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Article: The meaning of negative DAT SPECT and F-Dopa PET scans in patients with clinical Parkinson's disease.

Morrish, Paul

Movement disorders : official journal of the Movement Disorder Society

2005 Volume 20, Issue 1, Page(s) 117; author reply 117–8

MeSH term(s)	Dopamine Plasma Membrane Transport Proteins ; Humans ; Levodopa/pharmacokinetics ; Membrane Glycoproteins/metabolism ; Membrane Transport Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacokinetics ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Dopamine Plasma Membrane Transport Proteins ; Membrane Glycoproteins ; Membrane Transport Proteins ; Nerve Tissue Proteins ; Radiopharmaceuticals ; SLC6A3 protein, human ; Levodopa (46627O600J)
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.20304
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Article ; Online: The effect of trisodium phosphate crosslinking on the diffusion kinetics of caffeine from chitosan networks.

Morrish, Courtney / Whitehead, Felicity / Istivan, Taghrid / Kasapis, Stefan

Food chemistry

2022 Volume 381, Page(s) 132272

Abstract: This work examines the relationship between microstructural properties of hot-moulded chitosan networks, crosslinked with trisodium phosphate, and diffusive behaviour from these networks. Analysis through infrared spectroscopy (FTIR) confirmed successful ...

Abstract	This work examines the relationship between microstructural properties of hot-moulded chitosan networks, crosslinked with trisodium phosphate, and diffusive behaviour from these networks. Analysis through infrared spectroscopy (FTIR) confirmed successful crosslinking of the polymer chains and bioactive entrapment, while X-ray diffraction (WAXD) and dynamic oscillation in-shear elucidated the higher order structural properties of each matrix, as they transitioned from solutions to amorphous gels to semi-crystalline matrices. The picture of molecular motion observed in these systems and consequent application of the Flory-Rehner theory further indicated that different extents of chitosan crosslinking yielded a distinct water infusion functionality seen in the levels of swelling. Diffusion of caffeine from these delivery vehicles showed that network structural properties (governed by crosslinker concentration) had a significant effect on the release kinetics of the entrapped bioactive. The relationship between network mesh characteristics and diffusion properties were further confirmed by correlating caffeine release rates and molecular pore size.
MeSH term(s)	Caffeine ; Chitosan/chemistry ; Cross-Linking Reagents/chemistry ; Diffusion ; Kinetics ; Phosphates ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Chemical Substances	Cross-Linking Reagents ; Phosphates ; Caffeine (3G6A5W338E) ; Chitosan (9012-76-4) ; sodium phosphate (SE337SVY37)
Language	English
Publishing date	2022-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.132272
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Article: Reversal of Bilateral Sudden Deafness with Thrombectomy.

Morrish, Rosalie E / Joundi, Raed A / d'Esterre, Christopher D / McDougall, Connor C / Morrish, William F / Barber, Philip A

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 48, Issue 6, Page(s) 854

MeSH term(s)	Brain Ischemia ; Endovascular Procedures ; Hearing Loss, Sudden/etiology ; Hearing Loss, Sudden/surgery ; Humans ; Stroke ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2021.14
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Article: Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study.

Rakshi, J S / Uema, T / Ito, K / Bailey, D L / Morrish, P K / Ashburner, J / Dagher, A / Jenkins, I H / Friston, K J / Brooks, D J

Brain : a journal of neurology

1999 Volume 122 Pt 9, Page(s) 1637–1650

Abstract: ... advanced Parkinson's disease by applying statistical parametric mapping (SPM) to 3D [(18)F]dopa-PET. Data ... compared with that from 12 normal controls. Parametric images of [(18)F]dopa influx rate constant (K(i)(o ... were generated for each subject from dynamic 3D [(18)F]dopa datasets and transformed into standard ...

