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  1. Article ; Online: Chemoproteomic Profiling of Erastin-Interacting Proteins.

    Li, Zehua / Liu, Dongyang / Wang, Yankun / Wang, Chu

    Chemical research in toxicology

    2024  Volume 37, Issue 1, Page(s) 109–116

    Abstract: Ferroptosis is an iron-related cell death caused by irregular lipid peroxidation that has been implicated with a variety of disease. Erastin is a canonical ferroptosis inducer that is known to function by inhibiting system ... ...

    Abstract Ferroptosis is an iron-related cell death caused by irregular lipid peroxidation that has been implicated with a variety of disease. Erastin is a canonical ferroptosis inducer that is known to function by inhibiting system X
    MeSH term(s) Cell Death ; Piperazines/pharmacology ; Piperazines/metabolism ; Lipid Peroxidation ; Reactive Oxygen Species/metabolism
    Chemical Substances erastin ; Piperazines ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.3c00347
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Systemic Effects of a Phage Cocktail on Healthy Weaned Piglets.

    Liu, Yankun / Lin, Yan / Zhu, Weiyun

    Biology

    2024  Volume 13, Issue 4

    Abstract: Numerous studies have demonstrated that bacteriophages (phages) can effectively treat intestinal bacterial infections. However, research on the impact of phages on overall body health once they enter the intestine is limited. This study utilized weaned ... ...

    Abstract Numerous studies have demonstrated that bacteriophages (phages) can effectively treat intestinal bacterial infections. However, research on the impact of phages on overall body health once they enter the intestine is limited. This study utilized weaned piglets as subjects to evaluate the systemic effects of an orally administered phage cocktail on their health. Twelve 21-day-old weaned piglets were divided into control (CON) and phage gavage (Phages) groups. The phage cocktail consisted of five lytic phages, targeting
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13040271
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  3. Article ; Online: Catalytic Asymmetric Dehydrogenative Si-H/N-H Coupling: Synthesis of Silicon-Stereogenic Silazanes.

    Liu, Meng-Meng / Xu, Yankun / He, Chuan

    Journal of the American Chemical Society

    2023  Volume 145, Issue 21, Page(s) 11727–11734

    Abstract: Despite growing progress in the construction of silazanes, the catalytic asymmetric synthesis of silicon-stereogenic silazanes is significantly less explored and remains a considerable challenge. Herein, we report a highly enantioselective synthesis of ... ...

    Abstract Despite growing progress in the construction of silazanes, the catalytic asymmetric synthesis of silicon-stereogenic silazanes is significantly less explored and remains a considerable challenge. Herein, we report a highly enantioselective synthesis of silicon-stereogenic silazanes via catalytic dehydrogenative coupling of dihydrosilanes with anilines. The reaction readily produces a wide range of chiral silazanes and bis-silazanes in excellent yields and stereoselectivities (up to 99%
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c02263
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  4. Article ; Online: Efficacy of pharmacological treatments for Dravet syndrome: Systematic review and network meta-analysis.

    Xia, Dujiang / Zhang, Peng / Chen, Yankun / Liu, Xi / Chen, Yangmei

    Seizure

    2024  Volume 117, Page(s) 90–97

    Abstract: Background: Numerous anti-seizure medications (ASMs) have been developed to treat Dravet syndrome (DS). This network meta-analysis aimed to comprehensively analyse the efficacy of ASMs in DS patients, especially in non-seizure-free patients after ... ...

    Abstract Background: Numerous anti-seizure medications (ASMs) have been developed to treat Dravet syndrome (DS). This network meta-analysis aimed to comprehensively analyse the efficacy of ASMs in DS patients, especially in non-seizure-free patients after treatment.
    Methods: PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure databases were searched. The treatment efficacy was assessed by the percentage reduction in monthly convulsive seizure frequency (MCSF) from baseline or individuals who achieved at least a 50 % or 75 % reduction from baseline in convulsive seizure frequency (CSF).
    Results: Six randomised controlled trials with 633 participants and seven regimens based on four add-on ASMs-fenfluramine (FFA), stiripentol (STP), cannabidiol (CBD), and soticlestat-were included. All drug regimens were superior to the placebo at achieving at least 50 % and 75 % reductions in CSF, but only STP, 0.4 mg/kg/d FFA (FFA0.4), and 0.7 mg/kg/d FFA (FFA0.7) reduced MCSF. STP (50 mg/kg/d) had the highest correlation with reducing MCSF and achieving at least a 50 % reduction from baseline in CSF, followed by FFA0.4 and FFA0.7. Soticlestat and CBD may also be effective in reducing seizures in DS patients.
    Conclusion: STP can be recommended as the first choice among the included drug regimens for reducing seizures in DS patients, while FFA0.4 may be considered the second choice. Other drug regimens can be used as alternative treatments. STP, FFA0.4, and FFA0.7 may consistently present favourable efficacy in most DS patients, while other regimens may present prominent inter-individual variability. Appropriate dose selection and intense monitoring are necessary when treating DS using these drugs.
    MeSH term(s) Humans ; Epilepsies, Myoclonic/drug therapy ; Anticonvulsants/therapeutic use ; Network Meta-Analysis ; Cannabidiol/therapeutic use ; Dioxolanes
    Chemical Substances Anticonvulsants ; Cannabidiol (19GBJ60SN5) ; stiripentol (R02XOT8V8I) ; Dioxolanes
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article ; Systematic Review ; Meta-Analysis ; Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2024.02.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Spatial Distribution of

    Pak, Unil / Guo, Qingxi / Liu, Zhili / Wang, Xugao / Liu, Yankun / Jin, Guangze

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 16

    Abstract: Investigating the spatial distributions and associations of tree populations provides better insights into the dynamics and processes that shape the forest community. Korean pine ( ...

