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Article ; Online: Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients.

ElFihry, Raouia / Elmessaoudi-Idrissi, Mohcine / Jadid, Fatima-Zahra / Zaidane, Imane / Chihab, Hajar / Tahiri, Mohamed / Kabine, Mostafa / Badre, Wafaa / Chemin, Isabelle / Marchio, Agnes / Pineau, Pascal / Ezzikouri, Sayeh / Benjelloun, Soumaya

Virologica Sinica

2020 Volume 35, Issue 5, Page(s) 566–574

Abstract: Hepatitis C virus (HCV) is still one of the main causes of liver disease worldwide. Metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), induced by HCV have been shown to accelerate the progression of fibrosis to cirrhosis and to ... ...

Abstract	Hepatitis C virus (HCV) is still one of the main causes of liver disease worldwide. Metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), induced by HCV have been shown to accelerate the progression of fibrosis to cirrhosis and to increase the risk of hepatocellular carcinoma. An optimal peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) activity is crucial to prevent NAFLD installation. The present study aims to investigate the associations between two common PPARGC1A polymorphisms (rs8192678 and rs12640088) and the outcomes of HCV infection in a North African context. A series of 592 consecutive Moroccan subjects, including 292 patients with chronic hepatitis C (CHC), 100 resolvers and 200 healthy controls were genotyped using a TaqMan allelic discrimination assay. PPARGC1A variations at rs8192678 and rs12640088 were not associated with spontaneous clearance of HCV infection (adjusted ORs = 0.76 and 0.79 respectively, P > 0.05, for both). Furthermore, multivariable logistic regression analysis showed that both SNPs were not associated with fibrosis progression (OR = 0.71; 95% CI 0.20-2.49; P = 0.739; OR = 1.28; 95% CI 0.25-6.54; P = 0.512, respectively). We conclude that, in the genetic context of South Mediterranean patients, rs8192678 and rs12640088 polymorphisms of PPARGC1A are neither associated with spontaneous clearance nor with disease progression in individuals infected with HCV.
MeSH term(s)	Carcinoma, Hepatocellular ; Female ; Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic ; Humans ; Infant, Newborn ; Liver Cirrhosis ; Liver Neoplasms ; Male ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptors ; Polymorphism, Single Nucleotide
Chemical Substances	Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Peroxisome Proliferator-Activated Receptors
Language	English
Publishing date	2020-04-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1007/s12250-020-00220-7
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Article ; Online: Enrichment in selected genotypes, basal core and precore mutations of hepatitis B virus in patients with hepatocellular carcinoma in Cameroon.

Atsama Amougou, Marie / Marchio, Agnes / Bivigou-Mboumba, Berthold / Noah Noah, Dominique / Banai, Robert / Atangana, Paul Jean Adrien / Fewou Moundipa, Paul / Pineau, Pascal / Njouom, Richard

Journal of viral hepatitis

2019 Volume 26, Issue 9, Page(s) 1086–1093

Abstract: Worldwide, the development of hepatocellular carcinoma (HCC) is known to be influenced by several hepatitis B viral factors. However, the effect of hepatitis B virus (HBV) genotypes and a landscape of nucleotide changes affecting the precore (PC) and ... ...

Abstract	Worldwide, the development of hepatocellular carcinoma (HCC) is known to be influenced by several hepatitis B viral factors. However, the effect of hepatitis B virus (HBV) genotypes and a landscape of nucleotide changes affecting the precore (PC) and basal core promoter (BCP) during infection leading to HCC remain largely unknown in the Central Africa region. Thus, we performed a case-control study on patients with HBV-related HCC and matched controls without HCC but with chronic HBV infection. Genotypes and mutation spectrums were evaluated using a hemi-nested amplification and sequencing analysis focused on the BCP and PC regions. We identified the co-circulation of HBV quasi-subgenotype A3 (QS-A3) and genotype E in both groups. Interestingly, HBV-QS-A3 was significantly more prevalent in patients with HCC (80.0%) than in controls (31.9%, P = 4.5 E-7, OR = 11.5, 95% CI: 3.8-38.5). HBV mutation spectra and nucleotide changes were significantly more polymorphic in patients with HCC. Remarkably, HCC patients infected with HBV-QS-A3 were significantly more mutated compared to patients infected with genotype E (P < 0.0001). In addition, G:C>T:A transversions, generally associated with aflatoxin B1 exposure in tropical regions, were significantly more prevalent in HCC patients infected either with HBV-QS-A3 or HBV genotype E (P = 2.2 E-05) when compared to controls. In conclusion, our results indicate that patients infected with HBV-QS-A3 are at increased risk to develop HCC. In addition, viral genomes isolated for patients with tumour are more heavily altered than those found in controls. Preferential targeting of these patients for antiviral treatment is of paramount importance to reduce future HCC incidence in Cameroon.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cameroon/epidemiology ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/virology ; Case-Control Studies ; Child ; DNA, Viral/genetics ; Female ; Genotype ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/epidemiology ; Humans ; Incidence ; Liver Neoplasms/epidemiology ; Liver Neoplasms/virology ; Male ; Middle Aged ; Mutation ; Promoter Regions, Genetic ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2019-07-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212497-7
ISSN	1365-2893 ; 1352-0504
ISSN (online)	1365-2893
ISSN	1352-0504
DOI	10.1111/jvh.13131
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Article: HCV Defective Genomes Promote Persistent Infection by Modulating the Viral Life Cycle.

