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Article ; Online: Combination of electromagnetic navigation and probe-based LASER endomicroscopy to guide non-solid nodules sampling: Results from the CELTICS 2 study.

Kalifa, Jules / Plat, Gavin / Brindel, Aurélien / Héluain, Valentin / Brouchet, Laurent / Rouch, Axel / Mazières, Julien / Chapda, Marie-Christelle Pajiep / Villeneuve, Thomas / Guibert, Nicolas

Respiratory medicine and research

2024 Volume 85, Page(s) 101092

Language	English
Publishing date	2024-02-28
Publishing country	France
Document type	Journal Article
ISSN	2590-0412
ISSN (online)	2590-0412
DOI	10.1016/j.resmer.2024.101092
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Article: Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation.

Hug, Elisa / Villeneuve, Pauline / Bravard, Stephanie / Chorfa, Areski / Damon-Soubeyrand, Christelle / Somkuti, Stephen G / Moazamian, Aron / Aitken, R John / Gharagozloo, Parviz / Drevet, Joël R / Saez, Fabrice

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Routine exposure to chemicals omnipresent in the environment, particularly the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in testis. The decline in semen quality and ... ...

Abstract	Routine exposure to chemicals omnipresent in the environment, particularly the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in testis. The decline in semen quality and testicular abnormalities have been attributed to the disruption of endocrine signaling as well as oxidative stress. The present study set out to examine the effect of short-term exposure of two common EDCs widely used in the plastic industry: Dibutyl Phthalate (DBP) and Bisphenol AF (BPAF). Our research objective was to focus on the post-testicular compartment of the epididymis, where spermatozoa acquire their functional capacity and are stored. The data obtained indicated no significant effect for either chemicals on sperm viability, motility or acrosome integrity. Neither of the EDCs had a noticeable effect on the structures of the testis and epididymis. However, substantial impact on the integrity of the sperm nucleus and DNA structure was evidenced by a significant increase in nuclear decondensation and DNA base oxidation. The damage observed was postulated to arise from the pro-oxidant properties of the EDCs generating excess of reactive oxygen species (ROS) and triggering a state of oxidative stress. This hypothesis was confirmed when the observed damage was largely blocked by co-administering EDCs with an evidenced-based antioxidant formulation.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12051046
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Article ; Online: Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation

Hug, Elisa / Villeneuve, Pauline / Bravard, Stephanie / Chorfa, Areski / Damon-Soubeyrand, Christelle / Somkuti, Stephen G. / Moazamian, Aron / Aitken, R. John / Gharagozloo, Parviz / Drevet, Joël R. / Saez, Fabrice

Antioxidants. 2023 May 05, v. 12, no. 5

2023

Abstract	Routine exposure to chemicals omnipresent in the environment, particularly the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in testis. The decline in semen quality and testicular abnormalities have been attributed to the disruption of endocrine signaling as well as oxidative stress. The present study set out to examine the effect of short-term exposure of two common EDCs widely used in the plastic industry: Dibutyl Phthalate (DBP) and Bisphenol AF (BPAF). Our research objective was to focus on the post-testicular compartment of the epididymis, where spermatozoa acquire their functional capacity and are stored. The data obtained indicated no significant effect for either chemicals on sperm viability, motility or acrosome integrity. Neither of the EDCs had a noticeable effect on the structures of the testis and epididymis. However, substantial impact on the integrity of the sperm nucleus and DNA structure was evidenced by a significant increase in nuclear decondensation and DNA base oxidation. The damage observed was postulated to arise from the pro-oxidant properties of the EDCs generating excess of reactive oxygen species (ROS) and triggering a state of oxidative stress. This hypothesis was confirmed when the observed damage was largely blocked by co-administering EDCs with an evidenced-based antioxidant formulation.
Keywords	DNA ; acrosome ; acute exposure ; bisphenol AF ; dibutyl phthalate ; epididymis ; industry ; mice ; nucleobases ; oxidation ; oxidative stress ; reactive oxygen species ; semen quality ; sperm quality ; testes ; viability
Language	English
Dates of publication	2023-0505
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12051046
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Article ; Online: Clinical and molecular characterization of patients with YWHAG-related epilepsy.

