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Article ; Online: Nanomaterials for intelligent CRISPR-Cas tools: improving environment sustainability.

Bahl, Ekansh / Jyoti, Anupam / Singh, Abhijeet / Siddqui, Arif / Upadhyay, Sudhir K / Jain, Devendra / Shah, Maulin P / Saxena, Juhi

Environmental science and pollution research international

2024

Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is a desirable gene modification tool covering a wide area in various sectors of medicine, agriculture, and microbial biotechnology. The role of this ... ...

Abstract	Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is a desirable gene modification tool covering a wide area in various sectors of medicine, agriculture, and microbial biotechnology. The role of this incredible genetic engineering technology has been extensively investigated; however, it remains formidable with cargo choices, nonspecific delivery, and insertional mutagenesis. Various nanomaterials including lipid, polymeric, and inorganic are being used to deliver the CRISPR-Cas system. Progress in nanomaterials could potentially address these challenges by accelerating precision targeting, cost-effectiveness, and one-step delivery. In this review, we highlighted the advances in nanotechnology and nanomaterials as smart delivery systems for CRISPR-Cas so as to ameliorate applications for environmental remediation including biomedical research and healthcare, strategies for mitigating antimicrobial resistance, and to be used as nanofertilizers for enhancing crop growth, and reducing the environmental impact of traditional fertilizers. The timely co-evolution of nanotechnology and CRISPR technologies has contributed to smart novel nanostructure hybrids for improving the onerous tasks of environmental remediation and biological sustainability.
Language	English
Publishing date	2024-01-31
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32101-x
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Article ; Online: A Sustainable and Regenerative Process for the Treatment of Textile Effluents Using Nonphotocatalytic Water Splitting by Nanoporous Oxygen-Deficient Ferrite.

Shukla, Abha / Shah, Jyoti / Badola, Sunidhi / Mandal, Tuhin K / Agrawal, Ved V / Patra, Asit / Pulamte, Lalsiemlien / Kotnala, Ravinder K

ACS omega

2024 Volume 9, Issue 7, Page(s) 8490–8502

Abstract: Water is crucial for life. Being the world's third-largest industry, the textile industry pollutes 93 billion cubic meters of water each year. Only 28% of textile wastewater is treated by lower- to middle-income countries due to the costly treatment ... ...

Abstract	Water is crucial for life. Being the world's third-largest industry, the textile industry pollutes 93 billion cubic meters of water each year. Only 28% of textile wastewater is treated by lower- to middle-income countries due to the costly treatment methods. The present work demonstrates the utilization of surface oxygen defects and nanopores in Mg
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c09773
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Article ; Online: Management of polyneuropathy using yoga and naturopathic medicine in India: recommendations for future research and clinical practice.

Nair, Pradeep M K / Silwal, Karishma / Keswani, Jyoti / Kriplani, Sucheta / Khan, Vakeel / Maheshwari, Ayush / Shah, Mili Arpan / Jyoti, Naga / Rao, Vinutha / Sreedhar, Cijith / Bhalavat, Kinjal Dilipsinh / Mohanan, Renjish / Subha M, Jerin / Gupta, Rakesh / Sharma, Hemanshu / Tewani, Gulab Rai

Frontiers in pain research (Lausanne, Switzerland)

2023 Volume 4, Page(s) 1264450

Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-561X
ISSN (online)	2673-561X
DOI	10.3389/fpain.2023.1264450
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Article ; Online: New insights from the genetic work-up in early onset nephrotic syndrome: report from a registry in western India.

Sharma, Jyoti / Saha, Anshuman / Ohri, Alpana / More, Vaishali / Shah, Fagun / Dave, Jalpa / Jain, Brinda Panchal / Matnani, Manoj / Sathe, K / Bhansali, Pankaj / Chhajed, Puneet / Deore, Pawan / Pande, Nivedita / Shah, Chintan / Kinnari, Vala / Singhal, Jyoti / Krishnamurthy, Nisha / Agarwal, Meenal / Ali, Uma

Pediatric nephrology (Berlin, Germany)

2024

Abstract: Background: Eighty-five percent of infants with congenital nephrotic syndrome (CNS) and 66% with infantile NS (INS) are likely to have a monogenic etiology. There exists a significant genetic variability between different regions and ethnic groups. This ...

