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  1. Article ; Online: The Role of Ubiquitination and SUMOylation in DNA Replication.

    Abbas, Tarek

    Current issues in molecular biology

    2020  Volume 40, Page(s) 189–220

    Abstract: DNA replication is a tightly regulated conserved process that ensures the faithful transmission of genetic material to define heritable phenotypic traits. Perturbations in this process result in genomic instability, mutagenesis, and diseases, including ... ...

    Abstract DNA replication is a tightly regulated conserved process that ensures the faithful transmission of genetic material to define heritable phenotypic traits. Perturbations in this process result in genomic instability, mutagenesis, and diseases, including malignancy. Proteins involved in the initiation, progression, and termination of DNA replication are subject to a plethora of reversible post-translational modifications (PTMs) to provide a proper temporal and spatial control of replication. Among these, modifications involving the covalent attachment of the small protein ubiquitin or the small ubiquitin-like modifier (SUMO) to replication and replication-associated proteins are particularly important for the proper regulation of DNA replication as well as for optimal cellular responses to replication stress. In this article, we describe how the ubiquitination and SUMOylation processes impact DNA replication in eukaryotes and highlight the consequences of deregulated signals emanating from these two versatile regulatory pathways on cellular activities.
    MeSH term(s) Animals ; Cell Cycle/genetics ; Cell Proliferation/genetics ; DNA Damage/genetics ; DNA Replication/genetics ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation/genetics ; Ubiquitin/metabolism
    Chemical Substances Small Ubiquitin-Related Modifier Proteins ; Ubiquitin ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2020-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.21775/cimb.040.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
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  2. Article ; Online: Into the limelight: TPA for critically ill Covid-19 patients.

    Abbas, Eslam / Mahdy, Ahmed / Tarek, Rawad / Jabbour, Nawar / Al-Foudri, Huda

    EJHaem

    2022  Volume 3, Issue 3, Page(s) 581

    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Editorial
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Performance of Concentrically Loaded RC Wall-like Columns Upgraded with Innovative Hybrid NSM/CFRP System.

    Elsanadedy, Hussein / Abbas, Husain / Almusallam, Tarek / Al-Salloum, Yousef

    Polymers

    2023  Volume 15, Issue 2

    Abstract: In RC (reinforced concrete) frame structures, wall-like columns are laid within the space occupied by masonry walls to maximize usable space and thus minimize the column projections into the usable area. These columns often require strengthening owing to ...

    Abstract In RC (reinforced concrete) frame structures, wall-like columns are laid within the space occupied by masonry walls to maximize usable space and thus minimize the column projections into the usable area. These columns often require strengthening owing to various reasons, including increasing the number of stories, changes in building usage, and others. The use of a hybrid system comprising NSM (near-surface mounted) steel rebars combined with CFRP (carbon-fiber reinforced polymer) laminates may be considered a sound technique for strengthening such wall-like building columns. The prime aim of this study is to devise an efficient scheme using a hybrid NSM/CFRP system to strengthen existing RC wall-like columns. Six half-scale RC wall-like columns were prepared and tested under monotonic concentric axial compression. Two columns were unstrengthened to serve as control specimens (CW1 and CW2), and four specimens were strengthened using four different schemes (SW1, SW2, SW3, and SW4). As favored by architects, all strengthening schemes were designed so that the dimensions of the column cross-section were not increased. The effects of strengthening schemes on the enhancement of axial capacity, energy dissipated, and stiffness were evaluated to find the most efficient scheme. Among the four studied schemes, using vertical continuous NSM rebars in combination with the wrapping of the three CFRP layers onto the exterior column surface (in specimen SW2) was the most efficient as it enhanced the ultimate load capacity by 80%. Three-dimensional FE (finite element) analysis was also conducted to predict the response of test specimens. The test results matched well with the FE outputs, which justified the accuracy of the used constitutive models for concrete, steel rebars, and CFRP sheets.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15020378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guided Direct Time-of-Flight Lidar Using Stereo Cameras for Enhanced Laser Power Efficiency.

    Taneski, Filip / Gyongy, Istvan / Al Abbas, Tarek / Henderson, Robert K

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: Self-driving vehicles demand efficient and reliable depth-sensing technologies. Lidar, with its capability for long-distance, high-precision measurement, is a crucial component in this pursuit. However, conventional mechanical scanning implementations ... ...

