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Article ; Online: Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by

Meghil, Mohamed M / Tawfik, Omnia K / Elashiry, Mahmoud / Rajendran, Mythilypriya / Arce, Roger M / Fulton, David J / Schoenlein, Patricia V / Cutler, Christopher W

Frontiers in immunology

2019 Volume 10, Page(s) 2286

Abstract: As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, and ... ...

Abstract	As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, and dysregulation of dendritic cell (DC) and T cell responses. The aim of this study was to elucidate the underlying mechanisms by which the oral microbe
MeSH term(s)	Apoptosis ; Autophagy ; Bacteroidaceae Infections/immunology ; Bacteroidaceae Infections/virology ; Cells, Cultured ; Dendritic Cells/immunology ; Dendritic Cells/microbiology ; Fimbriae, Bacterial ; Forkhead Box Protein O1/immunology ; Homeostasis ; Humans ; Porphyromonas gingivalis ; Proto-Oncogene Proteins c-akt ; Toll-Like Receptor 1/immunology ; Toll-Like Receptor 2/immunology
Chemical Substances	FOXO1 protein, human ; Forkhead Box Protein O1 ; TLR1 protein, human ; TLR2 protein, human ; Toll-Like Receptor 1 ; Toll-Like Receptor 2 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-09-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells.

Pushpankur Ghoshal / Mythilypriya Rajendran / Nadine Odo / Tohru Ikuta

PLoS ONE, Vol 9, Iss 6, p e

2014 Volume 99363

Abstract: Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice ...

Abstract	Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice to survive hypoxic stress. In an effort to discover new mechanisms with which to inhibit P-selectin, we examined the role of glycosylation. P-selectin is a 90 kDa protein but was found to migrate as 90 and 140 kDa bands on gel electrophoresis. When P-selectin isolated from ECs was digested with peptide N-glycosidase F, but not O-glycosidase, the 140 kDa band was lost and the 90 kDa band was enhanced. Treatment of ECs with tunicamycin, an N-glycosylation inhibitor, suppressed CD62P (P-selectin) expression on the cell surface as well as the 140 kDa form in the cytoplasm. These results indicate that the 140 kDa band is N-glycosylated and glycosylation is critical for cell surface expression of P-selectin in ECs. Thrombin, which stimulates P-selectin expression on ECs, induced AKT phosphorylation, whereas tunicamycin inhibited AKT phosphorylation, suggesting that AKT signaling is involved in the tunicamycin-mediated inhibition of P-selectin expression. Importantly, the adhesion of sickle red blood cells (sRBCs) and leukocytes to ECs induced by thrombin or hypoxia was markedly inhibited by two structurally distinct glycosylation inhibitors; the levels of which were comparable to that of a P-selectin monoclonal antibody which most strongly inhibited cell adhesion in vivo. Knockdown studies of P-selectin using short-hairpin RNAs in ECs suppressed sRBC adhesion, indicating a legitimate role for P-selectin in sRBC adhesion. Together, these results demonstrate that P-selectin expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs. Glycosylation inhibitors may lead to a novel therapy which inhibits cell adhesion in SCD.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells.

Ghoshal, Pushpankur / Rajendran, Mythilypriya / Odo, Nadine / Ikuta, Tohru

PloS one

2014 Volume 9, Issue 6, Page(s) e99363

Abstract	Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice to survive hypoxic stress. In an effort to discover new mechanisms with which to inhibit P-selectin, we examined the role of glycosylation. P-selectin is a 90 kDa protein but was found to migrate as 90 and 140 kDa bands on gel electrophoresis. When P-selectin isolated from ECs was digested with peptide N-glycosidase F, but not O-glycosidase, the 140 kDa band was lost and the 90 kDa band was enhanced. Treatment of ECs with tunicamycin, an N-glycosylation inhibitor, suppressed CD62P (P-selectin) expression on the cell surface as well as the 140 kDa form in the cytoplasm. These results indicate that the 140 kDa band is N-glycosylated and glycosylation is critical for cell surface expression of P-selectin in ECs. Thrombin, which stimulates P-selectin expression on ECs, induced AKT phosphorylation, whereas tunicamycin inhibited AKT phosphorylation, suggesting that AKT signaling is involved in the tunicamycin-mediated inhibition of P-selectin expression. Importantly, the adhesion of sickle red blood cells (sRBCs) and leukocytes to ECs induced by thrombin or hypoxia was markedly inhibited by two structurally distinct glycosylation inhibitors; the levels of which were comparable to that of a P-selectin monoclonal antibody which most strongly inhibited cell adhesion in vivo. Knockdown studies of P-selectin using short-hairpin RNAs in ECs suppressed sRBC adhesion, indicating a legitimate role for P-selectin in sRBC adhesion. Together, these results demonstrate that P-selectin expression on ECs is regulated in part by glycosylation mechanisms and that glycosylation inhibitors efficiently reduce the adhesion of sRBCs and leukocytes to ECs. Glycosylation inhibitors may lead to a novel therapy which inhibits cell adhesion in SCD.
MeSH term(s)	Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/pathology ; Animals ; Cell Adhesion/drug effects ; Cell Adhesion/genetics ; Cell Hypoxia/genetics ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Gene Expression Regulation ; Glycosylation ; Leukocytes/metabolism ; Leukocytes/pathology ; Mice ; P-Selectin/biosynthesis ; P-Selectin/metabolism ; Thrombin/metabolism ; Tunicamycin/administration & dosage
Chemical Substances	P-Selectin ; Tunicamycin (11089-65-9) ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2014-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0099363
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Article ; Online: Ameliorating effect of Kalpaamruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins.