Abstract	Background: Eighty-five percent of infants with congenital nephrotic syndrome (CNS) and 66% with infantile NS (INS) are likely to have a monogenic etiology. There exists a significant genetic variability between different regions and ethnic groups. This study aimed to determine the genetic defects in children with CNS and INS by establishing a registry in western India. Methods: In this cross-sectional study, pediatric nephrologists from 13 private and government institutions shared relevant clinical data and details of the genetic evaluation of children presenting with NS within the first year of life. Results: The median age at presentation was 9 months (range 1-23, IQR 3-13 months), history of consanguinity between parents existed in 14 patients (34%), family history of similar illness in 6 (15%), and extra-renal manifestations in 17 (41%). Twenty-five (61%) were confirmed to have a monogenic etiology. NPHS1 gene was the most implicated (9/25) followed by PLCE1 (5/25). There were 12 variants of uncertain significance (VUS) involving 10 genes (10/25, 40%), and no definite genetic abnormality was found in 4 (25%). A re-analysis of these VUS attempted 2-3 years later facilitated reclassification of 7/12 (58%); increasing the diagnostic yield from 61 to 68.2%. Conclusions: Consistent with worldwide data, variants in NPHS1 gene were the most common cause of NS in infancy; however, PLCE1 was implicated more frequently in our cohort. NUP93 and COL4A3 were reported in early onset NS for the first time. Reclassification of VUS should be attempted, if feasible, since it may lead to a useful revision of diagnosis.
Language	English
Publishing date	2024-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06295-8
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Article: Highly Accelerated, Sustainable, Abundant Water Splitting at Room Temperature Generating Green Electricity by Sb-Doped SnO₂ Hydroelectric Cell

Shah, Jyoti / Shukla, Abha / Kotnala, R. K.

ACS sustainable chemistry & engineering. 2021 Nov. 01, v. 9, no. 45

2021

Abstract: Hydroelectric cell (HEC), a revolutionary invention, has created a new exclusive domain in green energy generation by defect-assisted water splitting/dissociation on metal oxides. In the present work, doping of metallic antimony (Sb) in tin oxide (SnO₂) ... ...

Abstract	Hydroelectric cell (HEC), a revolutionary invention, has created a new exclusive domain in green energy generation by defect-assisted water splitting/dissociation on metal oxides. In the present work, doping of metallic antimony (Sb) in tin oxide (SnO₂) abundantly produced oxygen vacancies. It significantly increased the active centers for adsorption and dissociation of water that ultimately led to highly accelerated water splitting to generate a record high current in a Sb–SnO₂-based HEC. The photoluminescence (PL) emission peak at 656 nm confirms the electronic transitions to defect levels generated by tin (Sn) interstitials. Raman spectroscopy showed enhanced in-plane oxygen vacancies with the presence of the prominent broadening of the 571 cm–¹ mode. The X-ray photoemission spectroscopy (XPS) results suggest that a large amount of antimony is segregated on the surface and grain boundaries in the 3+ oxidation state. A large number of defect pair Sb³⁺–Vₒ** centers accompanied by a highly reduced surface due to Sb led to 4-fold current production by the HEC based on Sb–SnO₂ compared to SnO₂. The g values calculated from electron paramagnetic resonance (EPR) spectroscopy for SnO₂ and Sb–SnO₂ as 2.12 and 2.15, respectively, confirmed oxygen vacancies. The Sb–SnO₂-based HEC recorded a remarkable short circuit current density, Iₛc ∼ 23.2 mA/cm², and peak output power, Pₒᵤₜ ∼ 32.2 mW/cm². Antimony doping decreases the bulk resistance of the cell by 45 times due to highly accelerated OH– and H₃O⁺ conduction in Sb–SnO₂ HEC as observed by Nyquist plots. The defects-decorated Sb–SnO₂-based HEC possesses an ultimate capability to replace solar cells and fuel cells.
Keywords	Raman spectroscopy ; X-ray photoelectron spectroscopy ; adsorption ; ambient temperature ; antimony ; dissociation ; electron paramagnetic resonance spectroscopy ; green chemistry ; oxidation ; oxygen ; photoluminescence ; tin ; tin dioxide
Language	English
Dates of publication	2021-1101
Size	p. 15229-15238.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.1c04899
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fabrication of a SnO

Gaur, Anurag / Kumar, Anurag / Kumar, Purushottam / Agrawal, Rekha / Shah, Jyoti / Kotnala, Ravinder K

ACS omega

2020 Volume 5, Issue 18, Page(s) 10240–10246

Abstract: The generation of electricity by dissociating water into ... ...

