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  1. Article ; Online: Bubble-water/catalyst triphase interface microenvironment accelerates photocatalytic OER via optimizing semi-hydrophobic OH radical.

    Ren, Guanhua / Zhou, Min / Hu, Peijun / Chen, Jian-Fu / Wang, Haifeng

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2346

    Abstract: Photocatalytic water splitting (PWS) as the holy grail reaction for solar-to-chemical energy conversion is challenged by sluggish oxygen evolution reaction (OER) at water/catalyst interface. Experimental evidence interestingly shows that temperature can ... ...

    Abstract Photocatalytic water splitting (PWS) as the holy grail reaction for solar-to-chemical energy conversion is challenged by sluggish oxygen evolution reaction (OER) at water/catalyst interface. Experimental evidence interestingly shows that temperature can significantly accelerate OER, but the atomic-level mechanism remains elusive in both experiment and theory. In contrast to the traditional Arrhenius-type temperature dependence, we quantitatively prove for the first time that the temperature-induced interface microenvironment variation, particularly the formation of bubble-water/TiO
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46749-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recapitulating and reversing human brain ribosomopathy defects via the maladaptive integrated stress response.

    Zhang, Wei / Zhang, Minjie / Ma, Li / Jariyasakulroj, Supawadee / Chang, Qing / Lin, Ziying / Lu, Zhipeng / Chen, Jian-Fu

    Science advances

    2024  Volume 10, Issue 5, Page(s) eadk1034

    Abstract: Animal or human models recapitulating brain ribosomopathies are incomplete, hampering development of urgently needed therapies. Here, we generated genetic mouse and human cerebral organoid models of brain ribosomopathies, caused by mutations in small ... ...

    Abstract Animal or human models recapitulating brain ribosomopathies are incomplete, hampering development of urgently needed therapies. Here, we generated genetic mouse and human cerebral organoid models of brain ribosomopathies, caused by mutations in small nucleolar RNA (snoRNA)
    MeSH term(s) Humans ; Animals ; Mice ; Brain ; Protein Biosynthesis ; Mutation ; Disease Models, Animal
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk1034
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  3. Article ; Online: The clinical manifestations, molecular mechanisms and treatment of craniosynostosis

    Eloise Stanton / Mark Urata / Jian-Fu Chen / Yang Chai

    Disease Models & Mechanisms, Vol 15, Iss

    2022  Volume 4

    Abstract: Craniosynostosis is a major congenital craniofacial disorder characterized by the premature fusion of cranial suture(s). Patients with severe craniosynostosis often have impairments in hearing, vision, intracranial pressure and/or neurocognitive ... ...

    Abstract Craniosynostosis is a major congenital craniofacial disorder characterized by the premature fusion of cranial suture(s). Patients with severe craniosynostosis often have impairments in hearing, vision, intracranial pressure and/or neurocognitive functions. Craniosynostosis can result from mutations, chromosomal abnormalities or adverse environmental effects, and can occur in isolation or in association with numerous syndromes. To date, surgical correction remains the primary treatment for craniosynostosis, but it is associated with complications and with the potential for re-synostosis. There is, therefore, a strong unmet need for new therapies. Here, we provide a comprehensive review of our current understanding of craniosynostosis, including typical craniosynostosis types, their clinical manifestations, cranial suture development, and genetic and environmental causes. Based on studies from animal models, we present a framework for understanding the pathogenesis of craniosynostosis, with an emphasis on the loss of postnatal suture mesenchymal stem cells as an emerging disease-driving mechanism. We evaluate emerging treatment options and highlight the potential of mesenchymal stem cell-based suture regeneration as a therapeutic approach for craniosynostosis.
    Keywords craniosynostosis ; human genetics ; environmental factors ; animal models ; mesenchymal stem cells ; tissue regeneration ; Medicine ; R ; Pathology ; RB1-214
    Subject code 616
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mass Transport and Electron Transfer at the Electrochemical-Confined Interface.

