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  1. Article ; Online: Effectiveness and safety of rivaroxaban for anticoagulation therapy in COVID-19: A meta-analysis of randomized controlled trials.

    Shen, Xiangbo / Qiu, Eryue / Liu, Zhao / Zhu, Xiaopeng / Zeng, Yiqian

    Saudi medical journal

    2024  Volume 45, Issue 4, Page(s) 341–348

    Abstract: Objectives: To evaluate the effectiveness and safety of rivaroxaban anticoagulation in COVID-19 patients.: Methods: PubMed, Embase, Cochrane Library electronic databases, and ClinicalTrials.gov were searched to identify all relevant randomized ... ...

    Abstract Objectives: To evaluate the effectiveness and safety of rivaroxaban anticoagulation in COVID-19 patients.
    Methods: PubMed, Embase, Cochrane Library electronic databases, and ClinicalTrials.gov were searched to identify all relevant randomized controlled trial studies from December 2019 to July 2023.
    Results: A total of 6 randomized controlled trials, which included a total of 3323 patients, were considered for evaluation. Overall, short-term all-cause mortality and hospitalization rates were not significantly different between the rivaroxaban and control groups. Thrombotic events were significantly reduced in the rivaroxaban prophylaxis group compared to the placebo control group. However, the reduction in thrombotic events was not significantly different between rivaroxaban therapy and heparin or low-molecular-weight heparin (LMWH). Rivaroxaban prophylaxis and the therapeutic dose may be associated with a higher rate of overall bleeding rate, but major bleeding rates did not differ substantially.
    Conclusion: Rivaroxaban may reduce thrombotic events in COVID-19 patients, but it does not appear to have an advantage over heparin or LMWH, and it may increase the risk of bleeding.
    MeSH term(s) Humans ; Rivaroxaban/therapeutic use ; Rivaroxaban/adverse effects ; Randomized Controlled Trials as Topic ; Anticoagulants/therapeutic use ; Anticoagulants/adverse effects ; COVID-19/complications ; COVID-19 Drug Treatment ; Hemorrhage/chemically induced ; Heparin, Low-Molecular-Weight/therapeutic use ; Heparin, Low-Molecular-Weight/adverse effects ; Factor Xa Inhibitors/therapeutic use ; Factor Xa Inhibitors/adverse effects ; Thrombosis/prevention & control ; Thrombosis/etiology ; Treatment Outcome ; Heparin/therapeutic use ; Heparin/adverse effects ; SARS-CoV-2
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Anticoagulants ; Heparin, Low-Molecular-Weight ; Factor Xa Inhibitors ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-04-23
    Publishing country Saudi Arabia
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    DOI 10.15537/smj.2024.45.4.20230728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2330: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 6: Show issues

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  2. Article ; Online: Reading the mind in the eyes in patients with idiopathic REM sleep behavior disorder.

    Li, Xudong / Shen, Miaoxin / Shen, Zhihong / Han, Ziling / Jiao, Jinsong / Tong, Xiaopeng

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Objectives: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by vocalizations, jerks, and motor behaviors during REM sleep, often associated with REM-related dream content, which is considered a prodromal stage of α- ... ...

