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  1. Book ; Online: Historical Background of Wang Yang-ming's Philosophy of Mind

    Dong, Ping

    2020  

    Abstract: This open access book offers comprehensive information on Wang Yang-ming's life, helping readers ... Wang Yang-ming's extraordinary life, his generous mind, deep thoughts and bright personality, inspiring ... identify and grasp the foundations on which his philosophy was established. Though a great man, Wang had ...

    Abstract This open access book offers comprehensive information on Wang Yang-ming's life, helping readers identify and grasp the foundations on which his philosophy was established. Though a great man, Wang had an extremely difficult life, full of many hardships. Based on various official histories, Wang's own writings, and his disciples' records, the book explores the legendary life of this ancient philosopher, who not only diligently pursued his objective of living as a sage, but also persistently sought the ideal state of a sage in ideology. The author also shares his own interpretations of the main aspects of Wang's philosophy using simple and straightforward language. This book will help readers understand and appreciate Wang Yang-ming's extraordinary life, his generous mind, deep thoughts and bright personality, inspiring them to pursue enriching lives. It offers a unique and insightful work for undergraduate students and all others interested in Wang's philosophy and life story
    Keywords Philosophy (General) ; Literature (General) ; Asien ; Philosophie ; Geschichte ; Wang, Yangming ; Philosophy of Mind ; Zeithintergrund
    Subject Historischer Hintergrund ; Geschichtlicher Hintergrund ; Mind ; Geist ; Philosophie des Geistes ; Philosophieren
    Size 1 electronic resource (199 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020589679
    ISBN 9789811530364 ; 981153036X
    DOI 10.1007/978-981-15-3036-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Historical Background of Wang Yang-ming’s Philosophy of Mind

    Dong, Ping

    From the Perspective of his Life Story

    2020  

    Author's details by Ping Dong
    Keywords Philosophy, Asian ; Oriental literature ; Asien ; Philosophie ; Geschichte ; Wang, Yangming ; Philosophy of Mind ; Zeithintergrund
    Subject Historischer Hintergrund ; Geschichtlicher Hintergrund ; Mind ; Geist ; Philosophie des Geistes ; Philosophieren
    Subject code 181
    Language English
    Size 1 Online-Ressource (X, 199 p. 1 illus)
    Edition 1st ed. 2020
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT020468204
    ISBN 978-981-15-3036-4 ; 9789811530357 ; 9789811530371 ; 9789811530388 ; 981-15-3036-X ; 9811530351 ; 9811530378 ; 9811530386
    DOI 10.1007/978-981-15-3036-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Erratum for Yang et al., "

    Yang, Hongxing / Hu, Shunli / Wang, Xiang / Chuang, Shaochuang / Jia, Weibin / Jiang, Jiandong

    Applied and environmental microbiology

    2020  Volume 86, Issue 12

    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.00957-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference.

    Jiang, Hui / Li, Xiaoyu / Fan, Yang / Wang, Junjie / Xie, Yiyi / Yu, Peilin

    Journal of ethnopharmacology

    2024  Volume 328, Page(s) 118036

    Abstract: ... root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome ... mechanisms.: Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was ... Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma ...

