuvants for COVID-19.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; beta-Glucans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Immunoglobulin Fc Fragments ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; beta-Glucans ; COVID-19 Vaccines ; Immunoglobulin Fc Fragments
    Language English
    Publishing date 2023-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 458: Show issues

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  3. Article ; Online: Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight COVID-19.

    Ikewaki, Nobunao / Kurosawa, Gene / Kisaka, Tomohiko / Abraham, Samuel J K

    Journal of food biochemistry

    2022  Volume 46, Issue 7, Page(s) e14156

    Abstract: Immune modulation, being one of the potential strategies to combat COVID-19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)-glucans have been suggested as nonspecific immunostimulatory adjuvants to ...

    Abstract Immune modulation, being one of the potential strategies to combat COVID-19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)-glucans have been suggested as nonspecific immunostimulatory adjuvants to beneficially boost protective antiviral immunity. Through this article, we wish to emphasize that β-glucans not only enhance the innate immunity but also possess the capability to modulate all the arms of the immunity viz., innate, adaptive, TRIM at different sites including those postulated to be the entry site of the SARS-CoV2. Other than immune modulation capabilities, the beneficial metabolic- and coagulation-related effects of β-glucans, a simple nutritional supplementation strategy, make them be considered for larger clinical studies to validate their prophylactic vaccine adjuvant and nutritional-based therapeutic supplement activities to effectively fight the COVID-19 pandemic. PRACTICAL APPLICATIONS: A 360° wholesome protection from viral infections is possible only when all the arms of the immune system function in a balanced and effective manner which is especially important in COVID-19. Nutritional supplementation using biological response modifier beta (β)-glucans (BRMGs) is worth considering for large-scale clinical studies based on their track record of safety and their beneficial regulation of all the arms of the immune system.
    MeSH term(s) Adjuvants, Immunologic ; COVID-19 ; Dietary Supplements ; Glucans ; Humans ; Immunity, Innate ; Pandemics/prevention & control ; RNA, Viral ; SARS-CoV-2 ; beta-Glucans/pharmacology ; beta-Glucans/therapeutic use
    Chemical Substances Adjuvants, Immunologic ; Glucans ; RNA, Viral ; beta-Glucans
    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14156
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    Z 3310: Show issues

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  4. Article ; Online: Commentary: Beyond "TRIM" Benefits of β-Glucan by Blood Glucose and Lipid Balancing Potentials in Its Defense Against COVID-19.

    Ikewaki, Nobunao / Dedeepiya, Vidyasagar Devaprasad / Iwasaki, Masaru / Abraham, Samuel J K

    Frontiers in immunology

    2021  Volume 12, Page(s) 620658

    MeSH term(s) Blood Glucose ; COVID-19 ; Humans ; Lipids ; SARS-CoV-2 ; beta-Glucans
    Chemical Substances Blood Glucose ; Lipids ; beta-Glucans
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.620658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients.

    Ikewaki, Nobunao / Iwasaki, Masaru / Abraham, Samuel J K

    Journal of diabetes and metabolic disorders

    2020  Volume 19, Issue 2, Page(s) 2041–2044

    Abstract: With the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor ...

    Abstract With the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeast
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-020-00664-4
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  6. Article: Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight COVID‐19

    Ikewaki, Nobunao / Kurosawa, Gene / Kisaka, Tomohiko / Abraham, Samuel J. K.

    Journal of food biochemistry. 2022 July, v. 46, no. 7

    2022  

    Abstract: Immune modulation, being one of the potential strategies to combat COVID‐19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)‐glucans have been suggested as nonspecific immunostimulatory adjuvants to ...

    Abstract Immune modulation, being one of the potential strategies to combat COVID‐19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)‐glucans have been suggested as nonspecific immunostimulatory adjuvants to beneficially boost protective antiviral immunity. Through this article, we wish to emphasize that β‐glucans not only enhance the innate immunity but also possess the capability to modulate all the arms of the immunity viz., innate, adaptive, TRIM at different sites including those postulated to be the entry site of the SARS‐CoV2. Other than immune modulation capabilities, the beneficial metabolic‐ and coagulation‐related effects of β‐glucans, a simple nutritional supplementation strategy, make them be considered for larger clinical studies to validate their prophylactic vaccine adjuvant and nutritional‐based therapeutic supplement activities to effectively fight the COVID‐19 pandemic. PRACTICAL APPLICATIONS: A 360° wholesome protection from viral infections is possible only when all the arms of the immune system function in a balanced and effective manner which is especially important in COVID‐19. Nutritional supplementation using biological response modifier beta (β)‐glucans (BRMGs) is worth considering for large‐scale clinical studies based on their track record of safety and their beneficial regulation of all the arms of the immune system.
    Keywords COVID-19 infection ; dietary supplements ; immune system ; immunomodulation ; immunostimulants ; innate immunity ; therapeutics ; vaccine adjuvants
    Language English
    Dates of publication 2022-07
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14156
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  7. Article ; Online: Integrating the Synergy of the Gut Microbiome into Regenerative Medicine: Relevance to Neurological Disorders.

