LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 59

Search options

  1. Book: Gadd45 stress sensor genes

    Zaidi, M. Raza / Liebermann, Dan

    (Advances in experimental medicine and biology ; 1360)

    2022  

    Title variant Gaddfortyfive stress sensor genes
    Author's details M. Raza Zaidi, Dan A. Lieberman editors
    Series title Advances in experimental medicine and biology ; 1360
    Collection
    Keywords Intracellular Signaling Peptides and Proteins / physiology ; Stress, Physiological ; Cell Cycle Checkpoints / physiology ; Signal Transduction ; Cell Cycle Proteins / metabolism ; Human molecular genetics ; Stress (Physiology) ; Cell physiology ; Cell metabolism/Regulation ; DNA repair ; Cellular control mechanisms ; Protein-protein interactions
    Subject code 611.01816
    Language English
    Size ix, 153 Seiten, Illustrationen, 26 cm
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT021374494
    ISBN 978-3-030-94803-0 ; 9783030948047 ; 3-030-94803-X ; 3030948048
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1360- not available for loan Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Gadd45 in Normal Hematopoiesis and Leukemia.

    Liebermann, Dan A

    Advances in experimental medicine and biology

    2022  Volume 1360, Page(s) 41–54

    Abstract: Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and modulation of normal blood cell development and leukemia. Each of the Gadd45 genes was shown to be regulated ... ...

    Abstract Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and modulation of normal blood cell development and leukemia. Each of the Gadd45 genes was shown to be regulated independently in myeloid cells in response to cytokine stimulation modulating blood cell survival and differentiation, including maintaining the quiescent stem cell pool. Gadd45a and Gadd45b were also shown to mediate the protective effects from UV in hematopoietic cells by separate signaling pathways involving either p38 activation or JNK inhibition. Furthermore, it was shown that gadd45a methylation in AML is predictive of poor survival. It was also shown that loss of Gadd45b accelerates the development of BCR-ABL driven CML in mice and leads to decreased median survival. The Gadd45b-deficient CML progenitors exhibited increased proliferation and decreased apoptosis, and this was associated with hyper-activation of c-Jun NH2-terminal kinase and Stat5. Moreover, loss of Gadd45a also accelerated the development of BCR-ABL driven CML, and this was associated with enhanced PI3K-AKT-mTOR-4E-BP1 signaling, upregulation of p30C/EBPα expression, and hyper-activation of p38 and Stat5. In human patients with chronic phase CML, gadd45a expression is up-regulated, whereas in accelerated and blast crisis phase patients, gadd45a is downregulated. Collectively, these results provide novel evidence that Gadd45a functions as a suppressor of BCR/ABL driven leukemia and may serve as a unique prognostic marker of CML progression. Thus Gadd45 proteins provide excellent targets for leukemia therapy.
    MeSH term(s) Animals ; Antigens, Differentiation/metabolism ; Apoptosis ; Cell Cycle Proteins/metabolism ; Hematopoiesis/genetics ; Humans ; Leukemia/genetics ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; STAT5 Transcription Factor/metabolism ; STAT5 Transcription Factor/pharmacology
    Chemical Substances Antigens, Differentiation ; Cell Cycle Proteins ; GADD45A protein, human ; STAT5 Transcription Factor
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-94804-7_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Gadd45 stress sensor genes

    Liebermann, Dan A. / Hoffman, Barbara

    (Advances in experimental medicine and biology ; 793)

    2013  

    Author's details Dan A. Liebermann ; Barbara Hoffman ed
    Series title Advances in experimental medicine and biology ; 793
    Collection
    Language English
    Size X, 134 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017836507
    ISBN 978-1-4614-8288-8 ; 9781461482895 ; 1-4614-8288-7 ; 1461482895
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -793- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Gadd45 in Senescence.

    Zaidi, M Raza / Liebermann, Dan A

    Advances in experimental medicine and biology

    2022  Volume 1360, Page(s) 109–116

    Abstract: Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and more recently in senescence. Evidence has accumulated that Gadd45a deficiency results in escape of mouse embryo ... ...