    Abstract Objectives: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by vocalizations, jerks, and motor behaviors during REM sleep, often associated with REM-related dream content, which is considered a prodromal stage of α-synucleinopathy. The results of the Reading the Mind in the Eyes (RME) reflecting affective Theory of Mind (ToM) are inconsistent in α-synucleinopathy. The present study tried to investigate the RME in patients with iRBD.
    Methods: A total of 35 patients with iRBD and 26 healthy controls were included in the study. All participants were administered the RME and the cognitive assessments according to a standard procedure. The patients with iRBD were further divided into two groups (high or low RME) according to the scores of the RME (> 21, or ≤ 20).
    Results: The patients with iRBD had worse scores on cognitive tests compared with healthy controls involving global cognitive screening, memory, and visuospatial abilities (p < 0.05), but the scores of the RME were similar between the two groups (20.83 ± 3.38, 20.58 ± 3.43) (p ˃ 0.05). Patients with low RME had more obvious cognitive impairments than healthy controls. After applying Bonferroni correction for multiple tests, the low REM group only performed worse on the Sum of trials 1 to 5 and delayed recall of the RAVLT compared with the healthy control group (p < 0.001, = 0.002). The RME correlated with the scores of cognitive tests involving executive function, attention, memory, and visuospatial function.
    Conclusions: The changes in RME had a relationship with cognitive impairments, especially memory, in patients with iRBD.
    Language English
    Publishing date 2024-01-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07303-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Genome-wide analysis of C2H2 zinc finger family and their response to abiotic stresses in apple.

    Liu, Ke / Hou, Qiandong / Yu, Runrun / Deng, Hong / Shen, Luonan / Wang, Qian / Wen, Xiaopeng

    Gene

    2024  Volume 904, Page(s) 148164

    Abstract: C2H2-type zinc finger proteins are one of the most widely studied families in plants and play important roles in abiotic stress responses. In the present study, the physicochemical properties, chromosomal locations, evolutionary relationships, and gene ... ...

    Abstract C2H2-type zinc finger proteins are one of the most widely studied families in plants and play important roles in abiotic stress responses. In the present study, the physicochemical properties, chromosomal locations, evolutionary relationships, and gene structures of 54 C2H2 zinc finger protein (ZFP) family members were analyzed in apple. The MdC2H2-ZFP genes were phylogenetically clustered into seven subfamilies distributed in different densities on 16 chromosomes. The RNA-seq data from various tissues revealed that MdC2H2-ZFPs differentially expressed among root, stem, leaf, flower, and fruits. Quantitative analysis of its expression characteristics showed that the MdC2H2-ZFP genes were rapidly induced as exposure to abiotic stresses such as drought, salt and low temperature etc. Under drought stress, the expression of eight members was significantly up-regulated, and the highest was obtained from MdC2H2-17; as exposure to salt stress, nine MdC2H2-ZFPs was obviously up-regulated, with the highest expression of MdC2H2-13; and under low temperature stress, the expression of seven members was highly up-regulated, and MdC2H2-13 also demonstrated the highest expression which is same as the case under salt stress. Therefore, some members of MdC2H2-ZFP gene family considerably involve in the multiple abiotic stress responses, which may better understand the function of this family and facilitate the breeding of apple for stress tolerance.
    MeSH term(s) CYS2-HIS2 Zinc Fingers/genetics ; Malus/genetics ; Malus/metabolism ; Plant Proteins/metabolism ; Gene Expression Regulation, Plant ; Plant Breeding ; Stress, Physiological/genetics ; Phylogeny ; Zinc Fingers/genetics
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2024.148164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Defects in the cell wall and its deposition caused by loss-of-function of three RLKs alter root hydrotropism in Arabidopsis thaliana.

    Chang, Jinke / Li, Xiaopeng / Shen, Juan / Hu, Jun / Wu, Liangfan / Zhang, Xueyao / Li, Jia

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2648

    Abstract: Root tips can sense moisture gradients and grow into environments with higher water potential. This process is called root hydrotropism. Here, we report three closely related receptor-like kinases (RLKs) that play critical roles in root hydrotropism: ... ...