Cetica, Valentina / Pisano, Tiziana / Lesca, Gaetan / Marafi, Dana / Licchetta, Laura / Riccardi, Florence / Mei, Davide / Chung, Hon-Yin B / Bayat, Allan / Balasubramanian, Meena / Lowenstein, Daniel H / Endzinienė, Milda / Alotaibi, Maha / Villeneuve, Nathalie / Jacobs, Julia / Isidor, Bertrand / Solazzi, Roberta / den Hollander, Nicolette S / Marjanovic, Dragan /

Rougeot-Jung, Christelle / Jung, Julien / Lesieur-Sebellin, Marion / Accogli, Andrea / Salpietro, Vincenzo / Saadi, Nebal W / Panagiotakaki, Eleni / Foiadelli, Thomas / Redon, Sylvia / Tsai, Meng-Han / Bisulli, Francesca / Hammer, Trine B / Lupski, James R / Parrini, Elena / Guerrini, Renzo

Epilepsia

2024

Abstract: Objective: YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial ... ...

Abstract	Objective: YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial dysmorphisms. Through description of a large cohort, which doubles the number of reported patients, we further delineate the spectrum of YWHAG-related epilepsy. Methods: We included in this study 24 patients, 21 new and three previously described, with pathogenic/likely pathogenic variants in YWHAG. We extended the analysis of clinical, electroencephalographic, brain magnetic resonance imaging, and molecular genetic information to 24 previously published patients. Results: The phenotypic spectrum of YWHAG-related disorders ranges from mild developmental delay to developmental and epileptic encephalopathy (DEE). Epilepsy onset is in the first 2 years of life. Seizure freedom can be achieved in half of the patients (13/24, 54%). Intellectual disability (23/24, 96%), behavioral disorders (18/24, 75%), neurological signs (13/24, 54%), and dysmorphisms (6/24, 25%) are common. A genotype-phenotype correlation emerged, as DEE is more represented in patients with missense variants located in the ligand-binding domain than in those with truncating or missense variants in other domains (90% vs. 19%, p < .001). Significance: This study suggests that pathogenic YWHAG variants cause a wide range of clinical presentations with variable severity, ranging from mild developmental delay to DEE. In this allelic series, a genotype-phenotype correlation begins to emerge, potentially providing prognostic information for clinical management and genetic counseling.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17939
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Article ; Online: Développement et validation de la version canadienne-française de l'échelle de Satisfaction des Adolescents de la gestion de la Douleur postopératoire - Scoliose idiopathique (SAD-S).

Ballard, Ariane / Le May, Sylvie / Khadra, Christelle / Théroux, Jean / Charette, Sylvie / Villeneuve, Edith / Chorney, Jill / Fortin, Christophe / Parent, Stefan

Canadian journal of pain = Revue canadienne de la douleur

2017 Volume 1, Issue 1, Page(s) 50–60

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2017-07-27
Publishing country	United States
Document type	Journal Article
ISSN	2474-0527
ISSN (online)	2474-0527
DOI	10.1080/24740527.2017.1324947
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Article ; Online: Impact of fatty acid chain length of rosmarinate esters on their antimicrobial activity against Staphylococcus carnosus LTH1502 and Escherichia coli K-12 LTH4263.

Suriyarak, Sarisa / Bayrasy, Christelle / Schmidt, Herbert / Villeneuve, Pierre / Weiss, Jochen

Journal of food protection

2013 Volume 76, Issue 9, Page(s) 1539–1548

Abstract: The effect of the addition of a newly synthesized series of rosmarinic acid (RA) estes (REs) and alcohols with chain lengths of 1, 4, 8, 10, 12, 16, and 18 carbons (RE1 to 18) on the growth behavior of Staphylococcus carnosus LTH1502 and Escherichia coli ...

Abstract	The effect of the addition of a newly synthesized series of rosmarinic acid (RA) estes (REs) and alcohols with chain lengths of 1, 4, 8, 10, 12, 16, and 18 carbons (RE1 to 18) on the growth behavior of Staphylococcus carnosus LTH1502 and Escherichia coli K-12 LTH4263 was investigated. An initial microtiter dilution assay indicated activity of compounds against S. carnosus LTH1502, whereas esters with chain lengths, RA, n-methyl rosmarinate (RE1), n-dodecyl rosmarinate (RE12), and n-octadecyl rosmarinate (RE18) were used in a time-kill assay S. carnosus LTH1502. Compounds were added at 0.75 mM in the log phase, 5 mM in the exponential phase, 10 mM in the stationary phase. RA had no effect in the lag and exponential phase but decreased cell counts during the stationary phase. In contrast, RE1 and RE12 decreased cell number in all three phase, will RE12 reducing counts most rapidly. Addition of RE18 did not affect regardless of the growth phase. Appearance and physiological state of S. carnosus LTH1502 cells indicated difference in the way the compounds interacted with and damaged cells. Results were attributed to the different physicochemical properties of RA and its esters.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Cinnamates/chemistry ; Cinnamates/pharmacology ; Colony Count, Microbial ; Depsides/chemistry ; Depsides/pharmacology ; Escherichia coli K12/drug effects ; Escherichia coli K12/growth & development ; Esters/chemistry ; Esters/pharmacology ; Fatty Acids/chemistry ; Fatty Acids/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus/drug effects ; Staphylococcus/growth & development ; Rosmarinic Acid
Chemical Substances	Anti-Infective Agents ; Cinnamates ; Depsides ; Esters ; Fatty Acids
Language	English
Publishing date	2013-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X.JFP-12-254
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Article ; Online: Comparison of the psychometric properties of 3 pain scales used in the pediatric emergency department: Visual Analogue Scale, Faces Pain Scale-Revised, and Colour Analogue Scale.

