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Article ; Online: Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case-control study.

Israel, Ariel / Cicurel, Assi / Feldhamer, Ilan / Stern, Felicia / Dror, Yosef / Giveon, Shmuel M / Gillis, David / Strich, David / Lavie, Gil

Internal and emergency medicine

2022 Volume 17, Issue 4, Page(s) 1053–1063

Abstract: Robust evidence of whether vitamin D deficiency is associated with COVID-19 infection and ... its severity is still lacking. The aim of the study was to evaluate the association between vitamin D levels ... for which vitamin D levels and body mass index (BMI) were available before the pandemic: group (A), in which 41,757 ...

Abstract	Robust evidence of whether vitamin D deficiency is associated with COVID-19 infection and its severity is still lacking. The aim of the study was to evaluate the association between vitamin D levels and the risks of SARS-CoV-2 infection and severe disease in those infected. A retrospective study was carried out among members of Clalit Health Services (CHS), the largest healthcare organization in Israel, between March 1 and October 31, 2020. We created two matched case-control groups of individuals for which vitamin D levels and body mass index (BMI) were available before the pandemic: group (A), in which 41,757 individuals with positive SARS-CoV-2 PCR tests were matched with 417,570 control individuals without evidence of infection, and group (B), in which 2533 patients hospitalized in severe condition for COVID-19 were matched with 2533 patients who were tested positive for SARS-CoV-2, but were not hospitalized. Conditional logistic models were fitted in each of the groups to assess the association between vitamin D levels and outcome. An inverse correlation was demonstrated between the level of vitamin D and the risks of SARS-CoV-2 infection and of severe disease in those infected. Patients with very low vitamin D levels (< 30 nmol/L) had the highest risks for SARS-CoV-2 infection and also for severe COVID-19 when infected-OR 1.246 [95% CI 1.210-1.304] and 1.513 [95% CI 1.230-1.861], respectively. In this large observational population study, we show a significant association between vitamin D deficiency and the risks of SARS-CoV-2 infection and of severe disease in those infected.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Case-Control Studies ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-01-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-021-02902-w
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Article ; Online: Residential Greenness, Lifestyle, and Vitamin D: A Longitudinal Cohort of South Asian Origin and Caucasian Ethnicity Women Living in the South of the UK.

Santana, Keila Valente de Souza de / Ribeiro, Helena / Darling, Andrea / Rios, Israel Henrique Ribeiro / Lanham-New, Susan

Nutrients

2024 Volume 16, Issue 8

Abstract: The global population is at risk of vitamin D deficiency due to low exposure to sunlight and low ... between vitamin D status and parathyroid hormone (PTH), ultraviolet radiation, lifestyle, ethnicity ... social conditions, and residential greenness. A 1-year longitudinal study assessed vitamin D status in 309 women ...

Abstract	The global population is at risk of vitamin D deficiency due to low exposure to sunlight and low intake of the vitamin through diet. The aim of this study was to investigate in women the association between vitamin D status and parathyroid hormone (PTH), ultraviolet radiation, lifestyle, ethnicity, social conditions, and residential greenness. A 1-year longitudinal study assessed vitamin D status in 309 women living at latitude 51°14' N. Blood samples were taken four times throughout the year for analysis of 25(OH)D and serum PTH concentration. After each seasonal visit, the individuals completed 4-day diet diaries and used two dosimeter badges for 1 week to estimate weekly UVR exposure. A questionnaire was applied to provide information about lifestyle and their ethnicity. Residential greenness was measured by Normalized Difference Vegetation Index (NDVI), within a 1000 m radius around each participant's home address. Women living in greener spaces were more likely to have improved vitamin D status (RR: 1.51; 95%CI: 1.13-2.02), as well as those who were more exposed to UVR (RR: 2.05; 95%CI: 1.44-2.92). Our results provide an insight into the connection between residential greenness, lifestyle, and vitamin D status comparing two ethnicities in a country with a temperate climate and with a high degree of urbanization.
MeSH term(s)	Humans ; Female ; Vitamin D/blood ; Vitamin D/analogs & derivatives ; Longitudinal Studies ; Life Style ; Middle Aged ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/ethnology ; Vitamin D Deficiency/epidemiology ; Adult ; White People ; Asian People ; Sunlight ; Parathyroid Hormone/blood ; United Kingdom/epidemiology ; Ultraviolet Rays ; Aged ; Residence Characteristics
Chemical Substances	Vitamin D (1406-16-2) ; Parathyroid Hormone ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081214
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Article ; Online: Association of free vitamin D