    Preethy, Senthilkumar / Ranganathan, Natarajan / Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Ikewaki, Nobunao / Abraham, Samuel J K

    Journal of Alzheimer's disease : JAD

    2022  Volume 87, Issue 4, Page(s) 1451–1460

    Abstract: A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further ... ...

    Abstract A new paradigm of cell therapy-based approaches as a solution to several diseases caused by damage or loss of cells/tissues leading to organ failure heralded the birth of a new branch in medicine called regenerative medicine (RM), which was further fueled by in vitro cell expansion and tissue engineering (TE) technologies, including the ability to grow embryonic stem cells, induce pluripotent stem cells, and so on. RM addresses organ failure by repair, regeneration, or restoration, rejuvenation using cells, stem cells, or progenitor cells as tools having added cell-derived products also as a tool, and extracellular matrix component-based support, either direct or indirect (e.g., matrix induced autologous chondrocyte implantation) using scaffolds. Now, the main objective of RM is to solve the functional loss of cells that have evolved from cells as tools to cell-derived factors and scaffolds per se as tools. In this context, an important yet indispensable group of cells that constitute the major portion of the human body in terms of the number of cells having several essential roles to play, both directly and indirectly, starting from digestion and the immune system to the growing evidence of influencing neuronal function, aging, and carcinogenesis has been ignored. We would like to focus on these in this review as they should essentially be considered as a tool of RM, especially for neurological disorders for their vital role. What we are indicating is the second genome or the gut microbiome.
    MeSH term(s) Gastrointestinal Microbiome ; Humans ; Nervous System Diseases/therapy ; Regenerative Medicine ; Stem Cells ; Tissue Engineering
    Language English
    Publishing date 2022-05-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Potentials to alleviate coagulopathy and enhance microglial function of beta (β)- glucans, making them worth a clinical study for COVID-19's neurological sequalae.

    Raghavan, Kadalraja / Kandaswamy, Ramesh Shankar / Ikewaki, Nobunao / Iwasaki, Masaru / Abraham, Samuel J K

    Journal of the neurological sciences

    2021  Volume 427, Page(s) 117554

    MeSH term(s) COVID-19 ; Humans ; Microglia ; SARS-CoV-2 ; beta-Glucans
    Chemical Substances beta-Glucans
    Language English
    Publishing date 2021-06-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2021.117554
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  9. Article ; Online: Corrigendum to "Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study" [IBRO Neurosci. Rep. 15 (2023), pp. 90-99].

    Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Srinivasan, Subramaniam / Pushkala, Subramanian / Bharatidasan, Sudhakar S / Ikewaki, Nobunao / Iwasaki, Masaru / Senthilkumar, Rajappa / Preethy, Senthilkumar / Abraham, Samuel J K

    IBRO neuroscience reports

    2023  Volume 15, Page(s) 149–150

    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomised, parallel-group pilot clinical study.

    Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Ikewaki, Nobunao / Sonoda, Tohru / Iwasaki, Masaru / Preethy, Senthilkumar / Abraham, Samuel Jk

    BMJ neurology open

    2022  Volume 4, Issue 1, Page(s) e000203

    Abstract: Background: Autism spectrum disorders (ASDs) are a wide range of behavioural disabilities for which there are no definite interventional modalities available. Remedial therapies remain the only option but with varying outcomes. We have evaluated the ... ...

    Abstract Background: Autism spectrum disorders (ASDs) are a wide range of behavioural disabilities for which there are no definite interventional modalities available. Remedial therapies remain the only option but with varying outcomes. We have evaluated the Childhood Autism Rating Scale (CARS) and alpha-synuclein levels in this parallel-group, multiple-arm pilot clinical study after supplementation with a biological response modifier beta-glucan food supplement (Nichi Glucan).
    Methods: Six subjects with ASD (n=6) Gr. 1 underwent conventional treatment comprising remedial behavioural therapies and L-carnosine 500 mg per day, and 12 subjects (n=12) Gr. 2 underwent supplementation with the Nichi Glucan 0.5 g two times per day along with the conventional treatment.
    Results: There was a significant decrease in the CARS score in all of the children of the Nichi Glucan Gr.2 compared with the control (p=0.034517). Plasma levels of alpha-synuclein were significantly higher in Gr. 2 (Nichi Glucan) than in the control group Gr. 1 (p=0.091701).
    Conclusion: Improvement of the behavioural pattern CARS score and a correlating alpha-synuclein level, followed by a safe beta-glucan food supplement, warrants further research on other parameters, such as gut-microbiota evaluation, and relevant neuronal biomarkers which is likely to cast light on novel solutions.
    Language English
    Publishing date 2022-01-18
    Publishing country England
    Document type Journal Article
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2021-000203
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