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  1. Article ; Online: Activated KRAS, polyamines, iASPP and TME: a multiple liaison in pancreatic cancer.

    Blandino, Giovanni

    Cell death and differentiation

    2023  Volume 30, Issue 6, Page(s) 1615–1617

    MeSH term(s) Humans ; Pancreatic Neoplasms/genetics ; Polyamines ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances KRAS protein, human ; Polyamines ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-023-01169-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
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  2. Article ; Online: Drugging the Master Regulator TP53 in Cancer: Mission Possible?

    Blandino, Giovanni

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 14, Page(s) 1595–1597

    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Tumor Suppressor Protein p53/genetics
    Chemical Substances TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.00192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  3. Article ; Online: Cancer at the time of the COVID-19 hurricane.

    Blandino, Giovanni

    Journal of experimental & clinical cancer research : CR

    2020  Volume 39, Issue 1, Page(s) 74

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Neoplasms ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Editorial
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-020-01575-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2065: Show issues Location:
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  4. Book ; Online: Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

    Haupt, Ygal / Blandino, Giovanni

    2016  

    Abstract: TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions ( ... ...

    Abstract TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation
    Keywords Medicine (General) ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    Size 1 electronic resource (97 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090680
    ISBN 9782889199617 ; 2889199614
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Circular RNA YAP1: a new player in gastric cancer.

    Verduci, Lorena / Blandino, Giovanni

    Translational cancer research

    2022  Volume 8, Issue Suppl 2, Page(s) S195–S197

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.02.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cancer at the time of the COVID-19 hurricane

    Giovanni Blandino

    Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Cancer at the time of the COVID-19 hurricane

    Blandino, Giovanni

    Journal of Experimental & Clinical Cancer Research

    2020  Volume 39, Issue 1

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-020-01575-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: José Baselga M.D., Ph.D. (1959-2021) leading cancer researcher and oncologist.

    Elkabets, Moshe / Blandino, Giovanni

    Journal of experimental & clinical cancer research : CR

    2021  Volume 40, Issue 1, Page(s) 156

    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-021-01966-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: MicroRNAs in head and neck squamous cell carcinoma: a possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies.

    Vahabi, Mahrou / Blandino, Giovanni / Di Agostino, Silvia

    Translational cancer research

    2022  Volume 10, Issue 6, Page(s) 3090–3110

    Abstract: Head and neck squamous cell carcinoma (HNSCC) are referred to a group of heterogeneous cancers that include structures of aerodigestive tract such as oral and nasal cavity, salivary glands, oropharynx, pharynx, larynx, paranasal sinuses, and local lymph ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) are referred to a group of heterogeneous cancers that include structures of aerodigestive tract such as oral and nasal cavity, salivary glands, oropharynx, pharynx, larynx, paranasal sinuses, and local lymph nodes. HNSCC is characterized by frequent alterations of several genes such as
    Language English
    Publishing date 2022-01-20
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-2530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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