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  1. Article ; Online: Etiological theories of addiction: A comprehensive update on neurobiological, genetic and behavioural vulnerability.

    Ouzir, Mounir / Errami, Mohammed

    Pharmacology, biochemistry, and behavior

    2016  Volume 148, Page(s) 59–68

    Abstract: Currently, about 246 million people around the world have used an illicit drug. The reasons for this use are multiple: e.g. to augment the sensation of pleasure or to reduce the withdrawal and other aversive effects of a given substance. This raises the ... ...

    Abstract Currently, about 246 million people around the world have used an illicit drug. The reasons for this use are multiple: e.g. to augment the sensation of pleasure or to reduce the withdrawal and other aversive effects of a given substance. This raises the problem of addiction, which remains a disease of modern society. This review offers a comprehensive update of the different theories about the etiology of addictive behaviors with emphasis on the neurobiological, environmental, psychopathological, behavioural and genetic aspects of addictions, discussed from an evolutionary perspective. The main conclusion of this review is that vulnerability to drug addiction suggests an interaction between many brain systems (including the reward, decision-making, serotonergic, oxytocin, interoceptive insula, CRF, norepinephrine, dynorphin/KOR, orexin and vasopressin systems), genetic predisposition, sociocultural context, impulsivity and drugs types. Further advances in biological and psychological science are needed to address the problems of addiction at its roots.
    MeSH term(s) Behavior, Addictive ; Cerebral Cortex/physiology ; Creativity ; Decision Making ; Dopamine/physiology ; Humans ; Impulsive Behavior ; Neurobiology ; Oxytocin/physiology ; Reward ; Serotonin/physiology ; Stress, Psychological/psychology ; Substance-Related Disorders/etiology ; Substance-Related Disorders/genetics ; Substance-Related Disorders/physiopathology ; Substance-Related Disorders/psychology
    Chemical Substances Serotonin (333DO1RDJY) ; Oxytocin (50-56-6) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/j.pbb.2016.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1060: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Renal Cell Carcinoma Metastatic to the Scalp.

    Errami, Mounir / Margulis, Vitali / Huerta, Sergio

    Rare tumors

    2016  Volume 8, Issue 4, Page(s) 6400

    Abstract: Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% ... ...

    Abstract Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% of patients with RCC will develop metastases. Metastatic lesions from RCC are usually observed in the lungs, liver or bone. Metastases to the brain or the skin from RCC are rare. Here we present a patient diagnosed with RCC, found to have no evidence of metastases at the time of nephrectomy, who presented two years later with metastases to the scalp. We review the literature of patients with this rare site of metastasis and outline the overall prognosis of this lesion compared to other site of metastases from RCC.
    Language English
    Publishing date 2016-12-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2514363-3
    ISSN 2036-3613 ; 2036-3605
    ISSN (online) 2036-3613
    ISSN 2036-3605
    DOI 10.4081/rt.2016.6400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Renal cell carcinoma metastatic to the scalp

    Mounir Errami / Vitaly Margulis / Sergio Huerta

    Rare Tumors, Vol 8, Iss

    2016  Volume 4

    Abstract: Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% ... ...

    Abstract Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to 50% of patients with RCC will develop metastases. Metastatic lesions from RCC are usually observed in the lungs, liver or bone. Metastases to the brain or the skin from RCC are rare. Here we present a patient diagnosed with RCC, found to have no evidence of metastases at the time of nephrectomy, who presented two years later with metastases to the scalp. We review the literature of patients with this rare site of metastasis and outline the overall prognosis of this lesion compared to other site of metastases from RCC.
    Keywords renal cell carcinoma ; skin ; scalp ; metastasis ; carcinogenesis ; Medicine ; R ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A tale of two citations.