    Abstract Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and more recently in senescence. Evidence has accumulated that Gadd45a deficiency results in escape of mouse embryo fibroblasts from senescence, whereas Gadd45b deficiency promotes premature senescence and skin aging. Moreover, recently Gadd45b deficiency was found to promote senescence and attenuate liver fibrosis, whereas Gadd45a was observed to exert a protective effect against hepatic fibrosis. These findings indicate that the Gadd45 stress response proteins play important roles in modulating cellular responses to senescence. Thus, exploring how Gadd45 proteins modulate cellular senescence has the potential to provide new and innovative tools to treat cancer as well as liver disease.
    MeSH term(s) Animals ; Antigens, Differentiation ; Apoptosis/genetics ; Cell Cycle Checkpoints ; Cellular Senescence/genetics ; DNA Repair ; Mice ; Skin Aging
    Chemical Substances Antigens, Differentiation ; Gadd45b protein, mouse
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-94804-7_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Loss of Gadd45b accelerates BCR-ABL-driven CML.

    Sha, Xiaojin / Hoffman, Barbara / Liebermann, Dan A

    Oncotarget

    2018  Volume 9, Issue 70, Page(s) 33360–33367

    Abstract: Gadd45b is a member of Gadd45 stress sensor protein family that also includes Gadd45a & Gadd45g. To investigate the effect of Gadd45b in bcr-abl oncogene driven chronic myeloid leukemia (CML) development, syngeneic wild type lethally irradiated mice were ...

    Abstract Gadd45b is a member of Gadd45 stress sensor protein family that also includes Gadd45a & Gadd45g. To investigate the effect of Gadd45b in bcr-abl oncogene driven chronic myeloid leukemia (CML) development, syngeneic wild type lethally irradiated mice were reconstituted with either wild type or Gadd45b null myeloid progenitors transduced with a retroviral vector expressing BCR-ABL. Loss of Gadd45b was observed to accelerate BCR-ABL driven CML development with shortened median mouse survival time. BCR-ABL Gadd45b deficient CML progenitors exhibited increased proliferation and decreased apoptosis, associated with hyper-activation of c-Jun NH
    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26076
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Loss of stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML.

    Hassan, Nunki / Yi, Hangyu / Malik, Bilal / Gaspard-Boulinc, Lucie Charlotte / Samaraweera, Saumya E E / Casolari, Debora A / Seneviratne, Janith A / Balachandran, Anushree / Chew, Tracy / Duly, Alastair / Carter, Daniel R R / Cheung, Belamy / Norris, Murray / Haber, Michelle / Kavallaris, Maria / Marshall, Glenn M / Zhang, Xu Dong / Liu, Tao / Wang, Jianlong /
    Liebermann, Dan A / D'Andrea, Richard J J / Wang, Jenny Y

    Blood

    2024  

    Abstract: The overall prognosis of acute myeloid leukemia (AML) remains dismal, largely due to the inability of current therapies to kill leukemia stem cells (LSCs) with intrinsic resistance. Loss of the stress sensor GADD45A is implicated in poor clinical ... ...

    Abstract The overall prognosis of acute myeloid leukemia (AML) remains dismal, largely due to the inability of current therapies to kill leukemia stem cells (LSCs) with intrinsic resistance. Loss of the stress sensor GADD45A is implicated in poor clinical outcomes but its role in LSCs and AML pathogenesis is unknown. Here we define GADD45A as a key downstream target of LGR4 oncogenic signaling and discover a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia. Knockout of GADD45A enhances AML progression in murine and patient-derived xenograft (PDX) mouse models. Deletion of GADD45A induces substantial mutations, increases LSC self-renewal and stemness in vivo and reduces levels of reactive oxygen species (ROS), accompanied by decreased response to ROS-associated genotoxic agents (e.g., ferroptosis inducer RSL3) and acquisition of an increasingly aggressive phenotype upon serial transplantation in mice. Our single-cell CITE-seq analysis on patient-derived LSCs in PDX mice and subsequent functional studies in murine LSCs and primary AML patient cells show that loss of GADD45A is associated with resistance to ferroptosis (an iron-dependent oxidative cell death caused by ROS accumulation) through aberrant activation of antioxidant pathways related to iron and ROS detoxification such as FTH1 and PRDX1, upregulation of which correlates with unfavorable outcomes in AML patients. These results reveal a therapy resistance mechanism contributing to poor prognosis and support a role for GADD45A loss as a critical step for leukemia-initiating activity and as a target to overcome resistance in aggressive leukemia.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2024024072
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Gadd45 in modulation of solid tumors and leukemia.

