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  1. Book ; Online ; E-Book: Wound healing, tissue repair, and regeneration in diabetes

    Bagchi, Debasis / Das, Amitava / Roy, Sashwati

    2020  

    Author's details edited by Debasis Bagchi, Sashwati Roy, Amitava Das
    Language English
    Size 1 Online-Ressource (640 Seiten)
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020441104
    ISBN 978-0-12-816414-3 ; 9780128164136 ; 0-12-816414-X ; 0128164131
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Chronic inflammation

    Roy, Sashwati / Bagchi, Debasis / Raychaudhuri, Siba P.

    molecular pathophysiology, nutritional and therapeutic interventions

    2013  

    Author's details ed. Sashwati Roy ; Debasis Bagchi ; Siba P. Raychaudhuri
    Keywords Inflammation / immunology ; Inflammation / therapy ; Chronic Disease / therapy ; Inflammation Mediators / immunology ; Anti-Inflammatory Agents / therapeutic use ; Nutrition Disorders / immunology
    Language English
    Size XXIX, 443 S., [4] Bl. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017337139
    ISBN 978-1-4398-7211-6 ; 1-4398-7211-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4035 order for loan Magazin

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  3. Article ; Online: Diabetic Peripheral Neuropathy Associated with Foot Ulcer: One of a Kind.

    Sen, Chandan K / Roy, Sashwati / Khanna, Savita

    Antioxidants & redox signaling

    2023  

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2022.0093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Collagenase-based wound debridement agent induces extracellular matrix supporting phenotype in macrophages.

    Banerjee, Pradipta / Das, Amitava / Singh, Kanhaiya / Khanna, Savita / Sen, Chandan K / Roy, Sashwati

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3257

    Abstract: Macrophages assume diverse phenotypes and functions in response to cues from the microenvironment. Earlier we reported an anti-inflammatory effect of Collagenase ... ...

    Abstract Macrophages assume diverse phenotypes and functions in response to cues from the microenvironment. Earlier we reported an anti-inflammatory effect of Collagenase Santyl
    MeSH term(s) Humans ; Debridement ; Collagenases/metabolism ; Macrophages/metabolism ; Extracellular Matrix/metabolism ; Phenotype
    Chemical Substances Collagenases (EC 3.4.24.-)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53424-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure.

    Sen, Chandan K / Roy, Sashwati

    The Journal of investigative dermatology

    2021  Volume 141, Issue 6, Page(s) 1382–1385

    Abstract: Iterative cycles of epithelial‒mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of the barrier function of the repaired skin ... ...

    Abstract Iterative cycles of epithelial‒mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of the barrier function of the repaired skin is a hallmark of functional wound closure. Both EMT and MET are subject to control by glycemic status. A new article by Tan et al (2020) supports the notion that hyperglycemia blunts epithelial plasticity.
    MeSH term(s) Animals ; Epithelial-Mesenchymal Transition ; Hyperglycemia ; Skin ; Stifle
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: miRNA in Macrophage Development and Function.

    Roy, Sashwati

    Antioxidants & redox signaling

    2016  Volume 25, Issue 15, Page(s) 795–804

    Abstract: Significance: MicroRNAs (miRNAs) control cellular gene expression via primarily binding to 3' or 5' untranslated region of the target transcript leading to translational repression or mRNA degradation. In most cases, miRNAs have been observed to fine- ... ...

    Abstract Significance: MicroRNAs (miRNAs) control cellular gene expression via primarily binding to 3' or 5' untranslated region of the target transcript leading to translational repression or mRNA degradation. In most cases, miRNAs have been observed to fine-tune the cellular responses and, therefore, act as a rheostat rather than an on/off switch. Transcription factor PU.1 is a master switch that controls monocyte/macrophage development from hematopoietic stem cells. Recent Advances: PU.1 induces a specific set of miRNAs while suppressing the miR17-92 cluster to regulate monocyte/macrophage development. In addition to development, miRNAs tightly control the macrophage polarization continuum from proinflammatory M1 or proreparative M2 by regulating expression of key transcription factors involved in the process of polarization.
    Critical issues: miRNAs are intricately involved with fine-tuning fundamental macrophage functions such as phagocytosis, efferocytosis, inflammation, tissue repair, and tumor promotion. Macrophages are secretory cells that participate in intercellular communication by releasing regulatory molecules and microvesicles (MVs). MVs are bilayered lipid membranes packaging a hydrophilic cargo, including proteins and nucleic acids. Macrophage-derived MVs carry functionally active miRNAs that suppress gene expression in target cells via post-transcriptional gene silencing, thus regulating cell function. In summary, miRNAs fine-tune several major facets of macrophage development and function. Such fine-tuning is critical in preventing exaggerated macrophage response to endogenous or exogenous stimuli.
    Future directions: A critical role of miRNAs in the regulation of innate immune response and macrophage biology, including development, differentiation, and activation, has emerged. A clear understanding of such regulation on macrophage function remains to be elucidated. Antioxid. Redox Signal. 25, 795-804.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Macrophage Activation/genetics ; Macrophage Activation/immunology ; Macrophages/cytology ; Macrophages/physiology ; MicroRNAs/genetics ; Monocytes/cytology ; Monocytes/immunology ; Monocytes/metabolism ; Myeloid Cells/cytology ; Myeloid Cells/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidation-Reduction ; Signal Transduction ; Wound Healing/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2016-08-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2016.6728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Sociogenomic Approach to Wound Care: A New Patient-Centered Paradigm.