    Lu, Si-Min / Chen, Jian-Fu / Wang, Hai-Feng / Hu, Peijun / Long, Yi-Tao

    The journal of physical chemistry letters

    2023  Volume 14, Issue 5, Page(s) 1113–1123

    Abstract: Single entity measurements based on the stochastic collision electrochemistry provide a promising and versatile means to study single molecules, single particles, single droplets, etc. Conceptually, mass transport and electron transfer are the two main ... ...

    Abstract Single entity measurements based on the stochastic collision electrochemistry provide a promising and versatile means to study single molecules, single particles, single droplets, etc. Conceptually, mass transport and electron transfer are the two main processes at the electrochemically confined interface that underpin the most transient electrochemical responses resulting from the stochastic and discrete behaviors of single entities at the microscopic scale. This perspective demonstrates how to achieve controllable stochastic collision electrochemistry by effectively altering the two processes. Future challenges and opportunities for stochastic collision electrochemistry are also highlighted.
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c03479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: [Yun fu bao jian shou ce]

    Wu, Wenhua / Chen, Wangqing

    [Handbook for the care of the expectant mother,

    1953  

    Author's details by Wenhua Wu and Wangqing Chen
    Keywords Pregnancy / Hygiene
    Language Chinese
    Size 2, 208 p.
    Edition Rev. and enl. ed.]
    Publisher Guangxieshuju
    Publishing place Shanghai
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: A new species of the congrid eel genus Bathycongrus (Order Anguilliformes) from eastern Taiwan.

    Huang, Jian-Fu / Ho, Hsuan-Ching / Chen, Hong-Ming / Chan, Tin-Yam

    Zootaxa

    2022  Volume 5189, Issue 1, Page(s) 78–86

    Abstract: A new species of the congrid eel genus Bathycongrus is described on the basis of three specimens collected from the deep waters of eastern Taiwan. Bathycongrus melanostomus sp. nov., belongs to the few vertebrae species complex and is distinct in having ... ...

    Abstract A new species of the congrid eel genus Bathycongrus is described on the basis of three specimens collected from the deep waters of eastern Taiwan. Bathycongrus melanostomus sp. nov., belongs to the few vertebrae species complex and is distinct in having a short and broad snout; a much reduced caudal fin; abdomen, mouth cavity and gill chamber blackish; small conical blunt teeth on vomer forming an elongate patch; total vertebrae 133-135, and total lateral-line pores 108-109.
    MeSH term(s) Animals ; Eels ; Taiwan ; Animal Distribution ; Gills ; Mouth
    Language English
    Publishing date 2022-09-23
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5189.1.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Fu you bao jian shou ce

    Chen, Qufei

    [Maternal and child health

    1951  

    MeSH term(s) Child Care ; Obstetrics
    Language Chinese
    Size 1, 3, 66 p., illus.
    Publisher Shan he shu dian
    Publishing place Kaifeng
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.

    Stanton, Eloise / Urata, Mark / Chen, Jian-Fu / Chai, Yang

    Disease models & mechanisms

    2022  Volume 15, Issue 4

    Abstract: Craniosynostosis is a major congenital craniofacial disorder characterized by the premature fusion of cranial suture(s). Patients with severe craniosynostosis often have impairments in hearing, vision, intracranial pressure and/or neurocognitive ... ...