Karamichali, Eirini / Chihab, Hajar / Kakkanas, Athanassios / Marchio, Agnes / Karamitros, Timokratis / Pogka, Vasiliki / Varaklioti, Agoritsa / Kalliaropoulos, Antonis / Martinez-Gonzales, Beatrice / Foka, Pelagia / Koskinas, Ioannis / Mentis, Andreas / Benjelloun, Soumaya / Pineau, Pascal / Georgopoulou, Urania

Frontiers in microbiology

2018 Volume 9, Page(s) 2942

Abstract: Defective interfering (DI) RNAs have been detected in several human viruses. HCV in-frame deletions mutants (IFDMs), missing mainly the envelope proteins, have been found in patient sera and liver tissues. IFDMs replicate independently and can ... ...

Abstract	Defective interfering (DI) RNAs have been detected in several human viruses. HCV in-frame deletions mutants (IFDMs), missing mainly the envelope proteins, have been found in patient sera and liver tissues. IFDMs replicate independently and can be
Language	English
Publishing date	2018-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2018.02942
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Article ; Online: Programmed cell death-1 3'-untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection.

Chihab, Hajar / Jadid, Fatima-Zahra / Foka, Pelagia / Zaidane, Imane / El Fihry, Raouia / Georgopoulou, Urania / Marchio, Agnes / Elhabazi, Abdellah / Chair, Mohammed / Pineau, Pascal / Ezzikouri, Sayeh / Benjelloun, Soumaya

Journal of medical virology

2018 Volume 90, Issue 11, Page(s) 1730–1738

Abstract: Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown ... ...

Abstract	Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3'-untranslated region (3'-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.
MeSH term(s)	3' Untranslated Regions ; Adult ; Aged ; Female ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Genotype ; Hepatitis B/genetics ; Hepatitis B/immunology ; Hepatitis B virus/immunology ; Humans ; Male ; Middle Aged ; Morocco ; Polymorphism, Single Nucleotide ; Programmed Cell Death 1 Receptor/genetics
Chemical Substances	3' Untranslated Regions ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2018-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25265
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Article ; Online: Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients.

Jadid, Fatima Zahra / Chihab, Hajar / Alj, Hanane Salih / Elfihry, Raouia / Zaidane, Imane / Tazi, Sanaa / Badre, Wafaa / Marchio, Agnes / El Filali, Kamal Marhoum / Tahiri, Mohammed / Saile, Rachid / Pineau, Pascal / Ezzikouri, Sayeh / Benjelloun, Soumaya

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2018 Volume 66, Page(s) 1–8

Abstract: Background & aims: Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate ... ...

