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  1. Article: Outlook on RNAi-Based Strategies for Controlling

    Osborne, Cameron J / Cohnstaedt, Lee W / Silver, Kristopher S

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: ... ...

    Abstract Culicoides
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12101251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Variable gut pH as a potential mechanism of tolerance to Bacillus thuringiensis subsp. israelensis toxins in the biting midge Culicoides sonorensis.

    Osborne, Cameron J / Su, Tianyun / Silver, Kristopher S / Cohnstaedt, Lee W

    Pest management science

    2024  

    Abstract: Background: Toxins of Bacillus thuringiensis subsp. israelensis (Bti) are safer alternatives for controlling dipteran pests such as black flies and mosquitoes. The biting midge Culicoides sonorensis (Diptera: Ceratopogonidae) is an important pest of ... ...

    Abstract Background: Toxins of Bacillus thuringiensis subsp. israelensis (Bti) are safer alternatives for controlling dipteran pests such as black flies and mosquitoes. The biting midge Culicoides sonorensis (Diptera: Ceratopogonidae) is an important pest of livestock in much of the United States and larval midges utilize semi-aquatic habitats which are permissive for Bti product application. Reports suggest that Bti products are ineffective at killing biting midges despite their taxonomic relation to black flies and mosquitoes. Here, we investigate the toxicity of a Bti-based commercial insecticide and its active ingredient in larval Culicoides sonorensis. A suspected mechanism of Bti tolerance is an acidic larval gut, and we used a pH indicator dye to examine larval Culicoides sonorensis gut pH after exposure to Bti.
    Results: The lethal concentration to kill 90% (LC
    Conclusion: We conclude that Bti is not practical for larval Culicoides sonorensis control at the same rates as mosquitos but show that alterations or additives to the environment could make the products more effective. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.8104
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  3. Article ; Online: Urinary supersaturation in a Randomized trial among Individuals with Nephrolithiasis comparing Empiric versus selective therapy (URINE): design and rationale of a clinical trial.

    Hsi, Ryan S / Koyama, Tatsuki / Silver, Heidi J / Goldfarb, David S

    Urolithiasis

    2023  Volume 51, Issue 1, Page(s) 28

    Abstract: Clinical guidelines disagree on whether the identification of abnormal urine chemistries should occur before starting diet and medication interventions to prevent the recurrence of kidney stone events. We describe the rationale and design of the Urinary ... ...

    Abstract Clinical guidelines disagree on whether the identification of abnormal urine chemistries should occur before starting diet and medication interventions to prevent the recurrence of kidney stone events. We describe the rationale and design of the Urinary supersaturation in a Randomized trial among Individuals with Nephrolithiasis comparing Empiric versus selective therapy (URINE) study, a randomized trial comparing two multi-component interventions to improve urinary supersaturation. Participants are randomized (1:1 ratio) to the empiric or selective arm. The target sample size is 56 participants. Adults ≥ 18 years of age with idiopathic calcium stone disease and two symptomatic stone events within the previous 5 years. Exclusion criteria include systemic conditions predisposing to kidney stones and pharmacologic treatment for stone prevention at baseline. Participants in the empiric arm receive standard diet therapy recommendations, thiazide, and potassium citrate. Participants in the selective arm receive tailored diet and nutrient recommendations and medications based on baseline and 1-month follow-up of 24-h urine testing results. The primary endpoints are urinary supersaturations of calcium oxalate and calcium phosphate at 2 months of follow-up. Secondary endpoints include side effects, diet and medication adherence, and changes in 24-h urine volume, calcium, oxalate, citrate, and pH. Short-term changes in urinary supersaturation may not reflect changes in future risk of stone events. The URINE study will provide foundational data to compare the effectiveness of two prevention strategies for kidney stone disease.
    MeSH term(s) Adult ; Humans ; Child, Preschool ; Calcium/urine ; Kidney Calculi/urine ; Calcium Oxalate/urine ; Potassium Citrate/therapeutic use ; Urinary Tract
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium Oxalate (2612HC57YE) ; Potassium Citrate (EE90ONI6FF)
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-022-01400-8
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  4. Article ; Online: Unwanted Inflation From Jet Ventilation: A Severe Barotrauma-Related Complication.

    Kim, Anne Doyoung / Silver, Jennifer A / Chan, David S / Khalife, Sarah / Kardash, Kenneth J / Yang, Stephen S / Marchica, Cinzia / Manoukian, John

    Ear, nose, & throat journal

    2024  , Page(s) 1455613241237082

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241237082
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  5. Article: Woman with Abdominal Pain.

    Case, Samuel / Silver, Matthew / Lapoint, Jeff

    The Journal of emergency medicine

    2023  Volume 66, Issue 4, Page(s) e538–e539

    MeSH term(s) Female ; Humans ; Abdominal Pain/etiology ; Foreign Bodies
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.11.019
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  6. Article ; Online: Levonorgestrel-Releasing Intrauterine System for Regression of Endometrial Hyperplasia.

