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Article ; Online: Anna Maria Lorusso – Claudio Paolucci – Patrizia Violi (eds.), Narratività. Problemi, analisi, prospettive

Marco Mondino

Between, Vol 4, Iss

2014 Volume 7

Abstract: Review of the book Narratività. Problemi, analisi, prospettive, edited by Anna Maria Lorusso ...

Abstract	Review of the book Narratività. Problemi, analisi, prospettive, edited by Anna Maria Lorusso, Claudio Paolucci and Patrizia Violi.
Keywords	Geography. Anthropology. Recreation ; G ; Language. Linguistic theory. Comparative grammar ; P101-410 ; Translating and interpreting ; P306-310
Language	English
Publishing date	2014-05-01T00:00:00Z
Publisher	Università degli Studi di Cagliari
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Leveraging the Tumor Immune Microenvironment To Overcome Genitourinary Cancers.

Bellone, Matteo / Mondino, Anna

European urology oncology

2023 Volume 6, Issue 3, Page(s) 273–274

MeSH term(s)	Humans ; Urogenital Neoplasms ; Tumor Microenvironment
Language	English
Publishing date	2023-05-03
Publishing country	Netherlands
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2023.04.002
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Article ; Online: Microbial short-chain fatty acids: a strategy to tune adoptive T cell therapy.

Rangan, Priya / Mondino, Anna

Journal for immunotherapy of cancer

2022 Volume 10, Issue 7

Abstract: The gut microbiota and its metabolites have been shown to play a pivotal role in the regulation of metabolic, endocrine and immune functions. Though the exact mechanism of action remains to be fully elucidated, available knowledge supports the ability of ...

Abstract	The gut microbiota and its metabolites have been shown to play a pivotal role in the regulation of metabolic, endocrine and immune functions. Though the exact mechanism of action remains to be fully elucidated, available knowledge supports the ability of microbiota-fermented short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, to influence epigenetic and metabolic cascades controlling gene expression, chemotaxis, differentiation, proliferation, and apoptosis in several non-immune and immune cell subsets. While used as preferred metabolic substrates and sources of energy by colonic gut epithelial cells, most recent evidence indicates that these metabolites regulate immune functions, and in particular fine-tune T cell effector, regulatory and memory phenotypes, with direct in vivo consequences on the efficacy of chemotherapy, radiotherapy and immunotherapy. Most recent data also support the use of these metabolites over the course of T cell manufacturing, paving the way for refined adoptive T cell therapy engineering. Here, we review the most recent advances in the field, highlighting in vitro and in vivo evidence for the ability of SCFAs to shape T cell phenotypes and functions.
MeSH term(s)	Cell- and Tissue-Based Therapy ; Colon ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome ; Microbiota
Chemical Substances	Fatty Acids, Volatile
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2021-004147
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Article ; Online: To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.

Mondino, Anna / Manzo, Teresa

Frontiers in immunology

2020 Volume 11, Page(s) 1915

Abstract: The generation of immunological memory is a hallmark of adaptive immunity by which the immune system "remembers" a previous encounter with an antigen expressed by pathogens, tumors, or normal tissues; and, upon secondary encounters, mounts faster and ... ...

