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  1. Article ; Online: Uncovering the potential molecular mechanism of liraglutide to alleviate the effects of high glucose on myoblasts based on high-throughput transcriptome sequencing technique.

    Fan, Dongmei / Zhang, Yunjie / Lu, Lanyu / Yin, Fuzai / Liu, Bowei

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 159

    Abstract: Background: Myoblasts play an important role in muscle growth and repair, but the high glucose environment severely affects their function. The purpose of this study is to explore the potential molecular mechanism of liraglutide in alleviating the ... ...

    Abstract Background: Myoblasts play an important role in muscle growth and repair, but the high glucose environment severely affects their function. The purpose of this study is to explore the potential molecular mechanism of liraglutide in alleviating the effects of high glucose environments on myoblasts.
    Methods: MTT, western blot, and ELISA methods were used to investigate the role of liraglutide on C2C12 myoblasts induced by high glucose. The high-throughput transcriptome sequencing technique was used to sequence C2C12 myoblasts from different treated groups. The DESeq2 package was used to identify differentially expressed-mRNAs (DE-mRNAs). Then, functional annotations and alternative splicing (AS) were performed. The Cytoscape-CytoHubba plug-in was used to identify multicentric DE-mRNAs.
    Results: The MTT assay results showed that liraglutide can alleviate the decrease of myoblasts viability caused by high glucose. Western blot and ELISA tests showed that liraglutide can promote the expression of AMPKα and inhibit the expression of MAFbx, MuRF1 and 3-MH in myoblasts. A total of 15 multicentric DE-mRNAs were identified based on the Cytoscape-CytoHubba plug-in. Among them, Top2a had A3SS type AS. Functional annotation identifies multiple signaling pathways such as metabolic pathways, cytokine-cytokine receptor interaction, cAMP signaling pathway and cell cycle.
    Conclusion: Liraglutide can alleviate the decrease of cell viability and degradation of muscle protein caused by high glucose, and improves cell metabolism and mitochondrial activity. The molecular mechanism of liraglutide to alleviate the effect of high glucose on myoblasts is complex. This study provides a theoretical basis for the clinical effectiveness of liraglutide in the treatment of skeletal muscle lesions in diabetes.
    MeSH term(s) Liraglutide/pharmacology ; Liraglutide/metabolism ; Transcriptome ; Muscle, Skeletal/metabolism ; Glucose/pharmacology ; Glucose/metabolism ; Myoblasts
    Chemical Substances Liraglutide (839I73S42A) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10076-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ablation of histone methyltransferase Suv39h2 in hepatocytes attenuates NASH in mice.

    Wu, Shiqiang / Ren, Wenjing / Hong, Jiameng / Yang, Yuyu / Lu, Yunjie

    Life sciences

    2024  Volume 343, Page(s) 122524

    Abstract: Aims: Non-alcoholic steatohepatitis (NASH) is characterized by aberrant lipid metabolism in hepatocytes. We investigated the involvement of a histone H3K9 methyltransferase Suv39h2 in the pathogenesis of NASH.: Methods and materials: NASH is induced ... ...

    Abstract Aims: Non-alcoholic steatohepatitis (NASH) is characterized by aberrant lipid metabolism in hepatocytes. We investigated the involvement of a histone H3K9 methyltransferase Suv39h2 in the pathogenesis of NASH.
    Methods and materials: NASH is induced by feeding the mice with a high-fat high-carbohydrate (HFHC) diet or a high-fat choline-deficient amino acid defined (HFD-CDAA) diet. The Suv39h2
    Key findings: Ablation of Suv39h2 in hepatocytes improved insulin sensitivity of the mice fed either the HFHC diet or the CDAA-HFD diet. Importantly, Suv39h2 deletion significantly ameliorated NAFLD as evidenced by reduced lipid accumulation, inflammation, and fibrosis in the liver. RNA-seq uncovered Vanin-1 (Vnn1) as a novel transcriptional target for Suv39h2. Mechanistically, Suv39h2 repressed Vnn1 transcription in hepatocytes exposed to free fatty acids. Consistently, Vanin-1 knockdown normalized lipid accumulation in Suv39h2-null hepatocytes. Importantly, a significant correlation between Suv39h2, Vanin-1, and hepatic triglyceride levels was identified in NASH patients.
    Significance: Our study uncovers a novel mechanism whereby Suv39h2 may contribute to NASH pathogenesis and suggests that targeting the Suv39h2-Vanin-1 axis may yield novel therapeutic solutions against NASH.
    MeSH term(s) Animals ; Humans ; Mice ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Hepatocytes/enzymology ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Lipid Metabolism
    Chemical Substances Suv39h2 protein, mouse (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2024.122524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Binary conformers of a flexible, long-chain fluoroalcohol: dispersion controlled selectivity and relative abundances in a jet.