Abstract	We have studied focal changes in dopaminergic function throughout the brain volume in early and advanced Parkinson's disease by applying statistical parametric mapping (SPM) to 3D [(18)F]dopa-PET. Data from seven early hemi-Parkinson's disease and seven advanced bilateral Parkinson's disease patients were compared with that from 12 normal controls. Parametric images of [(18)F]dopa influx rate constant (K(i)(o)) were generated for each subject from dynamic 3D [(18)F]dopa datasets and transformed into standard stereotactic space. Significant changes in mean voxel [(18)F]dopa K(i)(o) values between the normal control group and each Parkinson's disease group were localized with SPM. Conventional region of interest analysis was also applied to comparable regions on the untransformed image datasets. In early left hemi-Parkinson's disease, significant extrastriatal increases in [(18)F]dopa K(i)(o) were observed in the left anterior cingulate gyrus and the dorsal midbrain region (P < 0.05, corrected) along with decreases in striatal [(18)F]dopa K(i)(o). In advanced Parkinson's disease, significant extrastriatal decreases in [(18)F]dopa K(i)(o) were observed in the ventral and dorsal midbrain regions (P < 0.05, corrected). No significant changes in [(18)F]dopa K(i)(o) were observed in the anterior cingulate region. In a direct comparison between the early and late Parkinson's disease groups, we observed relative [(18)F]dopa K(i)(o) reductions in ventral and dorsal midbrain, and dorsal pontine regions along with striatal [(18)F]dopa K(i)(o) reductions. Similiar results were found with a region of interest approach, on non-transformed data, except for the focal midbrain [(18)F]dopa K(i)(o) increase seen in early Parkinson's disease. In conclusion, using SPM with [(18)F]dopa-PET, we have objectively localized changes in extrastriatal, pre-synaptic dopaminergic function in Parkinson's disease. The significance of the increased dopaminergic activity of anterior cingulate in early Parkinson's disease remains unclear, but may be compensatory. The [(18)F]dopa signal in dorsal midbrain and pontine regions suggests that [(18)F]dopa is taken up by serotonergic and noradrenergic neurons which also degenerate in advanced Parkinson's disease. This suggests, therefore, that Parkinson's disease is a monoaminergic neurodegenerative disorder.
MeSH term(s)	Biological Transport ; Brain Mapping ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Dihydroxyphenylalanine/analogs & derivatives ; Dihydroxyphenylalanine/pharmacokinetics ; Fluorine Radioisotopes/pharmacokinetics ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/metabolism ; Functional Laterality ; Humans ; Mesencephalon/diagnostic imaging ; Mesencephalon/metabolism ; Middle Aged ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; Reference Values ; Software ; Tissue Distribution ; Tomography, Emission-Computed
Chemical Substances	Fluorine Radioisotopes ; fluorodopa F 18 (2C598205QX) ; Dihydroxyphenylalanine (63-84-3)
Language	English
Publishing date	1999-09
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	0006-8950
ISSN	0006-8950
DOI	10.1093/brain/122.9.1637
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Article: Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (

Morrish, Fionnuala / Gingras, Helene / Noonan, Joanna / Huang, Li / Sweet, Ian R / Kuok, Iok Teng / Knoblaugh, Sue E / Hockenbery, David M

bioRxiv : the preprint server for biology

2023

Abstract: Genetic polymorphisms in nuclear respiratory factor-1 ( ...

Abstract	Genetic polymorphisms in nuclear respiratory factor-1 (
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.22.524153
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Article ; Online: micRo-manageMeNT of MYC during hypoxia.

Morrish, Fionnuala

Cell cycle (Georgetown, Tex.)

2009 Volume 8, Issue 18, Page(s) 2865

MeSH term(s)	Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/physiology ; Cell Survival ; Gene Expression Regulation ; Hypoxia/genetics ; MicroRNAs/physiology ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/physiology ; Repressor Proteins/physiology
Chemical Substances	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; MNT protein, human ; MicroRNAs ; Proto-Oncogene Proteins c-myc ; Repressor Proteins
Language	English
Publishing date	2009-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.8.18.9722
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Article: Single Cell Label-Free Probing of Chromatin Dynamics During B Lymphocyte Maturation.

Morrish, Rikke / Yim, Kevin Ho Wai / Pagliara, Stefano / Palombo, Francesca / Chahwan, Richard / Stone, Nicholas

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 646616

Abstract: Large-scale intracellular signaling during developmental growth or in response to environmental alterations are largely orchestrated by chromatin within the cell nuclei. Chemical and conformational modifications of the chromatin architecture are critical ...