Lima, John J / Castro, Mario / King, Tonya S / Lang, Jason E / Ortega, Victor E / Peters, Stephen P / Denlinger, Loren C / Israel, Elliot / Sorkness, Christine A / Wechsler, Michael E / Wenzel, Sally E / Smith, Lewis J

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2018 Volume 121, Issue 4, Page(s) 444–450.e1

Abstract: Background: Use of vitamin D: Objective: To determine associations between free vitamin D3 ... in the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma (VIDA) trial.: Methods: Free ... was inferior to total concentrations as a biomarker of efficacy of vitamin D ...

Abstract	Background: Use of vitamin D Objective: To determine associations between free vitamin D3 concentrations and rates of treatment failure and exacerbations in patients with asthma participating in the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma (VIDA) trial. Methods: Free concentrations were directly measured by enzyme-linked immunosorbent assay and stratified into low, medium, and high groups: less than 5pg/mL (n = 65), 5 to 9pg/mL (n = 84), and greater than 9pg/mL (n = 48) after 12 weeks of supplementation with oral vitamin D3 and associated with outcomes. Results: Outcomes did not associate with free concentrations: overall treatment failure rates were 0.60 (95% confidence interval [CI] 0.46-0.78), 0.53 (95%CI 0.40- 0.70), and 0.69 (95%CI 0.54-0.90)/person-year (P = .51), respectively; overall exacerbation rates were 0.28 (95%CI 0.17-0.48), 0.15 (95%CI 0.08-0.30) and 0.42 (95%CI 0.27-0.66)/person-year (P = .22). Mean (standard deviation) baseline free concentrations were lower in non-Hispanic blacks and Hispanics compared with non-Hispanic whites: 4.10 (1.33) and 4.38 (1.11) pg/mL vs 5.16 (1.65) pg/ml, (P < .001 and P = 0.038), respectively. Mean (standard deviation) baseline free concentrations differed between females and males: 4.57 (1.58) and 5.08 (1.41) (P = .026); and between non-overweight (body mass index [BMI] < 25) and overweight (BMI > 25): 5.45 (1.86) vs 4.54 (1.39) (P < .001). The free fraction differed by race and sex but not by BMI. Conclusion: The use of free concentrations was inferior to total concentrations as a biomarker of efficacy of vitamin D
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/diagnosis ; Asthma/therapy ; Body Mass Index ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Disease Progression ; Female ; Humans ; Male ; Risk ; Sex Factors ; Treatment Failure ; Vitamin D Deficiency ; Vitamin D-Binding Protein/metabolism
Chemical Substances	Adrenal Cortex Hormones ; Vitamin D-Binding Protein ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2018-06-14
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2018.06.001
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Article ; Online: The link between vitamin D deficiency and Covid-19 in a large population

Israel, A. / Cicurel, A. A. / Feldhamer, I. / Dror, Y. / Giveon, S. M. / Gillis, D. / Strich, D. / Lavie, G.

Abstract: BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection ... We collected results from vitamin D tests performed between 2010 and 2019 and used weighted linear regression ... to assess the relationship between prevalence of vitamin D deficiency and Covid-19 incidence in 200 ...