    Abstract Craniosynostosis is a major congenital craniofacial disorder characterized by the premature fusion of cranial suture(s). Patients with severe craniosynostosis often have impairments in hearing, vision, intracranial pressure and/or neurocognitive functions. Craniosynostosis can result from mutations, chromosomal abnormalities or adverse environmental effects, and can occur in isolation or in association with numerous syndromes. To date, surgical correction remains the primary treatment for craniosynostosis, but it is associated with complications and with the potential for re-synostosis. There is, therefore, a strong unmet need for new therapies. Here, we provide a comprehensive review of our current understanding of craniosynostosis, including typical craniosynostosis types, their clinical manifestations, cranial suture development, and genetic and environmental causes. Based on studies from animal models, we present a framework for understanding the pathogenesis of craniosynostosis, with an emphasis on the loss of postnatal suture mesenchymal stem cells as an emerging disease-driving mechanism. We evaluate emerging treatment options and highlight the potential of mesenchymal stem cell-based suture regeneration as a therapeutic approach for craniosynostosis.
    MeSH term(s) Animals ; Cranial Sutures ; Craniosynostoses/genetics ; Craniosynostoses/therapy ; Humans ; Mesenchymal Stem Cells ; Mutation ; Syndrome
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models.

    Jariyasakulroj, Supawadee / Zhang, Wei / Bai, Jianhui / Zhang, Minjie / Lu, Zhipeng / Chen, Jian-Fu

    Stem cell reports

    2023  Volume 18, Issue 12, Page(s) 2370–2385

    Abstract: Disruption of global ribosome biogenesis selectively affects craniofacial tissues with unclear mechanisms. Craniosynostosis is a congenital craniofacial disorder characterized by premature fusion of cranial suture(s) with loss of suture mesenchymal stem ... ...

    Abstract Disruption of global ribosome biogenesis selectively affects craniofacial tissues with unclear mechanisms. Craniosynostosis is a congenital craniofacial disorder characterized by premature fusion of cranial suture(s) with loss of suture mesenchymal stem cells (MSCs). Here we focused on ribosomopathy disease gene Snord118, which encodes a small nucleolar RNA (snoRNA), to genetically disturb ribosome biogenesis in suture MSCs using mouse and human induced pluripotent stem cell (iPSC) models. Snord118 depletion exhibited p53 activation, increased cell death, reduced proliferation, and premature osteogenic differentiation of MSCs, leading to suture growth and craniosynostosis defects. Mechanistically, Snord118 deficiency causes translational dysregulation of ribosomal proteins and downregulation of complement pathway genes. Further complement pathway disruption by knockout of complement C3a receptor 1 (C3ar1) exacerbated MSC and suture defects in mutant mice, whereas activating the complement pathway rescued MSC cell fate and suture growth defects. Thus, ribosome biogenesis controls MSC fate via the complement pathway to prevent craniosynostosis.
    MeSH term(s) Humans ; Mice ; Animals ; Cranial Sutures/metabolism ; Osteogenesis/genetics ; Induced Pluripotent Stem Cells/metabolism ; Craniosynostoses/genetics ; Craniosynostoses/metabolism ; Cell Differentiation/genetics ; Ribosomes
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current progression in application of extracellular vesicles in central nervous system diseases

    Xiang-Min Zhang / Jie Huang / Xiao-Ying Ni / Hui-Ru Zhu / Zhong-Xin Huang / Shuang Ding / Xin-Yi Yang / Yan-Di Tan / Jian-Fu Chen / Jin-Hua Cai

    European Journal of Medical Research, Vol 29, Iss 1, Pp 1-

    2024  Volume 14

    Abstract: Abstract Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood–brain barrier. Specific proteins and RNAs in brain-derived ... ...

    Abstract Abstract Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood–brain barrier. Specific proteins and RNAs in brain-derived extracellular vesicles (EVs) usually reflect the corresponding state of brain disease, and therefore, EVs can be used as diagnostic biomarkers for CNS diseases. In addition, EVs can be engineered and fused to target cells for delivery of cargo, demonstrating the great potential of EVs as a nanocarrier platform. We review the progress of EVs as markers and drug carriers in the diagnosis and treatment of neurological diseases. The main areas include visual imaging, biomarker diagnosis and drug loading therapy for different types of CNS diseases. It is hoped that increased knowledge of EVs will facilitate their clinical translation in CNS diseases.
    Keywords Extracellular vesicles ; Central nervous system diseases ; Image ; Molecular therapy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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