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  1. Article: Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.

    Collie, Gavin W / Michaelides, Iacovos N / Embrey, Kevin / Stubbs, Christopher J / Börjesson, Ulf / Dale, Ian L / Snijder, Arjan / Barlind, Louise / Song, Kun / Khurana, Puneet / Phillips, Christopher / Storer, R Ian

    ACS medicinal chemistry letters

    2020  Volume 12, Issue 1, Page(s) 162–167

    Abstract: ... of inhibitors able to bind to a rare conformation of the protein in which the P-loop adopts a collapsed, or ...

    Abstract We report here a fragment screen directed toward the c-MET kinase from which we discovered a series of inhibitors able to bind to a rare conformation of the protein in which the P-loop adopts a collapsed, or folded, arrangement. Preliminary SAR exploration led to an inhibitor (
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: p-Coumaric acid attenuates high-fat diet-induced oxidative stress and nephropathy in diabetic rats.

    Mani, Akhand / Kushwaha, Kriti / Khurana, Navneet / Gupta, Jeena

    Journal of animal physiology and animal nutrition

    2021  Volume 106, Issue 4, Page(s) 872–880

    Abstract: ... phytochemical p-coumaric can reduce diabetes-induced oxidative stress and improve diabetes-associated ... nephropathy in rats. The aim of this study is to analyse the protective effects of p-coumaric acid against ... of p-coumaric acid (20 mg/kg for 12 weeks) was found to significantly decrease the elevated levels ...

    Abstract The prevalence of persistent hyperglycaemia during diabetes, impair antioxidant defence system and generate reactive oxygen species, which majorly contribute to its progression and associated complications. Phytochemicals were suggested to scavenge-free radicals and exert antioxidant effects required to improve insulin sensitivity and reduce the occurrence of diabetes-associated complications. We hypothesise that a phenolic phytochemical p-coumaric can reduce diabetes-induced oxidative stress and improve diabetes-associated nephropathy in rats. The aim of this study is to analyse the protective effects of p-coumaric acid against diabetes-induced oxidative stress and nephropathy in high-fat diet-induced diabetic rats. The oral feeding of p-coumaric acid (20 mg/kg for 12 weeks) was found to significantly decrease the elevated levels of blood glucose in high-fat diet-induced type 2 diabetic rats. p-Coumaric acid treatment also decreases the kidney weight whilst increasing the total body weight of diabetic rats. Furthermore whilst evaluation of the different renal functioning tests, p-coumaric acid significantly improves histopathological changes and the levels of urea, creatinine and uric acid in serum of diabetic rats, which was otherwise elevated under diabetic conditions. Our results also highlight that p-coumaric acid is an efficient compound with antioxidant properties and improves the diabetes-induced change in lipid peroxidation and activities of antioxidant enzymes: catalase, glutathione-S-transferase and superoxide dismutase. p-Coumaric acid thus possesses the potential to prevent diabetic nephropathy by reducing oxidative stress and can thus serve as a potential drug target for pharmaceutical companies.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Blood Glucose ; Coumaric Acids ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/pathology ; Diabetic Nephropathies/prevention & control ; Diabetic Nephropathies/veterinary ; Diet, High-Fat/adverse effects ; Kidney ; Oxidative Stress ; Rats
    Chemical Substances Antioxidants ; Blood Glucose ; Coumaric Acids ; p-coumaric acid (IBS9D1EU3J)
    Language English
    Publishing date 2021-10-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 232729-6
    ISSN 1439-0396 ; 0044-3565 ; 0931-2439
    ISSN (online) 1439-0396
    ISSN 0044-3565 ; 0931-2439
    DOI 10.1111/jpn.13645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Induced pluripotent stem cell line heterozygous for p.R2447X mutation in filaggrin: KCLi002-A.

    Kolundzic, Nikola / Khurana, Preeti / Devito, Liani / Donne, Matthew / Hobbs, Carl / Jeriha, Jakob / Wong, Xuan Fei Colin Cornelius / Common, John A E / Lane, Ellen Birgitte / Dubrac, Sandrine / Gruber, Robert / Schmuth, Matthias / Mauro, Theodora M / Ilic, Dusko

    Stem cell research

    2019  Volume 38, Page(s) 101462

    Abstract: ... donor, heterozygous for the loss-of-function mutation p.R2447X in the filaggrin gene (FLG). Epidermal ...

    Abstract We have generated an induced pluripotent stem cell (iPSC) line KCLi002-A (iOP107) from a female donor, heterozygous for the loss-of-function mutation p.R2447X in the filaggrin gene (FLG). Epidermal keratinocytes were reprogrammed using non-integrating Sendai virus vectors. The entire process of derivation and expansion of iPSCs were performed under xeno-free culture conditions. Characterization of KCLi002-A line included molecular karyotyping, mutation screening using restriction enzyme digestion Sanger sequencing and next generation sequencing (NGS), whereas pluripotency and differentiation potential were confirmed by expression of associated markers in vitro and in vivo teratoma assay.
    MeSH term(s) Amino Acid Substitution ; Cell Line ; Female ; Heterozygote ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Loss of Function Mutation ; Mutation, Missense ; S100 Proteins/genetics ; S100 Proteins/metabolism
    Chemical Substances FLG protein, human ; S100 Proteins
    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2019.101462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Induced pluripotent stem cell line heterozygous for p.R501X mutation in filaggrin: KCLi003-A.

    Kolundzic, Nikola / Khurana, Preeti / Devito, Liani / Jeriha, Jakob / Marx, Jennifer / Hobbs, Carl / Wong, Xuan Fei Colin Cornelius / Common, John E A / Liovic, Mirjana / Dubrac, Sandrine / Gruber, Robert / Schmuth, Matthias / Mauro, Theodora M / Ilic, Dusko

    Stem cell research

    2019  Volume 39, Page(s) 101527

    Abstract: ... keratinocytes of a female donor, heterozygous for the loss-of-function mutation p.R501X in the filaggrin gene ...

    Abstract We have generated an induced pluripotent stem cell (iPSC) line KCLi003-A (iOP101) from epidermal keratinocytes of a female donor, heterozygous for the loss-of-function mutation p.R501X in the filaggrin gene (FLG), using non-integrating Sendai virus vectors. Derivation and expansion of iPSCs were performed under xeno-free culture conditions. Characterization and validation of KCLi003-A line included molecular karyotyping, mutation screening using restriction enzyme digestion, next generation sequencing (NGS), while pluripotency and differentiation potential were confirmed by expression of associated markers in vitro and by in vivo teratoma assay.
    MeSH term(s) Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cellular Reprogramming/genetics ; Cellular Reprogramming/physiology ; Fluorescent Antibody Technique ; Heterozygote ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Intermediate Filament Proteins/genetics ; Microsatellite Repeats/genetics ; Mycoplasma/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sendai virus/genetics
    Chemical Substances Intermediate Filament Proteins ; filaggrin
    Language English
    Publishing date 2019-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2019.101527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evidence for Collective Multiparticle Correlations in p-Pb Collisions.

    Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Bergauer, T / Dragicevic, M / Erö, J / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V / Krammer, M / Krätschmer, I / Liko, D /
    Mikulec, I / Rabady, D / Rahbaran, B / Rohringer, H / Schöfbeck, R / Strauss, J / Treberer-Treberspurg, W / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Alderweireldt, S / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Knutsson, A / Lauwers, J / Luyckx, S / Ochesanu, S / Rougny, R / Van De Klundert, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Daci, N / Heracleous, N / Keaveney, J / Lowette, S / Maes, M / Olbrechts, A / Python, Q / Strom, D / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Caillol, C / Clerbaux, B / De Lentdecker, G / Dobur, D / Favart, L / Gay, A P R / Grebenyuk, A / Léonard, A / Mohammadi, A / Perniè, L / Randle-conde, A / Reis, T / Seva, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Zenoni, F / Adler, V / Beernaert, K / Benucci, L / Cimmino, A / Costantini, S / Crucy, S / Fagot, A / Garcia, G / Mccartin, J / Ocampo Rios, A A / Poyraz, D / Ryckbosch, D / Salva Diblen, S / Sigamani, M / Strobbe, N / Thyssen, F / Tytgat, M / Yazgan, E / Zaganidis, N / Basegmez, S / Beluffi, C / Bruno, G / Castello, R / Caudron, A / Ceard, L / Da Silveira, G G / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Jafari, A / Jez, P / Komm, M / Lemaitre, V / Nuttens, C / Pagano, D / Perrini, L / Pin, A / Piotrzkowski, K / Popov, A / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Aldá Júnior, W L / Alves, G A / Brito, L / Correa Martins Junior, M / Dos Reis Martins, T / Molina, J / Mora Herrera, C / Pol, M E / Rebello Teles, P / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santaolalla, J / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Bernardes, C A / Dogra, S / Fernandez Perez Tomei, T R / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Genchev, V / Hadjiiska, R / Iaydjiev, P / Marinov, A / Piperov, S / Rodozov, M / Stoykova, S / Sultanov, G / Vutova, M / Dimitrov, A / Glushkov, I / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Chen, M / Cheng, T / Du, R / Jiang, C H / Plestina, R / Romeo, F / Tao, J / Wang, Z / Asawatangtrakuldee, C / Ban, Y / Liu, S / Mao, Y / Qian, S J / Wang, D / Xu, Z / Zhang, F / Zhang, L / Zou, W / Avila, C / Cabrera, A / Chaparro Sierra, L F / Florez, C / Gomez, J P / Gomez Moreno, B / Sanabria, J C / Godinovic, N / Lelas, D / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Kadija, K / Luetic, J / Mekterovic, D / Sudic, L / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Bodlak, M / Finger, M / Assran, Y / Ellithi Kamel, A / Mahmoud, M A / Radi, A / Kadastik, M / Murumaa, M / Raidal, M / Tiko, A / Eerola, P / Voutilainen, M / Härkönen, J / Karimäki, V / Kinnunen, R / Kortelainen, M J / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Peltola, T / Tuominen, E / Tuominiemi, J / Tuovinen, E / Wendland, L / Talvitie, J / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Favaro, C / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Titov, M / Baffioni, S / Beaudette, F / Busson, P / Chapon, E / Charlot, C / Dahms, T / Dobrzynski, L / Filipovic, N / Florent, A / Granier de Cassagnac, R / Mastrolorenzo, L / Miné, P / Naranjo, I N / Nguyen, M / Ochando, C / Ortona, G / Paganini, P / Regnard, S / Salerno, R / Sauvan, J B / Sirois, Y / Veelken, C / Yilmaz, Y / Zabi, A / Agram, J-L / Andrea, J / Aubin, A / Bloch, D / Brom, J-M / Chabert, E C / Collard, C / Conte, E / Fontaine, J-C / Gelé, D / Goerlach, U / Goetzmann, C / Le Bihan, A-C / Skovpen, K / Van Hove, P / Gadrat, S / Beauceron, S / Beaupere, N / Bernet, C / Boudoul, G / Bouvier, E / Brochet, S / Carrillo Montoya, C A / Chasserat, J / Chierici, R / Contardo, D / Courbon, B / Depasse, P / El Mamouni, H / Fan, J / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Kurca, T / Lethuillier, M / Mirabito, L / Pequegnot, A L / Perries, S / Ruiz Alvarez, J D / Sabes, D / Sgandurra, L / Sordini, V / Vander Donckt, M / Verdier, P / Viret, S / Xiao, H / Tsamalaidze, Z / Autermann, C / Beranek, S / Bontenackels, M / Edelhoff, M / Feld, L / Heister, A / Klein, K / Lipinski, M / Ostapchuk, A / Preuten, M / Raupach, F / Sammet, J / Schael, S / Schulte, J F / Weber, H / Wittmer, B / Zhukov, V / Ata, M / Brodski, M / Dietz-Laursonn, E / Duchardt, D / Erdmann, M / Fischer, R / Güth, A / Hebbeker, T / Heidemann, C / Hoepfner, K / Klingebiel, D / Knutzen, S / Kreuzer, P / Merschmeyer, M / Meyer, A / Millet, P / Olschewski, M / Padeken, K / Papacz, P / Reithler, H / Schmitz, S A / Sonnenschein, L / Teyssier, D / Thüer, S / Cherepanov, V / Erdogan, Y / Flügge, G / Geenen, H / Geisler, M / Haj Ahmad, W / Hoehle, F / Kargoll, B / Kress, T / Kuessel, Y / Künsken, A / Lingemann, J / Nowack, A / Nugent, I M / Pistone, C / Pooth, O / Stahl, A / Aldaya Martin, M / Asin, I / Bartosik, N / Behr, J / Behrens, U / Bell, A J / Bethani, A / Borras, K / Burgmeier, A / Cakir, A / Calligaris, L / Campbell, A / Choudhury, S / Costanza, F / Diez Pardos, C / Dolinska, G / Dooling, S / Dorland, T / Eckerlin, G / Eckstein, D / Eichhorn, T / Flucke, G / Garay Garcia, J / Geiser, A / Gizhko, A / Gunnellini, P / Hauk, J / Hempel, M / Jung, H / Kalogeropoulos, A / Karacheban, O / Kasemann, M / Katsas, P / Kieseler, J / Kleinwort, C / Korol, I / Krücker, D / Lange, W / Leonard, J / Lipka, K / Lobanov, A / Lohmann, W / Lutz, B / Mankel, R / Marfin, I / Melzer-Pellmann, I-A / Meyer, A B / Mittag, G / Mnich, J / Mussgiller, A / Naumann-Emme, S / Nayak, A / Ntomari, E / Perrey, H / Pitzl, D / Placakyte, R / Raspereza, A / Ribeiro Cipriano, P M / Roland, B / Ron, E / Sahin, M Ö / Salfeld-Nebgen, J / Saxena, P / Schoerner-Sadenius, T / Schröder, M / Seitz, C / Spannagel, S / Vargas Trevino, A D R / Walsh, R / Wissing, C / Blobel, V / Centis Vignali, M / Draeger, A R / Erfle, J / Garutti, E / Goebel, K / Görner, M / Haller, J / Hoffmann, M / Höing, R S / Junkes, A / Kirschenmann, H / Klanner, R / Kogler, R / Lapsien, T / Lenz, T / Marchesini, I / Marconi, D / Ott, J / Peiffer, T / Perieanu, A / Pietsch, N / Poehlsen, J / Poehlsen, T / Rathjens, D / Sander, C / Schettler, H / Schleper, P / Schlieckau, E / Schmidt, A / Seidel, M / Sola, V / Stadie, H / Steinbrück, G / Troendle, D / Usai, E / Vanelderen, L / Vanhoefer, A / Barth, C / Baus, C / Berger, J / Böser, C / Butz, E / Chwalek, T / De Boer, W / Descroix, A / Dierlamm, A / Feindt, M / Frensch, F / Giffels, M / Gilbert, A / Hartmann, F / Hauth, T / Husemann, U / Katkov, I / Kornmayer, A / Lobelle Pardo, P / Mozer, M U / Müller, T / Müller, Th / Nürnberg, A / Quast, G / Rabbertz, K / Röcker, S / Simonis, H J / Stober, F M / Ulrich, R / Wagner-Kuhr, J / Wayand, S / Weiler, T / Wolf, R / Anagnostou, G / Daskalakis, G / Geralis, T / Giakoumopoulou, V A / Kyriakis, A / Loukas, D / Markou, A / Markou, C / Psallidas, A / Topsis-Giotis, I / Agapitos, A / Kesisoglou, S / Panagiotou, A / Saoulidou, N / Stiliaris, E / Tziaferi, E / Aslanoglou, X / Evangelou, I / Flouris, G / Foudas, C / Kokkas, P / Manthos, N / Papadopoulos, I / Paradas, E / Strologas, J / Bencze, G / Hajdu, C / Hidas, P / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Zsigmond, A J / Beni, N / Czellar, S / Karancsi, J / Molnar, J / Palinkas, J / Szillasi, Z / Makovec, A / Raics, P / Trocsanyi, Z L / Ujvari, B / Swain, S K / Beri, S B / Bhatnagar, V / Gupta, R / Bhawandeep, U / Kalsi, A K / Kaur, M / Kumar, R / Mittal, M / Nishu, N / Singh, J B / Kumar, Ashok / Kumar, Arun / Ahuja, S / Bhardwaj, A / Choudhary, B C / Kumar, A / Malhotra, S / Naimuddin, M / Ranjan, K / Sharma, V / Banerjee, S / Bhattacharya, S / Chatterjee, K / Dutta, S / Gomber, B / Jain, Sa / Jain, Sh / Khurana, R / Modak, A / Mukherjee, S / Roy, D / Sarkar, S / Sharan, M / Abdulsalam, A / Dutta, D / Kumar, V / Mohanty, A K / Pant, L M / Shukla, P / Topkar, A / Aziz, T / Bhowmik, S / Chatterjee, R M / Dewanjee, R K / Dugad, S / Ganguly, S / Ghosh, S / Guchait, M / Gurtu, A / Kole, G / Kumar, S / Maity, M / Majumder, G / Mazumdar, K / Mohanty, G B / Parida, B / Sudhakar, K / Wickramage, N / Sharma, S / Bakhshiansohi, H / Behnamian, H / Etesami, S M / Fahim, A / Goldouzian, R / Khakzad, M / Mohammadi Najafabadi, M / Naseri, M / Paktinat Mehdiabadi, S / Rezaei Hosseinabadi, F / Safarzadeh, B / Zeinali, M / Felcini, M / Grunewald, M / Abbrescia, M / Calabria, C / Chhibra, S S / Colaleo, A / Creanza, D / Cristella, L / De Filippis, N / De Palma, M / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / My, S / Nuzzo, S / Pompili, A / Pugliese, G / Radogna, R / Selvaggi, G / Sharma, A / Silvestris, L / Venditti, R / Verwilligen, P / Abbiendi, G / Benvenuti, A C / Bonacorsi, D / Braibant-Giacomelli, S / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Codispoti, G / Cuffiani, M / Dallavalle, G M / Fabbri, F / Fanfani, A / Fasanella, D / Giacomelli, P / Grandi, C / Guiducci, L / Marcellini, S / Masetti, G / Montanari, A / Navarria, F L / Perrotta, A / Rossi, A M / Rovelli, T / Siroli, G P / Tosi, N / Travaglini, R / Albergo, S / Cappello, G / Chiorboli, M / Costa, S / Giordano, F / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Gallo, E / Gonzi, S / Gori, V / Lenzi, P / Meschini, M / Paoletti, S / Sguazzoni, G / Tropiano, A / Benussi, L / Bianco, S / Piccolo, D / Ferretti, R / Ferro, F / Lo Vetere, M / Robutti, E / Tosi, S / Dinardo, M E / Fiorendi, S / Gennai, S / Gerosa, R / Ghezzi, A / Govoni, P / 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    Physical review letters