    Silver, Sabrina / Arnold, James J

    American family physician

    2021  Volume 104, Issue 1, Page(s) 26–27

    MeSH term(s) Contraceptive Agents, Hormonal/pharmacology ; Endometrial Hyperplasia/therapy ; Female ; Humans ; Intrauterine Devices, Medicated ; Levonorgestrel/pharmacology
    Chemical Substances Contraceptive Agents, Hormonal ; Levonorgestrel (5W7SIA7YZW)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  7. Article ; Online: Association of Frailty with Healthcare Utilization for Patients over One Year Following Surgical Evaluation.

    Flinn, Stephen J / Silver, David S / Hodges, Jacob / Bilderback, Andrew L / Buchanan, Dan / Ludwig, Justin M / Schuster, James / Hall, Daniel E

    Annals of surgery

    2024  

    Abstract: Objective: Characterize the distribution of healthcare utilization associated with pre-operative frailty in the year following evaluation by a surgeon.: Summary background data: Frailty is associated with increased morbidity, mortality, and costs for ...

    Abstract Objective: Characterize the distribution of healthcare utilization associated with pre-operative frailty in the year following evaluation by a surgeon.
    Summary background data: Frailty is associated with increased morbidity, mortality, and costs for surgical patients. However, the total financial burden for frail patients beyond the index surgery and inpatient stay remains unknown.
    Methods: Prospective cohort assembled from February 2016 to December 2020 within a multi-hospital integrated healthcare delivery and finance system (IDFS), from patients evaluated with the Risk Analysis Index (RAI) of frailty. Inclusion criteria: age greater than 18, valid RAI, membership in the IDFS Health Plan. Data were stratified by frailty and surgical status.
    Results: The mean (SD) age was 54.7 (16.1) and 58.2% female of the cohort (n=86,572). For all patients with reimbursement for surgery (n=53,856), frail and very frail patients incurred respective increases of 8% ( P =0.027) and 29% ( P <0.001) on utilization relative to the normal group. Robust patients saw a 52% ( P <0.001) decrease. This pattern was more pronounced in the cohort without surgery (n=32,716). The increase over normal utilization for frail and very frail patients increased to 23% ( P =0.004) and 68% ( P <0.001), respectively. Utilization among robust patients decreased 62% ( P <0.001). Increases among the frail were primarily due to increased inpatient medical and post-acute care services (all P <0.001).
    Conclusions: Patient frailty is associated with increased total healthcare utilization, primarily via increased inpatient medical and post-acute care following surgery. Quantifying these frailty-related financial burdens may inform clinical decision making as well as the design of value-based reimbursement strategies.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006218
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  8. Article ; Online: New forays into measurement of ocular biomechanics.

    Hammelef, Emma / Rapuano, Christopher J / Benedetto, Dominick A / Syed, Zeba A / Myers, Jonathan S / Razeghinejad, M Reza / Silver, Fred H / Pulido, Jose S

    Current opinion in ophthalmology

    2024  Volume 35, Issue 3, Page(s) 225–231

    Abstract: Purpose of review: The field of corneal biomechanics has rapidly progressed in recent years, reflecting technological advances and an increased understanding of the clinical significance of measuring these properties. This review will evaluate in-vivo ... ...

    Abstract Purpose of review: The field of corneal biomechanics has rapidly progressed in recent years, reflecting technological advances and an increased understanding of the clinical significance of measuring these properties. This review will evaluate in-vivo biomechanical properties obtained by current technologies and compare them regarding their relevance to established biomechanical properties obtained by gold-standard ex-vivo techniques normally conducted on elastic materials.
    Recent findings: Several new technologies have appeared in recent years, including vibrational optical coherence tomography (VOCT) and the corneal indentation device (CID). These techniques provide promising new opportunities for minimally invasive and accurate measurements of corneal viscoelastic properties.
    Summary: Alterations in corneal biomechanics are known to occur in several corneal degenerative diseases and after refractive surgical procedures. The measurement of corneal biomechanical properties has the capability to diagnose early disease and monitor corneal disease progression. Several new technologies have emerged in recent years, allowing for more accurate and less invasive measurements of corneal biomechanical properties, most notably the elastic modulus.
    MeSH term(s) Humans ; Biomechanical Phenomena ; Cornea/surgery ; Refractive Surgical Procedures ; Tomography, Optical Coherence ; Corneal Diseases/surgery
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000001032
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  9. Article ; Online: Enrollment Patterns of Medicare Advantage Beneficiaries by Dental, Vision, and Hearing Benefits.

    Gupta, Avni / Silver, Diana / Meyers, David J / Murray, Genevra / Glied, Sherry / Pagán, José A

    JAMA health forum

    2024  Volume 5, Issue 1, Page(s) e234936

    Abstract: Importance: Most Medicare beneficiaries now choose to enroll in Medicare Advantage (MA) plans. Racial and ethnic minority group and low-income beneficiaries are increasingly enrolling in MA plans.: Objective: To examine whether dental, vision, and ... ...

