LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2036

Search options

  1. Article ; Online: Complete resection after abemaciclib targeted therapy in a patient with mediastinal liposarcoma extensively invading the pericardium and major vessels.

    Liu, Zhenkun / Wang, Rulan / Jiang, Rui / Zhou, Qinghua

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 1853–1854

    MeSH term(s) Humans ; Pericardium ; Mediastinal Neoplasms/drug therapy ; Mediastinal Neoplasms/surgery ; Aminopyridines ; Liposarcoma/drug therapy ; Liposarcoma/surgery ; Benzimidazoles
    Chemical Substances abemaciclib (60UAB198HK) ; Aminopyridines ; Benzimidazoles
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.166
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online: Single cell and immune repertoire profiling of COVID-19 patients reveal novel therapeutic candidates

    Qinghua Jiang

    2020  

    Abstract: COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early- ...

    Abstract COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early-recovery patients using scRNA-seq, HLA-genotyping and deep immune repertoire profling. Our analysis revealed 916 COVID-19-specific TCR groups enriched for a novel cytotoxic CD8+ phenotype with both resident memory (ZNF683+) and tissue exit (SIRP5) markers, and identified 114 statistically-confident virus epitopes. Further, we uncovered 374 BCR groups with somatic hypermutations and/or class switch recombinations. Molecular dynamics simulations revealed 15% of the highly expanded groups may serve as neutralizing antibodies against the virus Spike protein. Finally, we discovered that bacterial infection in COVID-19 patients may elevate monocytic myeloidderived suppressor cells via TLR4/NF!B signaling and cause disease aggravation. Together, we expect our findings and immune-receptor datasets to provide immediate therapeutic options against the pandemic of COVID-19.
    Keywords COVID-19 ; Single cell sequencing ; Immune repertoire profiling ; covid19
    Publishing date 2020-04-08
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online: Single cell and immune repertoire profiling of COVID-19 patients reveal novel therapeutic candidates

    Qinghua Jiang

    2020  

    Abstract: COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early- ...

    Abstract COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early-recovery patients using scRNA-seq, HLA-genotyping and deep immune repertoire profling. Our analysis revealed 916 COVID-19-specific TCR groups enriched for a novel cytotoxic CD8+ phenotype with both resident memory (ZNF683+) and tissue exit (SIRP5) markers, and identified 114 statistically-confident virus epitopes. Further, we uncovered 374 BCR groups with somatic hypermutations and/or class switch recombinations. Molecular dynamics simulations revealed 15% of the highly expanded groups may serve as neutralizing antibodies against the virus Spike protein. Finally, we discovered that bacterial infection in COVID-19 patients may elevate monocytic myeloidderived suppressor cells via TLR4/NF!B signaling and cause disease aggravation. Together, we expect our findings and immune-receptor datasets to provide immediate therapeutic options against the pandemic of COVID-19.
    Keywords COVID-19 ; Single cell sequencing ; Immune repertoire profiling ; covid19
    Publishing date 2020-04-08
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online: Single cell and immune repertoire profiling of COVID-19 patients reveal novel therapeutic candidates

    Qinghua Jiang

    2020  

    Abstract: COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early- ...

    Abstract COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early-recovery patients using scRNA-seq, HLA-genotyping and deep immune repertoire profling. Our analysis revealed 916 COVID-19-specific TCR groups enriched for a novel cytotoxic CD8+ phenotype with both resident memory (ZNF683+) and tissue exit (SIRP5) markers, and identified 114 statistically-confident virus epitopes. Further, we uncovered 374 BCR groups with somatic hypermutations and/or class switch recombinations. Molecular dynamics simulations revealed 15% of the highly expanded groups may serve as neutralizing antibodies against the virus Spike protein. Finally, we discovered that bacterial infection in COVID-19 patients may elevate monocytic myeloidderived suppressor cells via TLR4/NF!B signaling and cause disease aggravation. Together, we expect our findings and immune-receptor datasets to provide immediate therapeutic options against the pandemic of COVID-19.
    Keywords COVID-19 ; Single cell sequencing ; Immune repertoire profiling ; covid19
    Publishing date 2020-04-08
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Rebuttal to Correspondence on "Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case-Control Study in Eastern China".

    Liu, Mei / Li, An / Li, Yingming / Zhang, Qinghua / Jiang, Guibin

    Environmental science & technology

    2024  Volume 58, Issue 9, Page(s) 4460–4461

    MeSH term(s) Humans ; Flame Retardants/analysis ; Case-Control Studies ; Organophosphates ; Thyroid Neoplasms ; China/epidemiology ; Esters ; Environmental Monitoring ; Halogenated Diphenyl Ethers/analysis
    Chemical Substances Flame Retardants ; Organophosphates ; Esters ; Halogenated Diphenyl Ethers
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.4c00959
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen.

    Qi, Yue / Wang, Lin / Wang, Na / Wang, Siyi / Zhu, Xu / Zhao, Tie / Jiang, Qinghua

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1337161

    Abstract: Ethnopharmacological relevance: ...

    Abstract Ethnopharmacological relevance:
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1337161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A hybrid denoising approach for PPG signals utilizing variational mode decomposition and improved wavelet thresholding.

    Hu, Qinghua / Li, Min / Jiang, Linwen / Liu, Mei

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2024  

    Abstract: Background: Photoplethysmography (PPG) signals are sensitive to motion-induced interference, leading to the emergence of motion artifacts (MA) and baseline drift, which significantly affect the accuracy of PPG measurements.: Objective: The objective ... ...