    2015  Volume 115, Issue 1, Page(s) 12301

    Abstract: The second-order azimuthal anisotropy Fourier harmonics, v2, are obtained in p-Pb and PbPb ... The p-Pb data, corresponding to an integrated luminosity of 35  nb-1, were collected during the 2013 LHC ... p-Pb run at a nucleon-nucleon center-of-mass energy of 5.02  TeV by the CMS experiment. A sample ...

    Abstract The second-order azimuthal anisotropy Fourier harmonics, v2, are obtained in p-Pb and PbPb collisions over a wide pseudorapidity (η) range based on correlations among six or more charged particles. The p-Pb data, corresponding to an integrated luminosity of 35  nb-1, were collected during the 2013 LHC p-Pb run at a nucleon-nucleon center-of-mass energy of 5.02  TeV by the CMS experiment. A sample of semiperipheral PbPb collision data at √sNN=2.76  TeV, corresponding to an integrated luminosity of 2.5  μb-1 and covering a similar range of particle multiplicities as the p-Pb data, is also analyzed for comparison. The six- and eight-particle cumulant and the Lee-Yang zeros methods are used to extract the v2 coefficients, extending previous studies of two- and four-particle correlations. For both the p-Pb and PbPb systems, the v2 values obtained with correlations among more than four particles are consistent with previously published four-particle results. These data support the interpretation of a collective origin for the previously observed long-range (large Δη) correlations in both systems. The ratios of v2 values corresponding to correlations including different numbers of particles are compared to theoretical predictions that assume a hydrodynamic behavior of a p-Pb system dominated by fluctuations in the positions of participant nucleons. These results provide new insights into the multiparticle dynamics of collision systems with a very small overlapping region.
    Language English
    Publishing date 2015-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.115.012301
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  6. Article: p‐Coumaric acid attenuates high‐fat diet‐induced oxidative stress and nephropathy in diabetic rats

    Mani, Akhand / Kushwaha, Kriti / Khurana, Navneet / Gupta, Jeena

    Journal of animal physiology and animal nutrition. 2022 July, v. 106, no. 4

    2022  

    Abstract: ... phytochemical p‐coumaric can reduce diabetes‐induced oxidative stress and improve diabetes‐associated ... nephropathy in rats. The aim of this study is to analyse the protective effects of p‐coumaric acid against ... of p‐coumaric acid (20 mg/kg for 12 weeks) was found to significantly decrease the elevated levels ...