Mythilypriya, Rajendran / Sachdanandam, Palanivelu Shanthi / Sachdanandam, Panchanadam

Chemico-biological interactions

2009 Volume 179, Issue 2-3, Page(s) 335–343

Abstract: Background: As disease initiation and propagation still represents a research question in rheumatoid arthritis (RA), the cytokines play a central role in the inflammatory articular process including the synovial proliferation and cartilage destruction ... ...

Abstract	Background: As disease initiation and propagation still represents a research question in rheumatoid arthritis (RA), the cytokines play a central role in the inflammatory articular process including the synovial proliferation and cartilage destruction in RA and understanding the role of these cytokines in turn exploits them as therapeutic targets in RA. Objectives: The present study illustrates the beneficial outcome of the Siddha drug Kalpaamruthaa (KA) in reducing the pathological lesions caused by the proinflammatory cytokines in adjuvant induced arthritis (AIA) in rats. KA consists of Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis fruit and honey. Material and methods: Both SA and KA were administered at dose of 150 mg/kg b.wt. for 14 days after 14 days of adjuvant injection in rats. The protein expressions of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), the levels of acute phase proteins, immunoglobulins and the radiological, histopathological and electron microscopical changes in control and experimental animals were analyzed. Results and conclusion: Both SA and KA significantly regulated the inflammation in arthritic joints by reducing extracellular matrix degradation and cartilage and bone destruction via down regulating the levels of TNF-alpha and IL-1beta, as well the levels of acute phase proteins with appreciable increase in the levels of immunoglobulins in arthritic rats. Of both the drugs KA exhibited a profound effect than sole treatment of SA and the enhanced effect of KA might be attributed to the combined effect of the flavonoids, tannins, vitamin C and other phytoconstituents present in the drug.
MeSH term(s)	Acute-Phase Proteins/immunology ; Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/immunology ; Arthritis, Experimental/pathology ; Disease Models, Animal ; Down-Regulation/drug effects ; Down-Regulation/immunology ; Drug Evaluation, Preclinical ; Enzyme-Linked Immunosorbent Assay ; Extracellular Matrix/drug effects ; Extracellular Matrix/immunology ; Immunoglobulins/immunology ; Interleukin-1beta/immunology ; Male ; Microscopy, Electron ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Semecarpus/chemistry ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Acute-Phase Proteins ; Immunoglobulins ; Interleukin-1beta ; Kalpaamruthaa ; Plant Extracts ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2009-03-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2009.01.001
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Article: Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.

Mythilypriya, Rajendran / Shanthi, Palanivelu / Sachdanandam, Panchanadam

Inflammation

2008 Volume 31, Issue 6, Page(s) 391–398

Abstract: The present study was designed to evaluate the antiinflammatory properties of Kalpaamruthaa (KA) a modified indigenous Siddha formulation constituting Semecarpus anacardium nut milk extract (SA), Emblica officinalis (EO) and honey in acute and chronic ... ...