Abstract	BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection. In our population we observe major differences in Covid-19 incidence in ethnic groups and genders in each group. METHODS We carried out a population-based study among 4.6 million members of Clalit Health Services (CHS). We collected results from vitamin D tests performed between 2010 and 2019 and used weighted linear regression to assess the relationship between prevalence of vitamin D deficiency and Covid-19 incidence in 200 localities. Additionally, we matched 52,405 infected patients with 524,050 control individuals of the same sex, age, geographical region and used conditional logistic regression to assess the relationship between baseline vitamin D levels, acquisition of vitamin D supplements in the last 4 months, and positive Covid-19. RESULTS We observe a highly significant correlation between prevalence of vitamin D deficiency and Covid-19 incidence, and between female-to-male ratio for severe vitamin D deficiency and female-to-male ratio for Covid-19 incidence in localities (P<0.001). In the matched cohort, we found a significant association between low vitamin D levels and the risk of Covid-19, with the highest risk observed for severe vitamin D deficiency. A significant protective effect was observed for members who acquired liquid vitamin D formulations (drops) in the last 4 months. CONCLUSION In this large observational population study, we show a strong association between vitamin D deficiency and Covid-19 occurrence. After adjustment for baseline characteristics and prior vitamin D levels, acquisition of liquid vitamin D formulations is associated with decreased risk for Covid-19 infection.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.09.04.20188268
Database	COVID19

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Article ; Online: The link between vitamin D deficiency and Covid-19 in a large population

Israel, Ariel / Cicurel, Assi Albert / Feldhamer, Ilan / Dror, Yosef / Giveon, Shmuel M / Gillis, David / Strich, David / Lavie, Gil

medRxiv

Abstract	BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection. In our population we observe major differences in Covid-19 incidence in ethnic groups and genders in each group. METHODS We carried out a population-based study among 4.6 million members of Clalit Health Services (CHS). We collected results from vitamin D tests performed between 2010 and 2019 and used weighted linear regression to assess the relationship between prevalence of vitamin D deficiency and Covid-19 incidence in 200 localities. Additionally, we matched 52,405 infected patients with 524,050 control individuals of the same sex, age, geographical region and used conditional logistic regression to assess the relationship between baseline vitamin D levels, acquisition of vitamin D supplements in the last 4 months, and positive Covid-19. RESULTS We observe a highly significant correlation between prevalence of vitamin D deficiency and Covid-19 incidence, and between female-to-male ratio for severe vitamin D deficiency and female-to-male ratio for Covid-19 incidence in localities (P<0.001). In the matched cohort, we found a significant association between low vitamin D levels and the risk of Covid-19, with the highest risk observed for severe vitamin D deficiency. A significant protective effect was observed for members who acquired liquid vitamin D formulations (drops) in the last 4 months. CONCLUSION In this large observational population study, we show a strong association between vitamin D deficiency and Covid-19 occurrence. After adjustment for baseline characteristics and prior vitamin D levels, acquisition of liquid vitamin D formulations is associated with decreased risk for Covid-19 infection.
Keywords	covid19
Language	English
Publishing date	2020-09-07
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.09.04.20188268
Database	COVID19

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Article: Vitamin D levels in the pre- and post-COVID-19 pandemic periods in pediatric patients with chronic kidney disease.

Parra-Ortega, Israel / Zurita-Cruz, Jessie Nallely / Ortiz-Flores, Itzel / Romero-Navarro, Benjamin / Villasis-Keever, Miguel Angel / Martínez, Briceida López / Domínguez-Castillo, Veronica / Romo-Vázquez, José Carlos

Frontiers in nutrition

2023 Volume 10, Page(s) 1268347

Abstract: Introduction: Vitamin D (VD) deficiency is common in children with chronic kidney disease (CKD ... 25-[OH]D) in children with CKD.: Materials and methods: This retrospective study included patients ... between May 2019 and December 2022. Serum 25-(OH)D levels were measured before, during, and after ...

