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Article ; Online: Big data analysis of water quality monitoring results from the Xiang River and an impact analysis of pollution management policies.

Zeng, Yangyan / Zhou, Yidong / Cao, Wenzhi / Hu, Dongbin / Luo, Yueping / Pan, Haiting

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 5, Page(s) 9443–9469

Abstract: Water pollution prevention and control of the Xiang River has become an issue of great concern ... local governmental policies on water pollution prevention and control for the Xiang River, this study performs a big ... of the Xiang River, Hunan Province, China from 2005 to 2016. This study uses an evidential reasoning-based ...

Abstract	Water pollution prevention and control of the Xiang River has become an issue of great concern to China's central and local governments. To further analyze the effects of central and local governmental policies on water pollution prevention and control for the Xiang River, this study performs a big data analysis of 16 water quality parameters from 42 sections of the mainstream and major tributaries of the Xiang River, Hunan Province, China from 2005 to 2016. This study uses an evidential reasoning-based integrated assessment of water quality and principal component analysis, identifying the spatiotemporal changes in the primary pollutants of the Xiang River and exploring the correlations between potentially relevant factors. The analysis showed that a series of environmental protection policies implemented by Hunan Province since 2008 have had a significant and targeted impact on annual water quality pollutants in the mainstream and tributaries. In addition, regional industrial structures and management policies also have had a significant impact on regional water quality. The results showed that, when examining the changes in water quality and the effects of pollution control policies, a big data analysis of water quality monitoring results can accurately reveal the detailed relationships between management policies and water quality changes in the Xiang River. Compared with policy impact evaluation methods primarily based on econometric models, such a big data analysis has its own advantages and disadvantages, effectively complementing the traditional methods of policy impact evaluations. Policy impact evaluations based on big data analysis can further improve the level of refined management by governments and provide a more specific and targeted reference for improving water pollution management policies for the Xiang River.
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023415
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Article ; Online: A discussion of morphological differences within Claassenia qingzanga Xiang, Huo amp; Du, 2022 (Plecoptera: Perlidae) based on molecular data and a redescription of C. magna Wu, 1948.

Xiang, Ya-Nan / Huo, Qing-Bo / DU, Yu-Zhou

Zootaxa

2022 Volume 5141, Issue 3, Page(s) 287–294

Abstract: ... of males of Claassenia qingzanga Xiang, Huo Du, 2021 collected from the Qinghai Province of China have ...

Abstract	In the genus Claassenia Wu, 1934, the sensilla basiconica patch is an important identification characteristic, yet there are few studies that have investigated this trait. Recently, we found that tergum 8 of males of Claassenia qingzanga Xiang, Huo Du, 2021 collected from the Qinghai Province of China have a small, scattered basiconica patch, while the specimens collected from the Tibet Autonomous Region of China lack this characteristic. To verify their genetic relationship, we sequenced the mitochondrial cytochrome C oxidase subunit I gene of C. qingzanga collected from Tibet and Qinghai provinces. Phylogenetic analyses using Maximum Likelihood and Bayesian Inference methods, the two forms of C. qingzanga grouped together with strong nodal support and separate from the other Claassenia species analyzed. Genetic distance among these two forms of C. qingzanga is only about 1%. The molecular analyses confirmed that specimens with morphological differences are indeed the same species. A discussion of morphological differences within C. qingzanga and its genetic relationships are presented based on molecular data. Additionally, Claassenia magna Wu, 1948 is redescribed based on recent specimens.
MeSH term(s)	Animal Distribution ; Animals ; Bayes Theorem ; Insecta ; Male ; Neoptera ; Phylogeny
Language	English
Publishing date	2022-05-26
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5141.3.6
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Article ; Online: Quercetin serves as the major component of Xiang-lian Pill to ameliorate ulcerative colitis via tipping the balance of STAT1/PPARγ and dictating the alternative activation of macrophage.