    Abstract Ethnopharmacological relevance: The proper application of toxic medicines is one of the characteristics of traditional Chinese medicines, and the use of traditional Chinese medicines follows the principle of dialectical treatment. It is necessary to combine different "syndrome" or "disease" states with the toxicity of traditional Chinese medicines to form a reliable toxicity evaluation system. Fuzi, the lateral root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome, however, its toxic effects significantly limit its clinical application.
    Aim of the study: Herein, our research aimed to explore the toxic effects of Fuzi on syndrome models, and tried to reveal the underlying mechanisms.
    Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was established through intramuscular injection of 25 mg/kg hydrocortisone per day for 10 consecutive days. Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma metabolite concentrations and liver CYP3A4 enzyme activity were analyzed to reveal the possible mechanisms of the different pharmacological and toxicological effects of Fuzi in individuals with different physical constitutions.
    Results: It was found that the treatment with Fuzi (138 g/kg) had serious toxic effects on kidney yang deficiency mice, leading to the death of 80% of the mice, whereas it showed no lethal toxicity in normal mice. This indicates that Fuzi induced greater toxicity in kidney yang deficiency mice than in normal ones. The liver CYP3A4 enzyme activity in kidney yang deficiency mice was decreased by 20% compared to the controls, resulting in slower metabolism of the toxic diester diterpenoid alkaloids in Fuzi.
    Conclusion: In conclusion, our study showed that changes of the metabolic enzyme activity in individuals with different syndromes led to different toxic effects of Chinese medicines, emphasizing the crucial importance of considering individual physical syndromes in the clinical application of traditional Chinese medicine, and the significance of conducting safety evaluations and dose predictions on animal models with specific syndromes for traditional Chinese medicines.
    MeSH term(s) Mice ; Animals ; Medicine, Chinese Traditional ; Yang Deficiency/chemically induced ; Yang Deficiency/drug therapy ; Cytochrome P-450 CYP3A ; Drugs, Chinese Herbal/pharmacology ; Diterpenes/toxicity ; Diterpenes/therapeutic use ; Kidney ; Aconitum
    Chemical Substances fuzi drug herbal ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Drugs, Chinese Herbal ; Diterpenes
    Language English
    Publishing date 2024-03-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

    Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 129, Page(s) 155616

    Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

    Abstract Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate.
    Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model.
    Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis.
    Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice.
    Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Light People: Professor Yang Gao.

    Wang, Hui

    Light, science & applications

    2022  Volume 11, Issue 1, Page(s) 193

    Abstract: ... education and careers. She is Professor Yang Gao, winner of the Mulan Award 2019 in science and technology ...

    Abstract Editorial: The safe return to earth of the Shenzhou-13 crew not only marks a perfect ending to a successful mission, but also reignited the public's interest in the exploration of space. This month's Light People features a true "Space Explorer". In the past two decades, she has devoted to space robotics research and is recognized for advancing AI capabilities for future space missions. In addition, she has been actively promoting STEM through public outreach and setting role models to encourage women in STEM education and careers. She is Professor Yang Gao, winner of the Mulan Award 2019 in science and technology, a dedicated award to celebrate the achievements and success of Chinese women in the United Kingdom and wider. Prof. Gao is the Professor of Space Autonomous Systems at the University of Surrey's Space Centre, and founding head of the STAR LAB which specializes in robotic sensing, perception, visual GNC, and biomimetic mechanisms for industrial applications in extreme environments. She is also Editor-in-Chief of the Journal of Field Robotics, where she demonstrates leadership in serving the wider scientific community, strengthening academia-industry connections, and cultivating new generations of sci-tech talents. So what is Prof. Gao's story with Light? What unique insights does she have on the subject of scientific research? Please sit back, fasten up your seatbelt, and follow Prof. Gao and Science Editor on a journey to outer space.
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2662628-7
    ISSN 2047-7538 ; 2047-7538
    ISSN (online) 2047-7538
    ISSN 2047-7538
    DOI 10.1038/s41377-022-00869-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Kidney Yang Deficiency Syndrome Exacerbates Aβ

    Jiang, Xia / Chen, Lin / Fu, Qing / Ma, Dan Li / Liu, Xue Ting / Wang, Xiao Yi

    Current Alzheimer research

    2023  Volume 20, Issue 1, Page(s) 48–58

    Abstract: ... considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical ... for 14 days was used to produce KDS-Yang. On the 15th day, Aβ: Results: Hyperphosphorylation of tau ... in Aβ: Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is ...

