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Article ; Online: New and remaining problems with DSM-V.

Uchtenhagen, Ambros

2011 Volume 106, Issue 5, Page(s) 888–9; discussion 895–7

MeSH term(s)	Behavior, Addictive ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Social Stigma ; Substance-Related Disorders/classification ; Substance-Related Disorders/diagnosis ; Terminology as Topic
Language	English
Publishing date	2011-05
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/j.1360-0443.2010.03328.x
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Article ; Online: Development: Keeping Time with Transcription.

Ambros, Victor

Current biology : CB

2021 Volume 31, Issue 4, Page(s) R212–R214

Abstract: A new study shows that the pioneer transcription factor BLMP-1 governs the cyclic transcriptional output of hundreds of genes during Caenorhabditis elegans larval development. BLMP-1 is also critical for restarting the proper developmental dynamics of ... ...

Abstract	A new study shows that the pioneer transcription factor BLMP-1 governs the cyclic transcriptional output of hundreds of genes during Caenorhabditis elegans larval development. BLMP-1 is also critical for restarting the proper developmental dynamics of gene expression after nutritionally induced developmental arrest.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Gene Expression ; Gene Expression Regulation, Developmental ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; Transcription Factors
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2020.11.066
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Article ; Online: Mathematics of microRNAs: stabilizing gene regulatory networks.

Ambros, Victor

National science review

2019 Volume 6, Issue 6, Page(s) 1189–1190

Language	English
Publishing date	2019-08-13
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwz112
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Article ; Online: Identification of epigenetically regulated genes involved in plant-virus interaction and their role in virus-triggered induced resistance.

Corrêa, Régis L / Kutnjak, Denis / Ambrós, Silvia / Bustos, Mónica / Elena, Santiago F

BMC plant biology

2024 Volume 24, Issue 1, Page(s) 172

Abstract: ... mosaic virus. In order to identify genes directly targeted by the RdDM-related RNA Polymerase V (POLV) complex ...

Abstract	Background: Plant responses to a wide range of stresses are known to be regulated by epigenetic mechanisms. Pathogen-related investigations, particularly against RNA viruses, are however scarce. It has been demonstrated that Arabidopsis thaliana plants defective in some members of the RNA-directed DNA methylation (RdDM) or histone modification pathways presented differential susceptibility to the turnip mosaic virus. In order to identify genes directly targeted by the RdDM-related RNA Polymerase V (POLV) complex and the histone demethylase protein JUMONJI14 (JMJ14) during infection, the transcriptomes of infected mutant and control plants were obtained and integrated with available chromatin occupancy data for various epigenetic proteins and marks. Results: A comprehensive list of virus-responsive gene candidates to be regulated by the two proteins was obtained. Twelve genes were selected for further characterization, confirming their dynamic regulation during the course of infection. Several epigenetic marks on their promoter sequences were found using in silico data, raising confidence that the identified genes are actually regulated by epigenetic mechanisms. The altered expression of six of these genes in mutants of the methyltransferase gene CURLY LEAF and the histone deacetylase gene HISTONE DEACETYLASE 19 suggests that some virus-responsive genes may be regulated by multiple coordinated epigenetic complexes. A temporally separated multiple plant virus infection experiment in which plants were transiently infected with one virus and then infected by a second one was designed to investigate the possible roles of the identified POLV- and JMJ14-regulated genes in wild-type (WT) plants. Plants that had previously been stimulated with viruses were found to be more resistant to subsequent virus challenge than control plants. Several POLV- and JMJ14-regulated genes were found to be regulated in virus induced resistance in WT plants, with some of them poisoned to be expressed in early infection stages. Conclusions: A set of confident candidate genes directly regulated by the POLV and JMJ14 proteins during virus infection was identified, with indications that some of them may be regulated by multiple epigenetic modules. A subset of these genes may also play a role in the tolerance of WT plants to repeated, intermittent virus infections.
MeSH term(s)	Plant Viruses ; DNA Methylation ; Arabidopsis/genetics ; Histone Deacetylases ; Virus Diseases ; Arabidopsis Proteins ; Jumonji Domain-Containing Histone Demethylases
Chemical Substances	Histone Deacetylases (EC 3.5.1.98) ; JMJ14 protein, Arabidopsis (EC 1.14.11.-) ; Arabidopsis Proteins ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-024-04866-3
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Article: Lipidnyĭ obmen pri virusnykh infektsiiakh v éksperimente.

Ambros'eva, T V / Votiakov, V I / Andreeva, O T / Serebriakova, E V / Vladyko, G V / Samarina, M P

Biulleten' eksperimental'noi biologii i meditsiny

1992 Volume 114, Issue 9, Page(s) 302–304

Abstract: The effect of herpes simplex virus (HSV) and influenza virus (IV) on lipid metabolism was studied. In conditions of acute herpetic infection of rabbits we detected typical dyslipidemia, characterized by increased contents of total cholesterol, beta- ... ...