Abstract	The present study was designed to evaluate the antiinflammatory properties of Kalpaamruthaa (KA) a modified indigenous Siddha formulation constituting Semecarpus anacardium nut milk extract (SA), Emblica officinalis (EO) and honey in acute and chronic antiinflammatory studies. A dose of 150 mg/kg b.wt. of SA and KA were used for the present studies. The effect of KA was compared with standard drug diclofenac sodium. It was observed that the drug KA exhibited enhanced effect on antiinflammatory and antiarthritic properties than sole SA treatment and the collective effect of KA might be due to the combined interactions of the phytochemicals such as flavonoids, tannins and other compounds such as vitamin c present in KA.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Arthritis, Experimental/etiology ; Arthritis, Experimental/prevention & control ; Carrageenan ; Cotton Fiber ; Diclofenac/pharmacology ; Disease Models, Animal ; Edema/chemically induced ; Edema/prevention & control ; Freund's Adjuvant ; Inflammation/etiology ; Inflammation/prevention & control ; Male ; Medicine, Ayurvedic ; Nuts ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Semecarpus ; Time Factors
Chemical Substances	Anti-Inflammatory Agents ; Kalpaamruthaa ; Plant Extracts ; Diclofenac (144O8QL0L1) ; Carrageenan (9000-07-1) ; Freund's Adjuvant (9007-81-2)
Language	English
Publishing date	2008-12
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	434408-x
ISSN	0360-3997
ISSN	0360-3997
DOI	10.1007/s10753-008-9090-2
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Zs.A 1401: Show issues

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Article ; Online: Efficacy of Siddha formulation Kalpaamruthaa in ameliorating joint destruction in rheumatoid arthritis in rats.

Mythilypriya, Rajendran / Shanthi, Palanivelu / Sachdanandam, Panchanadam

Chemico-biological interactions

2008 Volume 176, Issue 2-3, Page(s) 243–251

Abstract: Background: Rheumatoid arthritis (RA) is a kind of chronic inflammatory autoimmune disease. The degradation of extracellular matrix and cartilage pave way in understanding the molecular mechanisms in RA. Degradation of cartilage is a more complex event ... ...

Abstract	Background: Rheumatoid arthritis (RA) is a kind of chronic inflammatory autoimmune disease. The degradation of extracellular matrix and cartilage pave way in understanding the molecular mechanisms in RA. Degradation of cartilage is a more complex event involving the local release of metallaoproteases and lysosomal enzymes that mediate inflammation in joints and in the synovial fluid in RA. Objectives: In the present study, the efficacy of a Siddha preparation named Kalpaamruthaa (KA) in ameliorating the disease process via markedly reducing the joint destruction was demonstrated in adjuvant induced arthritis rat model. KA consists of Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis fruit and honey. Material and methods: Both SA and KA were administered at dose of 150 mg/kg b.wt. for 14 days after 14 days of adjuvant injection in rats. The activity of lysosomal enzymes, the level of collagen, glycosaminoglycans (GAGs) and its degradative products were analyzed in control and experimental animals. Results and conclusion: The study revealed that KA exhibited a profound reduction (p<0.05) in the activities of lysosomal enzymes and thereby decreasing (p<0.05) the levels of GAGs and its fractions when compared to arthritis rats. The latter was confirmed by Safrannin O staining for GAGs in the interphalangeal joints of control and experimental animals. The effect of KA was found to be improved than SA and this might be due to the combined interactions of phytoconstituents present in KA.
MeSH term(s)	Acetylglucosaminidase/metabolism ; Acid Phosphatase/metabolism ; Animals ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Aspartic Acid Endopeptidases/metabolism ; Blood Proteins/analysis ; Cathepsin D/metabolism ; Collagen/analysis ; Disease Models, Animal ; Enzyme Activation/drug effects ; Glycosaminoglycans/analysis ; Glycoside Hydrolases/metabolism ; Hip Joint/drug effects ; Hip Joint/pathology ; Lysosomes/enzymology ; Male ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar
Chemical Substances	Blood Proteins ; Glycosaminoglycans ; Kalpaamruthaa ; Plant Extracts ; Collagen (9007-34-5) ; Acid Phosphatase (EC 3.1.3.2) ; Glycoside Hydrolases (EC 3.2.1.-) ; Acetylglucosaminidase (EC 3.2.1.52) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Cathepsin D (EC 3.4.23.5)
Language	English
Publishing date	2008-11-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2008.07.008
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Article: Salubrious effect of Kalpaamruthaa, a modified indigenous preparation in adjuvant-induced arthritis in rats--a biochemical approach.

Mythilypriya, Rajendran / Shanthi, Palanivelu / Sachdanandam, Panchanadam

Chemico-biological interactions

2008 Volume 173, Issue 2, Page(s) 148–158

Abstract: Background: Interactions between the phytochemicals and drugs and their combinations are capable of providing longer remissions and perhaps a complete cure for many diseases including rheumatoid arthritis (RA). In addition to articular manifestations in ...