Zhou, Hai-Feng / Yang, Chao / Li, Jun-Yi / He, Yu-Yao / Huang, Yun / Qin, Ren-Jie / Zhou, Qiao-Li / Sun, Fei / Hu, De-Sheng / Yang, Jia

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116557

Abstract: Ethnopharmacological relevance: The traditional Chinese herbal formula, Xiang-lian Pill (XLP), is ...

Abstract	Ethnopharmacological relevance: The traditional Chinese herbal formula, Xiang-lian Pill (XLP), is commonly prescribed for ulcerative colitis (UC) patients to relieve their clinical symptom. Nonetheless, the underlying cellular and molecular mechanisms of XLP's anti-UC effect remain incompletely understood. Aim of the study: To evaluate the therapeutic effect and elucidate the possible working mechanisms of XLP in UC treatment. The major active component of XLP was also characterized. Materials and methods: Colitis was induced in C57BL/6 mice with 3% dextran sulfate sodium (DSS) dissolved in drinking water for 7 consecutive days. The UC mice were grouped and treated with XLP (3640 mg/kg) or vehicle orally during the procedure of DSS induction. Mouse body weight, disease activity index (DAI) score and colon length were recorded. Histopathological changes and inflammatory cell infiltration were evaluated by pathological staining and flow cytometric analysis (FACS). Network pharmacology, bioinformatic analysis, widely targeted and targeted metabolomics analysis were performed to screen the potential effective ingredients and key targets. Bone marrow derived macrophages (BMDMs), peripheral blood mononuclear cells (PBMCs), RAW264.7 and THP-1 cells were used to dissect the anti-inflammatory effect of XLP. Results: Oral administration of XLP ameliorated DSS induced mouse colitis, as evidenced by reduced DAI and colonic inflammatory destruction. FACS results demonstrated that XLP treatment effectively restored immune tolerance in colon, inhibited the generation of monocyte derived macrophages and skewed macrophage polarization into M2 phenotype. Network pharmacology analysis suggested that innate effector modules related to macrophage activation comprise the major targets of XLP, and the counter-regulatory STAT1/PPARγ signaling possibly serves as the critical downstream pathway. Subsequent experiments unveiled an imbalance of STAT1/PPARγ signaling in monocytes derived from UC patients, and validated that XLP suppressed LPS/IFN-γ induced macrophage activation (STAT1 mediated) but facilitated IL-4 induced macrophage M2 polarization (PPARγ dependent). Meanwhile, our data showed that quercetin served as the major component of XLP to recapitulate the regulatory effect on macrophages. Conclusion: Our findings revealed that quercetin serves as the major component of XLP that regulates macrophage alternative activation via tipping the balance of STAT1/PPARγ, which provides a mechanistic explanation for the therapeutic effect of XLP in UC treatment.
MeSH term(s)	Animals ; Mice ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; PPAR gamma/metabolism ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Quercetin/metabolism ; Leukocytes, Mononuclear/metabolism ; Mice, Inbred C57BL ; Colon ; Colitis/drug therapy ; Macrophages ; Dextran Sulfate/toxicity ; Disease Models, Animal ; STAT1 Transcription Factor/metabolism
Chemical Substances	PPAR gamma ; Quercetin (9IKM0I5T1E) ; Dextran Sulfate (9042-14-2) ; Stat1 protein, mouse ; STAT1 Transcription Factor
Language	English
Publishing date	2023-05-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116557
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Article ; Online: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology

2022 Volume 298, Page(s) 115679

Abstract: Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal ...

Abstract	Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. Aims of the study: To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. Materials and methods: A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Results: Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. Conclusion: MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Medicine, Tibetan Traditional ; Mice ; NF-kappa B ; NLR Proteins ; Network Pharmacology ; Powders/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; NLR Proteins ; Powders
Language	English
Publishing date	2022-09-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Detection of genomic structure variants associated with wrinkled skin in Xiang pig by next generation sequencing.

Xiaoli, Liu / Fengbin, Hu / Shihui, Huang / Xi, Niu / Sheng, Li / Zhou, Wang / Xueqin, Ran / Jiafu, Wang

Aging

2021 Volume 13, Issue 22, Page(s) 24710–24739

Abstract: ... wrinkles and thickened skin was discovered in Xiang pig populations with incidence about 1-3%. The feature ... mechanisms for the mutant phenotype of Xiang pigs with systemic wrinkle (WXP), a genome-wide of structural ... variations (SVs) in WXP was described by next generation resequencing, taking Xiang pigs (XP) and European ...