    Errami, Mounir / Garner, Harold

    Nature

    2008  Volume 451, Issue 7177, Page(s) 397–399

    MeSH term(s) Authorship ; Bibliometrics ; Duplicate Publication as Topic ; Internationality ; MEDLINE ; Plagiarism ; Scientific Misconduct/statistics & numerical data ; Software ; Translations
    Language English
    Publishing date 2008-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/451397a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Ramsay hunt syndrome

    Imane Ouhbi / Saloua Ouraini / Mounir Kettani / Bouchaib Hemmaoui, Noureddine Errami / Mohamed Zalagh / Ali Jahidi, Fouad Benariba

    PAMJ Clinical Medicine, Vol 3, Iss

    case report

    2020  Volume 109

    Abstract: Ramsay-Hunt Syndrome is an uncommon disease caused by the reactivation of latent Varicella zoster virus in the geniculate ganglion. It is characterized with a herpes zoster oticus associated with an acute peripheral facial nerve paralysis, and possible ... ...

    Abstract Ramsay-Hunt Syndrome is an uncommon disease caused by the reactivation of latent Varicella zoster virus in the geniculate ganglion. It is characterized with a herpes zoster oticus associated with an acute peripheral facial nerve paralysis, and possible other cranial nerve lesions. We describe the case of a 27-year-old man who presented with severe ear pain for two days, with vesicular eruptions on the external ear and ipsilateral peripheric facial paralysis. He was treated with the association of intravenous steroids and acyclovir for 7 days. The evolution showed gratifying results. The one-year follow-up showed no relapse of the syndrome. The purpose of this report is to highlight the importance of a thorough clinical examination and early treatment of the Ramsay-Hunt syndrome.
    Keywords ramsay hunt syndrome ; varicella-zoster virus ; facial paralysis ; herpes zoster oticus ; Medicine ; R
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher PAMJ
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Exhaustive prediction of disease susceptibility to coding base changes in the human genome.

    Kulkarni, Vinayak / Errami, Mounir / Barber, Robert / Garner, Harold R

    BMC bioinformatics

    2008  Volume 9 Suppl 9, Page(s) S3

    Abstract: Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Bases are subject to various levels of selection pressure, reflected in ... ...

    Abstract Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Bases are subject to various levels of selection pressure, reflected in their inter-species conservation.
    Results: We propose a method that is not dependant on transcription information to score each coding base in the human genome reflecting the disease probability associated with its mutation. Twelve factors likely to be associated with disease alleles were chosen as the input for a support vector machine prediction algorithm. The analysis yielded 83% sensitivity and 84% specificity in segregating disease like alleles as found in the Human Gene Mutation Database from non-disease like alleles as found in the Database of Single Nucleotide Polymorphisms. This algorithm was subsequently applied to each base within all known human genes, exhaustively confirming that interspecies conservation is the strongest factor for disease association. For each gene, the length normalized average disease potential score was calculated. Out of the 30 genes with the highest scores, 21 are directly associated with a disease. In contrast, out of the 30 genes with the lowest scores, only one is associated with a disease as found in published literature. The results strongly suggest that the highest scoring genes are enriched for those that might contribute to disease, if mutated.
    Conclusion: This method provides valuable information to researchers to identify sensitive positions in genes that have a high disease probability, enabling them to optimize experimental designs and interpret data emerging from genetic and epidemiological studies.
    MeSH term(s) Algorithms ; Base Sequence ; Chromosome Mapping/methods ; DNA Mutational Analysis/methods ; Genetic Predisposition to Disease/genetics ; Genetic Testing/methods ; Genome, Human/genetics ; Humans ; Molecular Sequence Data ; Open Reading Frames/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait, Heritable ; Sequence Analysis, DNA/methods
    Language English
    Publishing date 2008-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/1471-2105-9-S9-S3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Scientific integrity. Responding to possible plagiarism.

    Long, Tara C / Errami, Mounir / George, Angela C / Sun, Zhaohui / Garner, Harold R

    Science (New York, N.Y.)

    2009  Volume 323, Issue 5919, Page(s) 1293–1294

    MeSH term(s) Authorship ; Editorial Policies ; Journal Impact Factor ; Plagiarism ; Retraction of Publication as Topic ; Scientific Misconduct ; Software ; Surveys and Questionnaires
    Language English
    Publishing date 2009-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1167408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 77: Show issues

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  8. Article: Medline: the knowledge buried therein, its potential, and cost.