Le May, Sylvie / Ballard, Ariane / Khadra, Christelle / Gouin, Serge / Plint, Amy C / Villeneuve, Edith / Mâsse, Benoit / Tsze, Daniel S / Neto, Gina / Drendel, Amy L / Auclair, Marie-Christine / McGrath, Patrick J / Ali, Samina

Pain

2018 Volume 159, Issue 8, Page(s) 1508–1517

Abstract: Appropriate pain measurement relies on the use of valid, reliable tools. The aim of this study was to determine and compare the psychometric properties of 3 self-reported pain scales commonly used in the pediatric emergency department (ED). The inclusion ...

Abstract	Appropriate pain measurement relies on the use of valid, reliable tools. The aim of this study was to determine and compare the psychometric properties of 3 self-reported pain scales commonly used in the pediatric emergency department (ED). The inclusion criteria were children aged 6 to 17 years presenting to the ED with a musculoskeletal injury and self-reported pain scores ≥30 mm on the mechanical Visual Analogue Scale (VAS). Self-reported pain intensity was assessed using the mechanical VAS, Faces Pain Scale-Revised (FPS-R), and Colour Analogue Scale (CAS). Convergent validity was assessed by Pearson correlations and the Bland-Altman method; responsiveness to change was assessed using paired sample t tests and standardized mean responses; and reliability was estimated using relative and absolute indices. A total of 456 participants were included, with a mean age of 11.9 years ± 2.7 and a majority were boys (252/456, 55.3%). Correlations between each pair of scales were 0.78 (VAS/FPS-R), 0.92 (VAS/CAS), and 0.79 (CAS/FPS-R). Limits of agreement (95% confidence interval) were -3.77 to 2.33 (VAS/FPS-R), -1.74 to 1.75 (VAS/CAS), and -2.21 to 3.62 (CAS/FPS-R). Responsiveness to change was demonstrated by significant differences in mean pain scores among the scales (P < 0.0001). Intraclass correlation coefficient and coefficient of repeatability estimates suggested acceptable reliability for the 3 scales at, respectively, 0.79 and ±2.29 (VAS), 0.82 and ±2.07 (CAS), and 0.76 and ±2.82 (FPS-R). The scales demonstrated good psychometric properties for children with acute pain in the ED. The VAS and CAS showed a strong convergent validity, whereas FPS-R was not in agreement with the other scales.
MeSH term(s)	Adolescent ; Child ; Diagnostic Self Evaluation ; Emergency Service, Hospital ; Female ; Humans ; Male ; Musculoskeletal Pain/diagnosis ; Pain Measurement/methods ; Pediatrics ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	2018-03-20
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000001236
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Article ; Online: Peritoneal Carcinomatosis of Rare Ovarian Origin Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Multi-Institutional Cohort from PSOGI and BIG-RENAPE.

Mercier, Frédéric / Bakrin, Naoual / Bartlett, David L / Goere, Diane / Quenet, François / Dumont, Frédéric / Heyd, Bruno / Abboud, Karine / Marolho, Christelle / Villeneuve, Laurent / Glehen, Olivier

Annals of surgical oncology

2018 Volume 25, Issue 6, Page(s) 1668–1675

Abstract: Purpose: Ovarian cancer is the most common deadly cancer of gynecologic origin. Patients often are diagnosed at advanced stage with peritoneal metastasis. There are many rare histologies of ovarian cancer; some have outcomes worse than serous ovarian ... ...