    Abstract The prevalence of persistent hyperglycaemia during diabetes, impair antioxidant defence system and generate reactive oxygen species, which majorly contribute to its progression and associated complications. Phytochemicals were suggested to scavenge‐free radicals and exert antioxidant effects required to improve insulin sensitivity and reduce the occurrence of diabetes‐associated complications. We hypothesise that a phenolic phytochemical p‐coumaric can reduce diabetes‐induced oxidative stress and improve diabetes‐associated nephropathy in rats. The aim of this study is to analyse the protective effects of p‐coumaric acid against diabetes‐induced oxidative stress and nephropathy in high‐fat diet‐induced diabetic rats. The oral feeding of p‐coumaric acid (20 mg/kg for 12 weeks) was found to significantly decrease the elevated levels of blood glucose in high‐fat diet‐induced type 2 diabetic rats. p‐Coumaric acid treatment also decreases the kidney weight whilst increasing the total body weight of diabetic rats. Furthermore whilst evaluation of the different renal functioning tests, p‐coumaric acid significantly improves histopathological changes and the levels of urea, creatinine and uric acid in serum of diabetic rats, which was otherwise elevated under diabetic conditions. Our results also highlight that p‐coumaric acid is an efficient compound with antioxidant properties and improves the diabetes‐induced change in lipid peroxidation and activities of antioxidant enzymes: catalase, glutathione‐S‐transferase and superoxide dismutase. p‐Coumaric acid thus possesses the potential to prevent diabetic nephropathy by reducing oxidative stress and can thus serve as a potential drug target for pharmaceutical companies.
    Keywords acid treatment ; animal nutrition ; antioxidant activity ; blood glucose ; blood serum ; body weight ; catalase ; creatinine ; diabetic nephropathy ; drugs ; glutathione transferase ; high fat diet ; histopathology ; hyperglycemia ; insulin resistance ; kidneys ; lipid peroxidation ; noninsulin-dependent diabetes mellitus ; oxidative stress ; p-coumaric acid ; phytochemicals ; reactive oxygen species ; superoxide dismutase ; urea ; uric acid
    Language English
    Dates of publication 2022-07
    Size p. 872-880.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 232729-6
    ISSN 0931-2439
    ISSN 0931-2439
    DOI 10.1111/jpn.13645
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Observation of Charge-Dependent Azimuthal Correlations in p-Pb Collisions and Its Implication for the Search for the Chiral Magnetic Effect.

    Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Asilar, E / Bergauer, T / Brandstetter, J / Brondolin, E / Dragicevic, M / Erö, J / Flechl, M / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / König, A /
    Krätschmer, I / Liko, D / Matsushita, T / Mikulec, I / Rabady, D / Rad, N / Rahbaran, B / Rohringer, H / Schieck, J / Strauss, J / Waltenberger, W / Wulz, C-E / Dvornikov, O / Makarenko, V / Zykunov, V / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Alderweireldt, S / De Wolf, E A / Janssen, X / Lauwers, J / Van De Klundert, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Abu Zeid, S / Blekman, F / D'Hondt, J / Daci, N / De Bruyn, I / Deroover, K / Lowette, S / Moortgat, S / Moreels, L / Olbrechts, A / Python, Q / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Parijs, I / Brun, H / Clerbaux, B / De Lentdecker, G / Delannoy, H / Fasanella, G / Favart, L / Goldouzian, R / Grebenyuk, A / Karapostoli, G / Lenzi, T / Léonard, A / Luetic, J / Maerschalk, T / Marinov, A / Randle-Conde, A / Seva, T / Vander Velde, C / Vanlaer, P / Vannerom, D / Yonamine, R / Zenoni, F / Zhang, F / Cimmino, A / Cornelis, T / Dobur, D / Fagot, A / Garcia, G / Gul, M / Khvastunov, I / Poyraz, D / Salva, S / Schöfbeck, R / Sharma, A / Tytgat, M / Van Driessche, W / Yazgan, E / Zaganidis, N / Bakhshiansohi, H / Beluffi, C / Bondu, O / Brochet, S / Bruno, G / Caudron, A / De Visscher, S / Delaere, C / Delcourt, M / Francois, B / Giammanco, A / Jafari, A / Jez, P / Komm, M / Krintiras, G / Lemaitre, V / Magitteri, A / Mertens, A / Musich, M / Nuttens, C / Piotrzkowski, K / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Wertz, S / Beliy, N / Aldá Júnior, W L / Alves, F L / Alves, G A / Brito, L / Hensel, C / Moraes, A / Pol, M E / Rebello Teles, P / Belchior Batista Das Chagas, E / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Huertas Guativa, L M / Malbouisson, H / Matos Figueiredo, D / Mora Herrera, C / Mundim, L / Nogima, H / Prado Da Silva, W L / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Ahuja, S / Bernardes, C A / Dogra, S / Fernandez Perez Tomei, T R / Gregores, E M / Mercadante, P G / Moon, C S / Novaes, S F / Padula, Sandra S / Romero Abad, D / Ruiz Vargas, J C / Aleksandrov, A / Hadjiiska, R / Iaydjiev, P / Rodozov, M / Stoykova, S / Sultanov, G / Vutova, M / Dimitrov, A / Glushkov, I / Litov, L / Pavlov, B / Petkov, P / Fang, W / Ahmad, M / Bian, J G / Chen, G M / Chen, H S / Chen, M / Chen, Y / Cheng, T / Jiang, C H / Leggat, D / Liu, Z / Romeo, F / Shaheen, S M / Spiezia, A / Tao, J / Wang, C / Wang, Z / Zhang, H / Zhao, J / Ban, Y / Chen, G / Li, Q / Liu, S / Mao, Y / Qian, S J / Wang, D / Xu, Z / Avila, C / Cabrera, A / Chaparro Sierra, L F / Florez, C / Gomez, J P / González Hernández, C F / Ruiz Alvarez, J D / Sanabria, J C / Godinovic, N / Lelas, D / Puljak, I / Ribeiro Cipriano, P M / Sculac, T / Antunovic, Z / Kovac, M / Brigljevic, V / Ferencek, D / Kadija, K / Mesic, B / Micanovic, S / Sudic, L / Susa, T / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Tsiakkouri, D / Finger, M / Carrera Jarrin, E / Abdelalim, A A / Mohammed, Y / Salama, E / Kadastik, M / Perrini, L / Raidal, M / Tiko, A / Veelken, C / Eerola, P / Pekkanen, J / Voutilainen, M / Härkönen, J / Järvinen, T / Karimäki, V / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Tuominiemi, J / Tuovinen, E / Wendland, L / Talvitie, J / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Favaro, C / Ferri, F / Ganjour, S / Ghosh, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Kucher, I / Locci, E / Machet, M / Malcles, J / Rander, J / Rosowsky, A / Titov, M / Zghiche, A / Abdulsalam, A / Antropov, I / Baffioni, S / Beaudette, F / Busson, P / Cadamuro, L / Chapon, E / Charlot, C / Davignon, O / Granier de Cassagnac, R / Jo, M / Lisniak, S / Miné, P / Nguyen, M / Ochando, C / Ortona, G / Paganini, P / Pigard, P / Regnard, S / Salerno, R / Sirois, Y / Strebler, T / Yilmaz, Y / Zabi, A / Agram, J-L / Andrea, J / Aubin, A / Bloch, D / Brom, J-M / Buttignol, M / Chabert, E C / Chanon, N / Collard, C / Conte, E / Coubez, X / Fontaine, J-C / Gelé, D / Goerlach, U / Le Bihan, A-C / Skovpen, K / Van Hove, P / Gadrat, S / Beauceron, S / Bernet, C / Boudoul, G / Bouvier, E / Carrillo Montoya, C A / Chierici, R / Contardo, D / Courbon, B / Depasse, P / El Mamouni, H / Fan, J / Fay, J / Gascon, S / Gouzevitch, M / Grenier, G / Ille, B / Lagarde, F / Laktineh, I B / Lethuillier, M / Mirabito, L / Pequegnot, A L / Perries, S / Popov, A / Sabes, D / Sordini, V / Vander Donckt, M / Verdier, P / Viret, S / Toriashvili, T / Tsamalaidze, Z / Autermann, C / Beranek, S / Feld, L / Heister, A / Kiesel, M K / Klein, K / Lipinski, M / Ostapchuk, A / Preuten, M / Raupach, F / Schael, S / Schomakers, C / Schulz, J / Verlage, T / Weber, H / Zhukov, V / Albert, A / Brodski, M / Dietz-Laursonn, E / Duchardt, D / Endres, M / Erdmann, M / Erdweg, S / Esch, T / Fischer, R / Güth, A / Hamer, M / Hebbeker, T / Heidemann, C / Hoepfner, K / Knutzen, S / Merschmeyer, M / Meyer, A / Millet, P / Mukherjee, S / Olschewski, M / Padeken, K / Pook, T / Radziej, M / Reithler, H / Rieger, M / Scheuch, F / Sonnenschein, L / Teyssier, D / Thüer, S / Cherepanov, V / Flügge, G / Kargoll, B / Kress, T / Künsken, A / Lingemann, J / Müller, T / Nehrkorn, A / Nowack, A / Pistone, C / Pooth, O / Stahl, A / Aldaya Martin, M / Arndt, T / Asawatangtrakuldee, C / Beernaert, K / Behnke, O / Behrens, U / Bin Anuar, A A / Borras, K / Campbell, A / Connor, P / Contreras-Campana, C / Costanza, F / Diez Pardos, C / Dolinska, G / Eckerlin, G / Eckstein, D / Eichhorn, T / Eren, E / Gallo, E / Garay Garcia, J / Geiser, A / Gizhko, A / Grados Luyando, J M / Gunnellini, P / Harb, A / Hauk, J / Hempel, M / Jung, H / Kalogeropoulos, A / Karacheban, O / Kasemann, M / Keaveney, J / Kleinwort, C / Korol, I / Krücker, D / Lange, W / Lelek, A / Leonard, J / Lipka, K / Lobanov, A / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Meyer, A B / Mittag, G / Mnich, J / Mussgiller, A / Ntomari, E / Pitzl, D / Placakyte, R / Raspereza, A / Roland, B / Sahin, M Ö / Saxena, P / Schoerner-Sadenius, T / Seitz, C / Spannagel, S / Stefaniuk, N / Van Onsem, G P / Walsh, R / Wissing, C / Blobel, V / Centis Vignali, M / Draeger, A R / Dreyer, T / Garutti, E / Gonzalez, D / Haller, J / Hoffmann, M / Junkes, A / Klanner, R / Kogler, R / Kovalchuk, N / Lapsien, T / Lenz, T / Marchesini, I / Marconi, D / Meyer, M / Niedziela, M / Nowatschin, D / Pantaleo, F / Peiffer, T / Perieanu, A / Poehlsen, J / Sander, C / Scharf, C / Schleper, P / Schmidt, A / Schumann, S / Schwandt, J / Stadie, H / Steinbrück, G / Stober, F M / Stöver, M / Tholen, H / Troendle, D / Usai, E / Vanelderen, L / Vanhoefer, A / Vormwald, B / Akbiyik, M / Barth, C / Baur, S / Baus, C / Berger, J / Butz, E / Caspart, R / Chwalek, T / Colombo, F / De Boer, W / Dierlamm, A / Fink, S / Freund, B / Friese, R / Giffels, M / Gilbert, A 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    Physical review letters