    Abstract Investigating the spatial distributions and associations of tree populations provides better insights into the dynamics and processes that shape the forest community. Korean pine (
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12162906
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  6. Article ; Online: Evaluation of an Algorithm for the Segmentation of Lung Nodules in Computerized Tomography Images Based on the Automatic Location of A Threshold.

    Wang, Enguo / Li, Jun / Liu, Lei / Liu, Yankun

    Current medical imaging

    2023  

    Abstract: Background: Early detection of pulmonary nodules is critical for the clinical diagnosis and management of pulmonary nodules. Computed tomography imaging is currently the best imaging method for detecting pulmonary nodules.: Objective: This study ... ...

    Abstract Background: Early detection of pulmonary nodules is critical for the clinical diagnosis and management of pulmonary nodules. Computed tomography imaging is currently the best imaging method for detecting pulmonary nodules.
    Objective: This study proposes and applies a new thresholding-based method for identifying pulmonary nodules in computed tomography images.
    Methods: The proposed method involves segmenting the lung volume and identifying candidate nodules based on their intensity levels, which are higher than those of the lung parenchyma. Reference points on the histogram curve are used to determine a threshold value, and filtering by geometric characteristics is applied to reduce false positives. The performance of the proposed method is evaluated on a training set consisting of 35 nodules distributed among 16 cases with ground truth using the SPIE-AAPM Lung CT Challenge Database and ELCAP Public Lung Image Database.
    Results: The proposed method shows a significant reduction in false positives, filtering from an average of 12,380 candidate nodules to 19 detected nodules. The method also demonstrates a sensitivity of 88.6% for detecting pulmonary nodules with an error of 1 nodule in cases where complete detection is not reached.
    Conclusion: The proposed thresholding-based method improves the sensitivity of identifying pulmonary nodules in computed tomography images while reducing false positives.
    Language English
    Publishing date 2023-08-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1573-4056
    ISSN (online) 1573-4056
    DOI 10.2174/1573405620666230801125013
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  7. Article: Microbial diversity in camel milk from Xinjiang, China as revealed by metataxonomic analysis.

    Sun, Miao / Shao, Wei / Liu, Zhengyu / Ma, Xianlan / Chen, He / Zheng, Nan / Zhao, Yankun

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1367116

    Abstract: The quality of raw camel milk is affected by its bacterial composition and diversity. However, few studies have investigated the bacterial composition and diversity of raw camel milk. In this study, we obtained 20 samples of camel milk during spring and ... ...

    Abstract The quality of raw camel milk is affected by its bacterial composition and diversity. However, few studies have investigated the bacterial composition and diversity of raw camel milk. In this study, we obtained 20 samples of camel milk during spring and summer in Urumqi and Hami, Xinjiang, China. Single-molecule real-time sequencing technology was used to analyze the bacterial community composition. The results revealed that there were significant seasonal differences in the bacterial composition and diversity of camel milk. Overall,
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1367116
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  8. Article ; Online: AoSte12 Is Required for Mycelial Development, Conidiation, Trap Morphogenesis, and Secondary Metabolism by Regulating Hyphal Fusion in Nematode-Trapping Fungus

    Bai, Na / Xie, Meihua / Liu, Qianqian / Wang, Wenjie / Liu, Yankun / Yang, Jinkui

    Microbiology spectrum

    2023  , Page(s) e0395722

    Abstract: Nematode-trapping (NT) fungi are a unique group of carnivorous microorganisms that can capture and digest nematodes by producing ingenious trapping devices (traps). ...

    Abstract Nematode-trapping (NT) fungi are a unique group of carnivorous microorganisms that can capture and digest nematodes by producing ingenious trapping devices (traps).
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03957-22
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  9. Article: Involvement of AoMdr1 in the Regulation of the Fluconazole Resistance, Mycelial Fusion, Conidiation, and Trap Formation of

    Liu, Yankun / Yang, Xuewei / Zhu, Meichen / Bai, Na / Wang, Wenjie / Yang, Jinkui

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: Multidrug resistance (Mdr) proteins are critical proteins for maintenance of drug resistance in fungi. Mdr1 has been extensively studied ... ...

    Abstract Multidrug resistance (Mdr) proteins are critical proteins for maintenance of drug resistance in fungi. Mdr1 has been extensively studied in
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061612
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  10. Article: Antimicrobial Susceptibility, and Molecular Characterization of

    Liu, Huimin / Dong, Lei / Zhao, Yankun / Meng, Lu / Wang, Jiaqi / Wang, Cheng / Zheng, Nan

    Frontiers in microbiology

    2022  Volume 13, Page(s) 840670

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.840670
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