Title translation	Lipid metabolism in experimental virus infections.
Abstract	The effect of herpes simplex virus (HSV) and influenza virus (IV) on lipid metabolism was studied. In conditions of acute herpetic infection of rabbits we detected typical dyslipidemia, characterized by increased contents of total cholesterol, beta-cholesterol and triglycerides in the absence of trustworthy differences in concentrations of alpha-cholesterol. The use of antiherpetic preparation furavir, on the background of infection, corrected lipid spectrum of the infected animals. Blood lipid disturbances in acute influenza virus infection of mice were not detected. HSV infection of cell culture of human aorta was accompanied by increased accumulation of free lipids in cells. IV infection, in the same conditions of experiment, did not change the contents of intracellular lipids. The obtained data deepen the existing notions of herpetic and influenza infections pathogenesis and may be useful in understanding etiopathogenesis of certain somatic metabolism diseases.
MeSH term(s)	Acute Disease ; Animals ; Cholesterol/blood ; Herpes Simplex/blood ; Herpes Simplex/metabolism ; Lipid Metabolism ; Lipids/blood ; Mice ; Orthomyxoviridae Infections/blood ; Orthomyxoviridae Infections/metabolism ; Rabbits ; Triglycerides/blood ; Virus Diseases/blood ; Virus Diseases/metabolism
Chemical Substances	Lipids ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	Russian
Publishing date	1992-09
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	127365-6
ISSN	0365-9615 ; 0006-4041
ISSN	0365-9615 ; 0006-4041
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Article ; Online: A review of the best practice in traffic calming evaluation.

Ambros, Jiří / Tomešová, Lenka / Jurewicz, Chris / Valentová, Veronika

Accident; analysis and prevention

2023 Volume 189, Page(s) 107073

Abstract: Traffic calming (TC) has been applied widely for several decades, although approaches to evaluating its effects on speeds have been inconsistent. This resulted in limited comparable and robust evidence to support practitioner guidance for TC design. To ... ...

Abstract	Traffic calming (TC) has been applied widely for several decades, although approaches to evaluating its effects on speeds have been inconsistent. This resulted in limited comparable and robust evidence to support practitioner guidance for TC design. To fill this gap and suggest best practices for the evaluation of TC effects on speeds, we performed a systematic review of 158 publications. We distilled information related to five research questions: Which measurement sensor was used? How was speed measured? Was free-flow speed considered? What was the sampling density? How were sample considerations reported? In addition to coding the studies based on these research questions, we rated them based on scientific robustness. The review confirmed the inconsistent state of evaluation practice. Most common evaluation approaches employed static detectors, low levels of control for bias (simple before-after), and unknown survey periods. The review found that the most robust evaluation practices involved multivariate before-after or cross-sectional study designs, used dynamic measurement of speeds (e.g., probe vehicles, simulations), large samples of vehicles, and more precise evaluation of speed changes using speed-distance graphs. These findings could guide more consistent and robust evaluation practice, and thus help to improve evidence-based TC guidance for creating safer and more sustainable neighborhoods.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Safety ; Cross-Sectional Studies
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2023.107073
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Article ; Online: A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans.

Mirza, Zeynep / Walhout, Albertha J M / Ambros, Victor

Cell reports

2023 Volume 42, Issue 10, Page(s) 113189

Abstract: Host-pathogen interactions are complex by nature, and the host developmental stage increases this complexity. By utilizing Caenorhabditis elegans larvae as the host and the bacterium Pseudomonas aeruginosa as the pathogen, we investigated how a ... ...

Abstract	Host-pathogen interactions are complex by nature, and the host developmental stage increases this complexity. By utilizing Caenorhabditis elegans larvae as the host and the bacterium Pseudomonas aeruginosa as the pathogen, we investigated how a developing organism copes with pathogenic stress. By screening 36 P. aeruginosa isolates, we found that the CF18 strain causes a severe but reversible developmental delay via induction of reactive oxygen species (ROS) and mitochondrial dysfunction. While the larvae upregulate mitophagy, antimicrobial, and detoxification genes, mitochondrial unfolded protein response (UPR
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Reactive Oxygen Species/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Quorum Sensing ; Virulence Factors/metabolism ; Bacteria/metabolism ; Pseudomonas aeruginosa/metabolism ; Mitochondria/metabolism ; Bacterial Proteins/metabolism
Chemical Substances	Reactive Oxygen Species ; Caenorhabditis elegans Proteins ; Virulence Factors ; Bacterial Proteins
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.113189
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Article ; Online: A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA.

Nelson, Charles / Ambros, Victor

G3 (Bethesda, Md.)

2021 Volume 11, Issue 3

Abstract: The let-7 gene encodes a highly conserved microRNA with critical functions integral to cell fate specification and developmental progression in diverse animals. In Caenorhabditis elegans, let-7 is a component of the heterochronic (developmental timing) ... ...

