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Article ; Online: Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of "metabolism-based pathology".

Masui, Kenta / Mischel, Paul S

2023 Volume 73, Issue 11, Page(s) 533–541

Abstract: Molecular genetic approaches are now mandatory for cancer diagnostics, especially for brain tumors. Genotype-based diagnosis has predominated over the phenotype-based approach, with its prognostic and predictive powers. However, comprehensive genetic ... ...

Abstract	Molecular genetic approaches are now mandatory for cancer diagnostics, especially for brain tumors. Genotype-based diagnosis has predominated over the phenotype-based approach, with its prognostic and predictive powers. However, comprehensive genetic testing would be difficult to perform in the clinical setting, and translational research is required to histologically decipher the peculiar biology of cancer. Of interest, recent studies have demonstrated discrete links between oncogenotypes and the resultant metabolic phenotypes, revealing cancer metabolism as a promising histologic surrogate to reveal specific characteristics of each cancer type and indicate the best way to manage cancer patients. Here, we provide an overview of our research progress to work on cancer metabolism, with a particular focus on the genomically well-characterized malignant tumor glioblastoma. With the use of clinically relevant animal models and human tissue, we found that metabolic reprogramming plays a major role in the aggressive cancer biology by conferring therapeutic resistance to cancer cells and rewiring their epigenomic landscapes. We further discuss our future endeavor to establish "metabolism-based pathology" on how the basic knowledge of cancer metabolism could be leveraged to improve the management of patients by linking cancer cell genotype, epigenotype, and phenotype through metabolic reprogramming.
MeSH term(s)	Animals ; Humans ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Epigenomics ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Epigenesis, Genetic
Language	English
Publishing date	2023-09-27
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13379
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Article ; Online: Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma.

Masui, Kenta / Onizuka, Hiromi / Muragaki, Yoshihiro / Kawamata, Takakazu / Kurata, Atsushi / Komori, Takashi

Brain tumor pathology

2024 Volume 41, Issue 2, Page(s) 92–95

MeSH term(s)	Humans ; Male ; Astrocytoma/genetics ; Astrocytoma/pathology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Gene Deletion ; Isocitrate Dehydrogenase/genetics ; Mutation ; Adult
Chemical Substances	CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; IDH1 protein, human (EC 1.1.1.42.) ; Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2024-04-10
Publishing country	Japan
Document type	Letter ; Case Reports
ZDB-ID	1193775-0
ISSN	1861-387X ; 1433-7398 ; 0914-8108
ISSN (online)	1861-387X
ISSN	1433-7398 ; 0914-8108
DOI	10.1007/s10014-024-00484-x
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Zs.A 4555: Show issues

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Article ; Online: Clinical Features of Pituitary or Parasellar Tumor Onset with Cranial Nerve Palsy: Surgical Intervention Considerations.

Oda, Yuichi / Amano, Kosaku / Masui, Kenta / Kawamata, Takakazu

World neurosurgery

2023 Volume 175, Page(s) e832–e840

Abstract: Objective: This study aimed to clarify the symptoms of pituitary or parasellar tumor onset with cranial nerve palsy (CNP) and to improve our knowledge of this rare symptom and its most appropriate treatment.: Methods: Among 1281 patients with ... ...

Abstract	Objective: This study aimed to clarify the symptoms of pituitary or parasellar tumor onset with cranial nerve palsy (CNP) and to improve our knowledge of this rare symptom and its most appropriate treatment. Methods: Among 1281 patients with pituitary or parasellar tumors surgically treated from 2003 to 2020, 30 cases (2.34%; 15 men and 15 women; mean age: 55.6 years, range: 6-83 years) first presenting with CNP were reviewed to evaluate the neurological symptoms, histological diagnosis, interval from onset to surgery, and time before complete CNP recovery. Results: Pathological diagnoses comprised 17 pituitary adenomas, including 10 pituitary apoplexies and 4 adrenocorticotropic hormone-positive adenomas, and 13 other tumors, including 3 chordomas, 2 xanthogranulomas, 2 malignant lymphomas, 2 metastatic tumors, 1 Rathke cleft cyst, 1 plasmacytoma, 1 craniopharyngioma, and 1 neuroendocrine carcinoma. The mechanisms causing CNP were pituitary apoplexy (n = 10), cranial nerve compression or involvement (n = 17), and inflammatory changes (n = 9). As the first manifestation, 20 (66.7%) patients presented with oculomotor nerve palsy, 2 (6.7%) with trochlear nerve palsy, and 13 (43.3%) with abducens nerve palsy. Full recovery of CNP was obtained in 25 patients (83.3%) after surgery alone and in 2 patients (6.7%) after adjuvant therapy. Early surgery provided no significant difference in full recovery rates although it reduced the time to reach full recovery. Conclusions: It is critical to determine the mechanisms of CNP and intervene surgically to improve symptoms, shorten the duration of the disorder, prevent relapses, and obtain the correct pathological diagnosis to select the proper adjuvant therapy.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Cranial Nerve Diseases/etiology ; Cranial Nerve Diseases/surgery ; Pituitary Apoplexy/surgery ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/surgery ; Pituitary Neoplasms/pathology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.04.031
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Zs.A 1159: Show issues

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Article: [Molecular Diagnostic Approaches for Diffuse Gliomas Based on Updated WHO Classification and cIMPACT-NOW Proposals].