    Abstract Importance: Most Medicare beneficiaries now choose to enroll in Medicare Advantage (MA) plans. Racial and ethnic minority group and low-income beneficiaries are increasingly enrolling in MA plans.
    Objective: To examine whether dental, vision, and hearing supplemental benefits offered in MA plans are associated with the plan choices of traditionally underserved Medicare beneficiaries.
    Design, setting, and participants: This exploratory observational cross-sectional study used data from the 2018 to 2020 Medicare Current Beneficiary Survey linked to MA plan benefits. The nationally representative sample comprised primarily community-dwelling MA beneficiaries enrolled in general enrollment MA plans. Data analysis was performed between April and October 2023.
    Exposures: Beneficiary self-identified race and ethnicity and combined individual and spouse income and educational attainment.
    Main outcomes and measures: Binary indicators were developed to determine whether beneficiaries were enrolled in a plan offering any dental, comprehensive dental, any vision, eyewear, any hearing, or hearing aid benefit. Mixed-effects logistic regression models were estimated to report average marginal effects adjusted for beneficiary-level demographic and health characteristics, plan attributes, and plan availability.
    Results: This study included 8139 (weighted N = 31 million) eligible MA beneficiaries, with a mean (SD) age of 77.7 (7.5) years. More than half of beneficiaries (54.9%) were women; 9.8% self-identified as Black, 2.0% as Hispanic, 83.9% as White, and 4.2% as other or multiple races or ethnicities. Plan choices by dental benefits were examined among 7516 beneficiaries who were not enrolled in any dental standalone plan, by vision benefits for 8026 beneficiaries not enrolled in any vision standalone plan, and by hearing benefits for 8131 beneficiaries not enrolled in any hearing standalone plan. Black beneficiaries were more likely to enroll in plans with any dental benefit (9.0 percentage points [95% CI, 3.4-14.4]; P < .001), any comprehensive dental benefit (11.2 percentage points [95% CI, 5.7-16.7]; P < .001), any eye benefit (3.0 percentage points [95% CI, 1.0 to 5.0]; P = .004), or any eyewear benefit (6.0 percentage points [95% CI, 0.6-11.5]; P = .03) compared with White beneficiaries. Lower-income individuals (earning ≤200% of the federal poverty level) were more likely to enroll in a plan with a comprehensive dental benefit (4.4 percentage-point difference [95% CI, 0.1-7.9]; P = .01) compared with higher-income beneficiaries. Beneficiaries without a college degree were more likely to enroll in a plan with a comprehensive dental benefit (4.7 percentage-point difference [95% CI, 1.4-8.0]; P = .005) compared with those with higher educational attainment.
    Conclusions and relevance: The results of this study suggest that racial and ethnic minority individuals and those with lower income or educational attainment are more likely to choose MA plans with dental or vision benefits. As the federal government prepares to adjust MA plan star ratings for health equity, implements MA payment cuts, and allows increasing flexibility in supplemental benefit offerings, these findings may inform benefit monitoring for MA.
    MeSH term(s) Aged ; Humans ; Female ; United States ; Male ; Medicare Part C ; Ethnicity ; Cross-Sectional Studies ; Minority Groups ; Hearing
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Observational Study ; Journal Article
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.4936
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  10. Article ; Online: Cancer stem cell hypothesis 2.0 in glioblastoma: Where are we now and where are we going?

    Sloan, Anthony R / Silver, Daniel J / Kint, Sam / Gallo, Marco / Lathia, Justin D

    Neuro-oncology

    2024  Volume 26, Issue 5, Page(s) 785–795

    Abstract: Over the past 2 decades, the cancer stem cell (CSC) hypothesis has provided insight into many malignant tumors, including glioblastoma (GBM). Cancer stem cells have been identified in patient-derived tumors and in some mouse models, allowing for a deeper ...

    Abstract Over the past 2 decades, the cancer stem cell (CSC) hypothesis has provided insight into many malignant tumors, including glioblastoma (GBM). Cancer stem cells have been identified in patient-derived tumors and in some mouse models, allowing for a deeper understanding of cellular and molecular mechanisms underlying GBM growth and therapeutic resistance. The CSC hypothesis has been the cornerstone of cellular heterogeneity, providing a conceptual and technical framework to explain this longstanding phenotype in GBM. This hypothesis has evolved to fit recent insights into how cellular plasticity drives tumor growth to suggest that CSCs do not represent a distinct population but rather a cellular state with substantial plasticity that can be achieved by non-CSCs under specific conditions. This has further been reinforced by advances in genomics, including single-cell approaches, that have used the CSC hypothesis to identify multiple putative CSC states with unique properties, including specific developmental and metabolic programs. In this review, we provide a historical perspective on the CSC hypothesis and its recent evolution, with a focus on key functional phenotypes, and provide an update on the definition for its use in future genomic studies.
    MeSH term(s) Glioblastoma/pathology ; Glioblastoma/metabolism ; Glioblastoma/genetics ; Humans ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/metabolism ; Animals ; Brain Neoplasms/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/genetics
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noae011
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