Abstract	Background & aims: Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate in the progression of liver disease. The present study aims to investigate the influence of two functional polymorphisms on SOCS3 mRNA expression and on the outcomes of CHC progression in a North African context. Patients & methods: In this case-control study, 601 Moroccan subjects composed of 200 healthy controls, 101 resolvers and 300 patients with persistent HCV infection including 95 mild chronic hepatitis, 131 Advanced Liver Diseases and 74 HCC were enrolled. They were genotyped for the 4874 A/G (rs4969170) and A + 930- > G (rs4969168) SOCS3 variants using TaqMan SNPs assays. SOCS3 mRNA expression was assessed using Real Time PCR technique. Results: Logistic regression analysis showed that variation at rs4969168 was associated with spontaneous clearance of HCV (P < 0.05). In addition, minor allele frequencies were significantly higher in AdLD patients when compared to the mCHC group both for rs4969168 (P = 7.0 E-04) and rs4969170 (P = 4.0 E-05). A significant association between haplotype and liver disease progression was also found. Moreover, SOCS3 mRNA was significantly more expressed in peripheral leukocytes from patients with HCC than in those from mCHC. Finally, rs4969170 was significantly associated with LDL-lipoprotein (P = 0.04), total cholesterol (P = 5.0 E-04), and higher fasting glucose levels (P = 0.005) in patients with persistent HCV infection. Conclusions: Our results underline the importance of the functional SOCS3 polymorphisms in the modulation of CHC progression and suggest their contribution to HCC development by affecting its mRNA expression and perturbing key metabolic parameters.
MeSH term(s)	Alleles ; Biomarkers ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Disease Progression ; Female ; Gene Expression Regulation ; Gene Frequency ; Genetic Linkage ; Genetic Predisposition to Disease ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/virology ; Humans ; Linkage Disequilibrium ; Liver Cirrhosis/etiology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Neoplasms/etiology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Viral Load
Chemical Substances	Biomarkers ; SOCS3 protein, human ; Suppressor of Cytokine Signaling 3 Protein
Language	English
Publishing date	2018-08-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2018.08.027
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Article ; Online: Anti-COVID-19 efficacy of ivermectin in the golden hamster

de Melo, Guilherme Dias / Lazarini, Françoise / Larrous, Florence / Feige, Lena / Kergoat, Lauriane / Marchio, Agnes / Pineau, Pascal / Lecuit, Marc / Lledo, Pierre-Marie / Changeux, Jean-Pierre / Bourhy, Herve

bioRxiv

Abstract: The devastating coronavirus disease 2019 (COVID-19) pandemic, due to SARS-CoV-2, has caused more than 47 million confirmed cases and more than 1.2 million human deaths around the globe, and most of the severe cases of COVID-19 in humans are associated ... ...

Abstract	The devastating coronavirus disease 2019 (COVID-19) pandemic, due to SARS-CoV-2, has caused more than 47 million confirmed cases and more than 1.2 million human deaths around the globe, and most of the severe cases of COVID-19 in humans are associated with neurological symptoms such as anosmia and ageusia, and uncontrolled inflammatory immune response. Among therapeutic options, the use of the anti-parasitic drug ivermectin (IVM), has been proposed, given its possible anti-SARS-CoV-2 activity. Ivermectin is a positive allosteric modulator of the alpha-7 nicotinic acetylcholine receptor, which has been suggested to represent a target for the control of Covid-19 infection, with a potential immunomodulatory activity. We assessed the effects of IVM in SARS-CoV-2-intranasally-inoculated golden Syrian hamsters. Even though ivermectin had no effect on viral load, SARS-Cov-2-associated pathology was greatly attenuated. IVM had a sex-dependent and compartmentalized immunomodulatory effect, preventing clinical deterioration and reducing olfactory deficit in infected animals. Importantly, ivermectin dramatically reduced the Il-6/Il-10 ratio in lung tissue, which likely accounts for the more favorable clinical presentation in treated animals. Our data support IVM as a promising anti-COVID-19 drug candidate.
Keywords	covid19
Language	English
Publishing date	2020-11-22
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2020.11.21.392639
Database	COVID19

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Article: Influence of hepatitis viruses on clinicopathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma.

Tanase, Anna-Maria / Dumitrascu, Traian / Dima, Simona / Grigorie, Razvan / Marchio, Agnes / Pineau, Pascal / Popescu, Irinel

Hepatobiliary & pancreatic diseases international : HBPD INT

2014 Volume 13, Issue 2, Page(s) 162–172

Abstract: Background: The global risk of hepatocellular carcinoma (HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the ...