    Garner, Harold R / Hicks, Justin / Wren, Jonathan D / Errami, Mounir

    IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society

    2006  Volume 26, Issue 3, Page(s) 73–74

    MeSH term(s) Authorship ; Health Knowledge, Attitudes, Practice ; MEDLINE/economics ; MEDLINE/statistics & numerical data ; Natural Language Processing ; Periodicals as Topic/economics ; Periodicals as Topic/statistics & numerical data ; United States
    Language English
    Publishing date 2006-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 165249-7
    ISSN 1937-4186 ; 0739-5175 ; 0278-0054
    ISSN (online) 1937-4186
    ISSN 0739-5175 ; 0278-0054
    DOI 10.1109/memb.2007.364934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2964: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications.

    Errami, Mounir / Wren, Jonathan D / Hicks, Justin M / Garner, Harold R

    Nucleic acids research

    2007  Volume 35, Issue Web Server issue, Page(s) W12–5

    Abstract: Authors, editors and reviewers alike use the biomedical literature to identify appropriate journals in which to publish, potential reviewers for papers or grants, and collaborators (or competitors) with similar interests. Traditionally, this process has ... ...

    Abstract Authors, editors and reviewers alike use the biomedical literature to identify appropriate journals in which to publish, potential reviewers for papers or grants, and collaborators (or competitors) with similar interests. Traditionally, this process has either relied upon personal expertise and knowledge or upon a somewhat unsystematic and laborious process of manually searching through the literature for trends. To help with these tasks, we report three utilities that parse and summarize the results of an abstract similarity search to find appropriate journals for publication, authors with expertise in a given field, and documents similar to a submitted query. The utilities are based upon a program, eTBLAST, designed to identify similar documents within literature databases such as (but not limited to) MEDLINE. These services are freely accessible through the Internet at http://invention.swmed.edu/etblast/etblast.shtml, where users can upload a file or paste text such as an abstract into the browser interface.
    MeSH term(s) Authorship ; Databases, Bibliographic ; Humans ; Informatics ; Information Storage and Retrieval ; Peer Review ; Periodicals as Topic ; PubMed/trends ; Publications ; Publishing ; Software ; Software Design ; User-Computer Interface
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205588-5
    ISSN 1362-4962 ; 1746-8272 ; 0305-1048 ; 0261-3166
    ISSN (online) 1362-4962 ; 1746-8272
    ISSN 0305-1048 ; 0261-3166
    DOI 10.1093/nar/gkm221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Conservation of amino acids into multiple alignments involved in pairwise interactions in three-dimensional protein structures.

    Errami, Mounir / Geourjon, Christophe / Deléage, Gilbert

    Journal of bioinformatics and computational biology

    2004  Volume 1, Issue 3, Page(s) 505–520

    Abstract: We present an original strategy, that involves a bioinformatic software structure, in order to perform an exhaustive and objective statistical analysis of three-dimensional structures of proteins. We establish the relationship between multiple sequences ... ...

    Abstract We present an original strategy, that involves a bioinformatic software structure, in order to perform an exhaustive and objective statistical analysis of three-dimensional structures of proteins. We establish the relationship between multiple sequences alignments and various structural features of proteins. We show that amino acids implied in disulfide bonds, salt bridges and hydrophobic interactions have been studied. Furthermore, we point out that the more variable the sequences within a multiple alignment, the more informative the multiple alignment. The results support multiple alignments usefulness for predictions of structural features.
    MeSH term(s) Amino Acid Sequence ; Computational Biology ; Conserved Sequence ; Disulfides/chemistry ; Hydrophobic and Hydrophilic Interactions ; Protein Conformation ; Protein Structure, Secondary ; Proteins/chemistry ; Proteins/genetics ; Salts/chemistry ; Sequence Alignment/statistics & numerical data ; Software
    Chemical Substances Disulfides ; Proteins ; Salts
    Language English
    Publishing date 2004-06-30
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2115015-1
    ISSN 1757-6334 ; 0219-7200
    ISSN (online) 1757-6334
    ISSN 0219-7200
    DOI 10.1142/s0219720003000228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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