Abstract	Wrinkling is prominent manifestation of aging skin. A mutant phenotype characterized by systemic wrinkles and thickened skin was discovered in Xiang pig populations with incidence about 1-3%. The feature in histological structure was epidermal hyperplasia and thickening, collagen fibers disorder. To uncover genetic mechanisms for the mutant phenotype of Xiang pigs with systemic wrinkle (WXP), a genome-wide of structural variations (SVs) in WXP was described by next generation resequencing, taking Xiang pigs (XP) and European pigs (EUP) as compares. Total of 32,308 SVs were detected from three pig groups and 965 SVs were identified specifically from WXP, involving 481 protein-coding genes. These genes were mainly enriched in nuclear structure, ECM components and immunomodulatory pathways. According to gene function and enrichment analysis, we found that 65 candidate SVs in 59 protein genes were probably related with the systemic wrinkle of WXP. Of these, several genes are reported to be associate with aging, such as
MeSH term(s)	Animals ; Female ; Genomic Structural Variation/genetics ; High-Throughput Nucleotide Sequencing ; Sequence Analysis, DNA ; Skin Aging/genetics ; Sus scrofa/genetics ; Swine
Language	English
Publishing date	2021-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203711
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Article: Comparative Analysis of Promoters and Enhancers in the Pituitary Glands of the Bama Xiang and Large White Pigs.

Zhou, Zhimin / Zhu, Yaling / Zhang, Zhen / Jiang, Tao / Ling, Ziqi / Yang, Bin / Li, Wanbo

Frontiers in genetics

2021 Volume 12, Page(s) 697994

Abstract: ... in the pituitary gland of adult Bama Xiang and Large White pigs, which have divergent evolutionary histories and large ... between Bama Xiang and Large White pigs. ...

Abstract	The epigenetic regulation of gene expression is implicated in complex diseases in humans and various phenotypes in other species. There has been little exploration of regulatory elements in the pig. Here, we performed chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to profile histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 acetylation (H3K27ac) in the pituitary gland of adult Bama Xiang and Large White pigs, which have divergent evolutionary histories and large phenotypic differences. We identified a total of 65,044 non-redundant regulatory regions, including 23,680 H3K4me3 peaks and 61,791 H3K27ac peaks (12,318 proximal and 49,473 distal), augmenting the catalog of pituitary regulatory elements in pigs. We found 793 H3K4me3 and 3,602 H3K27ac peaks that show differential activity between the two breeds, overlapping with genes involved in the Notch signaling pathway, response to growth hormone (GH), thyroid hormone signaling pathway, and immune system, and enriched for binding motifs of transcription factors (TFs), including JunB, ATF3, FRA1, and BATF. We further identified 2,025 non-redundant super enhancers from H3K27ac ChIP-seq data, among which 302 were shared in all samples of cover genes enriched for biological processes related to pituitary function. This study generated a valuable dataset of H3K4me3 and H3K27ac regions in porcine pituitary glands and revealed H3K4me3 and H3K27ac peaks with differential activity between Bama Xiang and Large White pigs.
Language	English
Publishing date	2021-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.697994
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Article: [Overview of traditional Chinese medicine of "Xiang Qi" theory of origins].

Zhou, X M / Lu, X / Chen, X G / Meng, Y M

Zhonghua yi shi za zhi (Beijing, China : 1980)

2018 Volume 48, Issue 3, Page(s) 153–157

Abstract: The theory of "Xiang Qi" (inspecting Qi or inspecting pneumata) is an important method of TCM ... inspection.It has important value in clinical diagnosis.The theoretical framework of "Xiang Qi" has been ...