Abstract	The generation of immunological memory is a hallmark of adaptive immunity by which the immune system "remembers" a previous encounter with an antigen expressed by pathogens, tumors, or normal tissues; and, upon secondary encounters, mounts faster and more effective recall responses. The establishment of T cell memory is influenced by both cell-intrinsic and cell-extrinsic factors, including genetic, epigenetic and environmental triggers. Our current knowledge of the mechanisms involved in memory T cell differentiation has instructed new opportunities to engineer T cells with enhanced anti-tumor activity. The development of adoptive T cell therapy has emerged as a powerful approach to cure a subset of patients with advanced cancers. Efficacy of this approach often requires long-term persistence of transferred T cell products, which can vary according to their origin and manufacturing conditions. Host preconditioning and post-transfer supporting strategies have shown to promote their engraftment and survival by limiting the competition with a hostile tumor microenvironment and between pre-existing immune cell subsets. Although in the general view pre-existing memory can confer a selective advantage to adoptive T cell therapy, here we propose that also "bad memories"-in the form of antigen-experienced T cell subsets-co-evolve with consequences on newly transferred lymphocytes. In this review, we will first provide an overview of selected features of memory T cell subsets and, then, discuss their putative implications for adoptive T cell therapy.
MeSH term(s)	Adaptive Immunity ; Animals ; Cell Differentiation ; Humans ; Immunologic Memory ; Immunotherapy, Adoptive ; Lymphocyte Activation ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Phenotype ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Tumor Escape ; Tumor Microenvironment
Language	English
Publishing date	2020-08-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.01915
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Article ; Online: Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy.

Pocaterra, Arianna / Catucci, Marco / Mondino, Anna

Current opinion in immunology

2021 Volume 74, Page(s) 53–59

Abstract: Adoptive T cell therapy (ACT) with tumor-reactive lymphocytes can overcome the immune desert of poorly immunogenic tumors and instruct tumor eradication. Several hurdles limit the efficacy of this strategy against solid tumor including, but not limited ... ...

Abstract	Adoptive T cell therapy (ACT) with tumor-reactive lymphocytes can overcome the immune desert of poorly immunogenic tumors and instruct tumor eradication. Several hurdles limit the efficacy of this strategy against solid tumor including, but not limited to, sub optimal T cell engraftment, tumor infiltration, poor tumor antigenicity/immunogenicity, and immunosuppressive or resistance mechanisms. Recent advances indicate that concomitant treatments can be set in place to offset such barriers. In this review, we highlight the beneficial effects of combining ACT with conventional chemo and/or radiotherapy. While originally classified as immunosuppressive, these methodologies can also promote the engraftment of ACT products, immunogenic cell death, and the reprogramming of more favorable microenvironments. Data indicates that systemic and local chemo/radiotherapy regimens promote intratumoral cytokine and chemokine upregulation, tumor antigen presentation and cross presentation, infiltration and in situ T cells reactivation. Here we review the most recent contributions supporting these notions and discuss further developments.
MeSH term(s)	Antigens, Neoplasm ; Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive/methods ; Neoplasms/metabolism ; T-Lymphocytes ; Tumor Microenvironment
Chemical Substances	Antigens, Neoplasm
Language	English
Publishing date	2021-11-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2021.10.004
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Article: Sleep and cognition in aging dogs. A polysomnographic study.

Mondino, Alejandra / Catanzariti, Magaly / Mateos, Diego Martin / Khan, Michael / Ludwig, Claire / Kis, Anna / Gruen, Margaret E / Olby, Natasha J

Frontiers in veterinary science

2023 Volume 10, Page(s) 1151266

Abstract: Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of sleep ...

Abstract	Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer's disease) report that their dogs suffer from difficulty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance. Methods: We performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated. Results: Dogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed differences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more affected dogs. Discussion: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography's potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1151266
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Article: Snow Metrics as Proxy to Assess Sarcoptic Mange in Wild Boar: Preliminary Results in Aosta Valley (Italy).

Viani, Annalisa / Orusa, Tommaso / Borgogno-Mondino, Enrico / Orusa, Riccardo

Life (Basel, Switzerland)

2023 Volume 13, Issue 4

Abstract: The widespread diffusion of the wild boar on the Italian territory and its consistent use for hunting have created the possibility to conduct multiple studies on the pathologies afflicting this ungulate. Nevertheless, in the last two decades, only some ... ...

Abstract	The widespread diffusion of the wild boar on the Italian territory and its consistent use for hunting have created the possibility to conduct multiple studies on the pathologies afflicting this ungulate. Nevertheless, in the last two decades, only some pathologies such as classical and African Swine Fever, Tuberculosis, Brucellosis from
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13040987
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Article ; Online: Correction: Monoallelic Germline TSC1 Mutations Are Permissive for T Lymphocyte Development and Homeostasis in Tuberous Sclerosis Complex Individuals.