Abstract	The let-7 gene encodes a highly conserved microRNA with critical functions integral to cell fate specification and developmental progression in diverse animals. In Caenorhabditis elegans, let-7 is a component of the heterochronic (developmental timing) gene regulatory network, and loss-of-function mutations of let-7 result in lethality during the larval to adult transition due to misregulation of the conserved let-7 target, lin-41. To date, no bilaterian animal lacking let-7 has been characterized. In this study, we identify a cohort of nematode species within the genus Caenorhabditis, closely related to C. elegans, that lack the let-7 microRNA, owing to absence of the let-7 gene. Using Caenorhabditis sulstoni as a representative let-7-lacking species to characterize normal larval development in the absence of let-7, we demonstrate that, except for the lack of let-7, the heterochronic gene network is otherwise functionally conserved. We also report that species lacking let-7 contain a group of divergent let-7 paralogs-also known as the let-7-family of microRNAs-that have apparently assumed the role of targeting the LIN-41 mRNA.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Gene Expression Regulation, Developmental ; MicroRNAs/genetics ; Transcription Factors/genetics
Chemical Substances	Caenorhabditis elegans Proteins ; LIN-41 protein, C elegans ; MicroRNAs ; Transcription Factors ; let-7 microRNA, C elegans
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkab022
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Article ; Online: Modeling neurodevelopmental disorder-associated human

Duan, Ye / Li, Li / Panzade, Ganesh Prabhakar / Piton, Amélie / Zinovyeva, Anna / Ambros, Victor

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 10, Page(s) e2308255121

Abstract: MicroRNAs (miRNA) associate with Argonaute (AGO) proteins and repress gene expression by base pairing to sequences in the 3' untranslated regions of target genes. De novo coding variants in the human AGO ... ...

Abstract	MicroRNAs (miRNA) associate with Argonaute (AGO) proteins and repress gene expression by base pairing to sequences in the 3' untranslated regions of target genes. De novo coding variants in the human AGO genes
MeSH term(s)	Animals ; Humans ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; MicroRNAs/metabolism ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Mutation ; Neurodevelopmental Disorders
Chemical Substances	Caenorhabditis elegans Proteins ; RNA-Binding Proteins ; MicroRNAs ; Argonaute Proteins
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2308255121
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Article ; Online: Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography.

Schnell, Oliver / Krebs, Bjarne / Carlsen, Janette / Miederer, Isabelle / Goetz, Claudia / Goldbrunner, Roland H / Wester, Hans-Jürgen / Haubner, Roland / Pöpperl, Gabriele / Holtmannspötter, Markus / Kretzschmar, Hans A / Kessler, Horst / Tonn, Jörg-Christian / Schwaiger, Markus / Beer, Ambros J

Neuro-oncology

2009 Volume 11, Issue 6, Page(s) 861–870

Abstract: Inhibitors targeting the integrin alpha(v)beta(3) are promising new agents currently tested ... of alpha(v)beta(3) expression in patients with GBM, suggesting eligibility for this kind of additional ... histologically and immunohistochemically for alpha(v)beta(3) integrin expression. While normal brain tissue did ...

Abstract	Inhibitors targeting the integrin alpha(v)beta(3) are promising new agents currently tested in clinical trials for supplemental therapy of glioblastoma multiforme (GBM). The aim of our study was to evaluate (18)F-labeled glycosylated Arg-Gly-Asp peptide ([(18)F]Galacto-RGD) PET for noninvasive imaging of alpha(v)beta(3) expression in patients with GBM, suggesting eligibility for this kind of additional treatment. Patients with suspected or recurrent GBM were examined with [(18)F]Galacto-RGD PET. Standardized uptake values (SUVs) of tumor hotspots, galea, and blood pool were derived by region-of-interest analysis. [(18)F]Galacto-RGD PET images were fused with cranial MR images for image-guided surgery. Tumor samples taken from areas with intense tracer accumulation in the [(18)F]Galacto-RGD PET images and were analyzed histologically and immunohistochemically for alpha(v)beta(3) integrin expression. While normal brain tissue did not show significant tracer accumulation (mean SUV, 0.09 +/- 0.04), GBMs demonstrated significant but heterogeneous tracer uptake, with a maximum in the highly proliferating and infiltrating areas of tumors (mean SUV, 1.6 +/- 0.5). Immunohistochemical staining was prominent in tumor microvessels as well as glial tumor cells. In areas of highly proliferating glial tumor cells, tracer uptake (SUVs) in the [(18)F]Galacto-RGD PET images correlated with immunohistochemical alpha(v)beta(3) integrin expression of corresponding tumor samples. These data suggest that [(18)F] Galacto-RGD PET successfully identifies alpha(v)beta(3) expression in patients with GBM and might be a promising tool for planning and monitoring individualized cancer therapies targeting this integrin.
MeSH term(s)	Adult ; Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/metabolism ; Female ; Fluorine Radioisotopes ; Galactose/analogs & derivatives ; Glioma/diagnostic imaging ; Glioma/metabolism ; Humans ; Immunoenzyme Techniques ; Integrin alphaVbeta3/metabolism ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Peptides, Cyclic ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals ; Tissue Distribution
Chemical Substances	Fluorine Radioisotopes ; Integrin alphaVbeta3 ; Peptides, Cyclic ; Radiopharmaceuticals ; fluorogalacto-RGD ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2009-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1215/15228517-2009-024
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