Abstract	Introduction: Vitamin D (VD) deficiency is common in children with chronic kidney disease (CKD) because of multiple factors. During the coronavirus disease 2019 (COVID-19) pandemic, it increased because of medicine shortage and no enough medical service for patients with non-COVID-19 diseases. Objective: To analyze the effects of the COVID-19 pandemic-related lockdown on the serum levels and status of 25-hydroxyvitamin D3 (25-[OH]D) in children with CKD. Materials and methods: This retrospective study included patients (6-18 years old) who were diagnosed with CKD stage 2-5 and routinely measured for serum VD levels between May 2019 and December 2022. Serum 25-(OH)D levels were measured before, during, and after the pandemic (2019, 2020-2021, and 2022, respectively). The daily dose of cholecalciferol supplementation and the readjustment (if required) were recorded. Results: This study included 171 patients (median age: 12 years). Before the pandemic, the median serum VD level was 25.0 ng/mL (19.3% VD deficiency). Then, VD supplementation was adjusted to 400-1,200 UI daily in 98.8% ( Conclusion: Decreased serum VD levels and increased VD deficiency frequency were observed in patients with CKD during the COVID-19 but improved after readjustment of supplementation.
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1268347
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Article ; Online: Transcontinental Dissemination of the L2b/D-Da Recombinant Chlamydia trachomatis Lymphogranuloma venereum (LGV) Strain: Need of Broad Multi-Country Molecular Surveillance.

Borges, Vítor / Isidro, Joana / Correia, Cristina / Cordeiro, Dora / Vieira, Luís / Lodhia, Zohra / Fernandes, Cândida / Rodrigues, Ana Maria / Azevedo, Jacinta / Alves, João / Roxo, João / Rocha, Miguel / Côrte-Real, Rita / Toscano, Cristina / Pessanha, Maria Ana / Nissan, Israel / Pilo, Shlomo / Rorman, Efrat / Dveyrin, Zeev /

Paitan, Yossi / Paran, Haim / Wagner-Kolasko, Gal / Beirnes, Jennifer / Gibbons, Suzanne / Severini, Alberto / Borrego, Maria José / Gomes, João Paulo

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 73, Issue 4, Page(s) e1004–e1007

Abstract: Previously, we identified a Chlamydia trachomatis lymphogranuloma venereum (LGV) recombinant strain possessing a non-LGV ompA genotype. Here, culture-independent genome sequencing confirms its circulation in Europe, Middle East, and North America, and ... ...

Abstract	Previously, we identified a Chlamydia trachomatis lymphogranuloma venereum (LGV) recombinant strain possessing a non-LGV ompA genotype. Here, culture-independent genome sequencing confirms its circulation in Europe, Middle East, and North America, and unveils emergence of antibiotic resistance. Broad surveillance is needed.
MeSH term(s)	Base Sequence ; Chlamydia trachomatis/genetics ; Europe ; Genotype ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/diagnosis ; Male
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab067
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Article ; Online: Fibrose pulmonaire au cours de la poïkilodermie héréditaire sclérosante associée à la mutation du gène FAM111B : à propos d’un cas.

Sanchis-Borja, M / Pastré, J / Mercier, S / Juvin, K / Benattia, A / Israël-Biet, D

Revue des maladies respiratoires

2018 Volume 35, Issue 9, Page(s) 968–973

Abstract: Introduction: Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP) is a recently described, extremely rare, entity belonging to the spectrum of inherited poikilodermas. It is provoked by a mutation of the ...