Pilipow, Karolina / Basso, Veronica / Migone, Nicola / Mondino, Anna

PloS one

2019 Volume 14, Issue 6, Page(s) e0218354

Abstract: This corrects the article DOI: 10.1371/journal.pone.0091952.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0091952.].
Language	English
Publishing date	2019-06-07
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0218354
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Article ; Online: Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer.

Rospo, Giuseppe / Chilà, Rosaria / Matafora, Vittoria / Basso, Veronica / Lamba, Simona / Bartolini, Alice / Bachi, Angela / Di Nicolantonio, Federica / Mondino, Anna / Germano, Giovanni / Bardelli, Alberto

Genome medicine

2024 Volume 16, Issue 1, Page(s) 15

Abstract: Background: Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes; ... ...

Abstract	Background: Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes; however, a systematic classification of the neoantigen repertoire in MMRd CRC is lacking. Mass spectrometry peptidomics has demonstrated the existence of MHC class I associated peptides (MAPs) originating from non-coding DNA regions. Based on these premises we investigated DNA genomic regions responsible for generating MMRd-induced peptides. Methods: We exploited mouse CRC models in which the MMR gene Mlh1 was genetically inactivated. Isogenic cell lines CT26 Mlh1 Results: Whole genome sequencing analyses revealed an unbalanced distribution of immune edited alterations across the genome in Mlh1 Conclusions: Our results suggest that-in comparison to MMR proficient CRC-MMRd tumors generate a significantly higher number of non-canonical mutated peptides able to elicit T cell responses. These results reveal the importance of evaluating the diversity of neoepitope repertoire in MMRd tumors.
MeSH term(s)	Animals ; Mice ; DNA Mismatch Repair/genetics ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Colorectal Neoplasms/pathology ; Colonic Neoplasms ; Peptides ; Histocompatibility Antigens Class I/genetics ; DNA ; Brain Neoplasms ; Neoplastic Syndromes, Hereditary
Chemical Substances	Peptides ; Histocompatibility Antigens Class I ; DNA (9007-49-2)
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-023-01275-3
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Book ; Online: Longitudinal survey data for diversifying temporal dynamics in flood risk modelling

Mondino, Elena / Scolobig, Anna / Borga, Marco / Baldassarre, Giuliano

eISSN: 1684-9981

2021

Abstract: Numerous scholars have unravelled the complexities and underlying uncertainties of coupled human and water systems in various fields and disciplines. These complexities, however, are not always reflected in the way in which the dynamics of human-water ... ...

Abstract	Numerous scholars have unravelled the complexities and underlying uncertainties of coupled human and water systems in various fields and disciplines. These complexities, however, are not always reflected in the way in which the dynamics of human-water systems are modelled. One reason is the lack of social data times series, which may be provided by longitudinal surveys. Here, we show the value of collecting longitudinal survey data to enrich sociohydrological modelling of flood risk. To illustrate, we compare and contrast two different approaches (repeated cross-sectional and panel) for collecting longitudinal data, and explore changes in flood risk awareness and preparedness in a municipality hit by a flash flood in 2018. We found that risk awareness has not changed significantly in the timeframe under study (one year). Perceived preparedness also did not change, but we observed differences related to damage severity. More precisely, preparedness increased only among those respondents who suffered low damages during the flood event. We also found gender differences across both approaches for most of the variables explored. Lastly, we argue that results that are consistent across the two approaches constitute robust data that can be used for the parametrisation of sociohydrological models. We posit that there is a need to improve socio-demographic heterogeneity in modelling human-water systems in order to better support risk management.
Subject code	910
Language	English
Publishing date	2021-03-31
Publishing country	de
Document type	Book ; Online
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