    Abstract Root tips can sense moisture gradients and grow into environments with higher water potential. This process is called root hydrotropism. Here, we report three closely related receptor-like kinases (RLKs) that play critical roles in root hydrotropism: ALTERED ROOT HYDROTROPIC RESPONSE 1 (ARH1), FEI1, and FEI2. Overexpression of these RLKs strongly reduce root hydrotropism, but corresponding loss-of-function mutants exhibit an increased hydrotropic response in their roots. All these RLKs show polar localization at the plasma membrane regions in root tips. The biosynthesis of the cell wall, cutin, and wax (CCW) is significantly impaired in root tips of arh1-2 fei1-C fei2-C. A series of known CCW mutants also exhibit increased root hydrotropism and reduced osmotic tolerance, similar to the characteristics of the triple mutant. Our results demonstrat that the integrity of the cell wall, cutin, and root cap wax mediate a trade-off between root hydrotropism and osmotic tolerance.
    MeSH term(s) Arabidopsis/metabolism ; Gravitropism/physiology ; Plant Roots/metabolism ; Tropism/physiology ; Arabidopsis Proteins/metabolism ; Water/metabolism ; Cell Wall/metabolism
    Chemical Substances Arabidopsis Proteins ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46889-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel magnetic compression technique for establishment of a vesicovaginal fistula model in Beagle dogs.

    Zhang, Miaomiao / Zhuang, Yingying / Mao, Jianqi / Shen, Linxin / Lyu, Xin / Lyu, Yi / Yan, Xiaopeng

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7907

    Abstract: Vesicovaginal fistula lacks a standard, established animal model, making surgical innovations for this condition challenging. Herein, we aimed to non-surgically establish vesicovaginal fistula using the magnetic compression technique, and the feasibility ...

    Abstract Vesicovaginal fistula lacks a standard, established animal model, making surgical innovations for this condition challenging. Herein, we aimed to non-surgically establish vesicovaginal fistula using the magnetic compression technique, and the feasibility of this method was explored using eight female Beagle dogs as model animals. In these dogs, cylindrical daughter and parent magnets were implanted into the bladder and vagina, respectively, after anesthesia, and the positions of these magnets were adjusted under X-ray supervision to make them attract each other, thus forming the structure of daughter magnet-bladder wall-vaginal wall-parent magnet. Operation time and collateral damage were recorded. The experimental animals were euthanized 2 weeks postoperatively, and the vesicovaginal fistula gross specimens were obtained. The size of the fistula was measured. Vesicovaginal fistula was observed by naked eye and under a light microscope. Magnet placement was successful in all dogs, and remained in the established position for the reminder of the experiment. The average operation time was 14.38 min ± 1.66 min (range, 12-17 min). The dogs were generally in good condition postoperatively and were voiding normally, with no complications like bleeding and urine retention. The magnets were removed from the vagina after euthanasia. The vesicovaginal fistula was successfully established according to gross observation, and the fistula diameters were 4.50-6.24 mm. Histological observation revealed that the bladder mucosa and vaginal mucosa were in close contact on the internal surface of the fistula. Taken together, magnetic compression technique is a simple and feasible method to establish an animal model of vesicovaginal fistula using Beagle dogs. This model can help clinicians study new surgical techniques and practice innovative approaches for treating vesicovaginal fistula.
    MeSH term(s) Humans ; Dogs ; Animals ; Female ; Vesicovaginal Fistula/surgery ; Vesicovaginal Fistula/etiology ; Urinary Bladder/surgery ; Vagina/surgery ; Magnetics ; Magnetic Phenomena
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55466-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Physiological, Proteomic, and Resin Yield-Related Genes Expression Analysis Provides Insights into the Mechanisms Regulating Resin Yield in Masson Pine.

    Li, Zhengchun / Zhou, Zijing / Hou, Qiandong / Shen, Luonan / Zhao, Hong / Wen, Xiaopeng

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Masson pine ( ...

    Abstract Masson pine (
    MeSH term(s) Proteomics ; Plant Breeding ; ATP-Binding Cassette Transporters ; Gene Expression Profiling
    Chemical Substances jasmonic acid (6RI5N05OWW) ; ATP-Binding Cassette Transporters
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813813
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  7. Article ; Online: Spontaneous Chirality Induction in the Assembly of a Single Layer 2D Network with Switchable Pores.