    Abstract Self-driving vehicles demand efficient and reliable depth-sensing technologies. Lidar, with its capability for long-distance, high-precision measurement, is a crucial component in this pursuit. However, conventional mechanical scanning implementations suffer from reliability, cost, and frame rate limitations. Solid-state lidar solutions have emerged as a promising alternative, but the vast amount of photon data processed and stored using conventional direct time-of-flight (dToF) prevents long-distance sensing unless power-intensive partial histogram approaches are used. In this paper, we introduce a groundbreaking 'guided' dToF approach, harnessing external guidance from other onboard sensors to narrow down the depth search space for a power and data-efficient solution. This approach centers around a dToF sensor in which the exposed time window of independent pixels can be dynamically adjusted. We utilize a 64-by-32 macropixel dToF sensor and a pair of vision cameras to provide the guiding depth estimates. Our demonstrator captures a dynamic outdoor scene at 3 fps with distances up to 75 m. Compared to a conventional full histogram approach, on-chip data is reduced by over twenty times, while the total laser cycles in each frame are reduced by at least six times compared to any partial histogram approach. The capability of guided dToF to mitigate multipath reflections is also demonstrated. For self-driving vehicles where a wealth of sensor data is already available, guided dToF opens new possibilities for efficient solid-state lidar.
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218943
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  5. Article: Practice recommendations for clinicians in ART centers in the context of COVID-19 pandemic: perspective of a developing country.

    Farghaly, Tarek A / Fawzy, Mohamed / Abbas, Ahmed M

    Middle East Fertility Society journal

    2020  Volume 25, Issue 1, Page(s) 28

    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2006354-4
    ISSN 2090-3251 ; 1110-5690
    ISSN (online) 2090-3251
    ISSN 1110-5690
    DOI 10.1186/s43043-020-00040-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5147: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Elevated uric acid in gestational diabetes and its risk on pregnancy outcomes.

    Ahmed, Marwa Mostafa / Saad, Nagwa Eid / Abbas, Shimaa Mohamed / El Azizi, Tarek Mohamed Saeed / El Sayed, Inas

    SAGE open medicine

    2024  Volume 12, Page(s) 20503121241241934

    Abstract: Background: Over the past few years, gestational diabetes mellitus has become more common. According to earlier research, gestational diabetes mellitus is linked to higher uric acid levels, and gestational hyperuricemia is linked to poor maternal and ... ...

    Abstract Background: Over the past few years, gestational diabetes mellitus has become more common. According to earlier research, gestational diabetes mellitus is linked to higher uric acid levels, and gestational hyperuricemia is linked to poor maternal and neonatal outcomes.
    Aim and objectives: To assess the influence of elevated uric acid >5 mg/dl on pregnancy outcomes such as neonatal weight, respiratory distress, preterm delivery, neonatal intensive care unit admission, premature membrane rupture, oligohydramnios, cesarean section, and intensive care admission for mothers.
    Setting and methods: It is a prospective cohort study, carried out at obstetric/family medicine outpatient clinics, Cairo University Hospitals on 221 pregnant females with gestational diabetes mellitus in their third trimester of pregnancy, selected by random sampling, performed structured interviews, and tested for serum uric acid level and were separated into two groups, those with elevated uric acid >5 mg/dl (121) and those without elevated uric acid ⩽5 mg/dl (100) patients and then followed up until delivery in Cairo University Hospitals for collecting pregnancy outcome data.
    Results: There were statistically significant differences between the antepartum uric acid and neonatal complications, maternal complications, preterm, macrosomia, neonatal intensive care unit admission, premature rupture of membranes, oligohydramnios, and cesarean section between both groups.
    Conclusions: This study showed that elevated serum uric acid >5 mg/dl can predict the incidence of maternal and neonatal problems in gestational diabetes mellitus including preterm, macrosomia, neonatal intensive care unit admission, premature rupture of membranes, oligohydramnios, and cesarean section.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121241241934
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  7. Article: Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant

    Abdulaal, Wesam H / Alhakamy, Nabil A / Asseri, Amer H / Radwan, Mohamed F / Ibrahim, Tarek S / Okbazghi, Solomon Z / Abbas, Hisham A / Mansour, Basem / Shoun, Aly A / Hegazy, Wael A H / Abdel-Halim, Mahmoud Saad

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1366459

    Abstract: The development of resistance to carbapenems ... ...

    Abstract The development of resistance to carbapenems in
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1366459
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  8. Article ; Online: Hybrid Steel/NSM/GFRP System versus GFRP Wrapping for Upgrading RC Wall-like Columns.

    Elsanadedy, Hussein / Abbas, Husain / Siddiqui, Nadeem / Almusallam, Tarek / Al-Salloum, Yousef

    Polymers

    2023  Volume 15, Issue 8

    Abstract: Reinforced concrete (RC) wall-like columns are commonly employed in structures in Saudi Arabia. These columns are preferred by architects owing to their minimum projection in the usable space. However, they often need strengthening due to several reasons, ...