    Sen, Chandan K / Roy, Sashwati

    Advances in wound care

    2019  Volume 8, Issue 11, Page(s) 523–526

    Abstract: Psychoneuroendocrinology studies provided first insight into social determinants of wound healing. Social stressors impede wound healing. In 2005, we first reported that the transcriptome of wound-site neutrophil is highly responsive to psychological ... ...

    Abstract Psychoneuroendocrinology studies provided first insight into social determinants of wound healing. Social stressors impede wound healing. In 2005, we first reported that the transcriptome of wound-site neutrophil is highly responsive to psychological stress in young men. Bioinformatics processing of transcriptome-wide data from neutrophils provided first insight into social transduction pathways relevant to wound healing. In 2010, Idaghdour
    Language English
    Publishing date 2019-10-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2019.1101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Collagen in Wound Healing.

    Mathew-Steiner, Shomita S / Roy, Sashwati / Sen, Chandan K

    Bioengineering (Basel, Switzerland)

    2021  Volume 8, Issue 5

    Abstract: Normal wound healing progresses through inflammatory, proliferative and remodeling phases in response to tissue injury. Collagen, a key component of the extracellular matrix, plays critical roles in the regulation of the phases of wound healing either in ...

    Abstract Normal wound healing progresses through inflammatory, proliferative and remodeling phases in response to tissue injury. Collagen, a key component of the extracellular matrix, plays critical roles in the regulation of the phases of wound healing either in its native, fibrillar conformation or as soluble components in the wound milieu. Impairments in any of these phases stall the wound in a chronic, non-healing state that typically requires some form of intervention to guide the process back to completion. Key factors in the hostile environment of a chronic wound are persistent inflammation, increased destruction of ECM components caused by elevated metalloproteinases and other enzymes and improper activation of soluble mediators of the wound healing process. Collagen, being central in the regulation of several of these processes, has been utilized as an adjunct wound therapy to promote healing. In this work the significance of collagen in different biological processes relevant to wound healing are reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided.
    Language English
    Publishing date 2021-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering8050063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Modeling the gene delivery process of the needle array-based tissue nanotransfection.

    Li, Zhigang / Xuan, Yi / Ghatak, Subhadip / Guda, Poornachander R / Roy, Sashwati / Sen, Chandan K

    Nano research

    2021  Volume 15, Issue 4, Page(s) 3409–3421

    Abstract: Hollow needle array-based tissue nanotransfection (TNT) presents ... ...

    Abstract Hollow needle array-based tissue nanotransfection (TNT) presents an
    Language English
    Publishing date 2021-12-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2442216-2
    ISSN 1998-0000 ; 1998-0124
    ISSN (online) 1998-0000
    ISSN 1998-0124
    DOI 10.1007/s12274-021-3947-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article: Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain.

    Palakurti, Ravichand / Biswas, Nirupam / Roy, Sashwati / Gnyawali, Surya C / Sinha, Mithun / Singh, Kanhaiya / Ghatak, Subhadip / Sen, Chandan K / Khanna, Savita

    Molecular therapy. Nucleic acids

    2023  Volume 31, Page(s) 276–292

    Abstract: The α-tocotrienol (TCT) form of natural vitamin E is more potent than the better known α-tocopherol against stroke. Angiographic studies of canine stroke have revealed beneficial cerebrovascular effects of TCT. This work seeks to understand the molecular ...

    Abstract The α-tocotrienol (TCT) form of natural vitamin E is more potent than the better known α-tocopherol against stroke. Angiographic studies of canine stroke have revealed beneficial cerebrovascular effects of TCT. This work seeks to understand the molecular basis of such effect. In mice, TCT supplementation improved perfusion at the stroke-affected site by inducing miR-1224. miRNA profiling of a laser-capture-microdissected stroke-affected brain site identified miR-1224 as the only vascular miR induced. Lentiviral knockdown of miR-1224 significantly blunted the otherwise beneficial effects of TCT on stroke outcomes. Studies on primary brain microvascular endothelial cells revealed direct angiogenic properties of miR-1224. In mice not treated with TCT, advance stereotaxic delivery of an miR-1224 mimic to the stroke site markedly improved stroke outcomes. Mechanistic studies identified
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2022.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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