Abstract	Background: Interactions between the phytochemicals and drugs and their combinations are capable of providing longer remissions and perhaps a complete cure for many diseases including rheumatoid arthritis (RA). In addition to articular manifestations in RA, extra-articular signs involving reticuloendothelial and hepatic systems are an indication of more severe disease and thus, have prognostic value. Objectives: The present study was designed to illustrate the beneficial outcome of the drug Kalpaamruthaa (constituting Semecarpus anacardium nut milk extract, fresh dried powder of Emblica officinalis fruit and honey) in adjuvant-induced arthritic rat model with respect to the changes in extra-articular manifestation involving hematological and cellular constituents. Material and methods: Levels of hematological parameters, cellular constituents, activities of marker enzymes and the level of DNA damage were assessed in control, arthritis-induced, SA, KA and drug control treated rats. Results and conclusion: Significant decrease (p<0.005) in the levels of Hb, RBC, PCV, total protein, albumin, A/G ratio, plasma uric acid, urinary urea, uric acid, creatinine, FFA, HDL and significant increase (p<0.05) in the levels of WBC, platelet count, ESR, globulin, plasma creatinine, blood glucose, urea, AST, ALT, ALP, TC, FC, TG, PL, LDL and VLDL were observed in arthritic rats. No other significant change was observed in tissue DNA and RNA levels of control and experimental animals. On the contrary an increase in DNA damage was observed in arthritic rats when compared to control animals. The above said derangements were brought back to near normal levels upon SA and KA treatments and KA revealed a profound beneficial effect than SA. The enhanced effect of KA might be attributed to the combined effects of phytoconstituents such as flavonoids, tannins and other compounds such as vitamin C present in KA. Thus KA via this preliminary protective effect might contribute to the amelioration of the disease process.
MeSH term(s)	Alanine Transaminase/metabolism ; Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/metabolism ; Aspartate Aminotransferases/metabolism ; Blood Cell Count ; Blood Chemical Analysis ; DNA Fragmentation/drug effects ; Hemoglobins/metabolism ; Kidney/drug effects ; Kidney/enzymology ; Kidney/metabolism ; Lipid Metabolism/drug effects ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Male ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Semecarpus/chemistry ; Urinalysis
Chemical Substances	Hemoglobins ; Kalpaamruthaa ; Plant Extracts ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2008-05-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2008.02.007
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Article: Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation--Kalpaamruthaa.

Mythilypriya, Rajendran / Shanthi, Palanivelu / Sachdanandam, Panchanatham

Phytotherapy research : PTR

2007 Volume 21, Issue 6, Page(s) 574–578

Abstract: A modified indigenous Siddha formulation Kalpaamruthaa (KA), containing Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis (EO) fruit and honey was evaluated for its analgesic, antipyretic and Ulcerogenic properties. Both SA ...

Abstract	A modified indigenous Siddha formulation Kalpaamruthaa (KA), containing Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis (EO) fruit and honey was evaluated for its analgesic, antipyretic and Ulcerogenic properties. Both SA and KA, at a dose of 150 mg/kg b. wt were compared with the standard drug diclofenac sodium. KA exhibited an enhanced effect on all properties compared with that found with sole SA treatment, and is likely to be due to synergistic and additive interactions within the complex mixture of phytochemicals present in KA.
MeSH term(s)	Analgesics/adverse effects ; Analgesics/chemistry ; Analgesics/pharmacology ; Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/chemistry ; Analgesics, Non-Narcotic/pharmacology ; Animals ; Arthritis, Rheumatoid/metabolism ; Diclofenac/chemistry ; Diclofenac/pharmacology ; Dinoprostone/metabolism ; Female ; Fruit/chemistry ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Male ; Mice ; Phyllanthus emblica/chemistry ; Plant Extracts/adverse effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Semecarpus/chemistry ; Stomach Ulcer/chemically induced ; Stomach Ulcer/pathology ; Time Factors
Chemical Substances	Analgesics ; Analgesics, Non-Narcotic ; Kalpaamruthaa ; Plant Extracts ; Diclofenac (144O8QL0L1) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2007-06
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.2116
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Article: Restorative and synergistic efficacy of Kalpaamruthaa, a modified Siddha preparation, on an altered antioxidant status in adjuvant induced arthritic rat model.

Mythilypriya, Rajendran / Shanthi, Palanivelu / Sachdanandam, Panchanatham

Chemico-biological interactions

2007 Volume 168, Issue 3, Page(s) 193–202

Abstract: Background: Rheumatoid arthritis (RA) is a prevalent and debilitating disease that affects the joints. Infiltration of blood-derived cells in the affected joints upon activation generate reactive oxygen/nitrogen species, resulting in an oxidative stress. ...