Masui, Kenta / Komori, Takashi

No shinkei geka. Neurological surgery

2021 Volume 49, Issue 3, Page(s) 510–519

Abstract: The updated 2016 World Health Organization(WHO)classification of tumors of the central nervous system(CNS)has incorporated molecular parameters into the histopathological diagnosis of the tumor in the name of "integrated diagnosis." It has enabled more ... ...

Abstract	The updated 2016 World Health Organization(WHO)classification of tumors of the central nervous system(CNS)has incorporated molecular parameters into the histopathological diagnosis of the tumor in the name of "integrated diagnosis." It has enabled more prognostically precise diagnoses of brain tumor entities; however, its practical application has also raised concerns about whether genotypes predominate over phenotypes in tumor diagnostics. In response, cIMAPCT-NOW(the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-"Not Official WHO")was established to provide a forum for evaluating and recommending proposed changes to future CNS tumor classifications. cIMPACT has thus far published seven updates on the proposal and clarification of existing and new terms and entities. Herein, we highlight the current status of clinical application of the 2016 WHO classification and cIMPACT proposals, and the future endeavor to incorporate comprehensive genomic and epigenomic profiling of CNS tumors with the aid of artificial intelligence technology for better clinical decision-making to achieve the goal of precision medicine for each patient with brain tumors.
MeSH term(s)	Artificial Intelligence ; Central Nervous System Neoplasms ; Glioma/diagnosis ; Glioma/genetics ; Humans ; Pathology, Molecular ; World Health Organization
Language	Japanese
Publishing date	2021-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	197053-7
ISSN	1882-1251 ; 0301-2603
ISSN (online)	1882-1251
ISSN	0301-2603
DOI	10.11477/mf.1436204423
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Article: Metabolic and Epigenetic Reprogramming in a Case of Nuclear Protein in Testis (NUT) Carcinoma of the Retroperitoneum.

Serizawa, Mika / Serizawa, Kaho / Masui, Kenta / Toguchi, Makoto / Murakami, Kumiko / Yamamoto, Tomoko / Nagashima, Yoji / Takagi, Toshio / Kurata, Atsushi

Cureus

2024 Volume 16, Issue 1, Page(s) e52814

Abstract: Nuclear protein in testis (NUT) carcinoma is a rare but highly aggressive carcinoma, driven by genetic rearrangement of the NUT midline carcinoma family member 1 ( ...

Abstract	Nuclear protein in testis (NUT) carcinoma is a rare but highly aggressive carcinoma, driven by genetic rearrangement of the NUT midline carcinoma family member 1 (
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52814
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Article: Endoscope-assisted Trans-lamina Terminalis Resection of Chordoid Glioma at the Third Ventricle: A Case Report.

Oda, Yuichi / Amano, Kosaku / Chiba, Kentaro / Masui, Kenta / Kawamata, Takakazu

NMC case report journal

2023 Volume 10, Page(s) 285–289

Abstract: As per the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, chordoid glioma (CG) is defined as a slow-growing glial neoplasm categorized as grade II tumor. This tumor is primarily located in the anterior part ... ...

Abstract	As per the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, chordoid glioma (CG) is defined as a slow-growing glial neoplasm categorized as grade II tumor. This tumor is primarily located in the anterior part of the third ventricle, often adheres to important surrounding structures, and is hemorrhagic in nature. Therefore, dissecting this tumor is extremely difficult. In this study, we present the case of a 44-year-old man who initially complained of mild headache and was diagnosed with a homogeneous gadolinium-enhanced lesion in the third ventricle via magnetic resonance imaging. The pathological diagnosis based on his biopsy at the previous hospital was CG. The patient demonstrated no neurological deficit at that time, but the tumor had gradually grown, hydrocephalus appeared 2 years after the tumor was detected, and the patient developed short memory disorder and daytime sleepiness. We resected the tumor via the anterior interhemispheric trans-lamina terminalis approach using a microscope and an endoscope. The residual tumor at the blind spot of the microscopic view was resected under an angled rigid endoscopic view using dedicated tools for transsphenoidal surgery. The tumor was grossly resected, and the histopathological diagnosis was CG. Postoperative neurological findings included slight memory disorder and hypothalamic adrenal dysfunction. No tumor recurrence was reported 3 years post resection. The endoscope-assisted anterior interhemispheric trans-lamina terminalis approach was determined useful for CG resection with minimal surgical complications and without tumor recurrence.
Language	English
Publishing date	2023-10-14
Publishing country	Japan
Document type	Case Reports
ISSN	2188-4226
ISSN	2188-4226
DOI	10.2176/jns-nmc.2023-0107
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Article ; Online: Recurrent high-grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation.