Abstract	The generation of electricity by dissociating water into H
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.9b03309
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Article: Effect of Li⁺, Mg²⁺, and Al³⁺ Substitution on the Performance of Nickel Ferrite-Based Hydroelectric Cells

Saini, Sandeep / Yadav, Kanhaiya L. / Shah, Jyoti / Kotnala, Ravinder K.

Energy & fuels. 2022 June 27, v. 36, no. 13

2022

Abstract: Defect engineering in nickel ferrite has been performed to enhance the power output of the hydroelectric cell (HEC). Oxygen vacancies can be tuned in the ferrite using different valence element substitutions to enhance water dissociation by hydroelectric ...

Abstract	Defect engineering in nickel ferrite has been performed to enhance the power output of the hydroelectric cell (HEC). Oxygen vacancies can be tuned in the ferrite using different valence element substitutions to enhance water dissociation by hydroelectric cells. In this work, Li⁺, Mg²⁺, and Al³⁺ substituted at the nickel site in nickel ferrite (NiFe₂O₄) are synthesized and studied for hydroelectric cell devices. Introducing these Li⁺, Mg²⁺, and Al³⁺ substituents (of a different atomic radius and valence charge state) in nickel ferrite leads to the generation of oxygen vacancy differently, which is discussed thoroughly in this work. In comparison to Mg and Al, lithium substitution lowers the overall cationic charge in nickel ferrite, leading to formation of a high number of oxygen vacancies for overall ionic charge compensation. Lithium-substituted nickel ferrite (NLFO) has a high number of defects (oxygen vacancies, etc.) compared to Mg-substituted (NMFO) and Al-substituted (NAFO) nickel ferrite, confirmed by X-ray photoelectron spectroscopy (XPS) and photoluminescence (PL) spectroscopy. The highest peak area of oxygen vacancies in the O 1s core-level spectra has been obtained for the case of NLFO among NLFO, NMFO, and NAFO. These vacancy sites provide a large number of adsorption sites for water molecule adsorption and dissociation. A high lattice strain (9.83 × 10–⁴) is induced in NLFO calculated by the Williamson–Hall plot. The porous nature of all samples has been confirmed from FESEM and BET analysis. The charge transfer processes in dry and wet HECs have been analyzed by fitting an equivalent RC circuit in the Nyquist spectra. The lithium-substituted nickel ferrite HEC with rich oxygen vacancies generates a high short-circuit current of ∼58.7 mA, which is ∼2 times higher than that of NMFO HEC and ∼3 times higher than that of NAFO HEC.
Keywords	X-ray photoelectron spectroscopy ; adsorption ; dissociation ; energy ; ferrimagnetic materials ; lithium ; nickel ; oxygen ; photoluminescence
Language	English
Dates of publication	2022-0627
Size	p. 7121-7129.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1483539-3
ISSN	1520-5029 ; 0887-0624
ISSN (online)	1520-5029
ISSN	0887-0624
DOI	10.1021/acs.energyfuels.2c01244
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Article ; Online: Fabrication of a SnO2‑Based Hydroelectric Cell for Green Energy Production

Anurag Gaur / Anurag Kumar / Purushottam Kumar / Rekha Agrawal / Jyoti Shah / Ravinder K. Kotnala

ACS Omega, Vol 5, Iss 18, Pp 10240-

2020 Volume 10246

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Feasibility of a "Salvage Regimen" Using Home-based Intravenous Meropenem Therapy With a Delamanid/Bedaquilline Containing Regimen in the Management of MDR/XDR Pediatric Tuberculosis.

Shah, Ira / Antony, Sonu / Jaiswal, Akanksha / Bodhanwala, Minnie / Shah, Daksha / Tipre, Pranita / Salve, Jyoti / Parmar, Malik / Sachdeva, K S

The Pediatric infectious disease journal

2022 Volume 41, Issue 5, Page(s) 401–404

Abstract: Introduction: The prevalence of multidrug resistant (MDR) tuberculosis (TB) with additional resistance to fluoroquinolones or second-line injectables (MDRFQ/SLI)/extensively drug-resistant TB (XDR-TB) in children is high in Mumbai. There are limited ... ...