Abstract	Background: Rheumatoid arthritis (RA) is a prevalent and debilitating disease that affects the joints. Infiltration of blood-derived cells in the affected joints upon activation generate reactive oxygen/nitrogen species, resulting in an oxidative stress. One approach to counteract this oxidative stress is the use of antioxidants as therapeutic agents. Objectives: Kalpaamruthaa (KA), a modified indigenous Siddha preparation constituting Semecarpus anacardium nut milk extract (SA), Emblica officinalis (EO) and honey was evaluated for its synergistic antioxidant potential in adjuvant induced arthritic rats than sole SA treatment. Materials and methods: Levels/activities of reactive oxygen species (ROS)/reactive nitrogen species (RNS), myeloperoxidase, lipid peroxide and enzymic and non-enzymic antioxidants were determined in control, arthritis induced, SA and KA treated (150 mg/kg b.wt.) animals. Results and conclusion: The levels/activities of ROS/RNS, myeloperoxidase and lipid peroxide were increased significantly (p<0.05) and the activities of enzymic and non-enzymic antioxidants were in turn decreased in arthritic rats, whereas these changes were reverted to near normal levels upon SA and KA treatment. KA showed an enhanced antioxidant potential than sole treatment of SA in adjuvant induced arthritic rats. KA via enhancing the antioxidant status in adjuvant induced arthritic rats than sole SA treatment proves to be an important therapeutic modality in the management of RA and thereby instituting the role of oxidative stress in the clinical manifestation of the disease RA. The profound antioxidant efficacy of KA than SA alone might be due to the synergistic action of the polyphenols such as flavonoids, tannins and other compounds such as vitamin C and hydroxycinnamates present in KA.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Arthritis/chemically induced ; Arthritis/drug therapy ; Disease Models, Animal ; Freund's Adjuvant/adverse effects ; Inflammation/chemically induced ; Inflammation/drug therapy ; Lipid Peroxidation/drug effects ; Male ; Medicine, Ayurvedic ; Peroxidase/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Synovial Membrane/drug effects ; Synovial Membrane/enzymology
Chemical Substances	Antioxidants ; Kalpaamruthaa ; Plant Extracts ; Reactive Oxygen Species ; Freund's Adjuvant (9007-81-2) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2007-07-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2007.04.005
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Article ; Online: Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis.

Rajendran, Mythilypriya / Looney, Stephen / Singh, Nagendra / Elashiry, Mahmoud / Meghil, Mohamed M / El-Awady, Ahmed R / Tawfik, Omnia / Susin, Cristiano / Arce, Roger M / Cutler, Christopher W

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 202, Issue 9, Page(s) 2690–2699

Abstract: Periodontitis (PD) is a common dysbiotic inflammatory disease that leads to local bone deterioration and tooth loss. PD patients experience low-grade bacteremias with oral microbes implicated in the risk of heart disease, cancer, and kidney failure. ... ...

Abstract	Periodontitis (PD) is a common dysbiotic inflammatory disease that leads to local bone deterioration and tooth loss. PD patients experience low-grade bacteremias with oral microbes implicated in the risk of heart disease, cancer, and kidney failure. Although Th17 effectors are vital to fighting infection, functional imbalance of Th17 effectors and regulatory T cells (Tregs) promote inflammatory diseases. In this study, we investigated, in a small pilot randomized clinical trial, whether expansion of inflammatory blood myeloid dendritic cells (DCs) and conversion of Tregs to Th17 cells could be modulated with antibiotics (AB) as part of initial therapy in PD patients. PD patients were randomly assigned to either 7 d of peroral metronidazole/amoxicillin AB treatment or no AB, along with standard care debridement and chlorhexidine mouthwash. 16s ribosomal RNA analysis of keystone pathogen
MeSH term(s)	Amoxicillin/administration & dosage ; Bacteria/immunology ; Bacteria/metabolism ; Bacterial Infections/blood ; Bacterial Infections/drug therapy ; Bacterial Infections/immunology ; Bacterial Infections/pathology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Female ; Humans ; Male ; Metronidazole/administration & dosage ; Middle Aged ; Periodontitis/blood ; Periodontitis/drug therapy ; Periodontitis/immunology ; Periodontitis/pathology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/parasitology ; T-Lymphocytes, Regulatory/pathology ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th17 Cells/pathology
Chemical Substances	Metronidazole (140QMO216E) ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1900046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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