    Abstract Background: Photoplethysmography (PPG) signals are sensitive to motion-induced interference, leading to the emergence of motion artifacts (MA) and baseline drift, which significantly affect the accuracy of PPG measurements.
    Objective: The objective of our study is to effectively eliminate baseline drift and high-frequency noise from PPG signals, ensuring that the signal's critical frequency components remain within the range of 1 ∼ 10 Hz.
    Methods: This paper introduces a novel hybrid denoising method for PPG signals, integrating Variational Mode Decomposition (VMD) with an improved wavelet threshold function. The method initially employs VMD to decompose PPG signals into a set of narrowband intrinsic mode function (IMF) components, effectively removing low-frequency baseline drift. Subsequently, an improved wavelet thresholding algorithm is applied to eliminate high-frequency noise, resulting in denoised PPG signals. The effectiveness of the denoising method was rigorously assessed through a comprehensive validation process. It was tested on real-world PPG measurements, PPG signals generated by the Fluke ProSim™ 8 Vital Signs Simulator with synthesized noise, and extended to the MIMIC-III waveform database.
    Results: The application of the improved threshold function let to a substantial 11.47% increase in signal-to-noise ratio (SNR) and an impressive 26.75% reduction in root mean square error (RMSE) compared to the soft threshold function. Furthermore, the hybrid denoising method improved SNR by 15.54% and reduced RMSE by 37.43% compared to the improved threshold function.
    Conclusion: This study proposes an effective PPG denoising algorithm based on VMD and an improved wavelet threshold function, capable of simultaneously eliminating low-frequency baseline drift and high-frequency noise in PPG signals while faithfully preserving their morphological characteristics. This advancement establishes the foundation for time-domain feature extraction and model development in the domain of PPG signal analysis.
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-231996
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Challenging diagnosis and successful management of phosphaturic mesenchymal tumor mimicking ankylosing spondylitis: A case report.

    Zhang, Yuan / Zhu, Jiang / Chen, Xuemeng / Bai, Ganping / Du, Yu / Zou, Qinghua

    International journal of rheumatic diseases

    2024  Volume 27, Issue 3, Page(s) e15120

    MeSH term(s) Humans ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/drug therapy ; Spondylarthritis ; Neoplasms
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Metabonomics and Transcriptomics Analyses Reveal the Development Process of the Auditory System in the Embryonic Development Period of the Small Yellow Croaker under Background Noise.

    Jiang, Qinghua / Liang, Xiao / Ye, Ting / Zhang, Yu / Lou, Bao

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Underwater noise pollution has become a potential threat to aquatic animals in the natural environment. The main causes of such pollution are frequent human activities creating underwater environmental noise, including commercial shipping, offshore ... ...

    Abstract Underwater noise pollution has become a potential threat to aquatic animals in the natural environment. The main causes of such pollution are frequent human activities creating underwater environmental noise, including commercial shipping, offshore energy platforms, scientific exploration activities, etc. However, in aquaculture environments, underwater noise pollution has also become an unavoidable problem due to background noise created by aquaculture equipment. Some research has shown that certain fish show adaptability to noise over a period of time. This could be due to fish's special auditory organ, i.e., their "inner ear"; meanwhile, otoliths and sensory hair cells are the important components of the inner ear and are also essential for the function of the auditory system. Recently, research in respect of underwater noise pollution has mainly focused on adult fish, and there is a lack of the research on the effects of underwater noise pollution on the development process of the auditory system in the embryonic development period. Thus, in this study, we collected embryo-larval samples of the small yellow croaker (
    MeSH term(s) Animals ; Humans ; Noise/adverse effects ; Sound ; Perciformes/genetics ; Fishes ; Gene Expression Profiling ; Embryonic Development
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25041954
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Pathological complete response to neoadjuvant therapy with serplulimab and chemotherapy in stage IIIB small cell lung cancer: a case report and literature review.

    Mei, Ting / Wang, Ting / Lei, Chuanfen / Jiang, Dan / Zhou, Qinghua

    Frontiers in immunology

    2024  Volume 14, Page(s) 1272450

    Abstract: Chemotherapy combined with immunotherapy has significantly improved survival in patients with extensive-stage small cell lung cancer (ES-SCLC), and neoadjuvant immunotherapy combined with chemotherapy has emerged as the standard treatment for those with ... ...

    Abstract Chemotherapy combined with immunotherapy has significantly improved survival in patients with extensive-stage small cell lung cancer (ES-SCLC), and neoadjuvant immunotherapy combined with chemotherapy has emerged as the standard treatment for those with resectable non-small cell lung cancer (NSCLC). However, the potential benefits of surgery following neoadjuvant immunotherapy combined with chemotherapy in locally advanced SCLC remain unclear. Herein, we report a patient diagnosed with stage IIIB SCLC, who was administered five cycles of neoadjuvant serplulimab combined with chemotherapy followed by surgery, and subsequently achieved a pathologic complete response (pCR). Within a follow-up duration of six months, the patient displayed neither recurrence nor metastasis and experienced no treatment-related adverse reactions of any grade. Based on this case, for locally advanced SCLC, neoadjuvant serplulimab combined with chemotherapy followed by surgery may present an effective, safe, and potentially curative treatment strategy. Nonetheless, further prospective studies are needed to verify our findings.
    MeSH term(s) Humans ; Small Cell Lung Carcinoma/drug therapy ; Neoadjuvant Therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Drug-Related Side Effects and Adverse Reactions ; Antibodies, Monoclonal ; Immune Checkpoint Inhibitors ; Pathologic Complete Response
    Chemical Substances Antibodies, Monoclonal ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1272450
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top