Abstract	Purpose: Ovarian cancer is the most common deadly cancer of gynecologic origin. Patients often are diagnosed at advanced stage with peritoneal metastasis. There are many rare histologies of ovarian cancer; some have outcomes worse than serous ovarian cancer. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can be considered for patients with recurrence. This study was designed to assess the impact of CRS and HIPEC on survival of patient with peritoneal metastasis from rare ovarian malignancy. Methods: A prospective, multicentric, international database was retrospectively searched to identify all patients with rare ovarian tumor (mucinous, clear cells, endometrioid, small cell hypercalcemic, and other) and peritoneal metastasis who underwent CRS and HIPEC through the Peritoneal Surface Oncology Group International (PSOGI) and BIG-RENAPE working group. The postoperative complications, long-term results, and principal prognostic factors were analyzed. Results: The analysis included 210 patients with a median follow-up of 43.5 months. Median overall survival (OS) was 69.3 months, and the 5-year OS was 57.7%. For mucinous tumors, median OS and DFS were not reached at 5 years. For granulosa tumors, median overall survival was not reached at 5 years, and median DFS was 34.6 months. Teratoma or germinal tumor showed median overall survival and DFS that were not reached at 5 years. Differences in OS were not statistically significant between histologies (p = 0.383), whereas differences in DFS were (p < 0.001). Conclusions: CRS and HIPEC may increases long-term survival in selected patients with peritoneal metastasis from rare ovarian tumors especially in mucinous, granulosa, or teratoma histological subtypes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Endometrioid/secondary ; Carcinoma, Endometrioid/therapy ; Cytoreduction Surgical Procedures/adverse effects ; Disease-Free Survival ; Female ; Follow-Up Studies ; Granulosa Cell Tumor/secondary ; Granulosa Cell Tumor/therapy ; Humans ; Hyperthermia, Induced ; Lymphatic Metastasis ; Middle Aged ; Neoplasms, Cystic, Mucinous, and Serous/secondary ; Neoplasms, Cystic, Mucinous, and Serous/therapy ; Neoplasms, Germ Cell and Embryonal/secondary ; Neoplasms, Germ Cell and Embryonal/therapy ; Ovarian Neoplasms/pathology ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy ; Rare Diseases/pathology ; Rare Diseases/therapy ; Retrospective Studies ; Survival Rate ; Teratoma/secondary ; Teratoma/therapy ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2018-04-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-018-6464-z
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Article ; Online: Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation.

Drogaris, Paul / Villeneuve, Valérie / Pomiès, Christelle / Lee, Eun-Hye / Bourdeau, Véronique / Bonneil, Eric / Ferbeyre, Gerardo / Verreault, Alain / Thibault, Pierre

Scientific reports

2012 Volume 2, Page(s) 220

Language	English
Publishing date	2012-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep00220
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Article: Validation of the scale on Satisfaction of Adolescents with Postoperative pain management - idiopathic Scoliosis (SAP-S).

Khadra, Christelle / Le May, Sylvie / Ballard, Ariane / Théroux, Jean / Charette, Sylvie / Villeneuve, Edith / Parent, Stefan / Tsimicalis, Argerie / MacLaren Chorney, Jill

Journal of pain research

2017 Volume 10, Page(s) 137–143

Abstract: Background: Spinal fusion is a common orthopedic surgery in children and adolescents and is associated with high pain levels postoperatively. If the pain is not well managed, negative outcomes may ensue. To our knowledge, there is no measure in English ... ...

Abstract	Background: Spinal fusion is a common orthopedic surgery in children and adolescents and is associated with high pain levels postoperatively. If the pain is not well managed, negative outcomes may ensue. To our knowledge, there is no measure in English that assesses patient's satisfaction with postoperative pain management following idiopathic scoliosis surgery. The aim of the present study was to assess the psychometric properties of the satisfaction subscale of the English version of the Satisfaction of Adolescents with Postoperative pain management - idiopathic Scoliosis (SAP-S) scale. Methods: Eighty-two participants aged 10-18 years, who had undergone spinal fusion surgery, fully completed the SAP-S scale at 10-14 days postdischarge. Construct validity was assessed through a principal component analysis using varimax rotation. Results: Principal component analysis indicated a three-factor structure of the 13-item satisfaction subscale of the SAP-S scale. Factors referred to satisfaction regarding current medication received (Factor 1), actions taken by nurses and doctors to manage pain (Factor 2) and information received after surgery (Factor 3). Cronbach's alpha was 0.91, showing very good internal consistency. Data on satisfaction and clinical outcomes were also reported. Conclusion: The SAP-S is a valid and reliable measure of satisfaction with postoperative pain management that can be used in both research and clinical settings to improve pain management practices. Although it was developed and validated with adolescents who had undergone spinal fusion surgery, it can be used, with further validation, to assess adolescents' satisfaction with pain management in other postoperative contexts.
Language	English
Publishing date	2017-01-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S124365
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