Abstract	Large-scale intracellular signaling during developmental growth or in response to environmental alterations are largely orchestrated by chromatin within the cell nuclei. Chemical and conformational modifications of the chromatin architecture are critical steps in the regulation of differential gene expression and ultimately cell fate determination. Therefore, establishing chemical properties of the nucleus could provide key markers for phenotypic characterization of cellular processes on a scale of individual cells. Raman microscopy is a sensitive technique that is capable of probing single cell chemical composition-and sub-cellular regions-in a label-free optical manner. As such, it has great potential in both clinical and basic research. However, perceived limitations of Raman spectroscopy such as low signal intensity and the difficulty in linking alterations in vibrational signals directly with ensuing biological effects have hampered advances in the field. Here we use immune B lymphocyte development as a model to assess chromatin and transcriptional changes using confocal Raman microscopy in combination with microfluidic devices and correlative transcriptomics, thereby linking changes in chemical and structural properties to biological outcomes. Live B lymphocytes were assessed before and after maturation. Multivariate analysis was applied to distinguish cellular components within each cell. The spectral differences between non-activated and activated B lymphocytes were then identified, and their correlation with known intracellular biological changes were assessed in comparison to conventional RNA-seq analysis. Our data shows that spectral analysis provides a powerful tool to study gene activation that can complement conventional molecular biology techniques and opens the way for mapping the dynamics in the biochemical makeup of individual cells.
Language	English
Publishing date	2021-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.646616
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Article ; Online: MYC and mitochondrial biogenesis.

Morrish, Fionnuala / Hockenbery, David

Cold Spring Harbor perspectives in medicine

2014 Volume 4, Issue 5

Abstract: Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of ... ...

Abstract	Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction, energy status, temperature). MYC provides the clearest example of a programmed expansion of mitochondrial content linked to the cell cycle. As an oncogene, MYC also presents intriguing questions about the role of its mitochondrial targets in cancer-related phenotypes, such as the Warburg effect and MYC-dependent apoptosis.
MeSH term(s)	Cell Proliferation/genetics ; Genes, myc/physiology ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Turnover/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Transcriptome/genetics
Chemical Substances	Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2014-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a014225
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Article ; Online: Carotid artery stenting: the dust has not yet settled.

Almekhlafi, Mohammed A / Morrish, William F / Hill, Michael D

The Canadian journal of cardiology

2014 Volume 30, Issue 1, Page(s) 14–15

MeSH term(s)	Blood Vessel Prosthesis Implantation/methods ; Carotid Arteries/surgery ; Carotid Stenosis/surgery ; Humans ; Stents ; Stroke/prevention & control
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2013.09.011
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Article ; Online: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.

Jaeger-Ruckstuhl, Carla A / Lo, Yun / Fulton, Elena / Waltner, Olivia G / Shabaneh, Tamer B / Simon, Sylvain / Muthuraman, Pranav V / Correnti, Colin E / Newsom, Oliver J / Engstrom, Ian A / Kanaan, Sami B / Bhise, Shruti S / Peralta, Jobelle M C / Ruff, Raymond / Price, Jason P / Stull, Sylvia M / Stevens, Andrew R / Bugos, Grace / Kluesner, Mitchell G /

Voillet, Valentin / Muhunthan, Vishaka / Morrish, Fionnuala / Olson, James M / Gottardo, Raphaël / Sarthy, Jay F / Henikoff, Steven / Sullivan, Lucas B / Furlan, Scott N / Riddell, Stanley R

Immunity

2024 Volume 57, Issue 2, Page(s) 287–302.e12

Abstract: The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive ... ...

Abstract	The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8
MeSH term(s)	TNF Receptor-Associated Factor 2/genetics ; TNF Receptor-Associated Factor 2/metabolism ; CD28 Antigens/metabolism ; Gene Regulatory Networks ; Signal Transduction ; Lymphocyte Activation ; Receptors, Antigen, T-Cell/metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism ; CD27 Ligand/genetics ; CD27 Ligand/metabolism ; CD8-Positive T-Lymphocytes
Chemical Substances	TNF Receptor-Associated Factor 2 ; CD28 Antigens ; Receptors, Antigen, T-Cell ; Tumor Necrosis Factor Receptor Superfamily, Member 7 ; CD27 Ligand
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2024.01.011
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Zs.MG 69: Show issues

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