Abstract	The theory of "Xiang Qi" (inspecting Qi or inspecting pneumata) is an important method of TCM inspection.It has important value in clinical diagnosis.The theoretical framework of "Xiang Qi" has been formed from the
MeSH term(s)	China ; Humans ; Medicine, Chinese Traditional ; Qi
Language	Chinese
Publishing date	2018-10-11
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.issn.0255-7053.2018.03.004
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Zs.A 4688: Show issues

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Article ; Online: Metabolomics Characterize the Differential Metabolic Markers between Bama Xiang Pig and Debao Pig to Identify Pork

Chen, Changyi / Zheng, Junwen / Xiong, Chenyong / Zhou, Hongjin / Wei, Chuntao / Hu, Xin / Qian, Xinxiu / He, Mengyi / Shi, Yandi / Liu, Yuwen / Li, Zongqiang

Foods. 2022 Dec. 20, v. 12, no. 1

2022

Abstract: The Bama Xiang pig (BM) is a unique pig species in Guangxi Province, China. Compared ... resistant to rough feeding and strong in stress resistance. These unique advantages of Bama Xiang pigs make ... Bama Xiang pigs (BM) and Debao pigs (DB) are largely unexplored. Here, we identified 214 differential ...

Abstract	The Bama Xiang pig (BM) is a unique pig species in Guangxi Province, China. Compared to other breeds of domestic pig, such as the Debao pig (DB), it is smaller in size, better in meat quality, resistant to rough feeding and strong in stress resistance. These unique advantages of Bama Xiang pigs make them of great edible value and scientific research value. However, the differences in muscle metabolites between Bama Xiang pigs (BM) and Debao pigs (DB) are largely unexplored. Here, we identified 214 differential metabolites between these two pig breeds by LC-MS. Forty-one such metabolites are enriched into metabolic pathways, and these metabolites correspond to 11 metabolic pathways with significant differences. In Bama pigs, the abundance of various metabolites such as creatine, citric acid, L-valine and hypoxanthine is significantly higher than in Debao pigs, while the abundance of other metabolites, such as carnosine, is significantly lower. Among these, we propose six differential metabolites: L-proline, citric acid, ribose 1-phosphate, L-valine, creatine, and L-arginine, as well as four potential differential metabolites (without the KEGG pathway), alanyl-histidine, inosine 2′-phosphate, oleoylcarnitine, and histidinyl hydroxyproline, as features for evaluating the meat quality of Bama pigs and for differentiating pork from Bama pigs and Debao pigs. This study provides a proof-of-concept example of distinguishing pork from different pig breeds at the metabolite level and sheds light on elucidating the biological processes underlying meat quality differences. Our pork metabolites data are also of great value to the genomics breeding community in meat quality improvement.
Keywords	arginine ; carnosine ; citric acid ; creatine ; genomics ; hydroxyproline ; hypoxanthine ; inosine ; meat quality ; metabolites ; metabolomics ; muscles ; pork ; proline ; ribose ; stress tolerance ; swine ; valine ; China
Language	English
Dates of publication	2022-1220
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12010005
Database	NAL-Catalogue (AGRICOLA)

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Article: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect ...

Abstract	Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
Keywords	cold ; flavonoids ; hyperuricemia ; kidney diseases ; mechanism of action ; mice ; mitogen-activated protein kinase ; models ; pharmacology ; terpenoids ; therapeutics ; traditional medicine ; transcription factor NF-kappa B
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	NAL-Catalogue (AGRICOLA)

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Article: Integrated Network Pharmacology and GC-MS-Based Metabolomics to Investigate the Effect of Xiang-Su Volatile Oil Against Menopausal Depression.

Li, Yao / Yang, Xinyi / Chen, Shanshan / Wu, Lei / Zhou, Jinyong / Jia, Keke / Ju, Wenzheng

Frontiers in pharmacology

2021 Volume 12, Page(s) 765638

Abstract: Menopausal depression perplexes a great number of women in later life. Xiangfu-Zisu (Xiang-Su ...

Abstract	Menopausal depression perplexes a great number of women in later life. Xiangfu-Zisu (Xiang-Su), a traditional Chinese herbal pair composed of rhizomes of
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.765638
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