    Shen, Bowen / Pan, Chunyu / Feng, Xiaopeng / Kim, Jehan / Sun, Mo / Lee, Myongsoo

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 18, Page(s) e202300658

    Abstract: Although two-dimensional (2D) chiral sheet structures are attractive because of their unique chemical and physical properties, single layer 2D chiral network structures with switchable pore interior remain elusive. Here we report spontaneous chirality ... ...

    Abstract Although two-dimensional (2D) chiral sheet structures are attractive because of their unique chemical and physical properties, single layer 2D chiral network structures with switchable pore interior remain elusive. Here we report spontaneous chirality induction in a single layer 2D network structure formed from the self-assembly of tetrapod azobenzene molecules. The chirality induction arises from multiple sublayers slipped in a preferred direction in which the sublayer consists of unidentical molecular arrangements in the in-plane a and b directions, breaking both the plane of symmetry and inversion symmetry. The protruded azobenzene units in the pore interior can be selectively isomerized upon UV irradiation, resulting in a reversible deformation of the chiral pores while maintaining the 2D frameworks. The chiral network can thus selectively entrap one enantiomer from a racemic solution with near perfect enantioselectivity, and then release it upon UV irradiation.
    Language English
    Publishing date 2023-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202300658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spontaneous Chirality Induction in the Assembly of a Single Layer 2D Network with Switchable Pores

    Shen, Bowen / Pan, Chunyu / Feng, Xiaopeng / Kim, Jehan / Sun, Mo / Lee, Myongsoo

    Angewandte Chemie International Edition. 2023 Apr. 24, v. 62, no. 18, p. e202300658

    2023  

    Abstract: Although two‐dimensional (2D) chiral sheet structures are attractive because of their unique chemical and physical properties, single layer 2D chiral network structures with switchable pore interior remain elusive. Here we report spontaneous chirality ... ...

    Abstract Although two‐dimensional (2D) chiral sheet structures are attractive because of their unique chemical and physical properties, single layer 2D chiral network structures with switchable pore interior remain elusive. Here we report spontaneous chirality induction in a single layer 2D network structure formed from the self‐assembly of tetrapod azobenzene molecules. The chirality induction arises from multiple sublayers slipped in a preferred direction in which the sublayer consists of unidentical molecular arrangements in the in‐plane a and b directions, breaking both the plane of symmetry and inversion symmetry. The protruded azobenzene units in the pore interior can be selectively isomerized upon UV irradiation, resulting in a reversible deformation of the chiral pores while maintaining the 2D frameworks. The chiral network can thus selectively entrap one enantiomer from a racemic solution with near perfect enantioselectivity, and then release it upon UV irradiation.
    Keywords deformation ; enantiomers ; enantioselectivity ; optical isomerism ; ultraviolet radiation
    Language English
    Dates of publication 2023-0424
    Size p. e202300658
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202300658
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Phonon Thermal Transport in Silicene/Graphene Heterobilayer Nanostructures

    Jiasheng Zhou / Haipeng Li / Ho-Kin Tang / Lei Shao / Kui Han / Xiaopeng Shen

    ACS Omega, Vol 7, Iss 7, Pp 5844-

    Effect of Interlayer Interactions

    2022  Volume 5852

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Anomalous layer-dependent photoluminescence spectra of supertwisted spiral WS

    Qi, Minru / Tong, Tong / Fan, Xiaopeng / Li, Xiangdong / Wang, Shen / Zhang, Guofeng / Chen, Ruiyun / Hu, Jianyong / Yang, Zhichun / Zeng, Ganying / Qin, Chengbing / Xiao, Liantuan / Jia, Suotang

    Optics express

    2024  Volume 32, Issue 6, Page(s) 10419–10428

    Abstract: Twisted stacking of two-dimensional materials with broken inversion symmetry, such as spiral ... ...

    Abstract Twisted stacking of two-dimensional materials with broken inversion symmetry, such as spiral MoTe
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.516177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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