Abstract	Background: The global risk of hepatocellular carcinoma (HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. Methods: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). Results: The patients of both HBV (56.0+/-11.3 years) and HBCV groups (56.0+/-9.9 years) were significantly younger than those of the HCV (61.0+/-8.5 years, P=0.001) and non-BC groups (61.0+/-13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%) than in any other subsets (72%-90%, P<0.002). Furthermore, the non-BC patients were more advanced according to the Barcelona Clinic Liver Cancer stages than the patients of the HCV or HBCV groups (P<0.020); accordingly, they were more frequently assessed beyond the Milan criteria than any other groups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. Conclusions: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the long-term prognosis after surgical treatment in patients with HCC; however, there is a trend for worse disease-free survival rates in HBCV patients, though statistical significance was not reached.
MeSH term(s)	Age Factors ; Aged ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/virology ; Catheter Ablation/adverse effects ; Catheter Ablation/mortality ; Disease-Free Survival ; Female ; Hepatectomy/adverse effects ; Hepatectomy/mortality ; Hepatitis B/complications ; Hepatitis B/diagnosis ; Hepatitis B/mortality ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Hepatitis C/mortality ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/virology ; Liver Transplantation/adverse effects ; Liver Transplantation/mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prevalence ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Romania/epidemiology ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2014-03-19
Publishing country	Singapore
Document type	Comparative Study ; Journal Article
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/s1499-3872(14)60026-6
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Article: Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients

Jadid, Fatima Zahra / Hajar Chihab / Hanane Salih Alj / Raouia Elfihry / Imane Zaidane / Sanaa Tazi / Wafaa Badre / Agnes Marchio / Kamal Marhoum El Filali / Mohammed Tahiri / Rachid Saile / Pascal Pineau / Sayeh Ezzikouri / Soumaya Benjelloun

Infection, genetics, and evolution. 2018 Dec., v. 66

2018

Abstract: Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate in the progression of ...

Abstract	Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate in the progression of liver disease. The present study aims to investigate the influence of two functional polymorphisms on SOCS3 mRNA expression and on the outcomes of CHC progression in a North African context.In this case-control study, 601 Moroccan subjects composed of 200 healthy controls, 101 resolvers and 300 patients with persistent HCV infection including 95 mild chronic hepatitis, 131 Advanced Liver Diseases and 74 HCC were enrolled. They were genotyped for the 4874 A/G (rs4969170) and A + 930– > G (rs4969168) SOCS3 variants using TaqMan SNPs assays. SOCS3 mRNA expression was assessed using Real Time PCR technique.Logistic regression analysis showed that variation at rs4969168 was associated with spontaneous clearance of HCV (P < 0.05). In addition, minor allele frequencies were significantly higher in AdLD patients when compared to the mCHC group both for rs4969168 (P = 7.0 E-04) and rs4969170 (P = 4.0 E-05). A significant association between haplotype and liver disease progression was also found. Moreover, SOCS3 mRNA was significantly more expressed in peripheral leukocytes from patients with HCC than in those from mCHC. Finally, rs4969170 was significantly associated with LDL-lipoprotein (P = 0.04), total cholesterol (P = 5.0 E-04), and higher fasting glucose levels (P = 0.005) in patients with persistent HCV infection.Our results underline the importance of the functional SOCS3 polymorphisms in the modulation of CHC progression and suggest their contribution to HCC development by affecting its mRNA expression and perturbing key metabolic parameters.
Keywords	case-control studies ; cholesterol ; chronic hepatitis C ; disease course ; gene expression ; gene frequency ; genotyping ; glucose ; haplotypes ; hepatoma ; insulin resistance ; leukocytes ; liver cirrhosis ; messenger RNA ; patients ; quantitative polymerase chain reaction ; regression analysis ; risk factors ; single nucleotide polymorphism
Language	English
Dates of publication	2018-12
Size	p. 1-8.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2018.08.027
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: First multicenter study for risk factors for hepatocellular carcinoma development in North Africa.

Bahri, Olfa / Ezzikouri, Sayeh / Alaya-Bouafif, Nissaf Ben / Iguer, Fella / Feydi, Abdallah Essaid El / Mestiri, Hafedh / Benazzouz, Moustapha / Khalfallah, Tahar / Afifi, Rajaa / Elkihal, Latifa / Berkane, Salah / Marchio, Agnes / Debzi, Nabil / Dejean, Anne / Pineau, Pascal / Triki, Hinda / Benjelloun, Soumaya

World journal of hepatology

2011 Volume 3, Issue 1, Page(s) 24–30

Abstract: Aim: To assess the role of the major risk factors for hepatocellular carcinoma (HCC) development in the western part of North Africa.: Methods: A multicenter case control study was conducted in Tunisia, Morocco and Algeria in collaboration with ... ...