    2017  Volume 118, Issue 12, Page(s) 122301

    Abstract: Charge-dependent azimuthal particle correlations with respect to the second-order event plane in p ... particles, are of similar magnitude in p-Pb and PbPb collisions at the same multiplicities. These results ...

    Abstract Charge-dependent azimuthal particle correlations with respect to the second-order event plane in p-Pb and PbPb collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV have been studied with the CMS experiment at the LHC. The measurement is performed with a three-particle correlation technique, using two particles with the same or opposite charge within the pseudorapidity range |η|<2.4, and a third particle measured in the hadron forward calorimeters (4.4<|η|<5). The observed differences between the same and opposite sign correlations, as functions of multiplicity and η gap between the two charged particles, are of similar magnitude in p-Pb and PbPb collisions at the same multiplicities. These results pose a challenge for the interpretation of charge-dependent azimuthal correlations in heavy ion collisions in terms of the chiral magnetic effect.
    Language English
    Publishing date 2017-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.118.122301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Measurement of prompt ψ(2S) to J/ψ yield ratios in Pb-Pb and p-p collisions at sqrt[sNN]=2.76  TeV.

    Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Bergauer, T / Dragicevic, M / Erö, J / Fabjan, C / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V / Krammer, M / Krätschmer, I /
    Liko, D / Mikulec, I / Rabady, D / Rahbaran, B / Rohringer, H / Schöfbeck, R / Strauss, J / Taurok, A / Treberer-Treberspurg, W / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Alderweireldt, S / Bansal, M / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Knutsson, A / Luyckx, S / Ochesanu, S / Roland, B / Rougny, R / Van De Klundert, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Daci, N / Heracleous, N / Keaveney, J / Lowette, S / Maes, M / Olbrechts, A / Python, Q / Strom, D / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Caillol, C / Clerbaux, B / De Lentdecker, G / Dobur, D / Favart, L / Gay, A P R / Grebenyuk, A / Léonard, A / Mohammadi, A / Perniè, L / Reis, T / Seva, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Adler, V / Beernaert, K / Benucci, L / Cimmino, A / Costantini, S / Crucy, S / Dildick, S / Fagot, A / Garcia, G / Mccartin, J / Ocampo Rios, A A / Ryckbosch, D / Salva Diblen, S / Sigamani, M / Strobbe, N / Thyssen, F / Tytgat, M / Yazgan, E / Zaganidis, N / Basegmez, S / Beluffi, C / Bruno, G / Castello, R / Caudron, A / Ceard, L / Da Silveira, G G / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Jez, P / Komm, M / Lemaitre, V / Nuttens, C / Pagano, D / Perrini, L / Pin, A / Piotrzkowski, K / Popov, A / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Aldá Júnior, W L / Alves, G A / Brito, L / Correa Martins Junior, M / Dos Reis Martins, T / Mora Herrera, C / Pol, M E / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santaolalla, J / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Bernardes, C A / Dogra, S / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Genchev, V / Iaydjiev, P / Marinov, A / Piperov, S / Rodozov, M / Stoykova, S / Sultanov, G / Tcholakov, V / Vutova, M / Dimitrov, A / Glushkov, I / Hadjiiska, R / Kozhuharov, V / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Chen, M / Du, R / Jiang, C H / Liang, S / Plestina, R / Tao, J / Wang, X / Wang, Z / Asawatangtrakuldee, C / Ban, Y / Guo, Y / Li, Q / Li, W / Liu, S / Mao, Y / Qian, S J / Wang, D / Zhang, L / Zou, W / Avila, C / Chaparro Sierra, L F / Florez, C / Gomez, J P / Gomez Moreno, B / Sanabria, J C / Godinovic, N / Lelas, D / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Kadija, K / Luetic, J / Mekterovic, D / Sudic, L / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Bodlak, M / Finger, M / Assran, Y / Ellithi Kamel, A / Mahmoud, M A / Radi, A / Kadastik, M / Murumaa, M / Raidal, M / Tiko, A / Eerola, P / Fedi, G / Voutilainen, M / Härkönen, J / Karimäki, V / Kinnunen, R / Kortelainen, M J / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Peltola, T / Tuominen, E / Tuominiemi, J / Tuovinen, E / Wendland, L / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Favaro, C / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Locci, E / Malcles, J / Rander, J / Rosowsky, A / Titov, M / Baffioni, S / Beaudette, F / Busson, P / Charlot, C / Dahms, T / Dalchenko, M / Dobrzynski, L / Filipovic, N / Florent, A / Granier de Cassagnac, R / Mastrolorenzo, L / Miné, P / Mironov, C / Naranjo, I N / Nguyen, M / Ochando, C / Paganini, P / Regnard, S / Salerno, R / Sauvan, J B / Sirois, Y / Veelken, C / Yilmaz, Y / Zabi, A / Agram, J-L / Andrea, J / Aubin, A / Bloch, D / Brom, J-M / Chabert, E C / Collard, C / Conte, E / Fontaine, J-C / Gelé, D / Goerlach, U / Goetzmann, C / Le Bihan, A-C / Van Hove, P / Gadrat, S / Beauceron, S / Beaupere, N / Boudoul, G / Bouvier, E / Brochet, S / Carrillo Montoya, C A / Chasserat, J / Chierici, R / Contardo, D / Depasse, P / El Mamouni, H / Fan, J / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Kurca, T / Lethuillier, M / Mirabito, L / Perries, S / Ruiz Alvarez, J D / Sabes, D / Sgandurra, L / Sordini, V / Vander Donckt, M / Verdier, P / Viret, S / Xiao, H / Tsamalaidze, Z / Autermann, C / Beranek, S / Bontenackels, M / Edelhoff, M / Feld, L / Hindrichs, O / Klein, K / Ostapchuk, A / Perieanu, A / Raupach, F / Sammet, J / Schael, S / Weber, H / Wittmer, B / Zhukov, V / Ata, M / Dietz-Laursonn, E / Duchardt, D / Erdmann, M / Fischer, R / Güth, A / Hebbeker, T / Heidemann, C / Hoepfner, K / Klingebiel, D / Knutzen, S / Kreuzer, P / Merschmeyer, M / Meyer, A / Millet, P / Olschewski, M / Padeken, K / Papacz, P / Reithler, H / Schmitz, S A / Sonnenschein, L / Teyssier, D / Thüer, S / Weber, M / Cherepanov, V / Erdogan, Y / Flügge, G / Geenen, H / Geisler, M / Haj Ahmad, W / Heister, A / Hoehle, F / Kargoll, B / Kress, T / Kuessel, Y / Lingemann, J / Nowack, A / Nugent, I M / Perchalla, L / Pooth, O / Stahl, A / Asin, I / Bartosik, N / Behr, J / Behrenhoff, W / Behrens, U / Bell, A J / Bergholz, M / Bethani, A / Borras, K / Burgmeier, A / Cakir, A / Calligaris, L / Campbell, A / Choudhury, S / Costanza, F / Diez Pardos, C / Dooling, S / Dorland, T / Eckerlin, G / Eckstein, D / Eichhorn, T / Flucke, G / Garay Garcia, J / Geiser, A / Gunnellini, P / Hauk, J / Hempel, M / Horton, D / Jung, H / Kalogeropoulos, A / Kasemann, M / Katsas, P / Kieseler, J / Kleinwort, C / Krücker, D / Lange, W / Leonard, J / Lipka, K / Lobanov, A / Lohmann, W / Lutz, B / Mankel, R / Marfin, I / Melzer-Pellmann, I-A / Meyer, A B / Mittag, G / Mnich, J / Mussgiller, A / Naumann-Emme, S / Nayak, A / Novgorodova, O / Nowak, F / Ntomari, E / Perrey, H / Pitzl, D / Placakyte, R / Raspereza, A / Ribeiro Cipriano, P M / Ron, E / Sahin, M Ö / Salfeld-Nebgen, J / Saxena, P / Schmidt, R / Schoerner-Sadenius, T / Schröder, M / Seitz, C / Spannagel, S / Vargas Trevino, A D R / Walsh, R / Wissing, C / Aldaya Martin, M / Blobel, V / Centis Vignali, M / Draeger, A R / Erfle, J / Garutti, E / Goebel, K / Görner, M / Haller, J / Hoffmann, M / Höing, R S / Kirschenmann, H / Klanner, R / Kogler, R / Lange, J / Lapsien, T / Lenz, T / Marchesini, I / Ott, J / Peiffer, T / Pietsch, N / Poehlsen, J / Poehlsen, T / Rathjens, D / Sander, C / Schettler, H / Schleper, P / Schlieckau, E / Schmidt, A / Seidel, M / Sola, V / Stadie, H / Steinbrück, G / Troendle, D / Usai, E / Vanelderen, L / Barth, C / Baus, C / Berger, J / Böser, C / Butz, E / Chwalek, T / De Boer, W / Descroix, A / Dierlamm, A / Feindt, M / Frensch, F / Giffels, M / Hartmann, F / Hauth, T / Husemann, U / Katkov, I / Kornmayer, A / Kuznetsova, E / Lobelle Pardo, P / Mozer, M U / Müller, Th / Nürnberg, A / Quast, G / Rabbertz, K / Ratnikov, F / Röcker, S / Simonis, H J / Stober, F M / Ulrich, R / Wagner-Kuhr, J / Wayand, S / Weiler, T / Wolf, R / Anagnostou, G / Daskalakis, G / Geralis, T / Giakoumopoulou, V A / Kyriakis, A / Loukas, D / Markou, A / Markou, C / Psallidas, A / Topsis-Giotis, I / Agapitos, A / Kesisoglou, S / Panagiotou, A / Saoulidou, N / Stiliaris, E / Aslanoglou, X / Evangelou, I / Flouris, G / Foudas, C / Kokkas, P / Manthos, N / Papadopoulos, I / Paradas, E / Bencze, G / Hajdu, C / Hidas, P / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Zsigmond, A J / Beni, N / Czellar, S / Karancsi, J / Molnar, J / Palinkas, J / Szillasi, Z / Raics, P / Trocsanyi, Z L / Ujvari, B / Swain, S K / Beri, S B / Bhatnagar, V / Gupta, R / Bhawandeep, U / Kalsi, A K / Kaur, M / Mittal, M / Nishu, N / Singh, J B / Kumar, Ashok / Kumar, Arun / Ahuja, S / Bhardwaj, A / Choudhary, B C / Kumar, A / Malhotra, S / Naimuddin, M / Ranjan, K / Sharma, V / Banerjee, S / Bhattacharya, S / Chatterjee, K / Dutta, S / Gomber, B / Jain, Sa / Jain, Sh / Khurana, R / Modak, A / Mukherjee, S / Roy, D / Sarkar, S / Sharan, M / Abdulsalam, A / Dutta, D / Kailas, S / Kumar, V / Mohanty, A K / Pant, L M / Shukla, P / Topkar, A / Aziz, T / Bhowmik, S / Chatterjee, R M / Dewanjee, R K / Dugad, S / Ganguly, S / Ghosh, S / Guchait, M / Gurtu, A / Kole, G / Kumar, S / Maity, M / Majumder, G / Mazumdar, K / Mohanty, G B / Parida, B / Sudhakar, K / Wickramage, N / Bakhshiansohi, H / Behnamian, H / Etesami, S M / Fahim, A / Goldouzian, R / Jafari, A / Khakzad, M / Mohammadi Najafabadi, M / Naseri, M / Paktinat Mehdiabadi, S / Rezaei Hosseinabadi, F / Safarzadeh, B / Zeinali, M / Felcini, M / Grunewald, M / Abbrescia, M / Barbone, L / Calabria, C / Chhibra, S S / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / My, S / Nuzzo, S / Pompili, A / Pugliese, G / Radogna, R / Selvaggi, G / Silvestris, L / Singh, G / Venditti, R / Verwilligen, P / Zito, G / Abbiendi, G / Benvenuti, A C / Bonacorsi, D / Braibant-Giacomelli, S / Brigliadori, L / Campanini, R / Capiluppi, P / Castro, A / Cavallo, F R / Codispoti, G / Cuffiani, M / Dallavalle, G M / Fabbri, F / Fanfani, A / Fasanella, D / Giacomelli, P / Grandi, C / Guiducci, L / Marcellini, S / Masetti, G / Montanari, A / Navarria, F L / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Tosi, N / Travaglini, R / Albergo, S / Cappello, G / Chiorboli, M / Costa, S / Giordano, F / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Gallo, E / Gonzi, S / Gori, V / Lenzi, P / Meschini, M / Paoletti, S / Sguazzoni, G / Tropiano, A / Benussi, L / Bianco, S / Piccolo, D / Ferro, F / Lo Vetere, M / Robutti, E / Tosi, S / Dinardo, M E / Fiorendi, S / Gennai, S / Gerosa, R / Ghezzi, A / Govoni, P / Lucchini, M T / Malvezzi, S / Manzoni, R A / Martelli, A / Marzocchi, B / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Ragazzi, S / Redaelli, N / Tabarelli 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H / Kim, G N / Kim, M S / Kong, D J / Lee, S / Oh, Y D / Park, H / Sakharov, A / Son, D C / Kim, T J / Kim, J Y / Song, S / Choi, S / Gyun, D / Hong, B / Jo, M / Kim, H / Kim, Y / Lee, B / Lee, K S / Park, S K / Roh, Y / Choi, M / Kim, J H / Park, I C / Park, S / Ryu, G / Ryu, M S / Choi, Y / Choi, Y K / Goh, J / Kim, D / Kwon, E / Lee, J / Seo, H / Yu, I / Juodagalvis, A / Komaragiri, J R / Md Ali, M A B / Castilla-Valdez, H / De La Cruz-Burelo, E / Heredia-de La Cruz, I / Lopez-Fernandez, R / Sanchez-Hernandez, A / Carrillo Moreno, S / Vazquez Valencia, F / Pedraza, I / Salazar Ibarguen, H A / Casimiro Linares, E / Morelos Pineda, A / Krofcheck, D / Butler, P H / Reucroft, S / Ahmad, A / Ahmad, M / Hassan, Q / Hoorani, H R / Khalid, S / Khan, W A / Khurshid, T / Shah, M A / Shoaib, M / Bialkowska, H / Bluj, M / Boimska, B / Frueboes, T / Górski, M / Kazana, M / Nawrocki, K / Romanowska-Rybinska, K / Szleper, M / Zalewski, P / Brona, G / Bunkowski, K / Cwiok, M / Dominik, W / Doroba, K / Kalinowski, A / Konecki, M / Krolikowski, J / Misiura, M / Olszewski, M / Wolszczak, W / Bargassa, P / Beirão Da Cruz E Silva, C / Faccioli, P / Ferreira Parracho, P G / Gallinaro, M / Nguyen, F / Rodrigues Antunes, J / Seixas, J / Varela, J / Vischia, P / Afanasiev, S / Golutvin, I / Karjavin, V / Konoplyanikov, V / Korenkov, V / Kozlov, G / Lanev, A / Malakhov, A / Matveev, V / Mitsyn, V V / Moisenz, P / Palichik, V / Perelygin, V / Shmatov, S / Skatchkov, N / Smirnov, V / Tikhonenko, E / Zarubin, A / Golovtsov, V / Ivanov, Y / Kim, V / Levchenko, P / Murzin, V / Oreshkin, V / Smirnov, I / Sulimov, V / Uvarov, L / Vavilov, S / Vorobyev, A / Vorobyev, An / Andreev, Yu / Dermenev, A / Gninenko, S / Golubev, N / Kirsanov, M / Krasnikov, N / Pashenkov, A / Tlisov, D / Toropin, A / Epshteyn, V / Gavrilov, V / Lychkovskaya, N / Popov, V / Safronov, G / Semenov, S / Spiridonov, A / Stolin, V / Vlasov, E / Zhokin, A / Andreev, V / Azarkin, M / Dremin, I / Kirakosyan, M / Leonidov, A / Mesyats, G / Rusakov, S V / Vinogradov, A / Belyaev, A / Boos, E / Ershov, A / Gribushin, A / Kaminskiy, A / Kodolova, O / Korotkikh, V / Lokhtin, I / Obraztsov, S / Petrushanko, S / Savrin, V / Snigirev, A / Vardanyan, I / Azhgirey, I / Bayshev, I / Bitioukov, S / Kachanov, V / Kalinin, A / Konstantinov, D / Krychkine, V / Petrov, V / Ryutin, R / Sobol, A / Tourtchanovitch, L / Troshin, S / Tyurin, N / Uzunian, A / Volkov, A / Adzic, P / Ekmedzic, M / Milosevic, J / Rekovic, V / Alcaraz Maestre, J / Battilana, C / Calvo, E / Cerrada, M / Chamizo Llatas, M / Colino, N / De La Cruz, B / Delgado Peris, A / Domínguez Vázquez, D / Escalante Del Valle, A / Fernandez Bedoya, C / Fernández Ramos, J P / Flix, J / Fouz, M C / Garcia-Abia, P / Gonzalez Lopez, O / Goy Lopez, S / Hernandez, J M / Josa, M I / Merino, G / Navarro De Martino, E / Pérez-Calero Yzquierdo, A / Puerta Pelayo, J / Quintario Olmeda, A / Redondo, I / Romero, L / Soares, M S / Albajar, C / de Trocóniz, J F / Missiroli, M / 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Glege, F / Guida, R / Gundacker, S / Guthoff, M / Hammer, J / Hansen, M / Harris, P / Hegeman, J / Innocente, V / Janot, P / Kousouris, K / Krajczar, K / Lecoq, P / Lourenço, C / Magini, N / Malgeri, L / Mannelli, M / Marrouche, J / Masetti, L / Meijers, F / Mersi, S / Meschi, E / Moortgat, F / Morovic, S / Mulders, M / Musella, P / Orsini, L / Pape, L / Perez, E / Perrozzi, L / Petrilli, A / Petrucciani, G / Pfeiffer, A / Pierini, M / Pimiä, M / Piparo, D / Plagge, M / Racz, A / Rolandi, G / Rovere, M / Sakulin, H / Schäfer, C / Schwick, C / Sharma, A / Siegrist, P / Silva, P / Simon, M / Sphicas, P / Spiga, D / Steggemann, J / Stieger, B / Stoye, M / Takahashi, Y / Treille, D / Tsirou, A / Veres, G I / Vlimant, J R / Wardle, N / Wöhri, H K / Wollny, H / Zeuner, W D / Bertl, W / Deiters, K / Erdmann, W / Horisberger, R / Ingram, Q / Kaestli, H C / Kotlinski, D / Langenegger, U / Renker, D / Rohe, T / Bachmair, F / Bäni, L / Bianchini, L / Bortignon, P / Buchmann, M A / Casal, B / Chanon, N / Deisher, A / Dissertori, G / Dittmar, M / Donegà, M / Dünser, M / Eller, P / Grab, C / Hits, D / Lustermann, W / Mangano, B / Marini, A C / Martinez Ruiz del Arbol, P / Meister, D / Mohr, N / Nägeli, C / Nessi-Tedaldi, F / Pandolfi, F / Pauss, F / Peruzzi, M / Quittnat, M / Rebane, L / Rossini, M / Starodumov, A / Takahashi, M / Theofilatos, K / Wallny, R / Weber, H A / Amsler, C / Canelli, M F / Chiochia, V / De Cosa, A / Hinzmann, A / Hreus, T / Kilminster, B / Lange, C / Millan Mejias, B / Ngadiuba, J / Robmann, P / Ronga, F J / Taroni, S / Verzetti, M / Yang, Y / Cardaci, M / Chen, K H / Ferro, C / Kuo, C M / Lin, W / Lu, Y J / Volpe, R / Yu, S S / Chang, P / Chang, Y H / Chang, Y W / Chao, Y / Chen, K F / Chen, P H / Dietz, C / Grundler, U / Hou, W-S / Kao, K Y / Lei, Y J / Liu, Y F / Lu, R-S / Majumder, D / Petrakou, E / Tzeng, Y M / Wilken, R / Asavapibhop, B / Srimanobhas, N / Suwonjandee, N / Adiguzel, A / Bakirci, M N / Cerci, S / Dozen, C / Dumanoglu, I / Eskut, 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/ Yagil, A / Yoo, J / Barge, D / Bradmiller-Feld, J / Campagnari, C / Danielson, T / Dishaw, A / Flowers, K / Franco Sevilla, M / Geffert, P / George, C / Golf, F / Gouskos, L / Incandela, J / Justus, C / Mccoll, N / Richman, J / Stuart, D / To, W / West, C / Apresyan, A / Bornheim, A / Bunn, J / Chen, Y / Di Marco, E / Duarte, J / Mott, A / Newman, H B / Pena, C / Rogan, C / Spiropulu, M / Timciuc, V / Wilkinson, R / Xie, S / Zhu, R Y / Azzolini, V / Calamba, A / Carlson, B / Ferguson, T / Iiyama, Y / Paulini, M / Russ, J / Vogel, H / Vorobiev, I / Cumalat, J P / Ford, W T / Gaz, A / Luiggi Lopez, E / Nauenberg, U / Smith, J G / Stenson, K / Ulmer, K A / Wagner, S R / Alexander, J / Chatterjee, A / Chu, J / Dittmer, S / Eggert, N / Mirman, N / Nicolas Kaufman, G / Patterson, J R / Ryd, A / Salvati, E / Skinnari, L / Sun, W / Teo, W D / Thom, J / Thompson, J / Tucker, J / Weng, Y / Winstrom, L / Wittich, P / Winn, D / Abdullin, S / Albrow, M / Anderson, J / Apollinari, G / Bauerdick, L 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    Physical review letters

