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  1. Article ; Online: Lipoxygenases as Targets for Drug Development.

    Mao, Xiao-Yuan

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2089, Page(s) 251–256

    Abstract: Lipoxygenases are key enzymes that catalyze the polyunsaturated fatty acids such as arachidic acid, linoleic acid (LA), and others unsaturated fatty acids. They are involved in important functions such as cell structure, metabolism, and signal ... ...

    Abstract Lipoxygenases are key enzymes that catalyze the polyunsaturated fatty acids such as arachidic acid, linoleic acid (LA), and others unsaturated fatty acids. They are involved in important functions such as cell structure, metabolism, and signal transduction mechanisms, finally mediating cell death process, especially ferroptosis, a novel type of cell death modality. Our present protocol described a colorimetric assay for measuring lipoxygenase activity as well as a high-performance liquid chromatography/electrospray ionization tandem mass spectrometry method for the quantification of arachidonic acid metabolites.
    MeSH term(s) Arachidonic Acid/metabolism ; Cell Line ; Chromatography, High Pressure Liquid/methods ; Drug Development/methods ; Fatty Acids, Unsaturated/metabolism ; HEK293 Cells ; Humans ; Linoleic Acid/metabolism ; Lipoxygenases/metabolism ; Tandem Mass Spectrometry/methods
    Chemical Substances Fatty Acids, Unsaturated ; Arachidonic Acid (27YG812J1I) ; Linoleic Acid (9KJL21T0QJ) ; Lipoxygenases (EC 1.13.11.-)
    Language English
    Publishing date 2019-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0163-1_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cell perturbation in choroid plexus and cortex aiding COVID-19 neurological symptoms.

    Mao, Xiao-Yuan / Jin, Wei-Lin

    Science bulletin

    2021  Volume 66, Issue 24, Page(s) 2442–2444

    Language English
    Publishing date 2021-08-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2021.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The COVID-19 Pandemic: Consideration for Brain Infection.

    Mao, Xiao-Yuan / Jin, Wei-Lin

    Neuroscience

    2020  Volume 437, Page(s) 130–131

    MeSH term(s) Betacoronavirus ; Brain Diseases/virology ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2020.04.044
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    Zs.A 1215: Show issues Location:
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  4. Article ; Online: iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2.

    Mao, Xiao-Yuan / Jin, Wei-Lin

    ACS chemical neuroscience

    2020  Volume 11, Issue 17, Page(s) 2489–2491

    Abstract: Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations ... ...

    Abstract Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020)
    MeSH term(s) Betacoronavirus ; Brain/pathology ; Brain/virology ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/transmission ; Feasibility Studies ; Humans ; Induced Pluripotent Stem Cells/pathology ; Induced Pluripotent Stem Cells/virology ; Organoids/pathology ; Organoids/virology ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.

    Zhang, Li / Tan, Min / Mao, Jing / Zhang, Juan / Wang, Xiao-Yuan / Zhang, Yan / Duo, Rui-Xue / Hao, Jia-Yao / Shen, Hai-Li

    Clinical rheumatology

    2024  Volume 43, Issue 3, Page(s) 959–969

    Abstract: Objective: Fibroblast-like synoviocytes (FLS) play a critical role on the exacerbation and deterioration of rheumatoid arthritis (RA). Aberrant activation of FLS pyroptosis signaling is responsible for the hyperplasia of synovium and destruction of ... ...

    Abstract Objective: Fibroblast-like synoviocytes (FLS) play a critical role on the exacerbation and deterioration of rheumatoid arthritis (RA). Aberrant activation of FLS pyroptosis signaling is responsible for the hyperplasia of synovium and destruction of cartilage of RA. This study investigated the screened traditional Chinese medicine berberine (BBR), an active alkaloid extracted from the Coptis chinensis plant, that regulates the pyroptosis of FLS and secretion of inflammatory factors in rheumatoid arthritis.
    Methods: First, BBR was screened using a high-throughput drug screening strategy, and its inhibitory effect on RA-FLS was verified by in vivo and in vitro experiments. Second, BBR was intraperitoneally administrated into the collagen-induced arthritis rat model, and the clinical scores, arthritis index, and joint HE staining were evaluated. Third, synovial tissues of CIA mice were collected, and the expression of NLRP3, cleaved-caspase-1, GSDMD-N, Mst1, and YAP was detected by Western blot.
    Results: The administration of BBR dramatically alleviated the severity of collagen-induced arthritis rat model with a decreased clinical score and inflammation reduction. In addition, BBR intervention significantly attenuates several pro-inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-17, and interleukin-18). Moreover, BBR can reduce the pyroptosis response (caspase-1, NLR family pyrin domain containing 3, and gasdermin D) of the RA-FLS in vitro, activating the Hippo signaling pathway (Mammalian sterile 20-like kinase 1, yes-associated protein, and transcriptional enhanced associate domains) so as to inhibit the pro-inflammatory effect of RA-FLS.
    Conclusion: These results support the role of BBR in RA and may have therapeutic implications by directly repressing the activation, migration of RA-FLS, which contributing to the attenuation of the progress of CIA. Therefore, targeting PU.1 might be a potential therapeutic approach for RA. Besides, BBR inhibited RA-FLS pyroptosis by downregulating of NLRP3 inflammasomes (NLRP3, caspase-1) and eased the pro-inflammatory activities via activating the Hippo signaling pathway, thereby improving the symptom of CIA.
    MeSH term(s) Rats ; Mice ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Berberine/pharmacology ; Berberine/therapeutic use ; Berberine/metabolism ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid/metabolism ; Synovial Membrane/metabolism ; Caspases/metabolism ; Caspases/pharmacology ; Caspases/therapeutic use ; Fibroblasts/metabolism ; Cells, Cultured ; Cell Proliferation ; Mammals
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein ; Berberine (0I8Y3P32UF) ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-024-06871-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1740: Show issues Location:
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  6. Article: Efficacy and Safety of Anlotinib Combined with PD-1 Blockades for Patients with Previously Treated Epithelial Ovarian Cancer: A Retrospective Study.