Title translation	Pulmonary fibrosis associated with hereditary fibrosing poikiloderma caused by FAM111B mutation: A case report.
Abstract	Introduction: Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP) is a recently described, extremely rare, entity belonging to the spectrum of inherited poikilodermas. It is provoked by a mutation of the FAM111B gene. Respiratory involvement has never been fully described but usually involves a restrictive respiratory pattern. We present here a case of pulmonary fibrosis associated with POIKTMP and describe the clinical, functional, radiological and evolutionary characteristics. Observation: A 38 year-old patient with poikiloderma diagnosed in childhood was referred on account of dyspnoea. Initial evaluation showed a diffuse, fibrosing, interstitial pneumonitis with upper lobe predominance, associated with severe muscular involvement on imaging that remained sub-clinical during the evolution of the disease. Lung function impairment was severe and a rapid worsening of the pulmonary fibrosis and an acute exacerbation led to death after a follow-up of 21 months. Conclusion: This case illustrates the fibrosing pulmonary involvement associated with POIKTMP and confirms its extreme severity. It is found only in adults and is universally fatal after a variable time. It highlights the necessity for a systematic screening as soon as the diagnosis of POIKTMP is confirmed in order to establish specialised respiratory management.
MeSH term(s)	Adult ; Cell Cycle Proteins/genetics ; Humans ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/genetics ; Male ; Mutation ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/genetics ; Radiography, Thoracic ; Sclerosis/complications ; Sclerosis/diagnosis ; Sclerosis/genetics ; Skin Abnormalities/complications ; Skin Abnormalities/diagnosis ; Skin Abnormalities/genetics ; Skin Diseases, Genetic/complications ; Skin Diseases, Genetic/diagnosis ; Skin Diseases, Genetic/genetics
Chemical Substances	Cell Cycle Proteins ; FAM111B protein, human
Language	French
Publishing date	2018-10-16
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2018.09.002
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Article ; Online: Time in range in patients with type 2 diabetes who are long-term users of d-Nav®, an artificial intelligence-driven technology for autonomous titration of insulin dosing.

Williams, Kevin J / Bashan, Eran / Kruse, Caitlin / Sritharan, Sajitha / Hodish, Israel

Diabetes, obesity & metabolism

2023 Volume 25, Issue 12, Page(s) 3845–3848

Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Letter
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15280
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Article: Efficacy and safety of vitamin D supplementation in hospitalized COVID-19 pediatric patients: A randomized controlled trial.

Zurita-Cruz, Jessie / Fonseca-Tenorio, Jeffry / Villasís-Keever, Miguel / López-Alarcón, Mardia / Parra-Ortega, Israel / López-Martínez, Briceida / Miranda-Novales, Guadalupe

Frontiers in pediatrics

2022 Volume 10, Page(s) 943529

Abstract: Background: Some studies suggested that adequate levels of vitamin D (VD) decrease the risk ...

Abstract	Background: Some studies suggested that adequate levels of vitamin D (VD) decrease the risk of severe COVID-19. Information about the effectiveness of VD supplementation in children is scarce. Objective: To assess the efficacy and safety of VD supplementation compared to the standard of care in hospitalized children with COVID-19. Patients and methods: An open-label randomized controlled single-blind clinical trial was carried out. We included patients from 1 month to 17 years, with moderate COVID-19, who required hospitalization and supplemental oxygen. They were randomized into two groups: the VD group, which received doses of 1,000 (children < 1 year) or 2,000 IU/day (from 1 to 17 years) and the group without VD (control). The outcome variables were the progression of oxygen requirement, the development of complications, and death. Statistical analysis: For comparison between groups, we used the chi-squared test or Fisher's exact test and the Mann-Whitney Results: From 24 March 2020 to 31 March 2021, 87 patients were eligible to participate in the trial; 45 patients were randomized: 20 to the VD group and 25 to the control group. There was no difference in general characteristics at baseline, including serum VD levels (median 13.8 ng/ml in the VD group and 11.4 ng/ml in the control group). Outcomes: 2/20 (10%) in the VD group vs. 9/25 (36%) in the control group progressed to a superior ventilation modality ( Conclusion: In this trial, VD supplementation in pediatric patients seems to decrease the risk of COVID-19 progression and death. More studies are needed to confirm these findings. Clinical trial registration: This protocol was registered on ClinicalTrials.gov with the registration number NCT04502667.
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.943529
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