    Lu, Tao / Xie, Fan / Seifert, Nathan A / Hamidi Mejlej, Reihaneh / Jäger, Wolfgang / Xu, Yunjie

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 14, Page(s) 10538–10545

    Abstract: The complex conformational panorama of binary 4,4,4-trifluoro-1-butanol (TFB) aggregates was investigated using chirped-pulse Fourier transform microwave spectroscopy, aided by conformational searches using CREST (Conformer-Rotamer Ensemble Sampling Tool) ...

    Abstract The complex conformational panorama of binary 4,4,4-trifluoro-1-butanol (TFB) aggregates was investigated using chirped-pulse Fourier transform microwave spectroscopy, aided by conformational searches using CREST (Conformer-Rotamer Ensemble Sampling Tool) and quantum chemistry calculations. From nearly 1500 initial dimer geometries, 16 most stable binary candidates were obtained within a relative energy window of ∼4 kJ mol
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d4cp00401a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fabrication of a tough, long-lasting adhesive hydrogel patch

    Lu, Yunjie / Li, Zhaohui / Li, Zewei / Zhou, Shihao / Zhang, Ning / Zhang, Jianming / Zong, Lu

    Nanoscale

    2024  Volume 16, Issue 2, Page(s) 645–656

    Abstract: Adhesive hydrogels (AHs) are considered ideal materials for flexible sensors. However, the lack of effective energy dissipation networks and sparse surface polar groups in AHs lead to poor mechanical properties and interfacial adhesion, which limit their ...

    Abstract Adhesive hydrogels (AHs) are considered ideal materials for flexible sensors. However, the lack of effective energy dissipation networks and sparse surface polar groups in AHs lead to poor mechanical properties and interfacial adhesion, which limit their practical application. Herein, a tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr05049a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production.

    Li, Zilong / Zhao, Qianwen / Lu, Yunjie / Zh, Yangxi

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 13, Page(s) e2201652

    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202201652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Adaptive response of flavonoids in Robinia pseudoacacia L. affected by the contamination of cadmium and elevated CO

    Zhang, Chunyan / Jia, Xia / Zhao, Yonghua / Wang, Lu / Wang, Yunjie

    Ecotoxicology and environmental safety

    2023  Volume 263, Page(s) 115379

    Abstract: As a key component in non-enzyme resistance system, flavonoids play a crucial role in the plant growth and defenses, which are significantly affected by biotic and abiotic factors such as fungi, bacteria, viruses, heavy metals, and atmospheric ... ...

    Abstract As a key component in non-enzyme resistance system, flavonoids play a crucial role in the plant growth and defenses, which are significantly affected by biotic and abiotic factors such as fungi, bacteria, viruses, heavy metals, and atmospheric CO
    MeSH term(s) Cadmium/toxicity ; Quercetin ; Carbon Dioxide ; Kaempferols ; Robinia ; Symbiosis ; Flavonoids ; Mycorrhizae
    Chemical Substances Cadmium (00BH33GNGH) ; Quercetin (9IKM0I5T1E) ; Carbon Dioxide (142M471B3J) ; Kaempferols ; Flavonoids
    Language English
    Publishing date 2023-08-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2023.115379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: DDIT4 S‐Nitrosylation Aids p38‐MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production

    Zilong Li / Qianwen Zhao / Yunjie Lu / Yangxi Zh

    Advanced Science, Vol 9, Iss 13, Pp n/a-n/a (2022)

    2022  

    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Biological evaluation and

    Wang, Yunjie / Liu, Zhaofeng / Lu, Jing / Wang, Wenyan / Wang, Lin / Yang, Yifei / Wang, Hongbo / Ye, Liang / Zhang, Jianzhao / Tian, Jingwei

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1161964

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1161964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between sugar-sweetened beverage consumption frequency and muscle strength

    Yunjie Zhang / Pan Xu / Yongjing Song / Nan Ma / Jinkui Lu

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    results from a sample of Chinese adolescents

    2023  Volume 9

    Abstract: Abstract Background Although sugar-sweetened beverage consumption has become an important and widespread concern, there are few studies on the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents. ... ...