    Hoffman, Barbara / Liebermann, Dan A

    Advances in experimental medicine and biology

    2013  Volume 793, Page(s) 21–33

    Abstract: The stress response gadd45 gene family participates in cell cycle control, cell survival, apoptosis, maintenance of genomic stability, DNA repair, and active DNA demethylation, in response to environmental and physiological stress including oncogenic ... ...

    Abstract The stress response gadd45 gene family participates in cell cycle control, cell survival, apoptosis, maintenance of genomic stability, DNA repair, and active DNA demethylation, in response to environmental and physiological stress including oncogenic stress. Given these diverse functions, it is anticipated that gadd45 genes can influence the initiation and progression of malignancy and the response to different treatments. This chapter will provide an overview of how the different members of the gadd45 gene family are expressed in different tumors and leukemia, how this may impact on progression of disease, and what happens when expression is manipulated. Studies from human tumor/leukemia samples, cell lines, and animal models are included in this review. An overriding theme is that each of the gadd45 genes has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event.
    MeSH term(s) Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/metabolism ; Apoptosis ; Cell Cycle Checkpoints ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; DNA/genetics ; DNA Repair ; Gene Expression Regulation, Neoplastic ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Leukemia/genetics ; Leukemia/metabolism ; Leukemia/pathology ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Signal Transduction
    Chemical Substances Antigens, Differentiation ; Cell Cycle Proteins ; GADD45A protein, human ; GADD45B protein, human ; GADD45G protein, human ; Intracellular Signaling Peptides and Proteins ; Nuclear Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-4614-8289-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: Gadd45 stress sensor genes

    Liebermann, Dan A / Hoffman, Barbara

    (Advances in experimental medicine and biology, ; 793)

    2013  

    Author's details Dan A. Liebermann, Barbara Hoffman, editors
    Series title Advances in experimental medicine and biology, ; 793
    MeSH term(s) Intracellular Signaling Peptides and Proteins/physiology ; Stress, Physiological/metabolism ; Cell Cycle Checkpoints/physiology ; Signal Trandsduction ; Cell Cycle Proteins/metabolism
    Language English
    Size x, 134 pages :, illustrations (some color) ;, 24 cm.
    Document type Book
    ISBN 9781461482888 ; 1461482887 ; 9781461482895 ; 1461482895
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online: Gadd45 Stress Sensor Genes

    Liebermann, Dan A / Hoffman, Barbara

    (Advances in Experimental Medicine and Biology ; 793)

    2013  

    Abstract: ... family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode ...

    Author's details edited by Dan A. Liebermann, Barbara Hoffman
    Series title Advances in Experimental Medicine and Biology ; 793
    Abstract Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.
    Keywords Biochemistry ; Human genetics ; Medical genetics ; Medicine ; Medizin / Gesundheit # Biochemie / Labormedizin ; Medizin / Gesundheit # Genetik ; Technik / Wissen # Biologie
    Language English
    Size Online-Ressource (X, 134 p. 18 illus., 11 illus. in color), online resource
    Publisher Springer New York
    Publishing place New York, NY ;s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781461482888 ; 9781461482895 ; 1461482887 ; 1461482895
    DOI 10.1007/978-1-4614-8289-5
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Prostate cancer: JunD, Gadd45a and Gadd45g as therapeutic targets.

    Liebermann, Dan A / Hoffman, Barbara

    Cell cycle (Georgetown, Tex.)

    2011  Volume 10, Issue 20, Page(s) 3428

    MeSH term(s) Apoptosis ; Cell Cycle Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Nuclear Proteins/metabolism ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Proteins c-jun/metabolism
    Chemical Substances Cell Cycle Proteins ; Intracellular Signaling Peptides and Proteins ; Nuclear Proteins ; Proto-Oncogene Proteins c-jun
    Language English
    Publishing date 2011-10-15
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.10.20.17528
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top