Abstract	Introduction: The prevalence of multidrug resistant (MDR) tuberculosis (TB) with additional resistance to fluoroquinolones or second-line injectables (MDRFQ/SLI)/extensively drug-resistant TB (XDR-TB) in children is high in Mumbai. There are limited therapeutic options available in management of such children. Carbapenems, although approved for this indication, requires 2 to 3 daily injections, which are cumbersome. Bedaquilline (Bdq) and Delamanid (Dlm), the new antitubercular drugs still remain inaccessible to this subset of patients caused by conditional approvals. Hence, newer strategies to combat MDRFQ/SLI/XDR-TB needs to be explored. Objectives: To study feasibility and interim outcomes of a "salvage regimen" using home-based carbapenem therapy through peripherally inserted central catheter as part of a longer (18-20 months) optimized background regimen including Dlm or Bdq or both in pediatric MDRFQ/SLI/XDR-TB patients who failed a standard MDR-TB regimen under the National Tuberculosis Elimination Programme in Mumbai, India. Design and methods: Retrospective descriptive analysis study. National Tuberculosis Elimination Programme medical records of all MDRFQ/SLI/XDR-TB patients enrolled at the pediatric TB clinic at BJ Wadia Hospital for Children, Mumbai who were initiated on such "salvage regimen" during the period between April 2018 and December 2020 were retrospectively studied. Treatment outcomes and adverse events were described. Results: Of the 15 patients enrolled, mean age of the patient population was 12.53 ± 2.47 years and the female:male ratio was 13:2. Seven patients had XDR-TB while 8 patients had MDRFQ/SLI. Most common adverse event noted was dyselectrolytemia (3 patients). Catheter-related complications were reported in 5 patients and included catheter blockage, leak, and thrombosis. Sputum culture conversion was reported in all of the patients. One child mortality was reported and 2 patients were lost to follow up during study period. Conclusions: Home-based meropenem therapy using peripherally inserted central catheter is feasible with few adverse effects. This can be a promising strategy in the management of MDRFQ/SLI/XDR-TB when an effective oral regimen cannot be otherwise constituted and needs to be explored further.
MeSH term(s)	Adolescent ; Antitubercular Agents ; Child ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Feasibility Studies ; Female ; Humans ; Male ; Meropenem/therapeutic use ; Nitroimidazoles ; Oxazoles ; Retrospective Studies ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/epidemiology
Chemical Substances	Antitubercular Agents ; Nitroimidazoles ; OPC-67683 ; Oxazoles ; Meropenem (FV9J3JU8B1)
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003486
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Article: Multiple Myeloma Therapy: Emerging Trends and Challenges.

Dima, Danai / Jiang, Dongxu / Singh, Divya Jyoti / Hasipek, Metis / Shah, Haikoo S / Ullah, Fauzia / Khouri, Jack / Maciejewski, Jaroslaw P / Jha, Babal K

Cancers

2022 Volume 14, Issue 17

Abstract: Multiple myeloma (MM) is a complex hematologic malignancy characterized by the uncontrolled proliferation of clonal plasma cells in the bone marrow that secrete large amounts of immunoglobulins and other non-functional proteins. Despite decades of ... ...

Abstract	Multiple myeloma (MM) is a complex hematologic malignancy characterized by the uncontrolled proliferation of clonal plasma cells in the bone marrow that secrete large amounts of immunoglobulins and other non-functional proteins. Despite decades of progress and several landmark therapeutic advancements, MM remains incurable in most cases. Standard of care frontline therapies have limited durable efficacy, with the majority of patients eventually relapsing, either early or later. Induced drug resistance via up-modulations of signaling cascades that circumvent the effect of drugs and the emergence of genetically heterogeneous sub-clones are the major causes of the relapsed-refractory state of MM. Cytopenias from cumulative treatment toxicity and disease refractoriness limit therapeutic options, hence creating an urgent need for innovative approaches effective against highly heterogeneous myeloma cell populations. Here, we present a comprehensive overview of the current and future treatment paradigm of MM, and highlight the gaps in therapeutic translations of recent advances in targeted therapy and immunotherapy. We also discuss the therapeutic potential of emerging preclinical research in multiple myeloma.
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14174082
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