    Abstract Background: Traditional Chinese medicine (TCM) indicates that Alzheimer's disease (AD) is considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical characteristics to glucocorticoid withdrawal syndrome. Ginsenoside Re (G-Re) has been found to ameliorate the symptoms and pathological impairments of AD. However, it's not clear whether G-Re could protect memory and synapse lesions against kidney deficiency dementia.
    Methods: Subcutaneous injection of hydrocortisone for 14 days was used to produce KDS-Yang. On the 15th day, Aβ
    Results: Hyperphosphorylation of tau in Aβ
    Conclusion: KDS-Yang might exacerbate AD pathological lesions. Importantly, G-Re is a potential ingredient for protecting against memory and synapse deficits in kidney deficiency dementia.
    MeSH term(s) Rats ; Animals ; Amyloid beta-Peptides/toxicity ; Yang Deficiency ; Alzheimer Disease/metabolism ; Disks Large Homolog 4 Protein ; Kidney/metabolism ; Kidney/pathology ; Synapses/metabolism ; Disease Models, Animal ; Peptide Fragments/toxicity
    Chemical Substances Amyloid beta-Peptides ; ginsenoside Re (46F3R0BL3I) ; Disks Large Homolog 4 Protein ; Peptide Fragments
    Language English
    Publishing date 2023-05-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/1567205020666230512094230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Yin and yang regulation of stress granules by Caprin-1.

    Song, Dan / Kuang, Lisha / Yang, Lin / Wang, Lei / Li, Hao / Li, Xiu / Zhu, Zhimin / Shi, Chaowei / Zhu, Haining / Gong, Weimin

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 44, Page(s) e2207975119

    Abstract: ... terminal domains of Caprin-1 regulate SG formation in a "yin and yang" fashion, mediating the dynamic and ...

    Abstract Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and RNAs in response to stress. Ras-GTPase-activating protein binding protein 1 (G3BP1) is a core SG protein. Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively. The crystal structures of the nuclear transport factor 2-like (NTF2L) domain of G3BP1 in complex with the G3BP1-interacting motif (GIM) of Caprin-1 and USP10 show that both GIMs bind to the same hydrophobic pocket of G3BP1. Moreover, both GIMs suppressed the liquid-liquid phase separation (LLPS) of G3BP1, suggesting that Caprin-1 likely facilitates SG formation via other mechanisms. Thus, we dissected various domains of Caprin-1 and investigated their role in LLPS in vitro and SG formation in cells. The C-terminal domain of Caprin-1 underwent spontaneous LLPS, whereas the N-terminal domain and GIM of Caprin-1 suppressed LLPS of G3BP1. The opposing effect of the N- and C-terminal domains of Caprin-1 on SG formation were demonstrated in cells with or without the endogenous Caprin-1. We propose that the N- and C-terminal domains of Caprin-1 regulate SG formation in a "yin and yang" fashion, mediating the dynamic and reversible assembly of SGs.
    MeSH term(s) RNA Recognition Motif Proteins/metabolism ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/metabolism ; DNA Helicases/metabolism ; Cytoplasmic Granules/metabolism ; Stress Granules ; GTPase-Activating Proteins/metabolism ; Ubiquitin-Specific Proteases/metabolism
    Chemical Substances RNA Recognition Motif Proteins ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; DNA Helicases (EC 3.6.4.-) ; GTPase-Activating Proteins ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2207975119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of Zuo's warming Yang acupuncture therapy combined with lifestyle interventions on prediabetes: A randomized controlled trial.

    Li, Yang / Xie, Kehang / Zeng, Xuanli / Ding, Lu / Wang, Yuting / Lu, Liming / Zuo, Changbo

    Complementary therapies in medicine

    2023  Volume 78, Page(s) 102985

    Abstract: ... on prediabetes. The purpose of this study was to evaluate the effect and safety of Zuo's warming Yang ... warming Yang acupuncture therapy per week. The primary outcomes measure fasting plasma glucose (FPG), 2 ... 5.40,5.80), P = 0.015). No severe adverse events were reported.: Conclusions: Zuo's warming Yang ...