    2014  Volume 113, Issue 26, Page(s) 262301

    Abstract: ... measured in Pb-Pb and p-p collisions at sqrt[sNN]=2.76  TeV. The analysis is based on Pb-Pb and p-p data ... N(J/ψ))(p-p) is computed in three Pb-Pb collision centrality bins and two kinematic ranges: one ...

    Abstract The ratio between the prompt ψ(2S) and J/ψ yields, reconstructed via their decays into μ+ μ-, is measured in Pb-Pb and p-p collisions at sqrt[sNN]=2.76  TeV. The analysis is based on Pb-Pb and p-p data samples collected by CMS at the Large Hadron Collider, corresponding to integrated luminosities of 150  μb(-1) and 5.4  pb(-1), respectively. The double ratio of measured yields (Nψ(2S)/N(J/ψ))(Pb-Pb)/(Nψ(2S)/N(J/ψ))(p-p) is computed in three Pb-Pb collision centrality bins and two kinematic ranges: one at midrapidity, |y|<1.6, covering the transverse momentum range 6.5<pT<30  GeV/c, and the other at forward rapidity, 1.6<|y|<2.4, extending to lower pT values, 3<pT<30  GeV/c. The centrality-integrated double ratio changes from 0.45±0.13(stat)±0.07(syst) in the first range to 1.67±0.34(stat)±0.27(syst) in the second. This difference is most pronounced in the most central collisions.<br />
    Language English
    Publishing date 2014-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.113.262301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles.

    Mehra, Chahat / Gala, Ravisha / Kakatkar, Aarti / Kumar, Vivekanand / Khurana, Raman / Chatterjee, Suchandra / Kumar, N Naveen / Barooah, Nilotpal / Bhasikuttan, Achikanath C / Mohanty, Jyotirmayee

    Chemical communications (Cambridge, England)

    2019  Volume 55, Issue 95, Page(s) 14275–14278

    Abstract: ... MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalix[6 ...

    Abstract The amelioration of antibacterial efficacy along with the reduced minimum inhibitory concentration (MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalix[6]arene functionalized silver nanoparticles. The large upward pKa shift and enhanced stability of SGR resulting from the favorable supra-nanomolecular strategy are deciphered into an improved antibacterial drug against different pathogenic micro-organisms including multi drug resistant bacteria.
    MeSH term(s) A549 Cells ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Benzophenanthridines/chemistry ; Benzophenanthridines/pharmacology ; CHO Cells ; Calixarenes/chemistry ; Cell Survival/drug effects ; Cricetulus ; Drug Synergism ; Escherichia coli/drug effects ; Humans ; Isoquinolines/chemistry ; Isoquinolines/pharmacology ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; Particle Size ; Phenols/chemistry ; Silver/chemistry ; Staphylococcus aureus/drug effects ; Surface Properties
    Chemical Substances Anti-Bacterial Agents ; Benzophenanthridines ; Isoquinolines ; Phenols ; calix(6)arene ; Calixarenes (130036-26-9) ; Silver (3M4G523W1G) ; sanguinarine (AV9VK043SS)
    Language English
    Publishing date 2019-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc07378g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Induced pluripotent stem cell line heterozygous for p.R501X mutation in filaggrin

    Nikola Kolundzic / Preeti Khurana / Liani Devito / Jakob Jeriha / Jennifer Marx / Carl Hobbs / Xuan Fei Colin Cornelius Wong / John E.A. Common / Mirjana Liovic / Sandrine Dubrac / Robert Gruber / Matthias Schmuth / Theodora M. Mauro / Dusko Ilic

    Stem Cell Research, Vol 39, Iss , Pp - (2019)

    KCLi003-A

    2019  

    Abstract: ... keratinocytes of a female donor, heterozygous for the loss-of-function mutation p.R501X in the filaggrin gene ...

    Abstract We have generated an induced pluripotent stem cell (iPSC) line KCLi003-A (iOP101) from epidermal keratinocytes of a female donor, heterozygous for the loss-of-function mutation p.R501X in the filaggrin gene (FLG), using non-integrating Sendai virus vectors. Derivation and expansion of iPSCs were performed under xeno-free culture conditions. Characterization and validation of KCLi003-A line included molecular karyotyping, mutation screening using restriction enzyme digestion, next generation sequencing (NGS), while pluripotency and differentiation potential were confirmed by expression of associated markers in vitro and by in vivo teratoma assay.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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