Abstract	Aim: To assess the role of the major risk factors for hepatocellular carcinoma (HCC) development in the western part of North Africa. Methods: A multicenter case control study was conducted in Tunisia, Morocco and Algeria in collaboration with Pasteur Institutes in these countries. A total of 164 patients with HCC and 250 control subjects without hepatic diseases were included. Prevalences of HBsAg, anti-hepatitis C virus (HCV) and diabetes were assessed. HCV and HBV genotyping were performed for anti-HCV and HBsAg positive patients. Results: The mean age of patients was 62 ± 10 years old for a 1.5 M:F sex ratio. Sixty percent of HCC patients were positive for anti-HCV and 17.9% for HBsAg. Diabetes was detected in 18% of cases. Odd ratio (OR) and 95% confidence intervals (CI) were 32.0 (15.8 - 65.0), 7.2 (3.2 - 16.1) and 8.0 (3.1 - 20.0) for anti-HCV, HBsAg and diabetes respectively. Multivariate analysis indicated that the three studied factors were independent. 1b HCV genotype and D HBV genotype were predominant in HCC patients. HCV was the only risk factor significantly associated with an excess of cirrhosis (90% vs 68% for all other risk factors collectively, P = 0.00168). Excessive alcohol consumption was reliably established for 19 (17.6%) cases among the 108 HCC patients for whom data is available. Conclusion: HCV and HBV infections and diabetes are the main determinants of HCC development in North Africa. An active surveillance and secondary prevention programs for patients with chronic hepatitis and nutrition-associated metabolic liver diseases are the most important steps to reduce the risk of HCC in the region.
Language	English
Publishing date	2011-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182 ; 1948-5182
ISSN (online)	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v3.i1.24
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Article ; Online: First multicenter study for risk factors for hepatocellular carcinoma development in North Africa

Olfa Bahri, Sayeh Ezzikouri, Nissaf Ben Alaya-Bouafif, Fella Iguer, Abdallah Essaid El Feydi, Hafedh Mestiri, Moustapha Benazzouz, Tahar Khalfallah, Rajaa Afifi, Latifa Elkihal, Salah Berkane, Agnes Marchio, Nabil Debzi, Anne Dejean, Pascal Pineau, Hinda

World Journal of Hepatology, Vol 3, Iss 1, Pp 24-

2011 Volume 30

Abstract: AIM: To assess the role of the major risk factors for hepatocellular carcinoma (HCC) development in the western part of North Africa.METHODS: A multicenter case control study was conducted in Tunisia, Morocco and Algeria in collaboration with Pasteur ... ...

Abstract	AIM: To assess the role of the major risk factors for hepatocellular carcinoma (HCC) development in the western part of North Africa.METHODS: A multicenter case control study was conducted in Tunisia, Morocco and Algeria in collaboration with Pasteur Institutes in these countries. A total of 164 patients with HCC and 250 control subjects without hepatic diseases were included. Prevalences of HBsAg, anti-hepatitis C virus (HCV) and diabetes were assessed. HCV and HBV genotyping were performed for anti-HCV and HBsAg positive patients.RESULTS: The mean age of patients was 62 ± 10 years old for a 1.5 M:F sex ratio. Sixty percent of HCC patients were positive for anti-HCV and 17.9% for HBsAg. Diabetes was detected in 18% of cases. Odd ratio (OR) and 95% confidence intervals (CI) were 32.0 (15.8 - 65.0), 7.2 (3.2 - 16.1) and 8.0 (3.1 - 20.0) for anti-HCV, HBsAg and diabetes respectively. Multivariate analysis indicated that the three studied factors were independent. 1b HCV genotype and D HBV genotype were predominant in HCC patients. HCV was the only risk factor significantly associated with an excess of cirrhosis (90% vs 68% for all other risk factors collectively, P = 0.00168). Excessive alcohol consumption was reliably established for 19 (17.6%) cases among the 108 HCC patients for whom data is available.CONCLUSION: HCV and HBV infections and diabetes are the main determinants of HCC development in North Africa. An active surveillance and secondary prevention programs for patients with chronic hepatitis and nutrition-associated metabolic liver diseases are the most important steps to reduce the risk of HCC in the region.
Keywords	Hepatocellular carcinoma ; Hepatitis B virus ; Hepatitis C virus ; Non-insulin-dependent diabetes mellitus ; North Africa ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Baishideng Publishing Group Co. Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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