    Abstract Reinforced concrete (RC) wall-like columns are commonly employed in structures in Saudi Arabia. These columns are preferred by architects owing to their minimum projection in the usable space. However, they often need strengthening due to several reasons, such as the addition of more stories and increasing the live load as a result of changing the usage of the building. This research aimed to obtain the best scheme for the axial strengthening of RC wall-like columns. The challenge in this research is to develop strengthening schemes for RC wall-like columns, which are favored by architects. Accordingly, these schemes were designed so that the dimensions of the column cross-section are not increased. In this regard, six wall-like columns were experimentally examined in the event of axial compression with zero eccentricity. Two specimens were not retrofitted to be used as control columns, whereas four specimens were retrofitted with four schemes. The first scheme incorporated traditional glass fiber-reinforced polymer (GFRP) wrapping, while the second one utilized GFRP wrapping combined with steel plates. The last two schemes involved the addition of near-surface mounted (NSM) steel bars combined with GFRP wrapping and steel plates. The strengthened specimens were compared with regard to axial stiffness, maximum load, and dissipated energy. Besides column testing, two analytical approaches were suggested for computing the axial capacity of tested columns. Moreover, finite element (FE) analysis was performed for evaluating the axial load versus displacement response of tested columns. As an outcome of the study, the best strengthening scheme was proposed to be used by practicing engineers for axial upgrading of wall-like columns.
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15081886
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  9. Article ; Online: Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent in

    Al-Rabia, Mohammed W / Asfour, Hani Z / Alhakamy, Nabil A / Abdulaal, Wesam H / Ibrahim, Tarek S / Abbas, Hisham A / Salem, Ibrahim M / Hegazy, Wael A H / Nazeih, Shaimaa I

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1382289

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Animals ; Mice ; Virulence/genetics ; Pseudomonas aeruginosa ; Biofilms ; Quorum Sensing ; Virulence Factors/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Benzoquinones
    Chemical Substances thymoquinone (O60IE26NUF) ; Virulence Factors ; Anti-Bacterial Agents ; Bacterial Proteins ; Benzoquinones
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1382289
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  10. Article ; Online: The Role of Awareness of Consequences in Predicting the Local Tourists’ Plastic Waste Reduction Behavioral Intention

    Adel Nasser Badawi / Tarek Sayed Adelazim Ahmed / Eid Kaadan Alotaibi / Ihab Saad Abbas / Ehab Rabee Ali / Eman Sarhan M. Shaker

    Sustainability, Vol 16, Iss 1, p

    The Extension of Planned Behavior Theory

    2024  Volume 436

    Abstract: Due to increasing concern about plastic waste and its impact on the ecosystem, it is vital to understand tourists’ behavioral intentions about plastic waste reduction on beaches. There have been several studies that have used the theory of planned ... ...

    Abstract Due to increasing concern about plastic waste and its impact on the ecosystem, it is vital to understand tourists’ behavioral intentions about plastic waste reduction on beaches. There have been several studies that have used the theory of planned behavior to investigate pro-environmental behaviors or intentions, but there are few specific research studies that have extended the theory of planned behavior by adding awareness of consequences to explain the power of behavioral intention. Accordingly, this paper aimed to investigate how awareness of consequences, subjective norms, attitudes, and behavioral control dimensions influence plastic waste behavioral intention on Jeddah’s beaches, in Saudi Arabia. This was performed on a random sample of 390 local tourists in Jeddah city from June to August 2023. A total of 340 of them agreed and answered the questionnaire, yielding a percentage response rate of 87%. This produced 271 valid questionnaires for data analysis after closely examining the survey. A self-complete questionnaire was used for data collection in using multiple statistical analyses to examine the hypotheses. The results demonstrated a positive influence of subjective norms, perceived behavioral control, and consequence awareness on environmental behavioral intention. On the other hand, attitude did not significantly contribute to predict environmental behavioral intention. This study’s findings made clear how crucial it is to consider any potential negative effects while making plans to cut down on plastic trash. Educating people about the possible harm that using plastic products on beaches is anticipated to cause to the environment might also be beneficial. It is intended that, through understanding behavior and behavior determinants, governmental bodies, pro-environmental organizations, businesses, and communities will be able to implement appropriate strategies to reduce the use of plastic in Saudi Arabia to protect marine life.
    Keywords attitude ; subjective norm ; awareness of consequences ; behavioral intention ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 150
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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