Masui, Kenta / Onizuka, Hiromi / Nitta, Masayuki / Muragaki, Yoshihiro / Kawamata, Takakazu / Komori, Takashi

Pathology international

2023 Volume 73, Issue 3, Page(s) 144–146

MeSH term(s)	Humans ; Isocitrate Dehydrogenase/genetics ; Mosaicism ; Astrocytoma/genetics ; Glioma/genetics ; Mutation ; Brain Neoplasms/genetics
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2023-01-16
Publishing country	Australia
Document type	Letter
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13308
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Article: [ATRX(alpha-thalassemia/mental retardation syndrome X-linked)].

Masui, Kenta / Komori, Takashi

Nihon rinsho. Japanese journal of clinical medicine

2019 Volume 74 Suppl 7, Page(s) 137–142

MeSH term(s)	Humans ; Mental Retardation, X-Linked ; alpha-Thalassemia
Language	Japanese
Publishing date	2019-01-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article: Systemic Metastasis of Pediatric Diffuse High-grade Astrocytoma: A Case Report.

Chiba, Kentaro / Aihara, Yasuo / Oda, Yuichi / Masui, Kenta / Komori, Takashi / Yokoo, Hideaki / Kawamata, Takakazu

NMC case report journal

2023 Volume 10, Page(s) 265–271

Abstract: Extracranial brain tumor metastases are extremely rare. The etiology, pathophysiology, and clinical progression of systemic metastatic brain cancer remain to be elucidated. We encountered a case of pediatric diffuse high-grade astrocytoma in a four-year- ... ...

Abstract	Extracranial brain tumor metastases are extremely rare. The etiology, pathophysiology, and clinical progression of systemic metastatic brain cancer remain to be elucidated. We encountered a case of pediatric diffuse high-grade astrocytoma in a four-year-old girl with subcutaneous and lymph node metastases. Numerous metastatic lesions emerged, progressed rapidly, and were difficult to manage despite temozolomide (TMZ) administration. The patient underwent repeated surgical resection for these lesions. Conversely, the primary intracranial lesions responded well to TMZ for some time. However, the patient died 15 months after the initial diagnosis. Extracranial metastasis and highly varying effects of chemotherapy were the characteristic clinical features in this case. Our analysis did not reveal definitive histopathological and molecular factors contributing to this presentation. The lack of notable molecular pathological features illustrates the unpredictability of glioma metastasis, and the treatment for extracranial metastasis remains unknown. A gene panel analysis revealed several genetic aberrations, including
Language	English
Publishing date	2023-10-14
Publishing country	Japan
Document type	Case Reports
ISSN	2188-4226
ISSN	2188-4226
DOI	10.2176/jns-nmc.2023-0018
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Article ; Online: Association Between Pretreatment

Kaneko, Koichiro / Koriyama, Shunichi / Tsuzuki, Shunsuke / Masui, Kenta / Kanasaki, Rie / Yamamoto, Atsushi / Nagao, Michinobu / Muragaki, Yoshihiro / Kawamata, Takakazu / Sakai, Shuji

World neurosurgery

2024

Abstract: Objective: To clarify the relationships between : Methods: A total of 125 newly diagnosed patients with ADG were enrolled. We compared the maximum standardized uptake value (SUVmax), tumor-to-normal background ratio (TNR), metabolic tumor volume (MTV) ...

Abstract	Objective: To clarify the relationships between Methods: A total of 125 newly diagnosed patients with ADG were enrolled. We compared the maximum standardized uptake value (SUVmax), tumor-to-normal background ratio (TNR), metabolic tumor volume (MTV), and total lesion methionine uptake (TLMU) to the histology and genetics of the patients with ADG. We also evaluated the prognoses of the 93 surgically treated patients. Results: The patients with isocitrate dehydrogenase wild ADG showed significantly higher MET-PET metrics (P < 0.05 for all parameters), significantly shorter overall survival and progression-free survival (P < 0.0001 for both) than those of the patients with isocitrate dehydrogenase mutant (IDHm) ADG. In the IDHm ADG group, the SUVmax, MTV, and TLMU values were significantly higher in patients with IDHm grade (G) 4 astrocytoma than patients with IDHm G2/3 astrocytoma (P < 0.05 for all), but not than patients with G2-3 oligodendroglioma. The progression-free survival was significantly shorter in the patients with G4 astrocytoma versus the patients with G2/3 astrocytoma and G3 oligodendroglioma (P < 0.05 for both). The SUVmax and TNR values were significantly higher in recurrent patients than nonrecurrent patients (P < 0.01 for both), but no significant differences were found in MTV or TLMU values. Conclusions: MET-PET metrics well reflect the histological subtype, WHO grade and prognosis of ADG based on the 2021 WHO classification, with the exception of oligodendroglial tumors. Volumetric parameters were not significantly associated with recurrence, unlike the SUVmax and TNR.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.164
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