    Abstract Abstract Background Although sugar-sweetened beverage consumption has become an important and widespread concern, there are few studies on the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents. The objective of this study was to analyze the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents. Methods A stratified whole-group sampling method was used to survey 25,893 adolescents aged 13–15 years old in China for sugar-sweetened beverage consumption frequency and muscle strength for grip strength and standing long jump. The subjects’ basic information, body mass index (BMI), and covariates were investigated. The association between sugar-sweetened beverage consumption frequency and muscle strength was analyzed by multivariate logisitc regression analysis. Results The proportions of Chinese adolescents who consumed sugar-sweetened beverage ≥ 3 times/week, 1–2 times/week, and < 1 time/week were 12.23%, 52.79%, and 34.98%, respectively. The differences in sugar-sweetened beverage consumption frequency were statistically significant when compared across gender, parental education, duration of physical activity, snacks, and mode of commuting to school (χ 2 values = 228.570, 51.422, 275.552, 3165.656, 10.988, P < 0.01). Logistic regression analysis showed that overall Chinese adolescents with sugary drinks 1–2 times/week (OR = 1.207, 95% CI:1.132–1.287) and sugary drinks ≥ 3 times/week (OR = 1.771, 95% CI:1.611–1.947) were associated with lower muscle strength compared to sugary drinks < 1 time/week showed a positive association (P < 0.01). The same trend was found for boys and girls. Conclusion Chinese adolescents’ sugar-sweetened beverage consumption is common, and high-frequency sugar-sweetened beverage consumption is associated with lower muscle strength. In the future, we should control the use of sugar-sweetened beverages and increase muscular strength training in Chinese adolescents to ...
    Keywords Adolescents ; Sugar-sweetened beverage consumption ; Muscle strength ; Cross-sectional survey ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Association between sugar-sweetened beverage consumption frequency and muscle strength: results from a sample of Chinese adolescents.

    Zhang, Yunjie / Xu, Pan / Song, Yongjing / Ma, Nan / Lu, Jinkui

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1010

    Abstract: Background: Although sugar-sweetened beverage consumption has become an important and widespread concern, there are few studies on the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents. The ... ...

    Abstract Background: Although sugar-sweetened beverage consumption has become an important and widespread concern, there are few studies on the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents. The objective of this study was to analyze the association between sugar-sweetened beverage consumption frequency and muscle strength in Chinese adolescents.
    Methods: A stratified whole-group sampling method was used to survey 25,893 adolescents aged 13-15 years old in China for sugar-sweetened beverage consumption frequency and muscle strength for grip strength and standing long jump. The subjects' basic information, body mass index (BMI), and covariates were investigated. The association between sugar-sweetened beverage consumption frequency and muscle strength was analyzed by multivariate logisitc regression analysis.
    Results: The proportions of Chinese adolescents who consumed sugar-sweetened beverage ≥ 3 times/week, 1-2 times/week, and < 1 time/week were 12.23%, 52.79%, and 34.98%, respectively. The differences in sugar-sweetened beverage consumption frequency were statistically significant when compared across gender, parental education, duration of physical activity, snacks, and mode of commuting to school (χ
    Conclusion: Chinese adolescents' sugar-sweetened beverage consumption is common, and high-frequency sugar-sweetened beverage consumption is associated with lower muscle strength. In the future, we should control the use of sugar-sweetened beverages and increase muscular strength training in Chinese adolescents to promote healthy growth.
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Body Mass Index ; East Asian People ; Muscle Strength ; Sugar-Sweetened Beverages
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15987-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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