    Abstract Background: Acupuncture has promising effects on diabetes, but there is limited evidence on prediabetes. The purpose of this study was to evaluate the effect and safety of Zuo's warming Yang acupuncture therapy on prediabetic patients.
    Methods: Fifty five individuals with prediabetes were recruited for the study. Participants in the non-acupuncture group received a 12-week lifestyle intervention, while those in the acupuncture group received the same lifestyle intervention in addition to two 50-minute sessions of Zuo's warming Yang acupuncture therapy per week. The primary outcomes measure fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), and Glycated hemoglobin determination (HbA1c) after 12 weeks of treatment.
    Results: Both acupuncture group and non-acupuncture group showed significant reductions in FPG and 2hPG levels after treatment, with a statistically significant difference between them (FPG:6.25 ± 0.48 vs 5.73 ± 0.50, P < 0.001; 6.21 ± 0.42 vs 6.04 ± 0.41, P = 0.035; 2hPG:8.90(8.44,9.88) vs 7.95(6.93,8.34), P < 0.001; 9.22 ± 1.15 vs 8.70 ± 1.34, P = 0.046; respectively). In addition, FPG and 2hPG in the acupuncture group decreased more significantly than those in the non-acupuncture group after treatment, and the difference was statistically significant (FPG:5.73 ± 0.50 vs 6.04 ± 0.41, P = 0.014;2hPG:7.95(6.93,8.34) vs 8.70 ± 1.34, P = 0.015; respectively). Although both groups showed reductions in HbA1c, only the decrease in the acupuncture group was statistically significant(5.80(5.60,5.90) vs 5.60(5.40,5.80), P = 0.015). No severe adverse events were reported.
    Conclusions: Zuo's warming Yang acupuncture therapy conjunction with lifestyle interventions was more effective than lifestyle interventions alone in reducing FPG, 2hPG and HbA1c levels in prediabetic patients. These results suggest that Zuo's warming Yang acupuncture therapy may be a safe and effective treatment option for prediabetes.
    MeSH term(s) Humans ; Prediabetic State/therapy ; Blood Glucose ; Glycated Hemoglobin ; Diabetes Mellitus ; Acupuncture Therapy ; Diabetes Mellitus, Type 2/therapy
    Chemical Substances Blood Glucose ; Glycated Hemoglobin
    Language English
    Publishing date 2023-09-18
    Publishing country Scotland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1155895-7
    ISSN 1873-6963 ; 0965-2299
    ISSN (online) 1873-6963
    ISSN 0965-2299
    DOI 10.1016/j.ctim.2023.102985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of Acupuncture Combined with Yi Qi Yang Yin and Blood Activating Formula on Blood Glucose and Renal Function in Early Diabetic Nephropathy: A Randomized Controlled Trial.

    Tang, Yange / Yang, Jiaxiang / Wang, Jing / Wu, Jie / Zheng, Zhiyuan / Gu, Mengjin

    Alternative therapies in health and medicine

    2024  

    Abstract: Objective: To study the effects of acupuncture combined with the formula of Yi Qi Yang Yin and ...

    Abstract Objective: To study the effects of acupuncture combined with the formula of Yi Qi Yang Yin and blood activating (A-YBF) on blood glucose levels and renal function in patients with early diabetic nephropathy.
    Methods: 96 patients with early diabetic nephropathy treated in our hospital from April 2021 to April 2022 were included in the study and divided into the control group (conventional medical treatment) and the study group (A-YBF), with 48 cases in each group. The efficacy and adverse effects were recorded by comparing the Chinese medicine symptom points, blood glucose level, renal function, and inflammatory factor level between the two groups before and after the treatment.
    Results: The clinical efficacy of the study group was significantly higher than that of the control group (P < .05). Before treatment, no difference was found between the primary and secondary symptom scores of the two groups (P > .05); after treatment, the primary and secondary symptom scores of the study group were lower than those of the control group (P < .05). Before treatment, there was no difference in fasting blood glucose (FPG) and 2h postprandial glucose (2hPG) levels; 24h urine protein quantification, cystatin C (Cys-C), urinary albumin excretion rate (UAER), and estimated glomerular filtration rate (eGFR) levels; and growth differentiation factor-15 (GDF-15), interleukin-1β (IL-1β), interleukin-17 (IL-17), and serum amyloid A (SAA) levels between the two groups (P > .05). After treatment, FPG and 2hPG levels; 24h urine protein quantification, Cys-C and UAER levels; and GDF-15, IL-1β, IL-17, and SAA levels were lower in the study group than in the control group, while eGFR levels were higher than those in the control group (P < .05).
    Conclusion: A-YBF can effectively reduce blood glucose levels and improve renal function in patients with early diabetic nephropathy and can be promoted in clinical application.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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