    Li, Xiao-Yuan / Rao, Yang / Sun, Bing / Mao, Xue-Mei

    International journal of general medicine

    2022  Volume 15, Page(s) 3977–3989

    Abstract: Purpose: This study was to investigate the efficacy and safety of anlotinib combined with programmed cell death protein 1 (PD-1) blockades for patients with previously treated advanced epithelial ovarian cancer (EOC).: Patients and methods: Present ... ...

    Abstract Purpose: This study was to investigate the efficacy and safety of anlotinib combined with programmed cell death protein 1 (PD-1) blockades for patients with previously treated advanced epithelial ovarian cancer (EOC).
    Patients and methods: Present study was designed as a retrospective study, a total of 32 patients with advanced EOC who progressed after at least two lines previously available standard therapy were included in this study. All the patients were administered with anlotinib combined with PD-1 blockades administration. Clinical activity was implemented and analyzed, which was assessed according to the change of target lesion by imaging evidence and all the subjects were followed up regularly. Safety profile were collected and documented during the treatment. Univariate analysis was carried out using log rank test and multivariate analysis were adjusted by Cox regression analysis.
    Results: The best overall response suggested that partial response was noted in 12 patients, stable disease was observed in 14 patients, progressive disease was found in 6 patients. Therefore, the objective response rate (ORR) of the 32 patients was 37.5% (95% CI: 21.1-56.3%), disease control rate (DCR) of the patients was 81.3% (95% CI: 63.6-92.8%). The median follow-up duration of this study was 17.5 months (follow-up range: 0.9-33.5 months). And the median PFS and OS of the 32-patient cohort was 6.8 months (95% CI: 2.64-10.96) and 18.5 months (95% CI: 14.08-22.92), respectively. The most common treatment-related adverse reactions were fatigue (68.8%), nausea and vomiting (56.3%), hypertension (50.0%) and diarrhea (40.6%). Multivariate Cox regression analysis for PFS indicated that ECOG performance status and FIGO stage were independent factors to predict PFS of patients with previously treated EOC.
    Conclusion: Anlotinib combined with PD-1 blockades demonstrated promising efficacy and tolerable safety profile for patients with previously treated advanced EOC preliminarily. The conclusion should be confirmed in more patients with advanced EOC subsequently.
    Language English
    Publishing date 2022-04-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S352536
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  8. Article: Identification and validation of roles of lysyl oxidases in the predictions of prognosis, chemotherapy and immunotherapy in glioma.

    Xia, Qin-Xuan / Yu, Jing / Wang, Zhao-Jun / Guan, Qi-Wen / Mao, Xiao-Yuan

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 990461

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.990461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The COVID-19 Pandemic

    Mao, Xiao-Yuan / Jin, Wei-Lin

    Neuroscience

    Consideration for Brain Infection

    2020  Volume 437, Page(s) 130–131

    Keywords General Neuroscience ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2020.04.044
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Systematic bibliometric analysis of research hotspots and trends on the application of premium IOLs in the past 2 decades.

    Li, Liang-Pin / Yuan, Li-Yun / Mao, De-Shen / Hua, Xia / Yuan, Xiao-Yong

    International journal of ophthalmology

    2024  Volume 17, Issue 4, Page(s) 736–747

    Abstract: Aim: To analysis of research hotspots and trends on the application of premium intraocular lens (PIOLs) in the past 2 decades.: Methods: The literature search was performed on the Web of Science and included PIOLs studies published between January ... ...

    Abstract Aim: To analysis of research hotspots and trends on the application of premium intraocular lens (PIOLs) in the past 2 decades.
    Methods: The literature search was performed on the Web of Science and included PIOLs studies published between January 2000 and December 2022. The retrieved literature was collated and analyzed by R-tool's Bibliometrix package, CitNetExplorer, CiteSpace and other software.
    Results: A total of 1801 articles about PIOLs were obtained, most of which were published in Spain and the United States. The organization that published the most articles was the University of Valencia in Spain. Alió JL, and Montés-Micó R, from Spain were the most influential authors in this field. The
    Conclusion: Bibliometric analysis can effectively help to identify multilevel concerns in PIOLs research and the prevailing research trends in the realm of PIOLs encompass the adoption of EDoF IOLs, trifocal IOLs, and their respective Toric models.
    Language English
    Publishing date 2024-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2024.04.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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